Abstract: Methods of inducing apoptosis in a tissue may include providing a tissue separation and equalization device having a generally elongated tissue insertion member, providing an incision in tissue, inserting the tissue insertion member of the tissue separation and equalization device through the incision into the tissue reducing a temperature of the tissue insertion member and removing the tissue insertion member from the tissue.

Abstract: Systems and methods for integrating a continuous glucose sensor, including a receiver, a medicament delivery device, a controller module, and optionally a single point glucose monitor are provided. Integration may be manual, semi-automated and/or fully automated.

Abstract: The invention provides a multi-channel automatic infusion pump, comprising: a pump body; a pump door; an infusion switching mechanism, an exhaust device and a bubble detection device arranged on the pump body; wherein the infusion switching mechanism includes a multi-channel liquid-stopping clamp, a liquid-stopping clamp fixing base and a driving structure; the multi-channel liquid-stopping clamp includes a body and N channels formed on the body, each channel includes a liquid-passing section and a liquid-stopping section, the liquid-passing section and the liquid-stopping section on each channel are arranged in a manner that any one of a plurality of upper branch tubes is located on the liquid-passing section of the corresponding channel while other upper branch tubes are located on the liquid-stopping section of the corresponding channel. The invention can access at least two bags of liquid medicine at one time, and has the advantages of simple operation, time and labor saving.

Abstract: A fluid flow sensing apparatus and method for detecting pressure and the presence of bubbles within a fluid tube. The flow sensor comprises a housing configured to receive a portion of the tube and to house the pressure sensor and the ultrasonic transmitter. The pressure sensor is positioned adjacent the tube and is configured to receive a pressure sensor signal, which correlates to a detected pressure differential within the tube. An internal controller transmits a drive signal to the ultrasonic transmitter, which emits ultrasonic waves through a portion of the tube and to the pressure sensor. The pressure sensor receives both the ultrasonic waves and a pressure sensor signal, and subsequently transmits an output signal to the internal controller. In the presence of a pressure differential or a bubble within the tube, the output signal will exhibit a DC shift or a distortion of its signal characteristics, respectively.

Abstract: Auto-injector for administering a dose of a liquid medicament includes a housing to contain a syringe with a hollow needle and a stopper for sealing the syringe and displacing the medicament, the housing having a distal end and a proximal end with an orifice to apply against an injection site. A spring means, upon activation, can push the needle from inside the housing through the orifice and past the proximal end, operate the syringe to supply the dose of medicament, and retract the syringe with the needle after delivering the medicament. An activating means can lock the spring means in a pressurized state prior to manual operation and capable of, upon manual operation, releasing the spring means for injection.

Abstract: Presented herein are methods, systems, and apparatus for administering an antibody treatment via an infusion device, e.g., a rapid infusion device, e.g., for the treatment of a disease or condition that requires one or more infusions of monoclonal and/or polyclonal antibodies.

Abstract: Presented herein are methods, systems, and apparatus for administering a monoclonal and/or polyclonal antibody treatment via a rapid infusion device, e.g., for the treatment of a disease, e.g., a disease caused by a pathogen, e.g., for the treatment of COVID-19, caused by the virus SARS-CoV-2, or for the treatment of other conditions/diseases, such as neurological diseases, organ and/or tissue transplants, or certain forms of cancer, that require infusions of monoclonal and/or polyclonal antibodies.

Abstract: A therapeutic device for treating an acute medical condition of a patient such as cardiac arrest is provided. The device includes one or more sensors that monitor parameters such as heart rhythm that relate to the patient's medical condition. The device also includes a plurality of medication reservoirs, each reservoir including a conduit, wherein each reservoir holds a predetermined medication that may be used to treat the condition. A manifold is connected with the reservoirs via their respective conduits. A delivery line is connected with the manifold to deliver fluids from the manifold to the patient intravenously. One or more medication pumps are in fluid connection with respective ones of the reservoirs. A processor is connected with the sensors. The processor includes a memory that stores processing instructions to interpret the parameters and to determine a recommended medication to deliver to the patient based on the parameters, the recommended medication being one of the predetermined medications.

Abstract: The present invention relates to a shell assembly for a medicament delivery device, which shell assembly comprises at least one first shell section provided with an entry passage and designed such that at least a major part of a medicament delivery device entered through said entry passage is accommodated inside said at least one first shell section, a closure element operably arranged to said at least one first shell section for closing said entry passage, and fixation elements arranged for fixating said medicament delivery device in relation to said at least one first shell section and said closure element.

Abstract: A modular medical device catheter including a parent module and an adapter module. An attachment mechanism couples the adapter module to a surface of an inner lumen of the parent module. The attachment mechanism includes a coil in which a surface of the coil directly engages with the surface of the lumen of the parent module. The adapter module can include an elongated element having one or more electrical conductors.

Abstract: A catheter for insertion into a body of a patient, and methods of making and using. The catheter can include a distal portion that remains stable during fluid infusion into the patient, thus reducing or eliminating whipping of the catheter distal tip. The catheter can include a proximal portion including a first cross sectional lumen area; a distal portion including a second cross sectional lumen area larger than the first cross sectional lumen area such that the distal portion prevents whipping when the catheter is disposed in a patient and a fluid exits the catheter. The catheter can be attached to a vascular access port and a method can include power injecting a fluid through the vascular access port and the catheter.

Abstract: A catheter for a hepatic artery introduced from an arm of a patient includes a first bent portion, a second bent portion distal of the first bent portion and bent to the same side as the first bent portion, a third bent portion disposed on a distal side of the second bent portion and bent to an opposite side from the second bent portion, and a most distal end portion disposed distal of the third bent portion, in which a minimum radius of curvature of the first bent portion is larger than a minimum radius of curvature of the second bent portion. The most distal end portion is directed to a common hepatic artery and the first bent portion comes into contact with an aorta wall on an opposite side from a celiac artery when the second bent portion contacts a blood vessel wall of the celiac artery.

Abstract: A hemostasis valve for use in a medical device. The hemostasis valve may include a generally cylindrical body having a proximal side, a distal side, and a thickness extending therebetween. The proximal side may include a tapered central region having a surface sloped towards a center of the body and the distal side may include a distally extending curved central region.

Abstract: An introducer sheath includes an elongate shaft having a proximal end, a distal end and a lumen extending therebetween. An actuatable hemostasis valve in a hub is adjacent the proximal end of the elongate shaft and may be used to prevent blood from escaping from the elongate shaft. The introducer sheath may also have a a self-expanding funnel adjacent the distal end of the elongate shaft.

Abstract: Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface (e.g., a surface of a tissue of a subject). The self-righting articles described herein may comprise one or more tissue engaging surfaces configured to engage (e.g., interface with, inject into, anchor) with a surface (e.g., a surface of a tissue of a subject). In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self-righting behavior of the article. In some embodiments, the self-righting article may comprise a tissue interfacing component and/or a pharmaceutical agent (e.g., for delivery of the active pharmaceutical agent to a location internal of the subject) such as a liquid pharmaceutical agent.

Abstract: A blood glucose control system is configured to modify therapy provided to a subject. The system can cause first therapy to be delivered by the blood glucose control system to a subject during a first therapy period. The first therapy can be delivered based at least in part on a first value of a control parameter used by a control algorithm to generate a dose control signal. The system can determine a first effect corresponding at least in part to the first therapy and autonomously generate a second value of the control parameter. The system can cause second therapy to be delivered by the blood glucose control system to the subject during a second therapy period, wherein the second therapy is delivered based at least in part on the second value of the control parameter.

Abstract: Provided is a flow rate control device for supplying liquid chemicals. The device according to an embodiment of the present disclosure includes a housing unit which is placed at the location from which liquid chemicals are supplied and comprises an inflow conduit on one side to which the liquid chemicals flow in and an outflow conduit from which the flowed-in liquid chemicals whose flow rate is controlled flow out; and a control unit which is integrated with the housing unit and comprises an inflow space which comes in contact with an inflow hole at a terminal portion of the inflow conduit, an outflow space which comes in contact with an outflow hole at a terminal portion of the outflow conduit and a control path which is connected between the inflow space and the outflow space to control the flow rate of the flowed-in liquid chemicals, wherein the control path has a controlled inner diameter and a controlled length according to the flow rate a use r aims at.

Abstract: Drug delivery devices and related methods of assembly are disclosed. The drug delivery device may include a housing and a container disposed therein. The container may include a reservoir containing a drug and a movable stopper. A first seal member may be connected to the container at a distal end of the reservoir. A first removable membrane may cover an exterior surface of the first seal member to maintain sterility of that surface prior to operation of the device. A fluid pathway assembly may be configured to establish fluid communication with the reservoir during operation of the device. A second seal member may be connected to a first end of the fluid pathway assembly. A second removable membrane may cover an exterior surface of the second seal member to maintain sterility of that surface prior to operation of the device.

Abstract: A blood glucose control system is configured to modify therapy provide to a subject and determine whether the modified therapy results in a statistically significant improvement in glycemic control. The system obtains glycemic control information resulting from delivery of first therapy using a first value of a control parameter and determines a first effect corresponding to the first therapy. The control parameter is set to a second value that differs from the first value. The system obtains glycemic control information resulting from the delivery of the second therapy using the second value of the control parameter and determines a second effect corresponding to the second therapy. The system can perform a comparative assessment and determine whether the second value for the control parameter results in a statistically significant improvement in glycemic control for the subject.

Abstract: An infusion pump for delivering an intravenous (“IV”) fluid includes a housing comprising an actuation area that engages a portion of an IV tube. The actuation area includes a first end that receives the IV tube from a fluid container and a second end that provides the IV tube to a patient. The housing also includes a seal section located along a perimeter of at least a portion of the actuation area. The seal section includes a gasket rib positioned along the seal section and a tube channel configured to cradle the IV tube. The example infusion pump also includes a door connected to the housing and configured to engage the gasket rib to enclose the actuation area of the housing.