Abstract: Certain embodiments provide multi-medicament infusion systems for preventing the cross-channeling of medicaments. The system may include one or more of an infusion pump, medicament cartridges, cartridge connectors, a multi-channel fluid conduit, and an infusion set. The infusion pump can have an inductively chargeable battery assembly that can be charged by an inductive charging pad.

Abstract: An injection device includes a product container having an injection needle, a needle protection cap detachably secured to the product container surrounds the injection needle and seals same in a sterile manner. A cap is connected to the needle protection cap, via a remover element having an engaging element, in such a way that the removal of the cap from the injection device brings about the removal of the needle protection cap from the product container, where the engaging element is in an engaging position in relation to the needle protection cap, where in the engaging position, a section of the needle protection cap is arranged distally in line with the engaging element, characterized in that the cap and the engaging element are coupled in such a way that the cap is or can be moved relative to the engaging element during the removal from the injection device.

Abstract: Provided is an apparatus for injecting a lipolysis composition, the apparatus including a lipolysis composition storage, a pump, and at least one nozzle-type needle.

Abstract: Bladders and elastomeric pumps for infusion assemblies are provided. For example, a bladder may comprise a body extending over a length from a first end to an opposing second end; an outer diameter; an inner diameter; and a wall thickness. The wall thickness may gradually transition from a first wall thickness at the first end to a second wall thickness at the second end. In other embodiments, the wall thickness at a midpoint of the length is different than the wall thickness at each of the first end and the second end. An elastomeric pump may comprise an inflatable elastomeric bladder and a mandrel. The bladder includes a body extending over a bladder length from a first bladder end to an opposing second bladder end and a wall thickness, which is different at a midpoint of the bladder length than at each of the first and second bladder ends.

Abstract: A segmented piston rod for an injection device includes multiple segments joined together via a hinge located on one side of each segment. The piston rod can be bent in one direction by articulating subsequent hinges while an axial force can be transmitted by the segmented piston rod to the stopper when the subsequent hinges are closed and the segments abut each other opposite to the one side of the hinge. The segmented piston rod is secured against rotation relative to the housing around the longitudinal axis of the segmented piston rod. The segmented piston rod has a last element which abuts the stopper in the reservoir and a first segment which is opposite to the last segment. The first segment is includes an internal thread matching an external thread of a drive sleeve and rotation of the drive sleeve advances the piston rod towards the stopper of the reservoir.

Abstract: A method for treating back pain in a patient in need of such treatment is provided. The method includes positioning a balloon catheter in or adjacent to a treatment zone containing a basivertebral nerve. A chemical denervation agent is administered with the balloon catheter such that the chemical denervation agent chemically ablates at least a portion of the basivertebral nerve. Kits, systems and methods are disclosed.

Abstract: The present invention relates generally to expandable medical devices including a light-activated shape-memory polymer. In certain embodiments, the devices include, for example, balloon catheters, used to treat narrowed or obstructed portions of a body vessel, and retrieval devices, used to remove obstructions from a body vessel. Certain aspects of the invention relate to methods of manufacturing and using such devices.

Abstract: A medical valve assembly includes a tube extending between proximal and distal tube ends. A plunger plate extends radially from the distal tube end, and a valve housing surrounds the tube and extends between proximal and distal valve housing ends. The valve housing includes a flange extending radially inwardly from the distal valve housing end and disposed in spaced relationship with the plunger plate to define a distance dimension D extending therebetween. An elastomeric seal is compressed between the plunger plate and the flange to establish a closed condition of the medical valve assembly. The elastomeric seal axially moves one of the valve housing and the tube relative to the other when a medical device is inserted into the medical valve assembly to automatically increase the distance dimension and establish an open and sealed condition of the medical valve assembly with the inserted medical valve.

Abstract: A compliance monitoring system is provided for an injection device having an unused state and a used state. The system includes one or more radio frequency tags attached to a surface of the injection device and a portable monitoring accessory that includes a housing, a radio frequency antenna disposed within the housing, a wireless transmitter module disposed within the housing, and a processing circuit disposed within the housing. The processing circuit is configured to receive, via the radio frequency antenna, a first signal from the one or more radio frequency tags via a radio frequency communication protocol. The processing circuit is also configured to transmit, via the wireless transmitter, a second signal to a mobile device via a wireless communication protocol different from the radio frequency communication protocol. Both of the first signal and the second signal include state information of the injection device.

Abstract: The present disclosure relates to an injection device. The injection device comprises a body for holding a syringe that has a needle at one end and a cap that is removably attached to the body. The cap has a needle shield to cover said needle. The injection device further comprises a gear assembly comprising a first rotary gear and a first linear gear to engage with the first rotary gear. The gear assembly is configured such that rotation of the first rotary gear drives the first linear gear to urge the needle shield away from the body. An actuator is provided that is configured to rotate the first rotary gear.

Abstract: An intravenous infusion system with real-time infusion rate monitoring and closed-loop infusion rate control is disclosed. The intravenous infusion system comprises: an infusion module, providing drug solution through an intravenous catheter; a flow sensor module, installed around an outer periphery of the intravenous catheter, transmitting ultrasounds to the intravenous catheter and receiving ultrasounds reflected or penetrated therefrom to determine a real-time volumetric flow rate of the drug solution in the intravenous catheter, and converting the real-time volumetric flow rate into a flow rate electronic signal; and a communicating module, electrically and signally connected with the flow sensor module, receiving the flow rate electronic signal and delivering the flow rate electronic signal to an external agent connected thereto.

Abstract: An infusion pump includes inlet and outlet valves and a squeezing element configured to squeeze a fluid line coupled to the infusion pump. A method includes at least one round of valve operation check prior to initiation of a delivery session of fluid to a subject, and subsequently, after an intake phase and before a delivery phase of at least one infusion pump cycle, determining for the at least one pump cycle, an absolute amount of air in the fluid line. The valve operation check and the determining of the amount of air each include: (A) closing the inlet valve to confine a section of the fluid line between the inlet and outlet valves; (B) squeezing the confined section; (C) measuring the pressure within the confined section; and (D) subsequently, relieving the pressure in the confined section. Other applications are also described.

Abstract: Implants comprising electrically-responsive hydrogel are described. Systems to provide electricity to induce response in hydrogel-containing implants are described. Methods for utilizing said system and methods for utilizing said hydrogel-containing implants are described.

Abstract: The present disclosure relates generally to the field of medical devices. In particular, the present disclosure relates to devices and methods to convey fluid delivered from a delivery catheter. Exemplary catheters are disclosed which include fluid distribution devices for delivery of fluid and delivery of pass-through medical instruments, such as cryodecompression tubes, within body lumens.

Abstract: Systems comprising: an analyte sensor for providing an analyte signal representative of an analyte level; a controller in data communication with the analyte sensor and programmed to provide a recommended medication dose based on the analyte level and a medication type, the controller comprising a user interface for inputting the medication type; and a model-based safety mechanism integrated with the controller for evaluating the recommended medication dose. Wherein the model-based safety mechanism overrides the recommended medication dose and provides a safety medication dose when the model-based safety mechanism detects a risk of insulin deprivation.

Abstract: Devices for cleaning a tube or clearing a blockage from a tube, such as an enteral feeding device are provided. The devices include an actuator and a syringe. The actuator is releasably attached to the syringe in a manner that allows the actuator to transition the syringe from a compressed position to an extended position, and vice-a-versa, without requiring the intervention of a user. A method of cleaning a tube or clearing a blockage in a tube is also provided. The tube cleaning device is filled with a liquid and the actuator pushes the liquid from the syringe into the tube when transitioning into a compressed position, and withdraws the liquid back into the syringe when transition into an extended position, causing the liquid to contact a blockage, and clear the blockage and/or clean the tube.

Abstract: Medical devices and methods for delivering fluid. The medical devices include one or more needles for delivering fluid. The methods may include expanding an expandable member such as an inflatable member to expand an expandable scaffold outward toward a lumen wall.

Abstract: A device for controlled delivery of an injection material to tissue spaces of an eye that are not normally open, such as the subconjunctival space, the suprachoroidal space and the subretinal space. The device comprises an elongated body with a hollow cannula at the distal end, a slidable plunger at the proximal end, and a reservoir for the material to be injected residing between the cannula and the plunger. The plunger is mechanically coupled to a source of force such as a spring or pressurized gas reservoir such that an injection force is applied to the injection material within the device prior to delivery of the injection material into an eye. A valve that is normally closed to prevent flow of the injection material during application of the injection force is placed in the flow path between the cannula and reservoir. Due to the injection force placed on the injection material, actuation of the valve allows controlled flow from the reservoir through the cannula and into the tissue space.

Abstract: The present invention relates to a mixing and injector device which can include: a housing having a plurality of separate and distinct chambers disposed therein; one or more displacement mechanisms corresponding to each of the plurality of chambers disposed within the housing; a needle assembly being provided about one of the plurality of chambers, the needle assembly including the following: a septum; a needle being separated from the plurality of chambers by the septum, the needle having a proximal end configured to pierce the septum in an actuated state; and a needle carrier, the needle carrier being configured to translate axially with respect to and toward the septum and pierce the septum and provide fluid communication from the plurality of chambers through the needle in the actuated state.

Abstract: A device for protecting an umbilical stump-catheter interface, includes: a shield having a wall that defines a cavity for accommodating an umbilical stump, wherein the shield further includes a base for attachment to a patient; and an opening at the shield for allowing an umbilical catheter to extend therethrough. A method for protecting an umbilical stump-catheter interface, includes: providing a device having a shield with a wall that defines a cavity for accommodating an umbilical stump, wherein the shield further includes a base for attachment to a patient, and wherein the device further includes an opening at the shield; shielding the umbilical stump from an environment using the shield; and accommodating an umbilical catheter using the opening at the shield.