Patents Examined by Jean Witz
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Patent number: 9017673Abstract: The object of the present invention is analogues of peptides or parent proteins, these peptide analogues, comprising at least one aza-?3 aminoacyl residue, and also their uses in pharmaceutical compositions or for the diagnosis of pathologies wherein the aforesaid peptides or parent proteins are involved.Type: GrantFiled: June 11, 2004Date of Patent: April 28, 2015Assignee: Centre National de la Recherche ScientifiqueInventors: Michèle Floc'h Baudy, Olivier Busnel, Sylviane Muller
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Patent number: 9017730Abstract: Improved synthetic copolypeptide antimicrobials contain cationic amino acid residues and may be based on a blocky sequence. These antimicrobials show low mammalian toxicity and may undergo directed self-assembly. The inventive synthetic copolypeptides are useful in treatment of wounds and other infections.Type: GrantFiled: February 25, 2013Date of Patent: April 28, 2015Assignees: The Regents of the University of California, Amicrobe, Inc.Inventors: Michael P. Bevilacqua, Diego Benitez, Timothy J. Deming, Jarrod A. Hanson, Lucas Koziol
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Patent number: 8962559Abstract: The present invention relates to pharmaceutical compositions for the controlled and sustained release of active substance comprising a biodegradable polymer or copolymer. Furthermore, the invention relates to pharmaceutical compositions for the controlled and sustained release of at least one active substance such as peptides or hormones and analogs thereof and the manufacturing process of such pharmaceutical compositions.Type: GrantFiled: April 29, 2010Date of Patent: February 24, 2015Assignee: Ipsen Pharma S.A.S.Inventors: Roland Cherif-Cheikh, Fédéric Lacombe, Maria-Luisa Torres Salgado, Perrine Cambriel, Mercé Cardus Malaspina, Isabel Diaz Del Consuelo, Martin Montes, Fabien Jeannerot, Marie Delporte, Anne Brochard, Joël Richard
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Patent number: 8937039Abstract: The present invention provides peptide-based peroxidase inhibitors having the formula AA1-AA2-AA3, wherein AA1 is a positively charged, negatively charged or neutral amino acid, AA2 is a redox active amino acid, and AA3 is an amino acid possessing a reducing potential such that AA3 is capable of undergoing a redox reaction with a radical of amino acid AA2 or a retro or retro-inverso analog thereof. The result of such a combination is a highly effective inhibitor of peroxidase activity that has potent anti-inflammatory properties in widely diverse models of vascular disease and injury. Exemplary tripeptides effectively inhibit peroxidase mediated LDL oxidation, increase vasodilation in SCD mice, inhibit eosinophil infiltration and collagen deposition in asthma mice, inhibit acute lung injury, and decrease ischemic injury of the heart.Type: GrantFiled: November 15, 2013Date of Patent: January 20, 2015Assignee: The Medical College of Wisconsin, Inc.Inventors: Hao Zhang, Yang Shi, Hao Xu, Kirkwood A. Pritchard, Jr.
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Patent number: 8912310Abstract: The present disclosure describes environmentally responsive polypeptides capable of displaying stimuli-triggered conformational changes in a reversible or irreversible manner that may be accompanied by aggregation. Polypeptides include a number of repeated motifs and may be elastomeric or non-elastomeric. The polypeptides may be used to deliver therapeutics to a biological site and to develop bioactive polypeptides that are environmentally responsive.Type: GrantFiled: May 29, 2013Date of Patent: December 16, 2014Assignee: Duke UniversityInventors: Ashutosh Chilkoti, Felipe Garcia Quiroz
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Patent number: 8883731Abstract: An agent for reducing risk in onset of diseases ascribable to non-dipping circadian profile of blood pressure is provided. This agent is capable of effectively lowering SBP from night to early morning in individuals with non-dipping circadian profile of blood pressure, in particular, normal individuals with normal SBP and DBP among them, and is thus capable of reducing risk in onset, particularly likely in the morning, of diseases caused by circadian variation of blood pressure. The agent is intended for administration to such subjects, and contains a hydrolysate or a concentrate thereof, containing Val-Pro-Pro and Ile-Pro-Pro and obtained by hydrolysis of animal milk protein.Type: GrantFiled: March 26, 2013Date of Patent: November 11, 2014Assignee: CALPIS Co., LtdInventors: Mari Takahashi, Naoyuki Yamamoto, Kazuhisa Yamada, Toshirou Iketani
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Patent number: 8846020Abstract: Conjugates are provided herein which comprise a protein attached to at least two polymeric moieties, at least one of which exhibits reverse thermal gelation. The conjugates are suitable for being cross-linked by non-covalent and/or covalent cross-linking. Compositions-of-matter comprising cross-linked conjugates are provided herein, as well as processes for producing same. Methods of controlling a physical property of compositions-of-matter are also provided herein. The conjugates and compositions-of-matter may be used for various applications, such as cell growth, tissue formation, and treatment of disorders characterized by tissue damage or loss, as described herein.Type: GrantFiled: December 16, 2010Date of Patent: September 30, 2014Assignee: Regentis Biomaterials Ltd.Inventors: Dror Seliktar, Yonatan Shachaf
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Patent number: 8802628Abstract: Solid, stable formulations of linaclotide suitable for oral administration are described herein as are methods for preparing such formulations. The formulations described herein contain a polypeptide consisting of the amino acid sequence Cys Cys Glu Tyr Cys Cys Asn Pro Ala Cys Thr Gly Cys Tyr (“linaclotide”; SEQ ID NO:1) or a pharmaceutically acceptable salt thereof. The linaclotide formulations described herein are stable and have a sufficient shelf life for manufacturing, storing and distributing the drug.Type: GrantFiled: August 14, 2009Date of Patent: August 12, 2014Assignees: Ironwood Pharmaceuticals, Inc., Forest Laboratories Holdings, Ltd.Inventors: Angelika Fretzen, Steven Witowski, Alfredo Grossi, Hong Zhao, Mahendra Dedhiya, Yun Mo
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Patent number: 8802078Abstract: According to some embodiments, the present invention provides a modified silicone surface for interference to pathogen colonization comprising: an activated silicone layer; a plurality of cross-linking dendrimers adsorbed onto to the activated silicone layer; a plurality of ligand derivatives, each bound to at least one of the plurality of cross-linking dendrimers; and a benign biofilm adhered to the plurality of ligand derivatives. According to some embodiments, the present invention provides a method for making a modified silicone surface for interference to pathogen colonization comprising activating a silicone surface; adsorbing a plurality of cross-linking dendrimers to the silicone surface; binding a plurality of ligand derivatives to the plurality of cross-linking dendrimers; and adhering a benign biofilm to the plurality of ligand derivatives.Type: GrantFiled: March 12, 2012Date of Patent: August 12, 2014Assignee: University of HoustonInventor: Chengzhi Cai
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Patent number: 8791241Abstract: The present invention relates to fluorescent proteins, in particular green fluorescent proteins (GFPs), with increased activity in cells, and thus increased signal strength. A further aspect of the present invention relates to the use of peptides for increasing the expression and/or stability of a protein in a cell.Type: GrantFiled: August 9, 2010Date of Patent: July 29, 2014Assignee: King Faisal Specialist Hospital & Research CentreInventor: Khalid S. Abu Khabar
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Patent number: 8772235Abstract: Described herein are compositions having a peptide sequence that includes at least one bone targeting moiety, wherein the bone targeting moiety is bonded to the peptide sequence by a linker, wherein the peptide sequence is calcitonin, and wherein the composition is neutral or a pharmaceutically acceptable salt or ester thereof. In one aspect, calcitonin inhibits or slows osteoclast mediated resorptive bone loss. The compounds described herein can be used in a number of therapeutic applications including treating or preventing conditions associated with bone loss, which include, but are not limited to, osteoporosis, Paget's disease, osteolytic tumors, Rheumatoid Arthritis, Psoriatic Arthritis, Ankylosing Spondylitis, Osteoarthritis, osteopenia, and hypercalcemia. Also described herein are the methods of making these compositions that prevent or treat conditions associated with bone loss and methods of preventing bone fractures.Type: GrantFiled: October 12, 2010Date of Patent: July 8, 2014Assignee: The Governors of the University of AlbertaInventors: Michael R. Doschak, Krishna Hari Bhandari
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Patent number: 8748564Abstract: The present invention relates to oxytocin receptor agonist compounds, pharmaceutical compositions comprising the same, use of such compounds for the manufacture of a medicament for treatment of inter alia, abdominal pain, irritable bowel syndrome (IBS), autism, erectile dysfunction, female sexual dysfunction, labor induction and maintenance, lactation induction and maintenance, postpartum hemorrhage, Post Traumatic Stress Disorder (PTSD), pain, anxiety and other conditions, as well as to methods for the treatment of such conditions, wherein such compounds are administered.Type: GrantFiled: September 21, 2010Date of Patent: June 10, 2014Assignee: Ferring B.V.Inventors: Kazimierz Wisniewski, Claudio Daniel Schteingart, Sudarkodi Alagarsamy, Robert Galyean
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Patent number: 8735351Abstract: The invention relates to a method for improving the procoagulant properties of TF expressed in eukaryotic cells by contacting microvesicles derived from said eukaryotic cells with a negatively-charged phospholipid such as phosphatidylserine. The invention also relates to microvesicles obtained using said method as well as to the uses thereof as procoagulant agents, for wound healing and for promoting angiogenesis.Type: GrantFiled: April 19, 2011Date of Patent: May 27, 2014Assignee: Thrombotargets Europe, S.L.Inventors: Jesús Murat Moreno, Juan Ramon Rodriguez Fernández-Alba
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Patent number: 8697637Abstract: The present invention relates to an antimicrobial peptide characterised in that said peptide includes the sequence SEQ ID No. 1 or the sequence SEQ ID No. 2, the sequence SEQ ID No. 2 representing a fragment of the sequence SEQ ID No. 1, for use as a drug. Advantageously according to the invention, the peptide having sequence SEQ ID No. 1 is used specifically for treating bacterial, viral and/or parasitic infections, and the peptide having sequence SEQ No. 2 is used for treating bacterial and/or viral infections.Type: GrantFiled: February 3, 2011Date of Patent: April 15, 2014Assignee: Institut de Recherche pour le Developpement (IRD)Inventors: Marthe Dorothée Misse Brumas, Natthanej Luplertlop, Hans Yssel, Frédéric Thomas, François Renaud
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Patent number: 8691195Abstract: The present invention relates to a transforming growth factor-beta (TGF-?)-mimicking peptide containing a particular amino acid sequence and a composition for preventing or treating TGF-?-effective disorders or conditions using the same. The peptide of the present invention may be much higher stability than natural-occurring TGF-? and improve drawbacks caused by high molecular weight of natural-occurring TGF-?. The peptide of this invention can be advantageously applied to treatment or improvement of TGF-?-effective disorders or conditions and have excellent efficacies on skin whitening and wrinkle improvement.Type: GrantFiled: April 14, 2009Date of Patent: April 8, 2014Assignee: Caregen Co., Ltd.Inventors: Young Ji Chung, Young Deug Kim, Eun Mi Kim, Jeong Jin Choi, Jun Young Choi
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Patent number: 8673848Abstract: The invention provides a synthetic polypeptide of Formula I?: or an amide, an ester or a salt thereof, wherein X1, X2, X3, X4, X5, X6, X7, X8, X9, X10, X11, X12 and X13 are defined herein. The polypeptides are agonist of the APJ receptor. The invention also relates to a method for manufacturing the polypeptides of the invention, and its therapeutic uses such as treatment or prevention of acute decompensated heart failure (ADHF), chronic heart failure, pulmonary hypertension, atrial fibrillation, Brugada syndrome, ventricular tachycardia, atherosclerosis, hypertension, restenosis, ischemic cardiovascular diseases, cardiomyopathy, cardiac fibrosis, arrhythmia, water retention, diabetes (including gestational diabetes), obesity, peripheral arterial disease, cerebrovascular accidents, transient ischemic attacks, traumatic brain injuries, amyotrophic lateral sclerosis, burn injuries (including sunburn) and preeclampsia.Type: GrantFiled: January 23, 2013Date of Patent: March 18, 2014Assignee: Novartis AGInventors: Frédéric Zecri, Andrei Golosov, Philipp Grosche, Kayo Yasoshima, Hongjuan Zhao, Qi-Ying Hu, Hidetomo Imase, David Thomas Parker
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Patent number: 8476418Abstract: The present invention is concerned with the provision of a polynucleotide encoding an AAV capsid polypeptide comprising an inserted peptide and a vector comprising said polynucleotide. Moreover, contemplated is a host cell comprising said polynucleotide or vector, a method for the manufacture of said capsid polypeptide as well as said polypeptide. Further included is an antibody specifically binding to said polypeptide and a medicament comprising said polynucleotide, vector, polypeptide, or antibody. Also contemplated are the use of said polynucleotide, vector, polypeptide, or antibody for the manufacture of a medicament for the treatment of vascular disease and a method for the identification of a compound binding to said polypeptide.Type: GrantFiled: May 28, 2010Date of Patent: July 2, 2013Assignees: Deutsches Krebsforschungszentrum, Ruprecht-Karls-Universitat HeidelbergInventors: Oliver Mueller, Hugo Katus, Karl Varadi, Jürgen Kleinschmidt
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Patent number: 8470967Abstract: The present disclosure describes environmentally responsive polypeptides capable of displaying stimuli-triggered conformational changes in a reversible or irreversible manner that may be accompanied by aggregation. Polypeptides include a number of repeated motifs and may be elastomeric or non-elastomeric. The polypeptides may be used to deliver therapeutics to a biological site and to develop bioactive polypeptides that are environmentally responsive.Type: GrantFiled: September 26, 2011Date of Patent: June 25, 2013Assignee: Duke UniversityInventors: Ashutosh Chilkoti, Felipe Garcia Quiroz, Miriam Amiram
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Patent number: 8039023Abstract: A composition is disclosed which provides relief from menstrual cramps and muscle cramps within three to seven minutes after ingestion. The composition is preferably a mixture in the form of an aqueous solution with components mixed within approximately fifty percent of the following amounts: 60 mg/liter of calcium gluconate, 75 mg/liter of potassium bicarbonate, 90 mg/liter of L glutamine, 5 mg/liter of calcium chloride, 150 mg/liter of potassium chloride; 60 mg/liter of calcium ascorbate; 100 mg/liter of magnesium glycinate, and 15 mg/liter of potassium citrate. The liquid solution is taken by a human in a dosage of one to four ounces, depending upon the body weight of the person, whether the person is experiencing menstrual cramps or muscle cramps, and the area affected when the person is seeking relief from muscle cramps.Type: GrantFiled: April 8, 2009Date of Patent: October 18, 2011Inventor: Robert Gaylon Ross, Sr.
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Patent number: 7993822Abstract: The present invention relates to a marker that can be used as aging biomarker. More specifically, the present invention relates to the analysis of N-glycans in serum and its relation to the virtual age of the subject. This aging biomarker can be used to study the effect of medication, food compounds and/or special diets on the wellness and virtual age of animals, including humans.Type: GrantFiled: November 29, 2005Date of Patent: August 9, 2011Assignees: Vlaams Interuniversitair Instituut Voor Biotechnologie VZW, Universiteit GentInventors: Cuiying Chen, Roland H. Contreras