Patents Examined by Jean Witz
  • Patent number: 7968127
    Abstract: A formulation or preparation for treating and preventing arterial and venous thrombi is provided. This preparation includes a non-metal containing photodynamic dye and a fat soluble vitamin. A method of administration for treatment and prophylaxis of arterial and venous thrombi is also provided. This method includes steps of: combining a non-metal containing photodynamic dye and a fat soluble vitamin; combining the non-metal containing photodynamic dye and fat soluble vitamin with a sodium solution; and administering the combination of non-metal containing photodynamic dye, fat soluble vitamin, and sodium solution as an intravenous drip.
    Type: Grant
    Filed: July 28, 2008
    Date of Patent: June 28, 2011
    Inventor: David E. Winslow
  • Patent number: 7022523
    Abstract: A carrier for cell culture comprising a water-containing polymer gel containing chitosan, wherein the water-containing polymer gel is coated with collagen and/or alginic acid, and a carrier for cell culture, which comprises a gel layer containing chitosan and an inorganic layer adjacently provided to the gel layer.
    Type: Grant
    Filed: October 24, 2003
    Date of Patent: April 4, 2006
    Assignee: Fuji Photo Film Co., Ltd.
    Inventors: Hirohiko Tsuzuki, Satoru Toda, Makoto Kato
  • Patent number: 5336495
    Abstract: The present invention relates to the use of staphylokinase for the preparation of a pharmaceutical composition for treating arterial thrombosis, such as e.g. myocardial infarction. It is demonstrated that staphylokinase can be particularly useful as a thrombolytic agent for the lysis of platelet-rich clots. Furthermore it is demonstrated that staphylokinase, unlike streptokinase, does not induce antibody induction upon repeated administration.
    Type: Grant
    Filed: July 14, 1993
    Date of Patent: August 9, 1994
    Assignees: Leuven Research & Development vcw, Desire J. Collen
    Inventors: Desire J. Collen, Jean-Marie Stassen, Henri R. Lijnen
  • Patent number: 5110918
    Abstract: Heparins, heparin fractions or fragments, optionally salified with pharmaceutically acceptable cations, having molecular weight ranging from 1.000 to 30.000 D, characterized by an EDTA content lower than 0.1%, by the absence, in the .sup.1 H--NMR spectra, of the signals due to EDTA between 2.50 and 4.00 p.p.m. and substantially free from bleeding effect and optionally free from signals, in the .sup.13 C--NMR spectrum, from 80 to 86 ppm.
    Type: Grant
    Filed: September 24, 1990
    Date of Patent: May 5, 1992
    Assignee: Sanofi S.A.
    Inventors: Benito Casu, Annamaria Naggi, Pasqua Oreste, Giangiacomo Torri, Giorgio Zoppetti, Giancarlo Sportoletti, Francesco De Santis
  • Patent number: 5057314
    Abstract: The present invention provides a low molecular weight anti-viral factors isolated from the serum of a hyperimmune regressor line chicken and methods of purifying same. The factors are useful in the treatment and prevention of certain disease states.
    Type: Grant
    Filed: June 20, 1989
    Date of Patent: October 15, 1991
    Inventors: Craig E. Whitfill, Nicholas R. Gyles, John A. Thoma
  • Patent number: 5023090
    Abstract: A topical composition comprising LYCD together with known topically active useful medicinal agents such as anti-wrinkling, antibiotic, anticancer, antifungal, antiinflammatory such as anti-acne, antiviral, wound healing, and hair-growing agents. The LYCD works together with the other active agents to achieve a synergistic result more effective than can be obtained from the topical agents individually, and more effective than could be predicted from the mere addition of the known efficacies of the individual ingredients.
    Type: Grant
    Filed: April 2, 1990
    Date of Patent: June 11, 1991
    Inventor: Robert H. Levin
  • Patent number: 5021243
    Abstract: A process for the preparation of a factor VIII:C-deficient plasma is made available, in which a starting plasma is consecutively treated with antibodies against von Willebrand factor and antibodies against factor VIII:Ag. The deficient plasma prepared in this way contains less than 0.5% residual activity of factor VIII:C.
    Type: Grant
    Filed: March 4, 1988
    Date of Patent: June 4, 1991
    Assignee: Behringwerke Akitengesellschaft
    Inventors: Udo Becker, Norbert Heimburger, Konrad Braun
  • Patent number: 5019402
    Abstract: There is disclosed a composition and process for disinfecting or essentially sterilizing blood fractions and components of blood. The composition is formed by adding a chlorine dioxide liberating compound with a weak organic acid and a heat activated saccharide.
    Type: Grant
    Filed: February 20, 1990
    Date of Patent: May 28, 1991
    Assignee: Alcide Corporation
    Inventors: Robert D. Kross, David I. Scheer
  • Patent number: 5019391
    Abstract: A composition for the treatment of the skin comprises a fraction of a mechanically obtained lysate of yeast cultures of the species Saccharomyces cerevisiae. The translation system contained in the compositions of the invention are obtained by lysing cultures of Saccharomyces cerevisiae. The application of such composition, in any suitable form, such as a cream, ointment, gel or the like, to skin promotes protein biosynthesis by the skin cells so that the metabolism of the extracellular matrix of the skin is restored to the physiologically correct balance and the skin is revitalized.
    Type: Grant
    Filed: August 23, 1988
    Date of Patent: May 28, 1991
    Assignee: HEYL Chemisch-parmazeutische Fabrik GmbH & Co KG
    Inventors: Thomas Bunte, Wolfgang Parr, Eduard Heyl
  • Patent number: 5013558
    Abstract: The present invention relates to pharmaceutical compositions for cerebral and neuronal diseases containing physiologically active substances extracted from infected tissues. The physiologically active substances of the present invention have NGF-like nerve growth stimulating effect. Therefore, the substances of the invention are useful as drugs for various cerebral and neuronal diseases such as dementia, post-herpetic neuralgia, brain edema and spino-cerebellar degeneration.
    Type: Grant
    Filed: June 15, 1989
    Date of Patent: May 7, 1991
    Assignee: Nippon Zoki Pharmaceutical Co., Ltd.
    Inventor: Jin-emon Konishi
  • Patent number: 5000963
    Abstract: Procedures are disclosed for eliminating immune competent cells from a population of human epidermal cells. The cells free of immune competent cells are used for growing tissue sheets suitable for transplantation to recipients unrelated to the donor.
    Type: Grant
    Filed: June 8, 1988
    Date of Patent: March 19, 1991
    Inventor: John M. Hefton
  • Patent number: 4985254
    Abstract: The present invention relates to physiologically active substances extracted from infected tissues inoculated with a poxvirus. The substances of the present invention have excellent actions to improve blood flow and recover functions of diseased tissues, thus are useful as drugs for various diseases caused by blood flow disorders.
    Type: Grant
    Filed: November 3, 1988
    Date of Patent: January 15, 1991
    Assignee: Nippon Zoki Pharmaceutical Co., Ltd.
    Inventor: Jin-emon Konishi
  • Patent number: 4980174
    Abstract: A novel method for alleviating depression comprises implanting monoamine producing living cells in the CNS of depressive subjects.
    Type: Grant
    Filed: December 23, 1988
    Date of Patent: December 25, 1990
    Inventors: Jacqueline Sagen, Caryl E. Sortwell, George D. Pappas
  • Patent number: 4957741
    Abstract: Lipid material or ganglioside from mammalian sources e.g. bovine and porcine brain or omentum is used to treat peptic ulcers.
    Type: Grant
    Filed: August 2, 1988
    Date of Patent: September 18, 1990
    Assignee: Angio-Medical Corp.
    Inventors: Ahmad R. Kamarei, Nicholas Catsimpoolas, Robert McCluer, Takashi Mise, Robert S. Sinn
  • Patent number: 4954340
    Abstract: A preparation for activating hemocytes of bivalves for pearl production containing a mitogen as an effective component, and a method for producing pearl through nucleus insertion operation of a bivalve for pearl production which comprises treating a section of the mantle part of a donor to be inserted with a mitogen.By the treatment with the present preparation, hemocytes of the wound site due to the nucleus insertion operation are activated, tissue growth of the section of the mantle part of the donor is accelerated and a good pearl sac is formed around the nucleus. As a result, the number ejected nuclei is decreased and the pearl quality and production amount are enhanced.These effects are further enhanced by using a mitogen treated with an aluminum adjuvant or the like.
    Type: Grant
    Filed: August 2, 1988
    Date of Patent: September 4, 1990
    Assignee: Juridical Foundation The Chemo-Sero-Therapeutic Research Institute
    Inventors: Haruhisa Maeda, Akira Tsujikawa, Sadao Susumi
  • Patent number: 4946678
    Abstract: A process and nourishing agent for treating and nourishing the scalp and hair to promote conditions for the natural growth of hair on a human head for the reversal of male pattern baldness in individual cases. The process includes the steps of cleansing the scalp and hair, opening the pores and follicles in the scalp and softening and removing clogging deposits from the pores and hair follicles, and then applying to the scalp a nourishing agent comprising a mixture of chalaza extracted from chicken eggs, unflavored powdered gelatin, and aqueous saline solution. In the preferred form of the invention, the pores of the scalp and hair follicles are opened and sanitized by repeated applications of a benzoic acid mixture and heat, and the clogging deposits and foreign matter are softened and separated by the application of a carbamide peroxide solution and heat.
    Type: Grant
    Filed: May 3, 1989
    Date of Patent: August 7, 1990
    Inventors: Thomas L. Dodd, David A. O'Steen
  • Patent number: 4940663
    Abstract: The invention relates to a process for the fermentation of carbohydrates by bacteria of the genus Xanthomonas for the production of a polysaccharide of the xanthane type, in which the source of nitrogen consists of a gelatin with a molecular weight of less than 5000.Application: preparation of xanthane.
    Type: Grant
    Filed: June 22, 1988
    Date of Patent: July 10, 1990
    Assignee: SANOFI, Societe Anonyme
    Inventor: Bruno Eyssautier
  • Patent number: 4929600
    Abstract: The body composition of poultry is improved by a hormonal strategy that involves either:(1). increasing plasma levels of thyroid hormone by about 2- to 3-fold during the finishing phase (e.g., for chickens, 3 to 6 or 7 weeks-of-age) by providing feed containing 0.1 to 1 ppm of metabolically-active thyroid hormone of the formula: ##STR1## wherein R1 is the residue of a carboxylic acid such as an alpha-amino acid or an aliphatic carboxylic acid, e.g. L-alanine, D-alanine, acetic acid, or propionic acidR3 is iodine (I)R5 is iodine (I) or hydrogen (H)R3' is iodine (I) or the residue of an aliphatic carboxylic acid such as butyric acid, or propionic acidR5' is iodine (I) or hydrogen (H)R4' is hydroxy (OH)(2). increasing plasma levels of metabolically-active thyroid hormone by 2- to 3-fold and increasing plasma levels of growth hormone or glucagon by 2- to 10-fold for 15 to 30% of each day with any suitable method during the finishing phase of poultry growth.
    Type: Grant
    Filed: March 18, 1988
    Date of Patent: May 29, 1990
    Assignee: University of Deleware
    Inventor: Larry A. Cogburn
  • Patent number: 4921705
    Abstract: A lipid powder having a cross-linked coating thereon comprises a core lipid powder and a water-soluble coating agent coating the core lipid powder. The water-soluble coating agent contains cross-linked protein. A process for preparing lipid powders each having a cross-linked coating thereon comprises the steps of emulsifying lipid and a water-soluble coating agent containing protein to obtain an emulsion, adding a cross-linking agent for the protein the the emulsion to thereby cross-link the protein, atomizing and drying the emulsion containing the cross-linked protein to terminate the cross-linking reaction and to obtain lipid powders each coated with the water-soluble coating agent, and cooling the coated lipid powders.
    Type: Grant
    Filed: July 8, 1988
    Date of Patent: May 1, 1990
    Assignee: Nippon Oil and Fats Co., Ltd.
    Inventors: Motoharu Arai, Masatsugu Ito
  • Patent number: 4873222
    Abstract: A human placenta-derived antiocoagulating substance is prepared by homogenizing a human plancenta, subjecting the resulting homogenate to centrifugal separation, extracting the thus-obtained sediment with a chelating agent, and then separating and purifying the extract. The substance has a molecular weight of 73,000.+-.2,000 as measured in reduced and non-reduced states by SDS-polyacrylamide gel electrophoresis. Its isoelectric point ranges from 6.2 to 6.6 as measured by isoelectric column electrophoresis using an ampholyte. It is inactivated by a heat treatment at 50.degree. C. for 30 minutes, is stable in a pH range of 5.5-8.5 (37.degree. C.) and is also stable in plasma at 37.degree. C. for 15 minutes. It can prolong the recalcification time, prothrombin time and activated partial thromboplastic time.
    Type: Grant
    Filed: October 2, 1987
    Date of Patent: October 10, 1989
    Assignee: Kowa Co, Ltd.
    Inventors: Koichi Arai, Hideo Yoshizaki