Patents Examined by Jennifer Pitrak
  • Method for selecting stable proteins in non-standard physicochemical conditions
    Patent number: 9903873
    Abstract: The invention relates to a method for selecting proteins stable in non-standard physicochemical conditions (temperature, pressure, pH, osmolarity, salinity, solvent, etc.) comprising the expression, in an extremophilic microorganism, of variants of the protein of interest in the form of a fusion protein with a reporter protein which is stable in extreme conditions and acts as a selection marker.
    Type: Grant
    Filed: April 4, 2006
    Date of Patent: February 27, 2018
    Assignee: BIOMETHODES
    Inventor: Marc Delcourt
  • Oligonucleotides comprising alternating segments and uses thereof
    Patent number: 9902953
    Abstract: The invention relates to oligonucleotides having alternating segments of sugar-modified nucleosides and 2?-deoxynucleosides, and uses thereof. The invention further related to oligonucleotides having alternating segments of sugar-modified nucleotides and 2?-deoxynucleotides, and uses thereof. Such uses include the preparation of antisense oligonucleotides and their use for the prevention or depletion of function of a target nucleic acid of interest, such as an RNA, in a system. Accordingly, and oligonucleotide of the invention is useful for therapeutic, analytical and diagnostic methods and uses, as well as component of compositions and commercial packages corresponding to such methods and uses.
    Type: Grant
    Filed: August 30, 2012
    Date of Patent: February 27, 2018
    Assignee: MCGILL UNIVERSITY
    Inventors: Masad J. Damha, Michael A. Parniak
  • Analogs of C5a and methods of using same
    Patent number: 9895411
    Abstract: Materials and methods for treating and preventing an infection or disease, and for directly killing microorganisms, using carboxy-terminal C5a analogs, are provided.
    Type: Grant
    Filed: June 29, 2011
    Date of Patent: February 20, 2018
    Assignees: SAN DIEGO STATE UNIVERSITY RESEARCH FOUNDATION, BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA
    Inventors: Sam D. Sanderson, Joy Arlene Phillips, Edward Leroy Morgan, Marilyn Louise Thoman, Tamsin Sheen, Kelly S. Doran, Elizabeth Louise Virts, Tammy Kielian, Mark Hanke
  • Peptide, method and composition for stimulating melanogenesis
    Patent number: 9895303
    Abstract: An isolated peptide for stimulating melanogenesis in a mammal subject is provided. The isolated peptide consisting of an amino acid sequence of FKCRRWQWRMK KLGAPSI (SEQ ID NO: 1). Also provided are methods and compositions for stimulating melanogenesis in a mammal subject.
    Type: Grant
    Filed: February 23, 2016
    Date of Patent: February 20, 2018
    Assignee: RENORIGIN INNOVATION INSTITUTE CO. LTD.
    Inventors: Hsiu-Chin Huang, Hsuan Lin
  • Methods for inducing cardiomyocyte proliferation
    Patent number: 9885043
    Abstract: Methods for inducing cardiomyocyte proliferation, e.g., in vivo, by administering a composition comprising miRNA17-92 cluster oligonucleotides, e.g., miR-19a oligonucleotides, miR-19b oligonucleotides, or both miR-19a and miR-19b oligonucleotides.
    Type: Grant
    Filed: March 24, 2016
    Date of Patent: February 6, 2018
    Assignee: Children's Medical Center Corporation
    Inventors: Da-Zhi Wang, Jinghai Chen
  • SV82 polypeptide, and cosmetic composition for reducing skin wrinkles and maintaining skin elasticity comprising SV82 polypeptide as active ingredient
    Patent number: 9879060
    Abstract: A spider venom (SV) 82 polypeptide has an amino acid sequence of SEQ ID NO: 2. An SV82 polypeptide-encoding gene having a nucleotide sequence of SEQ ID NO: 1 which is optimized for E. coli codon. A recombinant vector includes the SV82 polypeptide-encoding gene, An E. coli is transformed with the recombinant vector. A method of producing SV82 polypeptide includes transforming a host cell with the recombinant vector. A cosmetic composition for reducing skin wrinkles and maintaining skin elasticity includes SV82 polypeptide as an active ingredient.
    Type: Grant
    Filed: August 26, 2016
    Date of Patent: January 30, 2018
    Assignee: NEXGEN BIOTECHNOLOGIES, INC.
    Inventors: Sun Kyo Lee, Je Geun Yoo, Seong Ran Lee, Han Bong Ryu, Tae Won Choi, Jong Nam Choi, Tae Hyun Kim
  • Hydroxyl-polymer-drug-protein conjugates
    Patent number: 9872918
    Abstract: A drug conjugate is provided herein. The conjugate comprises a protein based recognition-molecule (PBRM) and a polymeric scaffold having one or more -LD-D, the PBRM being connected to the polymeric scaffold by LP, wherein the polymeric scaffold comprises a linear, branched or cyclic polymer having four or more —OH groups. Each occurrence of D is independently a therapeutic agent having a molecular weight ?5 kDa. LD and LP are linkers connecting the therapeutic agent and PBRM to the polymeric scaffold respectively. Also disclosed are polymeric scaffolds useful for conjugating with a PBRM to form a polymer-drug-PBRM conjugate described herein, compositions comprising the conjugates, methods of their preparation, and methods of treating various disorders with the conjugates or their compositions.
    Type: Grant
    Filed: December 12, 2013
    Date of Patent: January 23, 2018
    Assignee: Mersana Therapeutics, Inc.
    Inventor: Aleksandr V. Yurkovetskiy
  • Microrna inhibition for the treatment of inflammation and myeloproliferative disorders
    Patent number: 9862948
    Abstract: The present disclosure relates to the finding that microRNA-155 plays a role in inflammation, hematopoiesis and myeloproliferation, and that dysregulation of microRNA-155 expression is associated with particular myeloproliferative disorders. Disclosed herein are methods and compositions for diagnosing an treating disorders, including inflammation and myeloproliferation, modulating the levels of expression of one or more genes selected from the group consisting of Cutl1, Arnt1, Picalm, Jarid2, PU.1, Csf1r, HIF1?, Sla, Cebp?, and Bach1, and the like.
    Type: Grant
    Filed: February 4, 2016
    Date of Patent: January 9, 2018
    Assignee: California Institute of Technology
    Inventors: David Baltimore, Ryan M. O'Connell, Konstantin Taganov, Mark Boldin
  • Methods and compositions for ameliorating pancreatic cancer
    Patent number: 9827224
    Abstract: Embodiments of the present invention include methods and compositions for ameliorating cancer. Some embodiments include methods and compositions for ameliorating pancreatic cancer targeting the CXCR4 receptor and the CXCL12 ligand.
    Type: Grant
    Filed: January 26, 2016
    Date of Patent: November 28, 2017
    Assignee: University of South Alabama
    Inventors: Seema Singh, Ajay P. Singh
  • Method of utilizing refuses in urban and rural
    Patent number: 9776224
    Abstract: The present invention discloses a method of utilizing refuses in urban and rural areas. The method includes a refuses collection step, a refuse distributing step, a primary magnetic separation step, a primary crushing step, a primary elutriation and floatation step, a uniform cutting step, an acidification and anaerobic treatment step, a selection and separation step, a buffering and adjusting step, an additional anaerobic treatment step and a sludge sedimentation and concentration step. The present invention can make the anaerobic treatment method continuatively dispose the refuses, thereby thoroughly solving the problem that non-anaerobic refuses such as waste plastics, water fiber etc. can not be recycled and completely recycling resources in the refuses.
    Type: Grant
    Filed: April 2, 2011
    Date of Patent: October 3, 2017
    Assignee: WEIFANG JINSIDA INDUSTRIAL CO. LTD.
    Inventors: Guotian Liu, Mingquan Zhang, Ming'en Hu
  • Method for detection of urothelial cancer
    Patent number: 9772286
    Abstract: It is to provide a method for detecting urothelial cancer simply and with high accuracy. It is a method for detecting urothelial cancer comprising administering 5-aminolevulinic acid (ALA), a derivative thereof, or a salt of these to a test subject, collecting urine from the test subject, and detecting the presence of fluorescence or amount of fluorescence in the collected urine.
    Type: Grant
    Filed: June 20, 2011
    Date of Patent: September 26, 2017
    Assignees: SBI Pharmaceuticals Co., Ltd., National University Corporation Kochi University
    Inventors: Keiji Inoue, Taro Shuin, Mutsuo Furihata, Yoshihiko Hirao, Tohru Tanaka
  • Antisense oligonucleotides for the treatment of Leber congenital amaurosis
    Patent number: 9771580
    Abstract: The present invention relates to the fields of medicine and immunology. In particular, it relates to novel antisense oligonucleotides that may be used in the treatment, prevention and/or delay of Leber congenital amaurosis.
    Type: Grant
    Filed: April 25, 2012
    Date of Patent: September 26, 2017
    Assignee: Stichting Katholieke Universiteit
    Inventors: Robert Wilhelmus Johanna Collin, Franciscus Peter Maria Cremers, Antonia Ingrid Den Hollander
  • Device and method incorporating a slideable lid for extracting a targeted fraction from a sample
    Patent number: 9766166
    Abstract: A device and a method for isolating a target from a biological sample are provided. The target is bound to solid phase substrate to form target bound solid phase substrate. The device includes a lower plate with an upper surface having a plurality of regions. The biological sample is receivable on a first of the regions. An upper plate has a lower surface directed to the upper surface of the lower plate. A force is positioned adjacent the upper plate and attracts the target bound solid phase substrate toward the lower surface of the upper plate. At least one of the upper plate and the lower plate is movable from a first position wherein the target bound solid phase substrate in the biological sample are drawn to the lower surface of the upper plate and a second position wherein the target bound solid phase substrate are isolated from the biological sample.
    Type: Grant
    Filed: January 9, 2013
    Date of Patent: September 19, 2017
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: David J. Beebe, Ben P. Casavant, David J. Guckenberger, Scott M. Berry
  • Method for simultaneously determining multiple coagulation proteases
    Patent number: 9482673
    Abstract: The present invention relates to a chromogenic method for simultaneously determining the activity of multiple coagulation proteases or for simultaneously determining the inhibition of multiple coagulation proteases in a single test reaction. For this purpose, use is made of two chromogenic substrates which have different absorption maxima and whose color signals can be separated spectrally.
    Type: Grant
    Filed: January 5, 2015
    Date of Patent: November 1, 2016
    Assignee: SIEMENS HEALTHCARE DIAGNOSTICS PRODUCTS GMBH
    Inventor: Norbert Zander
  • Visfatin therapeutic agents for the treatment of acne and other conditions
    Patent number: 9393284
    Abstract: The present disclosure relates to compositions and methods for treating acne and other conditions. In particular, the compositions and methods are useful for the treatment of sebum associated conditions.
    Type: Grant
    Filed: August 31, 2014
    Date of Patent: July 19, 2016
    Assignee: ARAVA BIO-TECH LTD.
    Inventors: Tamar Tennenbaum, Liora Braiman-Wiksman, Revital Mandil-Levin
  • Serpinc1 iRNA compositions and methods of use thereof
    Patent number: 9376680
    Abstract: The invention relates to iRNA, e.g., double-stranded ribonucleic acid (dsRNA), compositions targeting the Serpinc1 gene, and methods of using such iRNA, e.g., dsRNA, compositions to inhibit expression of Serpinc1 and methods of treating subjects having a bleeding disorder, such as a hemophilia.
    Type: Grant
    Filed: July 22, 2015
    Date of Patent: June 28, 2016
    Assignee: Alnylam Pharmaceuticals, Inc.
    Inventors: Akin Akinc, Alfica Sehgal, Ivanka Toudjarska, Donald Foster, Stuart Milstein, Brian Bettencourt, Martin Maier, Klaus Charisse, Satyanarayana Kuchimanchi, Kallanthottathil G. Rajeev, Muthiah Manoharan
  • Compositions and methods related to protein displacement therapy for myotonic distrophy
    Patent number: 9371527
    Abstract: Disclosed are compositions and methods related to the interaction of polyCUG and polyCCUG repeat RNA and proteins that bind to these repetitive RNA sequences. Also disclosed are methods of treating DM1 or DM2 comprising inhibiting the interaction of poly(CUG)exp or poly(CCUG)exp RNA with muscleblind proteins, or by causing improvement of spliceopathy in myotonic dystrophy.
    Type: Grant
    Filed: June 5, 2014
    Date of Patent: June 21, 2016
    Assignee: University of Rochester
    Inventors: Charles A. Thornton, Thurman Wheeler, Krzysztof Sobczak, Robert Osborne, Jill Miller, Maurice Scott Swanson
  • Therapeutic and diagnostic strategies
    Patent number: 9347089
    Abstract: The present invention encompasses the finding that microRNAs (miRNAs) regulate certain key proteins involved in DNA repair. In some embodiments, a miRNA suppresses levels and/or activity of one or more DNA repair proteins. In some such embodiments, such suppression renders cells hypersensitive to certain DNA damage agents (e.g., ?-irradiation and genotoxic drugs, among others). The present invention provides various reagents and methods associated with these findings including, among other things, strategies for treating cell proliferative disorders, certain diagnostic systems, etc.
    Type: Grant
    Filed: September 18, 2009
    Date of Patent: May 24, 2016
    Assignee: Children's Medical Center Corporation
    Inventors: Judy Lieberman, Ashish Lal, Dipanjan Chowdhury
  • Methods and compositions for modulating MIR-204 activity
    Patent number: 9334498
    Abstract: The present invention provides compositions and methods for regulating insulin production.
    Type: Grant
    Filed: May 10, 2013
    Date of Patent: May 10, 2016
    Assignee: UAB Research Foundation
    Inventors: Anath Shalev, Guanlan Xu
  • Process for producing bio-based product from straw hemicellulose and fully utilizing the components thereof
    Patent number: 9309577
    Abstract: Provided is a process for producing biomass-based product from straw hemicellulose and utilizing the components thereof thoroughly. Steam-explosion and acid-hydrolysis are combined in the pre-treatment of straw in the process, thus a higher concentration of a sugar liquid can be obtained, and furfural and acetic acid can be recovered. The hemicellulose obtained by the pre-treatment can be used directly as ferment materials for producing butanol, succinic acid, butylene glycol, lactic acid, hydrogen and firedamp, which reduces the cost of these biomass-based products. The cellulose and lignin obtained by extracting the straw with an alkaline solution can produce products, such as sodium hydroxymethyl cellulose etc. In the process, all components in the straw can be utilized thoroughly and waste and pollutant will not be produced.
    Type: Grant
    Filed: January 28, 2011
    Date of Patent: April 12, 2016
    Assignee: Institute of Process Engineering, Chinese Academy of Sciences
    Inventors: Hongzhang Chen, Lan Wang