Abstract: An implantable medical device for use as an artificial urinary bladder can include a collection container configured to be placed in a patient's abdominal cavity and a pump configured to be subcutaneously placed outside the abdominal cavity to allow the patient to perceive the need for urination and controls timing of the urination. Flexible tubing can connect the patient's ureters to the collection container, connect the collection container to the pump, and connect the pump to the patient's urethra, with unidirectional valves where needed, to allow for urination through the patient's natural urethra. The implantable medical device can optionally include a cleaning port and tubing connecting the cleaning port to the collection container for introducing a liquid cleaning agent into internal urination circuit of the device for cleaning, disinfection, and prevention of stone formation.

Abstract: A prosthetic heart valve system includes a prosthetic heart valve having an inflow side, and an outflow side. The heart valve further includes a base at the inflow side, a plurality of commissure posts and valve leaflets secured to the commissure posts to permit flow through the heart valve. An anti-loop member has a first portion on the inflow side of the heart valve and a second portion on the outflow side of the heart valve. The second portion of the anti-loop member is arranged along each commissure post at the tip of each commissure post, and arranged along at least one commissure post twice to form a loop around all of the commissure posts. The anti-loop member is made of a material sufficiently flexible to be removed from the commissure posts without damaging the heart valve yet rigid enough to retain its shape when coming in contact with sutures.

Abstract: A prosthetic heart valve for the treatment of structural heart disease wherein the prosthetic heart valve includes an expandable frame that is formed of a rhenium containing metal alloy. The novel geometry of the expandable frame in combination with the frame being partially or fully formed of the rhenium containing alloy enables the formation of a frame that a) has an open cell geometry in the frame of the prosthetic heart valve that can be used to reduce delivery system size, b) has high radial strength, c) has improved restoration of the physiologic EOA, d) has lower recoil, e) has little or no longitudinal foreshortening, f) allows for proper placement of the bioprosthetic valve in relation to the native commissures of the valve, h) has symmetrical and cylindrical expansion of the prosthetic valve resulting in lower rates of leaflet thrombosis and structural valve deterioration, and i) prevents allergic response and restenosis associated with nickel content.

Abstract: An intra-corporal medical device, a medical device and a method of making an intra-corporal medical device. In one form, the device is formed from one or more tubes with a non-axisymmetric cross-sectional profile such that tines formed in a relatively planar surface of such a device exhibit the ability to accept larger deformations that will have improved mechanical properties, including a lower tendency to buckle under bending forces. In one form, the tube or tubes are made from shape memory materials such as Nitinol that can be expanded or bent in various directions in order to take advantage of shape memory effect, linear and non-linear pseudoelasticity and strain hardened cold work.

Abstract: An endoprosthesis configured to shift between a collapsed configuration and an expanded configuration may include a tubular scaffold formed from a single filament knitted about a central longitudinal axis and defining a length from a proximal end to a distal end, the tubular scaffold including a plurality of rows of loops and a plurality of rows of rungs arranged around the central longitudinal axis in an alternating fashion; and a polymeric covering extending along the tubular scaffold. Each row of loops and each row of rungs extends longitudinally along the tubular scaffold between the proximal end and the distal end. The tubular scaffold includes a first cutout region extending along a majority of the length of the tubular scaffold and a second cutout region extending along a majority of the length of the tubular scaffold. The polymeric covering is uninterrupted along the first cutout region and the second cutout region.

Abstract: An accommodating intraocular lens (AIOL) for implantation within a capsular bag of a patient's eye comprises first and second components coupled together to define an inner fluid chamber and an outer fluid reservoir. The inner region of the AIOL provides optical power with one or more of the shaped fluid within the inner fluid chamber or the shape of the first or second components. The fluid reservoir comprises a bellows region with fold(s) extending circumferentially around an optical axis of the eye. The bellows engages the lens capsule, and a compliant fold region between inner and outer bellows portions allows the profile of the AIOL to deflect when the eye accommodates for near vision. Fluid transfers between the inner fluid chamber and the outer fluid reservoir to provide optical power changes. A third lens component coupled to the first or second component provides additional optical power.

Abstract: An accommodating intraocular lens (AIOL) for implantation within a capsular bag of a patient's eye comprises first and second components coupled together to define an inner fluid chamber and an outer fluid reservoir. The inner region of the AIOL provides optical power with one or more of the shaped fluid within the inner fluid chamber or the shape of the first or second components. The fluid reservoir comprises a bellows region with fold(s) extending circumferentially around an optical axis of the eye. The bellows engages the lens capsule, and a compliant fold region between inner and outer bellows portions allows the profile of the AIOL to deflect when the eye accommodates for near vision. Fluid transfers between the inner fluid chamber and the outer fluid reservoir to provide optical power changes. A third lens component coupled to the first or second component provides additional optical power.

Abstract: An intraocular lens is provided which includes a single optical part, a haptic element, which is coupled to the optical part, and an optical main axis, which penetrates a front face and a rear face of the optical part, the haptic element having a first haptic part, which is in the form of a first ring and extends around the optical part, and at least one second haptic part, which is in the form of a second ring and extends around the optical part and is elastically movable relative to the first haptic part, at least one of the two rings being uneven in the peripheral direction about the optical main axis, at least one of the two rings having exactly two ring valleys and exactly two ring hills.

Abstract: A method for heart valve replacement comprises forming an incision in a wall of a ventricle of a heart and inserting a delivery apparatus and a prosthetic heart valve through the incision and into the ventricle of the heart. The prosthetic valve comprises a self-expanding frame having an annular main body and a valve member disposed within the annular main body. The prosthetic valve further comprises an atrial sealing member formed by an annular metal ring and a fabric, wherein only the fabric of the atrial sealing member is connected to the main body for enhancing the flexibility and conformability of the atrial sealing member. The method further comprises deploying the prosthetic valve from the delivery apparatus such that the atrial sealing member extends radially outwardly from the main body within an atrium of the heart and the main body self-expands to a deployed state within a native heart valve.

Abstract: A delivery apparatus including a measurement device to monitor the real-time diameter of a prosthetic heart valve can include a handle, at least one first actuator extending from the handle and being configured to apply a distally directed force to a proximal end portion of a prosthetic heart valve, at least one second actuator extending from the handle and being configured to apply a proximally directed force to a distal end portion of a prosthetic heart valve, a sensor, and first and second motion-transmitting members coupled to the first and second actuators, respectively, and having proximal ends coupled to the sensor, wherein the sensor senses relative movement between the motion-transmitting members upon actuation of the first and second actuators to determine the diameter of the prosthetic heart valve as it expands from a radially compressed configuration to a radially expanded configuration.

Abstract: Systems, methods, and devices for inserting an intraocular lens (IOL) assembly into an eye may be provided. An example optic management system may include a housing having a first end and a second end and a first side extending between the first end and the second end. The housing may include a cavity formed in the first side of the housing and configured to accommodate an intraocular lens, wherein the cavity comprises a first end portion, a second end portion, and a central portion. The housing may further include a bore formed in the housing, wherein a first portion of the bore extends from the first end to the cavity. The haptic optic management system may further include a ceiling disposed on the first side of the housing. The haptic optic management system may further include arms pivotably coupled to the housing in the cavity.

Abstract: Apparatus and methods are described for use with an annuloplasty ring (20), and an atrioventricular valve of a heart of a mammalian subject, the atrioventricular valve including a valve annulus, valve leaflets, chords, and papillary muscles. A plurality of chord-manipulation arms (26) are configured to be deployed among the chords of the atrioventricular valve, and to cause a size of the valve annulus to decrease, by the chord-manipulation arms (26) being rotated such as to twist the native atrioventricular valve and pull the native atrioventricular valve radially inwards, by the chord-manipulation arms (26) deflecting the chords. The chord-manipulation arms (26) are configured to subsequently provide a counterforce against which the annuloplasty ring (20) is pushed, during implantation of the annuloplasty ring (20). Other applications are also described.

Abstract: The present invention provides a valved vascular prosthesis and a manufacturing method thereof. The valved vascular prosthesis, comprising an artificial blood vessel and a valve disposed inside for obstruction; the valve is in a skirt state extending toward the centerline of the artificial blood vessel; the valve is made by sewing a tubular vascular material on the artificial blood vessel; one end of the vascular material is connected to the artificial blood vessel along its radial direction, and the other end is a free end; the entire tubular body of the vascular material is sewed on the artificial blood vessel by a plurality of sutures; the sutures are radially parallel to the tubular body of the vascular material, and are arranged at intervals along the circumference of the tubular body of the vascular material. The valved vascular prosthesis of the present invention adopts suture of a polymer material and an artificial blood vessel.

Abstract: The invention relates to an anchor hook and methods of using the same for subannular anchoring of a transcatheter heart valve replacement, and in particular for an orthogonally delivered (side-delivered) transcatheter prosthetic heart valve having a annular support frame having compressible wire cells that facilitate rolling and folding the valve length-wise, or orthogonally to the central axis of the flow control component, allowing a very large diameter valve to be delivered and deployed to the mitral or tricuspid valve from the inferior vena cava or superior vena cava, or trans-septally to the mitral valve, the valve having a height of about 5-60 mm and a diameter of about 25-80 mm, without requiring an oversized diameter catheter and without requiring a delivery catheter to bend 90 degrees during deployment.

Abstract: A stent delivery device that can be inserted into an endoscope. The device includes a guide catheter including a guide tube, an operating wire, and a joint portion that joins the guide tube and the wire. The device also includes a pusher catheter including a first tube through which the wire is inserted and a second tube through which the guide tube is inserted. The device may include a bite prevention portion that can prevent the wire from biting into an inner surface of the second tube. In a state where a distal end of the pusher catheter protrudes from the endoscope channel and the channel includes a curved portion in a curved state, a proximal end of the guide tube, which includes the joint portion, and/or the bite prevention portion can be positioned proximal of a proximal end of the curved portion in the endoscope channel.

Abstract: A loading tool to facilitate loading a prosthesis into a delivery system includes a hinged body with first and second body portions and a collar slidingly disposed over the hinged body. First ends of the body portions are attached and second ends of the body portions are not attached. Each body portion includes a resilient clip that includes a radial protrusion. Each resilient clip is configured to displaced radially inwards when a pinching force is applied thereto. The loading tool has an open configuration in which the second ends are radially spaced apart and the collar is disposed over the first ends. The loading tool has a closed configuration in which the second ends are disposed directly adjacent to each other and the collar is disposed over the second ends. The radial protrusions lock the loading tool in the closed configuration when the resilient clips are not displaced radially inwards.

Abstract: Aspects of the disclosure include delivery devices for transcatheter delivery of a cardiac implant. Delivery devices can include a handle assembly as well as a piston mount connected to the handle assembly and having a distal portion terminating at a nose cap. The distal portion includes a stop extending radially from and fixed to the distal portion. The delivery device further includes a capsule assembly including a biasing element for selectively sheathing the implant and a plurality of retraction members secured about a distal end of the biasing element to control deployment of the implant. In various examples, the biasing element is a helical compression spring and the implant is a prosthetic tricuspid heart valve. Methods of loading a delivery device and delivering an implant are also disclosed.

Abstract: An orthopedic medical device that is at least partially coated with an enhancement coating, and a method for inserting the orthopedic medical device in a patient. One type of enhancement coating that can be used includes titanium oxynitride or titanium nitride oxide (TiNOx) and/or zirconium oxynitride (ZrNxOy).

Abstract: A hair implant suitable for subcutaneous implantation is provided having an anchor comprising an anchor body, and at least one collagen receiving structure selected from the group consisting of at least one tunnel disposed through the anchor body and an external surface feature of the anchor body. The anchor further comprises at least one hair strand projecting from a distal end of the anchor body, wherein the at least one collagen receiving structure is configured to support collagen ligature growth after subcutaneous implantation of the hair implant to anchor the anchor to a hair implant recipient, and the collagen receiving structure is free of hair. A fracture line in the anchor body allows the body to fragment, thereby releasing collagen ligatures and allowing the implant fragments to “release” and fall out of the skin. The at least one hair strand may comprise a primary hair element with emerging hair elements.

Abstract: A retrieval device for retrieving a previously implanted device from a native valve of a patient's heart includes one or more retrieval components. The retrieval components include one or more of a device securing member, a device actuation member, and a clasp capturing member. The securing member is configured to attach the retrieval device to the previously implanted device. The actuation member engages the previously implanted device to move the previously implanted device from a closed configuration to an open configuration. The clasp capturing member is configured to attach to a clasp of the previously implanted device.