Abstract: A lower limb prosthesis comprises a knee chassis (10), a shin carrier (20) pivotally connected to the knee chassis (10) and a piston and cylinder assembly (30, 40) pivotally connected to the knee chassis (10) and the shin carrier (20). The piston and cylinder assembly (30, 40) comprises a piston assembly (40) comprising a piston (40) mounted on a piston rod (42), a cylinder body (32B) having a cavity (46) defining a cylinder within which the piston (44) is arranged to reciprocate along the piston and cylinder assembly axis, and a foot component attachment means (36) for attaching a foot component to the piston and cylinder assembly (30, 40).

Abstract: An accommodative intraocular lens capable of effectively exerting a focus adjustment function includes an optical portion and a plurality of support portions arranged around the optical portion. The support portion includes an anterior support portion and a posterior support portion, and the anterior support portion presses an anterior capsule and the posterior support portion presses a posterior capsule by the elastic force of the support portion. When the lens capsule is in a distance vision state or in a near vision state, as the pressing force of the anterior capsule against the anterior support portion increases or decreases, the anterior support portion deflects backward or returns forward while maintaining the radial position of the base end portion, so that the tip end portion of the anterior support portion moves backward or forward greatly while maintaining the radial position, and the optical portion moves backward or forward accordingly.

Abstract: A virtual aperture integrated into an intraocular lens is disclosed. Optical rays which intersect the virtual aperture are widely scattered across the retina causing the light to be virtually prevented from reaching detectable levels on the retina. The use of the virtual aperture helps remove monochromatic and chromatic aberrations yielding high-definition retinal images. For a given definition of acceptable vision, the depth of field is increased over a larger diameter optical zone. In addition, thinner intraocular lenses can be produced since the optical zone can have a smaller diameter. This in turn allows smaller corneal incisions and easier implantation surgery.

Abstract: An intervertebral implant for implantation in an intervertebral space between vertebrae. The implant includes a body extending from an upper surface to a lower surface. The body has a front end, a rear end and a pair of spaced apart first and second side walls extending between the front and rear walls such that an interior chamber is defined within the front and rear ends and the first and second walls. The body defines an outer perimeter and an inner perimeter extending about the internal chamber. At least one of the side walls is defined by a support structure and an integral porous structure, the porous structure extending from the outer perimeter to the inner perimeter. The porous structure embeds or encapsulates at least a portion of the support structure.

Abstract: Systems and methods for improving vision of a subject implanted with an intraocular lens (IOL) that has a non-zero residual spherical error that requires an estimated diffractive power addition in the IOL. In some embodiments, a plurality of laser pulses are applied to the IOL, the laser pulses being configured to produce, by refractive index writing on the IOL, the estimated diffractive power addition to correct for the residual spherical error.

Abstract: There is disclosed a mobility aid for use by a user having a lower body amputation site. The mobility aid includes a lower body exoskeleton (LBE). The LBE has a pelvic support structure and a first leg and a second leg. Each of the first and second legs are movably coupled to the pelvic support structure, wherein at least the first and second legs are selectively actuable to move the lower body exoskeleton relative to a surface on which the mobility aid is positioned. The LBE also includes a carrier selectively positionable with respect to the lower body exoskeleton and, which in use, supports the user at or about an amputation site; and a harness system configured to, when in use, secure the user to the lower body exoskeleton.

Abstract: Provided is an artificial bladder including: a main body which includes an inlet port, an outlet port, and a predetermined reservoir portion configured to store urine between the inlet port and the outlet port and is formed of a biocompatible polymer that is expandable so that a volume of the reservoir portion changes according to the amount of urine; a sensor which is attached to an outer wall of the main body, has a surface having a wrinkled structure, and is provided so that, when the volume of the reservoir portion increases, the wrinkled structure stretches out and resistance of the sensor changes; and an actuator which is provided at the outlet port and is configured to discharge the urine according a result detected by the sensor.

Abstract: The present disclosure relates to an arrangement, a loop-shaped support, a prosthetic heart valve and a method of repairing or replacing a native heart valve. With the method or the arrangement, leakage or regurgitation between a prosthetic heart valve and the surrounding valve tissue is prevented. In one embodiment, an arrangement for replacement or repair of a native heart valve is provided, which comprises a loop-shaped support 41 and a prosthetic heart valve 70 and wherein an outer segment 32 of the loop-shaped support 41 is positionable towards surrounding valve tissue of a native heart valve and wherein an outer surface 74 of the prosthetic heart valve 70 is positionable towards an inner segment 34 of the loop-shaped support 41 so as to prevent paravalvular leakage or regurgitation between the prosthetic heart valve 70 and the surrounding valve tissue of the native heart valve.

Abstract: A structured artificial construct that allows corneal endothelium to be regenerated from isolated cells outside the human or animal body is provided. The structured artificial construct is formed from a dome-shaped base body with a honeycomb structure formed in a concave side of the base body. Methods for generating the structured artificial construct are also provided.

Abstract: A system for converting a first joint prosthesis to a second joint prosthesis in-situ includes a plurality of inserts having a bone interface side and a component facing side and a plurality of articulating components having a cavity configured to receive at least one of the plurality of inserts. The plurality of inserts may be unicompartmental, bicompartmental, or tricompartmental. The inserts may be made of metal and may have a bone contacting surface made of a porous metal. The plurality of articulating components may be unicompartmental, bicompartmental, or tricompartmental. The articulating components may be sized and shaped to cover one or more of the plurality of bone interface components and span a distance therebetween. The articulating components may be made of a polymer.

Abstract: A multi-laminar electrospun nanofiber scaffold for use in repairing a defect in a tissue substrate is provided. The scaffold includes a first layer formed by a first plurality of electrospun polymeric fibers, and a second layer formed by a second plurality of electrospun polymeric fibers. The second layer is combined with the first layer. A first portion of the scaffold includes a higher density of fibers than a second portion of the scaffold, and the first portion has a higher tensile strength than the second portion. The scaffold is configured to degrade via hydrolysis after at least one of a predetermined time or an environmental condition. The scaffold is configured to be applied to the tissue substrate containing the defect, and is sufficiently flexible to facilitate application of the scaffold to uneven surfaces of the tissue substrate, and to enable movement of the scaffold by the tissue substrate.

Abstract: A reconstruction system and associated techniques for soft tissue repairs and repair augmentation. The reconstruction system is an internal soft tissue brace formed of at least one fixation device (for example, anchors or screws) and a replacement/reinforcement construct (for example, a suture construct in the form of a suture tape such as FiberTape® or a collagen tape or a suture with biological material or a collagen coated material, or a collagen patch, or a biological construct such as Arthroflex). The reinforcement construct and fixation devices may be used as a suture repair alone (to replace the ligament or tendon), or in conjunction with other traditional soft tissue repair procedures, acting as a reinforcement system for the repaired soft tissue.

Abstract: A collapsible stent for an implantable prosthetic valve incorporates leaflet-supporting members having relatively large surface area in comparison to other members defining the remainder of the stent. The leaflet-supporting members may have openings extending through them. The valve leaflets may be attached to the stent so that an attached edge of each leaflet extends along the leaflet-supporting members and is attached to the members by polymer integral with the leaflet overlying the leaflet supporting members and extending into the openings of the leaflet supporting members. The secure attachment resists stress on the leaflets.

Abstract: The present disclosure relates generally to the field of medical devices. In particular, the present disclosure relates to medical devices, systems and methods to treat a regurgitating cardiac valve, including, for example a tricuspid or mitral valve.

Abstract: Assisted walking devices for use by a person with at least one side paralysis or weakness and for paraplegics are provided with features for user friendly attachment and release of the devices. The assisted walking devices include features for controlled limitation of lateral gait movement that occurs in natural lateral walking gait motion.

Abstract: An implant for improving coaptation of an atrioventricular valve, the atrioventricular valve having a native first leaflet, a native second leaflet and an annulus and controlling blood flow from an upstream side to a downstream side of the valve, the implant comprising a support structure configured to be fixed to the annulus or to the native first leaflet, the implant further comprising a flexible artificial leaflet structure mounted to the support structure and comprising a rim section that is shaped to coapt with the native second leaflet, wherein said rim section comprises pockets that are open towards said downstream side and capable of being filled with blood from the downstream side each time the valve is closed.

Abstract: An implant includes a first plate and a second plate, a first wedge member and a second wedge member spaced from the first wedge member that couple the first and second plates together. The first and second wedge members configured to translate along the first and second plates from a first contracted configuration into a second expanded configuration. The implant includes an actuation member coupled to the first wedge member and the second wedge member. The actuating member defines a flange extending toward the first and second plates. The actuation member configured to move the first and second wedge members from the first contracted configuration into the second expanded configuration so that the first and second plates separate from each other.

Abstract: A nipple implant system wherein a nipple prosthetic device is attached to a microdermal anchor without the need for invasive surgery. The microdermal anchor is inserted through a hole punched at a selected locus. The nipple prosthetic device is configured for attachment to the microdermal anchor. An areola may be tattooed around the locus or the nipple prosthetic device may include a skirt simulating an areola to make the construction complete.

Abstract: An easy-to-control interventional instrument delivery device, comprising a core tube (7), a guiding head (2) and a fixing head (3) being fixed onto the core tube (7); the guiding head (2) is fixed at a distal end of the core tube (7), and the fixing head (3) extends from a proximal end side of the core tube (7), an interventional instrument mounting position being located between the guiding head (2) and the fixing head (3); the outer periphery of the interventional instrument mounting position is provided with an axially skiable outer sheathing tube (5), further being provided with a floating limiting strip (1); a proximal end of the floating limiting strip (1) is a starting end (13) that is connected near the fixed head (3), and a distal end is a terminal end (11, 101) that floats between the interventional instrument mounting position and the outer sheathing tube (5).

Abstract: An intraocular lens and a method of constructing the intraocular lens are described. The intraocular lens is implanted in a human eye to treat conditions of the eye. The intraocular lens includes a central deformable optic and an annular ring coupled to the deformable optic. The intraocular lens is made by subjecting the deformable optic to compressive forces that reduce the optical power of the deformable optic, and then molding the annular lens to the deformable optic while the deformable optic is undergoing the compressive forces. Once the compressive forces are released, the deformable optic stresses the annular ring along a radial axis of the deformable optic when the intraocular lens is in a natural, unstressed state. The stress or tension between the deformable optic and the annular ring keep the deformable optic from developing deformities that cause visual aberrations.