Abstract: An antiperspirant aerosol product having good sustainability characteristics and comprising an anhydrous antiperspirant aerosol composition comprising particulate antiperspirant active suspended in a carrier oil, the ratio of propellant to base composition being from 2:1 to 4:1 by weight and an aerosol dispenser comprising a container body, an aerosol valve, and a valve actuator; characterised in that the particulate antiperspirant active comprises a basic aluminium chloride compound of formula Al2(OH)4.4Cl1.6 to Al2(OH)4.9Cl1.1, water soluble calcium salt and an amino acid and the aerosol valve of the aerosol dispenser has a vapor phase tap (VTP) to restrictive tailpiece (RTP) ratio of from 0.6:1 to 1.2:1.
Type:
Grant
Filed:
November 1, 2016
Date of Patent:
June 16, 2020
Assignee:
Conopco, Inc.
Inventors:
Sebastian Alvarez, Kevin Ronald Franklin, Philip Christopher Waterfield
Abstract: A submicron structure includes a silica body defining a plurality of pores that are suitable to receive molecules therein, the silica body further defining an outer surface between pore openings of said plurality of pores; and a plurality of anionic molecules attached to the outer surface of the silica body. The anionic molecules provide hydrophilicity to the submicron structure and are suitable to provide repulsion between other similar submicron structures, and the submicron structure has a maximum dimension less than one micron.
Type:
Grant
Filed:
June 1, 2018
Date of Patent:
June 2, 2020
Assignee:
The Regents of the University of California
Inventors:
Monty Liong, Jie Lu, Fuyuhiko Tamanoi, Jeffrey I. Zink, Andre E. Nel
Abstract: An antiperspirant aerosol product having good environmental sustainability and comprising an anhydrous antiperspirant aerosol composition comprising an AP active comprising a basic aluminium chloride compound of formula Al2(OH)4.4Cl1.6 to Al2(OH)4.9Cl1.1, water soluble calcium salt and amino acid, and an aerosol dispenser comprising a container body, an aerosol valve, and a valve actuator; characterised in that the product has a Combined Sustainability Index (CSI) of less than 3.0, where: CSI=AlF+VOCF+MCB/N AlF being the weight (in centigrams) of aluminium expelled per spray; VOCF being the weight of VOC (in grams) expelled per spray; MCB being the weight of metal (in grams) in the container body; and N is the number of spray applications possible from the fully charged product, each figure being based on a spray duration of 2 seconds.
Type:
Grant
Filed:
November 1, 2016
Date of Patent:
May 26, 2020
Assignee:
Conopco, Inc.
Inventors:
Sebastian Alvarez, Kevin Ronald Franklin, John Matthew Henry King, Philip Christopher Waterfield
Abstract: A method is for making a hemostat device. The method includes preparing a homogenous solution of gelatin and chitosan by adding gelatin to water to form a gelatin solution, adding an acid to the gelatin solution to provide an acidified gelatin solution, and adding chitosan to the acidified gelatin solution to form the homogenous solution of gelatin and chitosan. The method also may include air drying the homogenous solution of gelatin and chitosan to provide an air dried scaffold, processing the air dried scaffold to provide a porous sponge, loading the porous sponge with a clotting agent by exposing the porous sponge to the clotting agent in an aqueous solution, and drying the loaded porous sponge.
Type:
Grant
Filed:
November 8, 2018
Date of Patent:
May 19, 2020
Assignee:
Datt Life Sciences Private Limited
Inventors:
Rajan Datt, Ramadhar Kumar, Pallavi Shrivastava
Abstract: A composition includes particles of pimobendan with an integral coating of a carrier matrix which serve to ensure a rapid dissolution of the active substance at each pH condition representing the gastrointestinal tract and therefore a reliable absorption, and a method of pimobendan microencapsulation using the spray congealing technology and incorporating the coated particles into oral formulations, for example into tablets.
Abstract: In one embodiment, a confectionary comprises at least one sweetener, at least one stabilizer, at least one emulsifier, water, a first active ingredient, and an enrobing layer. The water may comprise 2 to 20 wt. % of the confectionary. The confectionary may have a water activity of from 0.45 to 0.65. The confectionary may be aerated such that the density of the confectionary is 0.7 to 1.25 grams per cubic centimeter. The confectionary may have a pH of 5.0 to 8.0.
Abstract: An oral product includes a body that is wholly receivable in an oral cavity. The body includes a mouth-stable polymer matrix, cellulosic fibers embedded in the mouth-stable polymer matrix, and an additive dispersed in the mouth-stable polymer matrix. The oral product is adapted to release the additive from the body when the body is received within the oral cavity and exposed to saliva.
Type:
Grant
Filed:
December 21, 2017
Date of Patent:
May 5, 2020
Assignee:
Altria Client Services LLC
Inventors:
Feng Gao, Frank Scott Atchley, Gregory James Griscik, Christopher Joseph DiNovi, Phillip M. Hulan, Diane L. Gee, Gerd Kobal
Abstract: The present invention relates to mixed crystals comprising a) leavening agent and b) 0.1 to 5000 ppm by weight of crystallization aid, based on the total amount of the leavening agent, in the form of at least polymer, wherein when hydrophilic cellulose derivatives are used as crystallization aid, the amount thereof is reduced to less than 100 ppm by weight, based on the total amount of the leavening agent. The present invention further relates to the production of the mixed crystals and to the use thereof in the production of bakery products, as acid regulator in foods, in the production of cosmetics products, in the synthesis and formulation of pharmaceutical products, and also as blowing agent in industrial processes such as, for example, the production of foam rubber, or for fire-extinguishing formulations. The present invention relates, furthermore, to the production of bakery products.
Type:
Grant
Filed:
January 10, 2018
Date of Patent:
April 7, 2020
Assignee:
BASF SE
Inventors:
Ralf Diener, Jürgen Schneider, Herbert Seiter, Manfred Schaefer, Walther Schmid
Abstract: Methods for identifying premature infants at risk for developing bronchopulmonary dysplasia and/or most likely to benefit from administration of inhaled nitric oxide for prevention of bronchopulmonary dysplasia (BPD). Methods for treating premature infants identified as at risk and/or likely to benefit are provided. also provided are methods for identifying premature infants that are not at risk for developing bronchopulmonary dysplasia and/or unlikely to benefit from administration of inhaled nitric oxide for prevention of bronchopulmonary dysplasia, and methods for avoiding risks of toxicity and undesirable side effects associated with inhaled nitric oxide therapy comprising administering only non-iNO treatment modalities to these infants.
Type:
Grant
Filed:
June 18, 2015
Date of Patent:
April 7, 2020
Assignee:
Mallinckrodt Hospital Products IP Limited
Inventors:
Douglas Stuart Greene, Joseph J. Medicis, Jim Potenziano
Abstract: The present invention includes an ultraviolet radiation absorbing polymer composition comprising the polymer compound of formula and compositions containing such an ultraviolet radiation absorbing polymer composition.
Abstract: Oral dosage forms containing an opioid antagonist in a sequestered form are described. The opioid antagonist is sequestered such that it is not released or substantially not released in the gastrointestinal tract from the dosage form which is administered orally intact. However, when the dosage form is chewed, crushed, heated or dissolved in a solvent, and then administered orally, intranasally, parenterally or sublingually, the opioid antagonist is released and at least partially blocks effects of the opioid agonist.
Type:
Grant
Filed:
June 5, 2019
Date of Patent:
March 17, 2020
Assignee:
Purdue Pharma L.P.
Inventors:
Benjamin Oshlack, Curtis Wright, J. David Haddox
Abstract: Systems and methods provide sugar alcohol to heat stressed ruminants to improve performance. During periods of high temperature or humidity, heat stressed ruminants may exhibit decreased dry matter intake, and in response, an effective amount of sugar alcohol such as sorbitol may be provided in the ruminant diet to cause performance to increase, which may include increased milk yield, improved feed efficiency or both compared to heat stressed dairy cattle without sugar alcohol in the diet.
Type:
Grant
Filed:
April 3, 2019
Date of Patent:
March 17, 2020
Assignee:
PURINA ANIMAL NUTRITION LLC
Inventors:
Bill L. Miller, Jill A. Davidson, Cindie M. Luhman
Abstract: The present disclosure relates to compositions and methods for contraception that also enhance the efficacy of microbicides. Such compositions serve the dual purpose of preventing pregnancy and lessening the risk of spreading sexually transmitted diseases. More specifically, the compositions and methods relate to syngergistic contraceptive microbicide and antiviral compositions comprising a combination of a contraceptive microbicide and an antiviral agent in an acidic carrier that enhances the efficacy of both the contraceptive microbicide and antiviral agent.
Abstract: Nanostructures having a core, a lipid layer and a lipoprotein which are useful for delivering therapeutic agents are provided herein. Methods of treating disease using the nanostructures are also provided, including methods of treating cancer, infectious disease, vascular disease etc.
Type:
Grant
Filed:
August 13, 2014
Date of Patent:
February 25, 2020
Assignee:
Northwestern University
Inventors:
C. Shad Thaxton, Leo I. Gordon, Raja Kannan Mutharasan, Casey N. Grun, Linda Foit
Abstract: A solid oral dosage form is provided, comprising a compound of Formula I or a pharmaceutically acceptable salt thereof, tenofovir alafenamide or a pharmaceutically acceptable salt thereof, and emtricitabine or a pharmaceutically acceptable salt thereof.
Type:
Grant
Filed:
November 8, 2016
Date of Patent:
February 4, 2020
Assignee:
Gilead Sciences, Inc.
Inventors:
Benjamin Micah Collman, Lei Hong, Joanna M. Koziara
Abstract: A pharmaceutically active composition containing an effective amount of a pharmacologically active ingredient such as an antifungal and a carrier. The carrier comprises dimethyl isosorbide, undecylenic acid, a lower carboxylic acid other than undecylenic acid, a monohydric alcohol having from 2 to 4 carbon atoms, and urea.
Abstract: The present invention provides nutritional compositions, preferably printed, comprising at least one nutrient for which a deficiency in nutrient intake and/or nutrient status in a subject was detected. Such nutritional composition is comprised by an administration unit, and the nutrient is present at an amount corresponding to the difference between the target value and actual value of the nutrient intake and/or status in the subject. The invention further provides medical uses of such printed nutritional compositions, e.g. in the treatment or prophylaxis of malnutrition. The invention also provides administration units comprising such the nutritional compositions, as well as a system and method for producing the same.
Abstract: Certain dermatological formulations for direct skin application that correct for hyperpigmentation effects are provided. Such formulations include a number of different compounds that work synergistically to effectuate multiple and varied pathways to pigment removal and/or brightening within the dermal layer. The ability to do so without the necessity for hydroquinone, and thus with a suitable composition that is safe for handling and utilization by pregnant and nursing women, is accorded through a combination of specific ingredients in limited proportional ranges, as well. Such ingredients include kojic acid, niacinamide, sodium hyaluronate, tocopherol, and licorice extract in very narrow ranges proportionally within an aqueous serum. The method of manufacture and use thereof such formulations are encompassed within the invention as well.
Abstract: The antimicrobial foaming composition of the present invention comprises a cationic active ingredient, a cationic compatible surfactant, a foam booster, a foam structure enhancing agent, dermal adjuvants, and a carrier. The present antimicrobial compositions are free of the antimicrobial agents triclosan (i.e., 2,4,4?-trichloro-2?hydroxy-diphenylether) and lower alcohols. They are also free of anionic surfactants. The foaming compositions have rapid cidal activity, provide stable, copious foam, and exhibit enhanced tissue (e.g. skin) compatibility.
Type:
Grant
Filed:
March 23, 2018
Date of Patent:
December 31, 2019
Assignee:
Ecolab USA Inc.
Inventors:
Hilina Emiru, Cheryl A. Littau, Joseph R. Wegner, Daniel E. Pedersen, Mai Le, Amanda L. Wessinger
Abstract: The presently disclosed subject matter describes the use of fluorinated elastomer-based materials, in particular perfluoropolyether (PFPE)-based materials, in high-resolution soft or imprint lithographic applications, such as micro- and nanoscale replica molding, and the first nano-contact molding of organic materials to generate high fidelity features using an elastomeric mold. Accordingly, the presently disclosed subject matter describes a method for producing free-standing, isolated nanostructures of any shape using soft or imprint lithography technique.
Type:
Grant
Filed:
December 19, 2017
Date of Patent:
December 31, 2019
Assignee:
THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
Inventors:
Joseph M. DeSimone, Jason P. Rolland, Benjamin W. Maynor, Larken E. Euliss, Ginger Denison Rothrock, Ansley E. Dennis, Edward T. Samulski, R. Jude Samulski