Patents Examined by Jessica Worsham
  • Acid tablet composition and methods of preparing and using the same
    Patent number: 10512270
    Abstract: Compositions, tablets, prills and granules are provided including (a) about 95 to about 99.999 weight percent of at least one alkali metal hydrogen sulfate; and (b) about 0.001 to less than 0.08 weight percent of at least one alkali metal salt of a fatty carboxylic acid and/or at least one alkaline earth metal salt of a fatty carboxylic acid; wherein the composition includes less than 1 weight percent of chlorite and/or hypochlorite and less than 1 weight percent of alkali metal salt and/or alkaline earth metal salt that is chemically different from the at least one alkali metal hydrogen sulfate, the at least one alkali metal salt of a fatty carboxylic acid and the at least one alkaline earth metal salt of a fatty carboxylic acid, on a basis of total weight of the composition. Methods of use also are provided.
    Type: Grant
    Filed: March 27, 2017
    Date of Patent: December 24, 2019
    Assignee: Eagle US 2 LLC
    Inventor: Christopher M. Kareis
  • Cosmetic use of heparan sulphate
    Patent number: 10493012
    Abstract: Affinity purification of fibroblast growth factor 2-binding heparan sulphate from porcine mucosa (HS8) is disclosed. Also disclosed is a process for the care of keratinous material(s), comprising the application or administration of HS8, or a composition comprising thereof, to keratinous material(s). The composition may be used to improve the condition of skin, such as smoothing the skin, restoring skin elasticity and firmness, or decreasing or preventing wrinkles, and may be formulated for topical or transdermal administration.
    Type: Grant
    Filed: November 19, 2015
    Date of Patent: December 3, 2019
    Assignees: Agency for Science, Technology and Research, L'Oreal
    Inventors: Simon Cool, Victor Nurcombe, Charbel Bouez, Diah Saraswati Bramono
  • Fibrous structures comprising a surface softening composition
    Patent number: 10479960
    Abstract: Fibrous structures containing a plurality of wood pulp fibers and a surface having thereon a surface softening composition containing a metathesized unsaturated polyol ester having one or more of the following properties: (i) a weight average molecular weight of from about 5,000 Daltons to about 50,000 Daltons; (ii) an oligomer index from greater than 0 to 1; and (iii) an iodine value of from about 30 to about 200 is provided.
    Type: Grant
    Filed: July 7, 2016
    Date of Patent: November 19, 2019
    Assignee: The Procter & Gamble Company
    Inventors: Khosrow Parviz Mohammadi, Beth Ann Schubert, Jeffrey John Scheibel
  • Antimicrobial compositions and methods
    Patent number: 10471036
    Abstract: Antimicrobial compositions, especially those useful when applied topically, particularly to mucosal tissues (i.e., mucous membranes), including, in particular, an antimicrobial lipid component, such as a fatty acid ester, fatty ether, or alkoxide derivative thereof. The compositions can also include an enhancer component, a surfactant, a hydrophobic component, and/or a hydrophilic component. Such compositions provide effective topical antimicrobial activity and are accordingly useful in the treatment and/or prevention of conditions that are caused, or aggravated by, microorganisms (including viruses).
    Type: Grant
    Filed: July 15, 2013
    Date of Patent: November 12, 2019
    Assignee: 3M Innovative Properties Company
    Inventors: Matthew T. Scholz, Dianne L. Gibbs, John T. Capecchi, Jeffrey F. Andrews
  • Nutritional supplement composition suitable for improving lean tissue mass status in an adult human
    Patent number: 10455853
    Abstract: “A nutritional supplement composition suitable for improving lean tissue mass status in a mammal” A nutritional supplement suitable for increasing lean tissue mass in a mammal comprises protein, vitamin D, and calcium. The protein comprises a casein-based milk protein composition, a hydrolyzed whey-based milk protein composition having insulinotropic bioactivity, and a hydrolyzed whey-based milk protein composition having anti-oxidant bioactivity. The supplement increases lean tissue mass in a subject.
    Type: Grant
    Filed: May 26, 2015
    Date of Patent: October 29, 2019
    Assignee: UNIVERSITY OF LIMERICK
    Inventor: Phil Jakeman
  • Rapidly degrading embolic particles with therapeutic agent release
    Patent number: 10456361
    Abstract: In accordance with one aspect, embolic particles are provided which comprise sub-particles that comprise a therapeutic agent of low solubility dispersed in a matrix that comprises a biodegradable polymer. Other aspects pertain to injectable compositions that comprise such particles and to methods of treatment that employ such injectable compositions. Still other aspects pertain to methods of making such particles.
    Type: Grant
    Filed: February 5, 2015
    Date of Patent: October 29, 2019
    Assignee: Boston Scientific Scimed, Inc.
    Inventor: Steven L. Kangas
  • Manufacture of peanut formulations for oral desensitization
    Patent number: 10449118
    Abstract: The present application relates to a method for managing the development and manufacturing process of a therapeutically effective formulation. Peanut proteins are characterized from peanut flour and encapsulated formulations made using the peanut flour for oral immunotherapy of peanut allergies.
    Type: Grant
    Filed: October 24, 2017
    Date of Patent: October 22, 2019
    Assignee: AIMMUNE THERAPEUTICS, INC.
    Inventors: Bryan Walser, Howard V. Raff
  • Amorphous vortioxetine and salts thereof
    Patent number: 10414741
    Abstract: The present invention relates to an amorphous vortioxetine and salts thereof. In particular, the invention relates to a process for the preparation of an amorphous vortioxetine hydrobromide. Further, the invention also relates to a process for preparation of amorphous vortioxetine free base. The invention also relates to pharmaceutical compositions comprising an amorphous vortioxetine or hydrobromide salt thereof for oral administration for treatment of major depressive disorder (MDD) and generalized anxiety disorder (GAD).
    Type: Grant
    Filed: September 30, 2014
    Date of Patent: September 17, 2019
    Assignee: CADILA HEALTHCARE LIMITED
    Inventors: Shri Prakash Dhar Dwivedi, Kumar Kamlesh Singh, Jitendra Maganbhai Gajera, Dinesh Kumar Raikwar, Brij Khera
  • Double chamber pouch for the bleaching of human hair
    Patent number: 10406080
    Abstract: The present disclosure relates to a cosmetic agent for lightening keratin fibers, which contains two separate powder-formed preparations (A) and (B), each of which is packaged in a water-soluble film, and a method for lightening keratin fibers using the agent. The cosmetic agent of the present disclosure does not require the use of free hydrogen peroxide.
    Type: Grant
    Filed: October 10, 2017
    Date of Patent: September 10, 2019
    Assignee: Henkel AG & Co. KGaA
    Inventors: Udo Erkens, Burkhard Mueller
  • Process for manufacturing double-walled microcapsules, microcapsules prepared by this process and the use thereof
    Patent number: 10399056
    Abstract: Process for manufacturing reservoir microcapsules containing an active principle in a polymer shell comprising the steps of: (iii) dispersion of a lipophilic active principle in an aqueous continuous phase, forming an oil-in-water emulsion, (iv) introduction into the lipophilic phase of one or more compounds A bearing alkoxysilane groups, (v) introduction into the aqueous phase of amine-containing organic monomers B comprising at least one group selected from melamine, urea, glycoluril, benzoguanamine or dicyandiamide groups and one or more aldehydes, or pre-polymers thereof and (vi) hydrolysis and polymerization, in situ, of the compounds A and B in an acid medium to give a silicone polymer and an amine-containing polymer, bonded together by polar, hydrogen or covalent bonds, forming the wall of the shell of the microcapsules, containing the active principle.
    Type: Grant
    Filed: December 4, 2014
    Date of Patent: September 3, 2019
    Assignee: MICROCAPSULES TECHNOLOGIES
    Inventor: Gerard Daniel Habar
  • Jelly-like medicinal composition of potassium iodide
    Patent number: 10398728
    Abstract: A jelly-like potassium iodide pharmaceutical composition exhibits excellent storage stability and excellent dissolution properties, and can be taken easily. The jelly-like potassium iodide pharmaceutical composition includes potassium iodide as an active ingredient, a gelling agent, and a dispersion medium.
    Type: Grant
    Filed: November 17, 2016
    Date of Patent: September 3, 2019
    Assignee: Nichi-Iko Pharmaceutical Co., Ltd.
    Inventors: Naoko Yoshizawa, Sho Suzuki
  • Cataplasm and method for producing the same
    Patent number: 10369115
    Abstract: A gel patch comprising a plaster layer on a support, the plaster layer comprising a mixture of at least a neutralized polyacrylic acid, a poly(methyl acrylate/2-ethylhexyl acrylate) emulsion, and water, wherein the poly(methyl acrylate/2-ethylhexyl acrylate) emulsion is an emulsion having an evaporation residue of 57 to 61% by heating at or above the boiling point of the medium and is present in an amount of at least 2.5 times and preferably at least 3 times the mass of the neutralized polyacrylic acid.
    Type: Grant
    Filed: August 21, 2014
    Date of Patent: August 6, 2019
    Assignee: HISAMITSU PHARMACEUTICAL CO., LTD.
    Inventors: Keiichiro Tsurushima, Yasuhisa Kose, Shinji Yamasoto, Seiichiro Tsuru, Takaaki Yoshinaga
  • Methods and compositions using peptides and proteins with C-terminal elements
    Patent number: 10370245
    Abstract: Disclosed are compositions and methods useful for targeting and internalizing molecules into cells of interest and for penetration by molecules of tissues of interest. The compositions and methods are based on peptide sequences that are selectively internalized by a cell, penetrate tissue, or both. The disclosed internalization and tissue penetration is useful for delivering therapeutic and detectable agents to cells and tissues of interest.
    Type: Grant
    Filed: June 22, 2010
    Date of Patent: August 6, 2019
    Assignee: Sanford-Burnham Medical Research Institute
    Inventors: Erkki Ruoslahti, Tambet Teesalu, Kazuki Sugahara
  • Abuse-proofed dosage form
    Patent number: 10369109
    Abstract: A solid administration form, protected from parenteral abuse and containing at least one viscosity-increasing agent in addition to one or more active substances that have parenteral abuse potential. The agent forms, when a necessary minimum amount of an aqueous liquid is added, on the basis of an extract obtained from the administration form, a preferably injectable gel that remains visually distinct when introduced into another quantity of an aqueous liquid.
    Type: Grant
    Filed: July 11, 2018
    Date of Patent: August 6, 2019
    Assignee: GRÜNENTHAL GMBH
    Inventors: Johannes Bartholomaeus, Heinrich Kugelmann
  • All-in-one skin-brightening formulations
    Patent number: 10363207
    Abstract: Certain dermatological formulations for direct skin application that correct for hyperpigmentation effects are provided. Such formulations include a number of different compounds that work synergistically to effectuate multiple and varied pathways to pigment removal and/or brightening within the dermal layer. The ability to do so without the necessity for hydroquinone, and thus with a suitable composition that is safe for handling and utilization by pregnant and nursing women, is accorded through a combination of specific ingredients in limited proportional ranges, as well. Such ingredients include kojic acid, niacinamide, sodium hyaluraonate, tocopherol, and licorice extract in very narrow ranges proportionally within an aqueous serum. The method of manufacture and use thereof such formulations are encompassed within the invention as well.
    Type: Grant
    Filed: April 29, 2016
    Date of Patent: July 30, 2019
    Inventor: Purvisha Patel
  • Stabilized modified release vitamin D formulation and method of administering same
    Patent number: 10357502
    Abstract: A stabilized formulation for controlled release of a vitamin D compound is disclosed. The formulation comprises one or both of 25-hydroxyvitamin D2 and 25-hydroxyvitamin D3 and a cellulosic compound. The stabilized formulations exhibit a stable dissolution profile following exposure to storage conditions and demonstrate improved pharmacokinetic parameters compared to unstabilized formulations.
    Type: Grant
    Filed: May 25, 2018
    Date of Patent: July 23, 2019
    Assignee: OPKO IRELAND GLOBAL HOLDINGS, LTD.
    Inventors: Jay A. White, Samir P. Tabash, Sammy A. Agudoawu, Joel Z. Melnick
  • Stabilized modified release vitamin D formulation and method of administering same
    Patent number: 10350224
    Abstract: A stabilized formulation for controlled release of a vitamin D compound is disclosed. The formulation comprises one or both of 25-hydroxyvitamin D2 and 25-hydroxyvitamin D3 and a cellulosic compound. The stabilized formulations exhibit a stable dissolution profile following exposure to storage conditions and demonstrate improved pharmacokinetic parameters compared to unstabilized formulations.
    Type: Grant
    Filed: September 29, 2017
    Date of Patent: July 16, 2019
    Assignee: OPKO IRELAND GLOBAL HOLDINGS, LTD.
    Inventors: Jay A. White, Samir P. Tabash, Sammy A. Agudoawu, Joel Z. Melnick
  • Tamper resistant oral opioid agonist formulations
    Patent number: 10350173
    Abstract: Oral dosage forms containing an opioid antagonist in a sequestered form are described. The opioid antagonist is sequestered such that it is not released or substantially not released in the gastrointestinal tract from the dosage form which is administered orally intact. However, when the dosage form is chewed, crushed, heated or dissolved in a solvent, and then administered orally, intranasally, parenterally or sublingually, the opioid antagonist is released and at least partially blocks effects of the opioid agonist.
    Type: Grant
    Filed: September 26, 2017
    Date of Patent: July 16, 2019
    Assignee: Purdue Pharma L.P.
    Inventors: Benjamin Oshlack, Curtis Wright, J. David Haddox
  • Cationic polymer coated mesoporous silica nanoparticles and uses thereof
    Patent number: 10343903
    Abstract: A submicron structure having a silica body defining a plurality of pores is described. The submicron body may be spherical or non-spherical, and may include a cationic polymer or co-polymer on the surface of said silica body. The submicron structure may further include an oligonucleotide and be used to deliver the oligonucleotide to a cell. The submicron structure may further include a therapeutic agent and be used to deliver the therapeutic agent to a cell. An oligonucleotide and therapeutic agent may be used together. For example, when the oligonucleotide is an siRNA, the composition may be used to decrease cellular resistance to the therapeutic agent by decreasing translation of a resistance gene.
    Type: Grant
    Filed: September 7, 2017
    Date of Patent: July 9, 2019
    Assignee: The Regents of the University of California
    Inventors: Jeffrey I. Zink, Andre E. Nel, Tian Xia, Zhaoxia Ji, Huan Meng, Zongxi Li, Monty Liong, Min Xue, Derrick Y. Tarn, Sanaz Gardner
  • Infant nutritional product with RRR alpha-tocopherol
    Patent number: 10328049
    Abstract: This invention relates to a method of improving CNS maturation in an infant by administering a mixture of natural tocopherols, wherein the composition contains an optimum tocopherol profile similar to that found in human breast milk, and can encompass a tocopherol profile from early stage to transitional to mature human breast milk. For ease of administration and maximized efficacy, the optimized mixture of natural tocopherols are typically delivered in an oral dosage form with a limited level of non-RRR alpha-tocopherols to maximize efficacy of the RRR alpha-tocopherol on stimulating post-natal CNS development.
    Type: Grant
    Filed: December 1, 2017
    Date of Patent: June 25, 2019
    Assignee: ABBOTT LABORATORIES
    Inventors: Chron-Si Lai, Matthew Kuchan, Gary Katz