Patent number: 8138118
Abstract: Compounds of the formula (I) or salts thereof in which R1 is carboxyl or a derivative of a carboxyl group, preferably a radical of the formula —CN, —C(?X)—Y—R or —C(?X)-Het, in which X is O, S or NRa or N—NRaRb, Y is O, S, NRc or NRc—NRdRe, R is H, a (subst.) hydrocarbon radical (HR) or acyl, and Het is an aliphatic nitrogen heterocycle, where each of the radicals Ra, Rb, Rc, Rd and Re is as defined for R or a radical of the formula —OR*, where R* is as defined for R, R2 is H or (subst.) HR or a heterocyclic radical, or, if Z?O or S, also an acyl radical, (R3)n are n radicals R3, as defined in claim 1, Z is a group of the formula O or S(O)x, where x=0, 1 or 2, and n is an integer 0, 1, 2, 3 or 4, as safeners for crop plants or useful plants against phytotoxic actions of agrochemicals, preferably as safeners against the action of pesticides, such as herbicides, in these plants.
Type:
Grant
Filed:
August 4, 2004
Date of Patent:
March 20, 2012
Assignee:
Bayer CropScience AG
Inventors:
Udo Bickers, Lothar Willms, Christopher Rosinger
Patent number: 8138226
Abstract: Chemical syntheses and medical uses of novel inhibitors of the uptake of monoamine neurotransmitters and pharmaceutically acceptable salts and prodrugs thereof, for the treatment and/or management of psychotropic disorders, anxiety disorder, generalized anxiety disorder, depression, post-traumatic stress disorder, obsessive-compulsive disorder, panic disorder, hot flashes, senile dementia, migraine, hepatopulmonary syndrome, chronic pain, nociceptive pain, neuropathic pain, painful diabetic retinopathy, bipolar depression, obstructive sleep apnea, psychiatric disorders, premenstrual dysphoric disorder, social phobia, social anxiety disorder, urinary incontinence, anorexia, bulimia nervosa, obesity, ischemia, head injury, calcium overload in brain cells, drug dependence, and/or premature ejaculation are described.
Type:
Grant
Filed:
September 19, 2008
Date of Patent:
March 20, 2012
Assignee:
Auspex Pharmaceuticals
Inventors:
Thomas G. Gant, Sepehr Sarshar