Abstract: A steerable sheath with a deflection mechanism assembly is provided. The assembly includes a tubular shaft that receives first and second longitudinal movement wires at a distal end. A control handle includes a main body configured to receive first and second bevel gears. The first longitudinal movement wire is coupled to the first bevel gear and the second longitudinal movement wire is coupled to the second bevel gear. A rotatable adjustment knob is engageable with the control handle and has an external geared portion matingly engageable with the first and second bevel gears and the rotatable adjustment knob is moveable between a first and second position.

Abstract: A medical device may include an insertion portion longitudinally extending between a proximal end and a distal end. The insertion portion may define a channel extending therethrough. The medical device may further include a handle coupled to the proximal end of the insertion portion. The handle may further include an irrigation port in fluid communication with the channel and coupled to a source of irrigation fluid. Additionally, the handle may include an actuator and a pressurizer. Manipulation of the actuator may be configured to actuate the pressurizer to urge irrigation fluid distally through the channel.

Abstract: The present invention provides a system and a method for managing occlusions and reducing eye tissue damage during phacoemulsification surgery. More specifically, the present invention provides automated control of the application of ultrasonic energy to a partial or full occlusion of a surgical tool. The present invention measures the vacuum pressure and automatically adjusts the application of ultrasonic energy when the vacuum pressure indicates an occlusion or an occlusion break.

Abstract: Systems and methods for providing a reinforced cannula for use in a blood pump assembly. The reinforced cannula comprises one or more thermoformed reinforced end portions. The thermoformed reinforced end portions may be stiffer than a medial portion of the cannula, allowing the medial portion of the cannula body to stretch and bend more readily than the cannula ends when the cannula is subject to an applied stress, reducing the stress and strain on the cannula ends.

Abstract: A needle hub for a drug delivery device includes a needle holder and a needle attached to the needle holder, a needle actuation assembly configured to move the needle holder from a retracted position, to an insertion position, and back to the retracted position, and a pressure interlock comprising an inlet configured to be in fluid communication with a fluid source, an outlet in fluid communication with the needle, and a lock member. The lock member having a first position where the lock member prevents actuation of the needle actuation assembly and a second position where the lock member allows actuation of the needle actuation assembly. The lock member is moved from the first position to the second position based on a pressure within the pressure interlock.

Abstract: Embodiments of a deployment system may include a catheter having a distal end and a proximal end. An actuator may be disposed at the distal end of the catheter and may be operatively connected to electrical connectors extending longitudinally along the catheter from the proximal end to the actuator. The electrical connectors may be configured for transmission of signals to the actuator. One or more connections may be coupled to the actuator and to a deployable medical device disposed at the distal end of the catheter.

Abstract: Disclosed herein are steerable catheter assemblies that utilize various mechanisms to accomplish independent control of catheter flex magnitude and catheter flex direction to provide improved steerability of an attached catheter. Some embodiments include a catheter with two or more pull wires that flex the catheter and a control handle coupled to the catheter. The control handle can include a direction control coupled to the two or more pull wires such that adjustment of the direction control adjusts a direction of catheter flex by the two or more pull wires, and the control handle can include a magnitude control coupled to the two or more pull wires such that adjustment of the magnitude control adjusts the magnitude of catheter flex.

Abstract: The systems, methods, and devices can efficiently express breast milk while being visually and audibly discreet, and portable. The breastmilk expression system for extracting milk from a breast of a female may include an interface configured to deliver suction to a nipple of the breast. The system may include a breastmilk storage container configured to store breastmilk. The system may include a control device operatively coupled to the breastmilk storage container and the interface. The control device may include one or more pressure reservoirs configured to store negative pressure. The control device may be configured to cause passive suction at the interface to cause extraction of the breast milk by controlling delivery of the negative pressure stored in the one or more pressure reservoirs to the interface.

Abstract: For treating a treatment area in the vasculature, this disclosure relates to a first, pre-dilation catheter having a first shaft including a first distal portion adapted for positioning at the treatment area and a first proximal portion including a first marking at a first location. A second, dilation catheter includes a second shaft including a second distal portion adapted for positioning at the treatment area and a second proximal portion including a second marking at a second location substantially matching a first location of the first marking. Related methods are disclosed.

Abstract: The disclosed sleeve according to various aspects of the present technology may comprise a tubular body adapted to be fitted around a barrel of an injection gun. The tubular body may comprise an interior surface and an exterior surface. The interior surface may define a cavity in the tubular body for receiving the barrel of the injection gun, wherein the interior surface may be configured to enclose the barrel of the injection gun. The exterior surface may comprise at least one marking formed thereon. The sleeve may also comprise an open first end terminating in a first peripheral annular edge and an open second end opposite the open first end and terminating in a second peripheral annular edge.

Abstract: Catheters for percutaneous applications are disclosed. The catheter according to example embodiments may comprise a substantially straight section, an anchoring section positioned proximal to the substantially straight section. The anchoring section can have a curvature for providing longitudinal traction with a tissue to anchor the catheter to the tissue and a pathway extending through the catheter for transporting fluids. The pathway may comprise a first section and a second section in fluid communication with each other, where the first section extends through the length of the straight section, and the second section extends through the anchoring section and has a curvature which mimics the curvature of the anchoring section.

Abstract: A method for generating microbubbles may include providing a syringe having a barrel defining an interior volume, a plunger, a tip and a check valve assembly. The check valve assembly may have an inlet port; a check valve that is configured to open when the plunger is drawn back by a user; and a nozzle in fluid communication with the interior volume and, when the check valve is open, in fluid communication with the inlet port. The method may include drawing liquid into the interior volume; removing a seal from the inlet port and drawing gas adjacent the inlet ports into the interior volume to form microbubbles in the liquid already drawn in; coupling the tip to an intravenous line associated with a patient undergoing a bubble study; and depressing the plunger to force the liquid and the formed microbubbles into the intravenous line.

Abstract: A needle assembly for an injection device is provided to facilitate delivery of a dermal filler. The assembly includes a cannula and a hub. The hub can be coupled to a syringe. The hub includes an inner bore that has a proximal retention section, a stepped section, and a cannula retention section. The stepped section, the proximal retention section, and the cannula retention section are configured to reduce the dead space within the inner bore for preventing detachment of the hub from the syringe during an injection procedure.

Abstract: A connector for medical fluid vessels includes a fluid-seal fitting such as a male plug defining a lumen and mating with a cooperating connector, a mechanical fastener such as a screw thread for mating with the cooperating connector, and an outer housing positioned around the plug to form an annular space. Optionally, a cap can be provided with a fluid-seal fitting such as a male plug for mating with the lumen of the connector. The connector includes one or more vent openings for drainage and air-drying of any residual fluid in the annular space when capped, as well as for breaking a vacuum to prevent fluid backflow and thus ensure more accurate dosing. In some embodiments, the vent openings are provided in the outer housing. And in some embodiments, the vent openings are provided in the cap.

Abstract: A syringe-based apparatus includes a housing having an open proximal end and a distal end, a needle coupled with the distal end of the housing, an actuator mechanism coupled with the housing, the actuator mechanism including a syringe body and a plunger, the syringe body and the plunger being insertable into the open proximal end of the housing. A medicament reservoir is defined at least partially by the housing and the actuator mechanism, and a reconstitution fluid reservoir is defined at least partially by the syringe body and the plunger of the actuator mechanism. The plunger is operably configured to move relative to the syringe body to expel the amount of the fluid from the reconstitution fluid reservoir into the medicament reservoir. The actuator mechanism is operably configured to move relative to the housing to expel the amount of the fluid from the medicament reservoir through the needle.

Abstract: A system for learning actual phacoemulsification energy setpoints at the time of occlusion breaks during ophthalmic surgery. Phacoemulsification energy setpoints may be recorded over different periods of time, such as during current cases and over a lifetime of cases. The recorded data would then be used to determine future phacoemulsification energy setting amounts.

Abstract: Disclosed herein are catheter control handles that include various mechanisms for controlling the circumferential angle and radial magnitude of flexion of an attached catheter. Control handles can comprise a housing. Control wires extend from a distal end of the housing and into a steerable transluminal device. A flex control member is operable to control tension on the pull wires to adjust a magnitude of radial flexion of the steerable transluminal device. A position control member is operable to control tension on the pull wires to adjust a circumferential angle in which the radial flexion of the steerable transluminal device is directed.

Abstract: A cap for a medical connector, the cap including a body having a closed proximal end and an open distal end, an interior volume within the body, an elongate member comprising an antimicrobial extending from the proximal end of body axially through at least a portion of the interior volume, the elongate member, threads for securing the cap to a medical connector, and a radially inwardly facing sealing surface on the cap, the inwardly facing sealing surface located distal to the threads and providing a liquid-tight seal between the cap and the medical connector when the cap is installed on the medical connector.

Abstract: An intravascular catheter for peri-vascular and/or peri-urethral tissue ablation includes multiple needles advanced through supported guide tubes which expand around a central axis to engage the interior surface of the wall of the renal artery or other vessel of a human body allowing the injection an ablative fluid for ablating tissue, and/or nerve fibers in the outer layer or deep to the outer layer of the vessel, or in prostatic tissue. The system may also include a means to limit and/or adjust the depth of penetration of the ablative fluid into and beyond the tissue of the vessel wall. The catheter may also include structures which provide radial and/or lateral support to the guide tubes so that the guide tubes expand uniformly and maintain their position against the interior surface of the vessel wall as the sharpened injection needles are advanced to penetrate into the vessel wall.

Abstract: A bolus delivery device is provided that comprises a housing and a reservoir defined by an activation dome and a reservoir seat and disposed within the housing for receipt of a volume of a fluid. The bolus delivery device further comprises a bladder disposed in the housing that is in fluid communication with the reservoir for receipt of the fluid from the reservoir; an actuator; an inlet conduit in fluid communication with the reservoir for providing the fluid to the reservoir; and an outlet conduit in fluid communication with the bladder for providing the fluid to a patient. The actuator is in operative communication with the reservoir to initiate a flow of the fluid from the reservoir to the bladder. The bladder expands as the bladder receives the fluid and contracts as the bladder dispenses the fluid. An infusion assembly including a bolus delivery device also is provided.