Abstract: Systems and methods for multi-chambered syringes are described. In some embodiments, a multi-chamber syringe includes a housing with an internal cavity and first and second plungers disposed at least partially within the internal cavity. The first and second plungers are slidably displaceable relative to the housing, and are associated with first and second chambers respectively. A barrier is disposed at least partially between the first and second plungers to form the first and second chambers. The barrier is slidably displaceable relative to the plungers and barrel to selectively place the first and second chambers including first and second materials respectively in fluid communication. When the barrier is displaced, the first and second materials mix in a combined volume of the first and second chambers. Displacing the first plunger, the second plunger, and the barrier may dispense the mixed materials from the combined volume.

Abstract: Provided is a method of cleaning a body cavity using a device by coupling a distal end portion of a first cannula to the housing such that a lumen is in fluid communication with the first portion of the inner volume, the first cannula coupled to a vacuum source, then coupling a distal end portion of a second cannula to the housing such that a lumen is in fluid communication with the second portion of the inner volume, the second cannula being coupled to a fluid source, inserting a portion of the housing into a body cavity, conveying a fluid from the fluid source to the body cavity via the lumen of the second cannula, and withdrawing the fluid from the body cavity into the vacuum source concurrently with the conveying the fluid, via the lumen of at least the first cannula.

Abstract: A syringe device with preferred and alternate embodiments structured to store, mix (if appropriate), and dispense multiple compounds (fluids, gels, suspensions, powdered solids, etc.) without the need for multiple syringes or the repeated use of a syringe. In a first embodiment, the device stores two separate compounds for use and mixes the compounds before dispensing the combined mixture. In a second embodiment, the device stores two separate fluids for use and dispenses the first fluid followed sequentially by dispensing the second. The device may be used with a variety of dispensing structures such as an applicator or a cannula (syringe needle). The present invention finds specific application, for example, in a syringe device for storing and combining a diluent with a lyophilized drug/vaccine. Overall, the device structures a unique arrangement of chambers and channels for the accurate storage, mixing, and dispensing of multiple compounds (fluids, gels, suspensions, powdered solids, etc.).

Abstract: A system for removing a blood clot includes a first catheter having an inner sheath, the sheath having an interior passage and a plurality of apertures for delivering a drug, and a second catheter having a hollow outer sheath sized to fit over the inner sheath, the second catheter having an agitating element to break apart or loosen the blood clot.

Abstract: Rapidly insertable central catheters (“RICCs”) and methods are disclosed. A RICC can include a first section of a first polymeric material in a distal portion of a catheter tube, a second section of a second polymeric material proximal of the first section, and a tapered junction therebetween. The first polymeric material has a first durometer. The second polymeric material has a second, lesser durometer. The junction is formed of the second polymeric material or a third polymeric material having a third durometer closer to the second durometer than the first durometer. The first section has a proximal portion disposed in a receptacle of the junction. An abluminal surface of a distal portion of the junction smoothly transitions onto an abluminal surface of the proximal portion of the first section without an edge that catches on skin when the RICC is inserted into an insertion site of a patient.

Abstract: Intelligent systems are disclosed for monitoring of enteral feeding pumps. The systems include a structure with a pivot mechanism, a fluid pump, a force-responsive electrical component, and an optional computing device. The pivot mechanism moves in response to force. The fluid pump moves feeding fluid, and the force-responsive electrical component changes electrical properties in response to force and alters resistance in the presence of an obstruction. The optional computing device can transmit an alert to a healthcare provider, for example, via smartphone. The force-responsive electrical component provides an electrical response in proportion to tension on a conduit and decreases resistance when there is an obstruction in the conduit. The systems sends an alert signal when the electrical response indicates an obstruction in the conduit.

Abstract: A catheter assembly may include a catheter adapter having a proximal end, a distal end, and a lumen extending therebetween. A wedge adapter may be retained within the lumen and have a wedge coupled thereto. The wedge may be configured to retain an end of a catheter such that a tip of the catheter extends through the distal end of the catheter adapter. A control feature may extend through an end or side wall of the catheter adapter. The control feature may be configured to manipulate the wedge to control a position of the tip of the catheter to open a fluid path within a vasculature.

Abstract: A syringe for obtaining a target volume of blood is presented. The syringe (1) comprises a barrel (2), wherein a plunger (4) is arranged within the barrel (2) to be displaceable along a displacement direction (X). Furthermore the barrel (2) and the plunger (4) together provide for a first stop (20) and second stop (22), wherein the first stop (20) is configured for positioning a filter (100) at a predetermined location along the displacement direction (X) thereby defining a target volume of blood and a buffer volume. Moreover, the second stop (22) is configured to stop the plunger (4) from expelling more than the buffer volume from the syringe (1) for obtaining the target volume of blood when the plunger (4) is pushed towards the distal end (30) of the syringe (1) along the displacement direction (X).

Abstract: Disclosed are a catheter support apparatus and a transluminal intervention system. The catheter support apparatus comprises a plurality of flexible supporting strips. A plurality of meshing units arranged at intervals in a strip length direction are formed on the flexible supporting strips. The meshing units of the plurality of flexible supporting strips are at least partially meshed to jointly surround, define, and form a catheter placing cavity for accommodating a catheter. The flexible supporting strips are adopted such that, by means of the meshing units on the flexible supporting strips, the plurality of flexible supporting strips can be meshed and formed into the catheter placing cavity. By means of the catheter placing cavity, the catheter can be accommodated to enable wrapping of the catheter, thereby ensuring the support for the catheter.

Abstract: A system for delivering treatment to a biological subject, the system including: at least one substrate including a plurality of microstructures configured to breach a stratum corneum of the subject; at least one sensor operatively connected to at least one microstructure, the at least one sensor being configured to measure response signals from the at least one microstructure; at least one treatment delivery mechanism operatively coupled to at least one microstructure to deliver treatment via at least one microstructure; and, one or more electronic processing devices that are configured to control the at least one treatment delivery mechanism to thereby deliver treatment to the subject at least partially in accordance with the measured response signals.

Abstract: Apparatuses and methods for delivering a fluid, including a viscous fluid. These apparatuses may include a fluid reservoir, two or more piston chambers, a manifold, a delivery port, and a drive assembly and may be configured to inject either a predetermined amount of fluid or a continuous stream of fluid. These apparatuses may also be configured to switch between filling, injection and aspiration modes. These apparatuses may generally be hand-held and lightweight and may provide a significant mechanical advantage to the user.

Abstract: Polymeric tubing, for use with catheters or other medical devices, where the polymeric tubing can have regions of customized properties including, but not limited to, durometer, torque control, flexibility, axial strength, stiffness, etc. One variation of the device allows for transitions between regions to be configured such that there can be gradual or customized transitions between various regions such that the structural characteristics differential between the regions selectively designed. Additional variations include outer layers having a plurality of material sections extending in a spiral direction along the axial length to form a continuous wall of the outer layer. In certain variations, the structural characteristic differential is minimized or eliminated as compared to conventional catheters.

Abstract: An elongate tubular shaft having a lumen extending from a proximal portion to a distal portion may include an outer jacket forming an outer surface of the elongate tubular shaft, the outer jacket being formed from a first material having a first modulus of elasticity, a helical member extending from the proximal portion to the distal portion, a braided support member disposed about the helical member, and a strain relief layer formed from a second material having a second modulus of elasticity less than the first modulus of elasticity, wherein the strain relief layer is disposed about the helical member and radially inward of the outer jacket.

Abstract: A system for strain relieving intravenous (IV) assembly includes a dressing and an anchor portion for use with the dressing. In various embodiments, the dressing may cover an injection site into a portion of a patient's body for an intravenous (IV) assembly that provides fluid communication between the injection site and a fluid reservoir remote from the injection site through a flexible tube. In an illustrative example, the anchor portion may include a first member and a second member. The first member may be secured, for example, to the dressing and may, in some examples, wrap around the tubing so as to resist axial movement of the tubing relative to the dressing. The second member may be secured to the dressing and may wrap around the tubing and a portion of the patient's body so as to resist radial movement of the tubing relative to the body.

Abstract: An apparatus for infusing medical liquid, the apparatus including: a needle module having at least one needle portion formed to be injected into a user's body; a medical liquid storage portion having an inner space to store medical liquid delivered to the needle module, wherein an inner surface of the inner space includes a surface-treated shape; and a driving portion connected to the medical liquid storage portion to transfer the medical liquid of the medical liquid storage portion to the needle module.

Abstract: An inflation control system is provided for use with an occlusion catheter having an inflatable occlusion member for at least partial occlusion of a patient vessel. The inflation control system includes a fluid source in fluid communication with the inflatable occlusion member, a pressure source coupled to the fluid source and configured to move fluid between the fluid source and the inflatable occlusion member, and a controller operably coupled to the pressure source. The controller is configured to receive at least one patient vital sign as feedback and operate the pressure source to modulate an inflation volume of the occlusion member based, at least in part, on the feedback.

Abstract: Polymeric tubing, for use with catheters or other medical devices, where the polymeric tubing can have regions of customized properties including, but not limited to, durometer, torque control, flexibility, axial strength, stiffness, etc. One variation of the device allows for transitions between regions to be configured such that there can be gradual or customized transitions between various regions such that the structural characteristics differential between the regions selectively designed. Additional variations include outer layers having a plurality of material sections extending in a spiral direction along the axial length to form a continuous wall of the outer layer. In certain variations, the structural characteristic differential is minimized or eliminated as compared to conventional catheters.

Abstract: An infusion adapter for connection with an infusion fluid container includes a connection portion configured to engage an injection port of an infusion fluid container, and a port configured to connect to an intravenous line, with the port in fluid communication with the connection portion. The connection portion includes a retaining ring extending radially outward from the connection portion, with the retaining ring configured to securely connect the infusion adapter to the infusion fluid container to substantially prevent disconnection of the infusion adapter from the infusion fluid container once the infusion adapter is connected to the infusion fluid container. The retaining ring includes an indicator configured to provide visualization of insertion of the connection portion into an injection port of an infusion fluid container.

Abstract: Methods for fragmenting atherosclerotic material within a zone of attention within a blood vessel are provided. An intravascular catheter device includes a balloon and a plurality of incising devices spaced apart about an outer surface of the balloon and extending parallel with a longitudinal axis of the balloon. The balloon is manipulated along a guide wire to a distal portion of the zone of attention. The balloon is inflated and retracted along the zone of attention to incise and fragment the atherosclerotic material. The balloon is deflated.

Abstract: Disclosed is a catheter system. The catheter system includes: a catheter module including a catheter and a first fastening magnet coupled to a tip of the catheter; and a magnetic robot including a second fastening magnet magnetically coupled to the first fastening magnet, and coupled to and released from the catheter module.