Patents Examined by John A. Sopp
  • Patent number: 4816600
    Abstract: Modified organic isocyanate composition containing urea and/or biuret groups and/or salts of these groups, obtained from the reaction of a blocked polyamine composition and an unblocked isocyanate composition.
    Type: Grant
    Filed: September 14, 1987
    Date of Patent: March 28, 1989
    Assignee: ICI Americas Inc.
    Inventor: Herbert R. Gillis, Jr.
  • Patent number: 4808752
    Abstract: A process for the preparation of 2-aminophenyl thioethers of the formula (1) ##STR1## in which R represents an alkylC.sub.1 -C.sub.6 group which can be substituted by hydroxyl, alkoxyC.sub.1 -C.sub.4, carboxyl, --COO-alkyl-C.sub.1 -C.sub.4, alkenylC.sub.2 -C.sub.6 or phenyl groups or by the radical ##STR2## and X and Y are each a hydrogen or halogen atom or an alkylC.sub.1 -C.sub.6, alkoxyC.sub.1 -C.sub.
    Type: Grant
    Filed: July 31, 1986
    Date of Patent: February 28, 1989
    Assignee: Hoechst Aktiengesellschaft
    Inventor: Theodor Papenfuhs
  • Patent number: 4806688
    Abstract: Prepare diamino- or dialkylaminobenzenediols by hydrogenating benzoquinone compounds in the presence of a solvent and a catalyst.
    Type: Grant
    Filed: May 16, 1986
    Date of Patent: February 21, 1989
    Assignee: The Dow Chemical Company
    Inventors: Muthiah N. Inbasekaran, Robert M. Strom
  • Patent number: 4806690
    Abstract: A method for producing amines, the method comprising contacting at reactive conditions at least one alcohol, aldehyde or ketone, or a mixture thereof, with an aminating agent in the presence of a catalyst, is improved by employing as the catalyst a composition comprising cobalt, copper, and a third component selected from a group consisting of iron, zinc, zirconium and mixtures thereof.
    Type: Grant
    Filed: May 13, 1985
    Date of Patent: February 21, 1989
    Assignee: The Dow Chemical Company
    Inventor: Robert G. Bowman
  • Patent number: 4806689
    Abstract: A process is provided for producing dimethylamine, comprising reacting methanol and/or dimethylether and ammonia, in amounts sufficient to provide a carbon/nitrogen (C/N) ratio of from about 0.2 to about 1.5, at a temperature from about 250.degree. C. to about 450.degree. C., in the presence of a catalytic amount of an acidic zeolite rho.
    Type: Grant
    Filed: October 3, 1985
    Date of Patent: February 21, 1989
    Assignee: E. I. Du Pont de Nemours and Company
    Inventors: Thurman E. Gier, Robert D. Shannon, George C. Sonnichsen, David R. Corbin, Michael Keane, Jr.
  • Patent number: 4806686
    Abstract: N-(D)-ribitylxylidine (I) is prepared by reacting (D)-ribose (II) with 3,4-dimethylaniline (III) or 3,4-dimethyl-1-nitrobenzene (IV) in aqueous or aqueous/organic solution or in solution in a water-soluble organic solvent under an elevated hydrogen pressure and in the presence of a hydrogenation catalyst and of a boric acid compound,(a) using the boric acid compound in a catalytic amount of from about 6 to 35 mmol, preferably from 6 to 20 mmol, per mol of ribose,(b) carrying out the reaction under a hydrogen pressure of from 1 to 20, preferably from 2 to 9, bar and(c) carrying out the hydrogenation at from 40.degree. to 80.degree. C. over Raney nickel as hydrogenation catalyst.
    Type: Grant
    Filed: April 27, 1987
    Date of Patent: February 21, 1989
    Assignee: BASF Aktiengesellschaft
    Inventors: Hansgeorg Ernst, Hartmut Leininger, Joachim Paust
  • Patent number: 4804783
    Abstract: Diphenylamines or N,N'-diphenyl-phenylenediamines can be obtained by heat-reacting an aniline or a phenylenediamine with preferably an excess of a phenol in an amount of 4 to 20 moles per mole of the aniline or phenylenediamine in the presence of a hydrogen transfer catalyst and a cyclohexanone corresponding to said phenol.The excess phenol used in the reaction undergoes reduction in the reaction system to form a cyclohexanone, which in turn reacts with the aniline or phenylenediamine to form a Schiff base and is thus consumed. The Schiff base forms the intended product by means of a dehydrogenation reaction, and the hydrogen evolved at this time reduces the phenol to form a cyclohexanone.The phenol present in excess thus becomes in the system a solvent, a starting material for the cyclohexanone, and an acceptor of the hydrogen that forms as a by-product at the time of formation of the intended product.
    Type: Grant
    Filed: July 31, 1987
    Date of Patent: February 14, 1989
    Assignee: Mitsui Toatsu Chemicals, Inc.
    Inventors: Teruyuki Nagata, Akihiro Tamaki, Nobuyuki Kajimoto, Masaru Wada
  • Patent number: 4803304
    Abstract: Recovery of bis(hexamethylene)triamine from still heels of hexamethylenediamine by extraction using an aliphatic hydrocarbon having a boiling point between about 34.degree. C. and 210.degree. C.
    Type: Grant
    Filed: April 15, 1987
    Date of Patent: February 7, 1989
    Assignee: E. I. Du Pont de Nemours and Company
    Inventor: Robert A. Smiley
  • Patent number: 4803225
    Abstract: There are provided compounds of formula I, ##STR1## and pharmaceutically acceptable derivatives thereof. There are also described the use of the compounds of formula I as pharmaceuticals, methods for making the compounds and pharmaceutical, e.g. cardiac, compositions containing the compounds.
    Type: Grant
    Filed: December 2, 1987
    Date of Patent: February 7, 1989
    Assignee: Fisons, plc
    Inventors: John Dixon, Francis Ince
  • Patent number: 4801751
    Abstract: Alkylated aromatic primary amines undergo disproportionation and transalkylation in the presence of a carbon-containing catalyst at a temperature between 200.degree. C. and 500.degree. C. The carbon-containing catalyst may have carbon as the only active component, or optionally, may also contain a Group VIIIA metal, such as platimum, palladium, nickel, cobalt or mixtures thereof.
    Type: Grant
    Filed: September 30, 1986
    Date of Patent: January 31, 1989
    Assignee: Air Products and Chemicals, Inc.
    Inventors: Andrew F. Nordquist, Ronald Pierantozzi
  • Patent number: 4801752
    Abstract: The present invention relates to a vapor phase process for the production of N-alkyl and N,N-dialkylaniline by alkylation of aniline with an alcohol, preferably methanol and ethanol, in the presence of a ZSM-5 catalyst. A modified ZSM-5 catalyst has the advantage of high selectivity for N-alkylation while suppressing the formation of undesired by-products, such as toluidines. The molar ratio of silica to alumina in the catalyst is from about 20:1 to 700:1 and preferably from about 30:1 to 200:1. The silica-alumina may be modified with alkali metal, alkali earth metal or transition metal ions, preferably cesium, potassium, magnesium and iron, to form the finished catalyst. The reactants are contacted in the presence of the catalyst at a temperature of from about 300.degree. to 500.degree. C., at a pressure of from about 1 to 3 atmospheres, and at a molar ratio of alcohol to aniline of from about 1 to 6. The feed rates expressed as weight hourly space velocity (g feed/g catalyst/hour) are broadly from about 0.
    Type: Grant
    Filed: February 12, 1987
    Date of Patent: January 31, 1989
    Assignee: Industrial Technology Research Institute
    Inventors: Po Y. Chen, Shiao J. Chu, Mei C. Chen, Nan S. Chang, Wen C. Lin
  • Patent number: 4798910
    Abstract: An improved method for amine regeneration wherein a rich amine out of a first heat exchanger is temperature controlled prior to transfer to a second heat exchanger. At least a portion of the hot overhead gasses exiting from a stripping still are transferred to the second heat exchanger. Temperature controlled heated rich amine liquid passes through the second exchanger and contacts the hot overhead gasses. The rich amine liquid is increased in higher temperature thereby and then is transferred to yet a third exchanger and finally to the stripping still for regeneration of lean amine. The reduced temperature overhead gasses are transferred to the reflux condensor for final cooling.
    Type: Grant
    Filed: October 21, 1986
    Date of Patent: January 17, 1989
    Inventor: J. Pearman Herrin
  • Patent number: 4795834
    Abstract: The catalytic alkylation of primary and secondary amino groups in linear polyamines using an "activated" copper catalyst.
    Type: Grant
    Filed: March 2, 1987
    Date of Patent: January 3, 1989
    Assignee: Stepan Company
    Inventors: Zdzislaw Dudzinski, Phillip Adams
  • Patent number: 4795828
    Abstract: Procainamide and N-acetylprocainamide (NAPA) immunogens, antibodies prepared therefrom, labeled conjugates, synthetic intermediates, and the use of such antibodies and labeled conjugates in immunoassays for determining the respective drugs. The immunogens comprise the drugs coupled at the .alpha.-position of the amide side chain to an immunogenic carrier material. The labeled conjugates and synthetic intermediates similarly are .alpha.-position derivatives of the drugs or precursors thereof. The antibodies and labeled conjugates are particularly useful in homogeneous nonradioisotopic immunoassays for measuring the respective drugs in biological fluids such as serum.
    Type: Grant
    Filed: September 25, 1986
    Date of Patent: January 3, 1989
    Assignee: Miles Inc.
    Inventors: Robert T. Buckler, Frederick E. Ward
  • Patent number: 4795833
    Abstract: A process is disclosed for preparing an isomeric mixture of methyl-substituted aniline comprising contacting at least one of said analines with a specified zeolite catalyst.
    Type: Grant
    Filed: February 4, 1987
    Date of Patent: January 3, 1989
    Assignee: E. I. Du Pont de Nemours and Company
    Inventor: Richard S. Mitchell
  • Patent number: 4794199
    Abstract: This invention concerns the synthesis of primary amines from olefins, synthesis gas and ammonia via an amination process in the presence of a cobalt catalyst, an ether solvent and a tertiary group VB donor ligand.
    Type: Grant
    Filed: October 1, 1987
    Date of Patent: December 27, 1988
    Assignee: Texaco Inc.
    Inventors: Jiang-Jen Lin, John F. Knifton
  • Patent number: 4794197
    Abstract: All-cis-1,3,5-Triamino-2,4,6-trihydroxycyclohexane derivatives corresponding to the general formula I ##STR1## wherein the symbols R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5 and R.sub.6 are identical or different and represent hydrogen atoms, alkyl groups or --CO-alkyl groups wherein the alkyl in the alkyl or --CO-alkyl group has 1 to 18 carbon atoms and the alkyl and --CO-alkyl groups may contain, independently of one another, one or more identical or different functional groups, and at least one of the groups R.sub.1 to R.sub.6 is one of the above mentioned unsubstituted or substituted alkyl groups or --CO-alkyl groups, and their salts with pharmacologically conventionally used inorganic or organic acids and their quaternary ammonium salts, processes for their preparation and their use, and pharmaceutical preparations containing these compounds.
    Type: Grant
    Filed: January 31, 1986
    Date of Patent: December 27, 1988
    Inventors: Walter Schneider, Isidor Erni, Hans K. Hegetschweiler
  • Patent number: 4792628
    Abstract: Indane derivatives and their salts represented by the general formula (1), ##STR1## wherein R.sup.1 is an amino group which may have lower alkyl groups as the substituents, a hydroxylimino group, an alkanoylamino group having 1 to 10 carbon atoms which may have halogen atoms as the substituents, a lower alkylsulfonylamino group, a phenylsulfonylamino group which may have lower alkyl groups as the substituents on the phenyl ring, a benzoylamino group having lower alkyl groups as the substituents on the phenyl ring, and a phenyl-lower alkylamino group having a hydroxyl groups or a lower alkyl groups as the substituents on the phenyl ring, R.sup.2 is a hydrogen atom, a lower alkyl group, a halogen atom, a nitro group, an amino group, an amino-lower alkyl group, a lower alkanoylamino group, a lower alkanoylamino-lower alkyl group which may have halogen atoms as the substituents, a lower alkylthio group, a 1-piperidinesulfonyl group, or a lower alkenyl group; R.sup.
    Type: Grant
    Filed: April 16, 1987
    Date of Patent: December 20, 1988
    Assignee: Otsuka Pharmaceutical Co., Ltd.
    Inventors: Yasuo Oshiro, Hiraki Ueda, Kazuyuki Nakagawa
  • Patent number: 4792630
    Abstract: A process for preparing an aminoacetaldehyde dialkyl acetal which comprises reacting a halogenoacetaldehyde dialkyl acetal with ammonia or an alkylamine in an aqueous medium in the simultaneous presence of an alkali metal hydroxide or of an alkaline earth metal hydroxide, and distilling the resulting reaction mixture.
    Type: Grant
    Filed: February 13, 1987
    Date of Patent: December 20, 1988
    Assignee: Nippon Gosei Kagaku Kogyo Kabushiki Kaisha
    Inventors: Akira Taisha, Takeo Kawabata, Takehiko Kakimoto, Kazumasa Hirata
  • Patent number: 4792622
    Abstract: A secondary amine is effectively prepared by reacting an alcohol or an aldehyde with a primary amine in the presence of a catalyst of copper, nickel and a metal element belonging to the platinum group VIII at a pressure of the atmospheric pressure to 5 kg/cm.sup.2 G at a temperature of 150.degree. to 250.degree. C., while water produced in the reaction is being removed out, and separating the resulting secondary amine from the product mixture.
    Type: Grant
    Filed: November 21, 1986
    Date of Patent: December 20, 1988
    Assignee: Kao Corporation
    Inventors: Yukinaga Yokota, Yuzi Sawamoto, Hideki Taniguchi, Kazuhiko Okabe