Patents Examined by John McGuirk
  • Patent number: 12130300
    Abstract: A sample measuring apparatus, a reagent container, and a method of measuring a sample are provided. The sample measuring apparatus includes a reagent container holder and a measuring unit. The reagent container holder holds, by suspending, a reagent container that stores a reagent. The measuring unit that measures a sample by using the reagent.
    Type: Grant
    Filed: July 24, 2020
    Date of Patent: October 29, 2024
    Assignee: SYSMEX CORPORATION
    Inventors: Yutaka Kawamoto, Tomohiro Kuroiwa, Shingo Kaida
  • Patent number: 12121891
    Abstract: Described herein are systems and methods used for washing needle assemblies with multiple needles.
    Type: Grant
    Filed: August 16, 2021
    Date of Patent: October 22, 2024
    Assignee: Waters Technologies Corporation
    Inventors: Rose Solow, David A. Simpson, Colin F. Fredette, Marc E. Lemelin, Joshua A. Burnett
  • Patent number: 12122664
    Abstract: Provided are a method for preparing a microfluidic device, a microfluidic device and a microfluidic system. The method includes: providing a mold having a groove; injecting a liquid metal into the groove of the mold, and solidifying the liquid metal to obtain a solid metal; separating the solid metal from the mold; providing the solid metal with an electrode; providing a cladding layer on a surface of the solid metal provided with the electrode, such that the solid metal is wrapped by the cladding layer, and at least a part of the electrode extends outside the cladding layer, so as to obtain a preform; and fixing the preform in a substrate, melting the solid metal and extending at least a part of the electrode outside the substrate, to obtain the microfluidic device.
    Type: Grant
    Filed: December 7, 2018
    Date of Patent: October 22, 2024
    Assignees: INSTITUTE OF FLEXIBLE ELECTRONICS TECHNOLOGY OF THU, ZHEJIANG, TSINGHUA UNIVERSITY
    Inventors: Xue Feng, Baicheng Zhang, Ying Chen, Haoran Fu, Ye Jiang, Lanlan Liu
  • Patent number: 12123887
    Abstract: The present invention is one for achieving an improvement in analysis accuracy, and a sample analyzing device that measures light emitted by introducing a reagent to a sample contained in a container to analyze the sample, and the sample analyzing device includes: a holder that holds the container; a casing that has a door for taking in/out the holder; a nozzle to/from which a pipette tip for injecting the reagent into the container can be attached/detached; a photodetector that measures the light emitted from the sample in the container supported by the holder; and a disposal box into which the pipette tip after injection is disposed of, in which the disposal box is configured to be arranged in the casing and to be taken in/out via the door.
    Type: Grant
    Filed: July 17, 2018
    Date of Patent: October 22, 2024
    Assignee: HORIBA ADVANCED TECHNO, CO., LTD.
    Inventors: Hideki Nakayama, Kazuya Nakagawa, Hiroshi Iida, Yoko Nakai
  • Patent number: 12109568
    Abstract: The present invention describes a secondary tube tray for use in an automated processing system, the tray comprising a base module and a secondary tube insert. Furthermore, the present invention describes a secondary tube handling module of an automated processing system for automatically processing biological sample, and a method of handling secondary tubes for use in automatically processing biological sample in an automated processing system.
    Type: Grant
    Filed: January 22, 2019
    Date of Patent: October 8, 2024
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Lawrence Chiu, Reiner Hitt, Raphael Haag, Erich Caflisch, Nicolas Lehner
  • Patent number: 12105107
    Abstract: A jig assembly for connecting first and second consoles with predefined relative positioning includes first and second positioning pins attached or attachable to the first console and a positioning connection bracket attached or attachable to the second console and including a longitudinal span and first and second transverse legs including first and second pin recesses at respective free ends thereof. The first and second pin recesses receive the first and second positioning pins, respectively, when the first and second consoles are moved laterally toward each other. The first and second transverse legs may be attached to the first console with a first and second leg attachment brackets, respectively. The first and second positing pins and the first and second leg attachment brackets may be fixed with respect to the first console by attachment to a mounting rail that is fixed to the first console.
    Type: Grant
    Filed: January 18, 2023
    Date of Patent: October 1, 2024
    Assignee: GEN-PROBE INCORPORATED
    Inventors: Rolf Silbert, HongRan Peng
  • Patent number: 12097491
    Abstract: Aspects of the present disclosure are directed to a method and a device for carrying out chemical, biochemical and/or immunochemical analyses of liquid samples, which are present in a sample store of an automatic analyzer, with the aid of liquid reagents, which are present in at least one reagent store of the analyzer. In one embodiment, a analyzer is disclosed including cuvettes for holding the liquid samples and reagents, the cuvettes are arranged in at least one stationary, linear cuvette array. The analyzer further has an optical measurement unit with a stationary light-supplying unit which has at least one light distributor device that feeds the light from a plurality of LED light sources emitting in a spectrally different manner in the UV/VIS/NIR wavelength range into the inlet windows of the individual cuvettes of the cuvette array. The optical measurement unit further includes a stationary detection unit assigned to outlet windows of the cuvettes and further includes a plurality of photodiodes.
    Type: Grant
    Filed: April 12, 2019
    Date of Patent: September 24, 2024
    Assignee: Meon Medical Solutions GmbH & Co KG
    Inventors: Herfried Huemer, Arnold Bartel, Patrick Kraus-Füreder, Robert Scholz-Mareich, Wolfgang Sprengers, Michael Bergbaur, Reinhard Marik
  • Patent number: 12097624
    Abstract: Systems and methods applicable, for instance, to pipette robots. A pipette robot can perform one or more tip presence check operations, one or more tip seal check operations, and/or one or more distance sensing operations, including distance sensing operations which regard determining the height of the surface of a liquid.
    Type: Grant
    Filed: January 31, 2020
    Date of Patent: September 24, 2024
    Assignee: Opentrons Labworks Inc.
    Inventors: Chiu Chau, Jane Shmushkis
  • Patent number: 12085563
    Abstract: Described is a lateral flow high throughput assay device analyzer for preparing and analyzing a plurality of lateral flow assay samples. The analyzer comprises a cartridge stage for supporting an assay cartridge, an elevation adjustment mechanism, and a translation adjustment mechanism for aligning the cartridge stage and assay cartridge relative to a vertical support structure, fluid metering device, and detection device for high throughput lateral flow assay analysis.
    Type: Grant
    Filed: December 20, 2019
    Date of Patent: September 10, 2024
    Assignee: Kenota Inc.
    Inventors: Christopher J. Harder, David Andrew McMullin, Eric Blondeel, Kien Vu
  • Patent number: 12078648
    Abstract: Disclosed is a sample measurement device comprising a first processing unit that performs a first measurement on a sample contained in a first container in a first cycle; a second processing unit that performs a second measurement on a sample contained in a second container in a second cycle different from the first cycle; and a relay section which is disposed between the first processing unit and the second processing unit and in which the second container is positioned, wherein the first processing unit performs a transferring operation of transferring the second container to the relay section, and the second processing unit performs a receiving operation of receiving the second container that has been transferred to the relay section from the relay section.
    Type: Grant
    Filed: March 19, 2020
    Date of Patent: September 3, 2024
    Assignee: SYSMEX CORPORATION
    Inventors: Masaki Shiba, Hiroki Kotake, Akihito Kato
  • Patent number: 12064740
    Abstract: The present invention provides a system for performing reactions, where the system comprises a plurality of synthesisers that are in communication via a communal reporting platform. A synthesiser is programmed for the automated synthesis of one or more chemical or biological reactions, and the synthesiser comprises a reaction vessel which is supplied by a reagent delivery system, an analytical system for analysing a reaction, and a controller for managing the reagent delivery system and the analytical system, and for communication with the reporting platform. Also provided are methods for performing a plurality or reactions using the system.
    Type: Grant
    Filed: March 6, 2019
    Date of Patent: August 20, 2024
    Assignee: Chemify Limited
    Inventor: Leroy Cronin
  • Patent number: 12064769
    Abstract: Systems and methods for conducting surface-mediated chemical and/or biochemical reactions within an enclosed chamber are disclosed. Systems and methods of the present disclosure may be used in conducting hybridization reactions of biopolymers. In some examples, an improved method for mixing thin films of solutions in a hybridization chamber includes altering the direction of mixing at least once over the course of a reaction. In some examples, an improved method for mixing thin films of solutions in a hybridization chamber includes altering the speed of mixing at least once over the course of a reaction. In some examples, an improved method for mixing thin films of solutions in a hybridization chamber includes altering the speed of mixing and the direction of mixing at least once over the course of a reaction.
    Type: Grant
    Filed: December 22, 2022
    Date of Patent: August 20, 2024
    Assignee: SomaLogic Operating Co., Inc.
    Inventors: Jason Paul Cleveland, Jon Monserud, Barry Patrick John Vant-Hull, Alex Kislukhin
  • Patent number: 12048421
    Abstract: A saliva detection device, a saliva detection system and an operation method of the same are provided. The saliva detection device includes a flexible friction power generation assembly configured to supply power to the saliva detection device and including: a first electrode; a first macromolecule polymer layer which is disposed in contact with a surface of the first electrode and has a concave-convex structure on a surface thereof distal to the first electrode; a second macromolecule polymer layer having a concavo-convex structure on a surface thereof proximal to the first macromolecule polymer layer and a second electrode disposed in contact with a surface of the second macromolecule polymer layer distal to the concavo-convex structure thereof, in response to flexible deformation of the flexible friction power generation assembly, the concavo-convex structures of the first macromolecule polymer layer and the second macromolecule polymer layer rub against each other.
    Type: Grant
    Filed: December 23, 2019
    Date of Patent: July 30, 2024
    Assignee: BOE TECHNOLOGY GROUP CO., LTD.
    Inventor: Zheng Wu
  • Patent number: 12019085
    Abstract: An automatic analysis device and an automatic analysis system capable of executing separate operations by respective analysis units even in a device configuration where a same control part controls two or more analysis units, the automatic analysis device including a biochemistry analysis unit; an electrolyte analysis unit; one analysis unit control CPU for controlling operations of the biochemistry analysis unit and the electrolyte analysis unit; and a storage part for storing time charts of operations having different purposes for the biochemistry analysis unit and the electrolyte analysis units. Two or more of the biochemistry analysis units and the electrolyte analysis units operate independently to each other based on the time charts stored in the storage part.
    Type: Grant
    Filed: May 28, 2019
    Date of Patent: June 25, 2024
    Assignee: HITACHI HIGH-TECH CORPORATION
    Inventors: Kunio Enta, Masashi Akutsu
  • Patent number: 11998920
    Abstract: A configurable device for the flexible provision of connections and/or functions in a biopharmaceutical process includes a body in which predefined pipe sections and plug-in locations are formed by recesses in the material of the body. The configurable device further includes a plurality of functional elements which are adapted to be inserted into the plug-in locations.
    Type: Grant
    Filed: March 13, 2019
    Date of Patent: June 4, 2024
    Assignee: SARTORIUS STEDIM BIOTECH GMBH
    Inventor: Jan Schaefer
  • Patent number: 12000850
    Abstract: A laboratory sample distribution system with a number of sample container carriers, each comprising at least one magnetically active device and adapted to carry a sample container; a transport plane adapted to support the carriers; a number of electro-magnetic actuators stationary arranged below the transport plane and adapted to move a corresponding carrier located on top of the transport plane by applying a magnetic force to the carrier; a touch panel arranged below the transport plane adapted to generate position signals (PS) depending on positions of the carriers located on top of the transport plane; a position determination unit adapted to determine the positions of the carriers located on top of the transport plane in response to the position signals (PS); and a control unit adapted to control the operation of the laboratory sample distribution system in response to the determined positions of the carriers.
    Type: Grant
    Filed: June 3, 2021
    Date of Patent: June 4, 2024
    Assignee: ROCHE DIAGNOSTICS OPERATIONS, INC.
    Inventor: Norbert Schmitt
  • Patent number: 12000847
    Abstract: In one embodiment, a diagnostic system includes an instrument coupled to a client device and having at least one sample processing bay. The diagnostic system has a software architecture including instrument software (ISW) associated with the instrument. The ISW receives an assay definition file (ADF) that has a control file and an assay analysis module (AAM) file. The processing bay prepares and senses the sample according to parameters in the OPUS file and then generates sensor scan data. The diagnostic system then analyzes the sensor scan data and prepares a report according to the AAM file.
    Type: Grant
    Filed: March 2, 2022
    Date of Patent: June 4, 2024
    Assignee: ROCHE MOLECULAR SYSTEMS, INC.
    Inventors: Michael Thomas Nguyen, Sean Ford, Nikolas James Hansen
  • Patent number: 11994527
    Abstract: A sample measuring apparatus and a method of circulating air in a reagent storage are provided. The sample measuring apparatus includes: a measuring unit that measures a sample by using a reagent stored in a reagent container; a reagent storage that stores the reagent container; a reagent container holder arranged in the reagent storage and that holds the reagent container; a fin that circulates air in the reagent storage; and a driving unit that drives the reagent container holder and the fin to rotate.
    Type: Grant
    Filed: July 24, 2020
    Date of Patent: May 28, 2024
    Assignee: SYSMEX CORPORATION
    Inventors: Yutaka Kawamoto, Tomohiro Kuroiwa, Shingo Kaida
  • Patent number: 11994528
    Abstract: Purifying target biomolecules, such as nucleic acids or proteins, from a biological source is a time intensive process and is typically performed by a skilled technician or scientist owing to the highly technical nature of the work. Systems, devices, and methods disclosed herein enable the automated bioprocessing and purification of target biomolecules from a biological source. For example, an instrument and disposable cartridge are provided for automatedly isolating and purifying nucleic acids (such as plasmid DNA from a bacterial culture) or for isolating protein from any biological sample. Such an exemplary instrument and cartridge can work in concert to timely release, mix, and move the target biomolecule and various reagents and buffers through a target biomolecule purification process, resulting in a purified target biomolecule with less manual oversight than traditional approaches.
    Type: Grant
    Filed: December 15, 2020
    Date of Patent: May 28, 2024
    Assignee: LIFE TECHNOLOGIES CORPORATION
    Inventors: Alexandre Vlassov, Timothy Barta, Justin Inslee, Ethan Gentert, Robert Smith, Sara Thiele, Carolyn Adams, Kraig Kruger, Robert Schneider, Wade Lukianow, Jay Greco, Jason Jones, David Cerrone, Sumonto Ghosh, Brian Vajda, Andrew Basta, Allan Evans, Christopher Crowley, Robert Setterquist, Anne Cox, Mark Mayernick
  • Patent number: 11988683
    Abstract: A moving mechanism and a spray mechanism are controlled to spray a reagent from a nozzle to a sample plate while relatively moving the sample plate and the nozzle. The reagent is applied to an entire application area by moving a spray spot of the reagent sprayed from the nozzle, on the sample plate from a start point to an end point. At this time, the spray spot is moved in a sample placement area after a spray amount of the reagent from the nozzle and a moving speed of the spray spot become constant.
    Type: Grant
    Filed: September 11, 2020
    Date of Patent: May 21, 2024
    Assignee: SHIMADZU CORPORATION
    Inventors: Mio Tsukahara, Kenta Terashima, Yoshitake Yamamoto, Daisuke Oda