Patents Examined by John McGuirk
  • Patent number: 11892461
    Abstract: The present disclosure provides devices, systems, methods for processing and/or analyzing a biological sample. An analytic device for processing and/or analyzing a biological sample may comprise a moving carriage. The analytic device may be portable. The analytic device may receive instructions for performing an assay from a mobile electronic device external to a housing of the analytic device.
    Type: Grant
    Filed: March 16, 2023
    Date of Patent: February 6, 2024
    Assignee: BIOMEME, INC.
    Inventors: Marc DeJohn, Christopher Cox, Thomas Welsh, Luke Gary, Alexia Quinn
  • Patent number: 11885826
    Abstract: A biochemical analysis apparatus includes a piercer for piercing a cover member, a nozzle that passes through the piercer which has pierced the cover member and suctions a specimen, a liquid surface sensor that detects contact of the nozzle with the specimen, and a controller that drives the nozzle and the piercer, in which the controller provides an error notification upon detection of contact of the nozzle with the accommodation object inside the piercer, and upon detection of a collision of the nozzle with the cover member.
    Type: Grant
    Filed: December 11, 2020
    Date of Patent: January 30, 2024
    Assignee: SHIMADZU CORPORATION
    Inventors: Takanori Onoki, Kiyohiro Sugiyama
  • Patent number: 11846580
    Abstract: A flow cell package includes first and second surface-modified patterned wafers and a spacer layer. The first surface-modified patterned wafer includes first depressions separated by first interstitial regions, a first functionalized molecule bound to a first silane or silane derivative in at least some of the first depressions, and a first primer grafted to the first functionalized molecule in the at least some of the first depressions. The second surface-modified patterned wafer includes second depressions separated by second interstitial regions, a second functionalized molecule bound to a second silane or silane derivative in at least some of the second depressions, and a second primer grafted to the second functionalized molecule in the at least some of the second depressions. The spacer layer bonds at least some first interstitial regions to at least some second interstitial regions, and at least partially defines respective fluidic chambers of the flow cell package.
    Type: Grant
    Filed: March 3, 2021
    Date of Patent: December 19, 2023
    Assignees: Illumina, Inc., Illumina Cambridge Limited
    Inventors: James Tsay, Anmiv Prabhu, David Heiner, Edwin Li, Alexandre Richez, John M. Beierle, Kevan Samiee, Kristina Munoz, Leonid Malevanchik, Ludovic Vincent, Naiqian Zhan, Peyton Shieh, Robert Yang, Samantha Schmitt, Sang Park, Scott Bailey, Sean M. Ramirez, Sunmin Ahn, Valerie Uzzell, Wei Wei, Yuxiang Huang, Tyler Jamison Dill
  • Patent number: 11821906
    Abstract: A sample feeding apparatus, a sample analyzing device, and a control method for a sample feeding apparatus are disclosed. At least two of a feeding unit, a temporary storage unit, and a recovery unit together form a vertical stack structure, and a dispatching manipulator transfers a sample vessel among the feeding unit, the temporary storage unit, the recovery unit, and a sample aspiration region. The space in a vertical direction can be reasonably utilized, superposition is performed in space to simplify the dispatching process, and the occupation of a horizontal space is reduced. As a result, the floor space is reduced, and the apparatus is further miniaturized.
    Type: Grant
    Filed: September 5, 2020
    Date of Patent: November 21, 2023
    Assignee: SHENZHEN MINDRAY BIO-MEDICAL ELECTRONICS CO., LTD.
    Inventors: JuanJuan Sun, Yanwen Weng, Chuanfen Xie, Yang Zhou
  • Patent number: 11815523
    Abstract: A method of detecting a level of a liquid in a well of a container. The method includes looking up an expected liquid level of the liquid in the well of a container; measuring and recording a measured liquid level of the liquid in the well; changing a level of the liquid in the well based upon an expected amount of the liquid to be added or removed; and calculating a next expected liquid level at least in part based on multi-point filtering. Apparatus for carrying out the method are provided, as are other aspects.
    Type: Grant
    Filed: October 6, 2021
    Date of Patent: November 14, 2023
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: William D. Dunfee, Mark H. Sprenkle, Colin Ingersoll
  • Patent number: 11808671
    Abstract: It is necessary to efficiently agitate a small amount of sample (such as blood) and reagent (such as diluted solution) in a short time with a dispensing probe having a constant tube inner diameter. An automatic analysis device, by a dispensing probe, executes an aspiration step of aspirating a reagent from a reagent vessel; a first dispensing and aspiration step of dispensing a first liquid amount of the aspirated reagent to a reaction vessel and aspirating, from the reaction vessel, a second liquid amount of a mixed liquid obtained by mixing the reagent and the sample in the reaction vessel; and a final dispensing step of dispensing the aspirated mixed liquid and the reagent in a predetermined dispensing amount. A first liquid amount Va is less than a predetermined dispensing amount Vdil.
    Type: Grant
    Filed: March 11, 2019
    Date of Patent: November 7, 2023
    Assignee: HITACHI HIGH-TECH CORPORATION
    Inventors: Sakuichiro Adachi, Kyoko Yamamoto, Chie Yabutani, Rei Konishi, Akihisa Makino
  • Patent number: 11796551
    Abstract: Clusters of multiple diagnostic analyzers, as well as, alternatively, to one single analyzer that consists of multiple parallel cores (basic analyzer modules) to provide a scalable and user-friendly system architecture. The invention provides a terminal for loading, identifying and hosting samples and/or consumables to at least two automated analyzer systems, the system comprising a distribution robot with four linear drives and a rotational drive, wherein a first linear drive comprises a sledge that can only move linear and horizontally on a rail; the rotational drive comprises a platform that can rotate around the sledge; a second linear drive comprises a carrier that can only move linear and horizontally on the platform; a third linear drive comprises a hook that can only move linear and horizontally on the carrier; and a fourth linear drive comprises a drive for vertically moving the platform over the sledge.
    Type: Grant
    Filed: December 11, 2020
    Date of Patent: October 24, 2023
    Assignee: STRATEC SE
    Inventor: Bernd Gröhbühl
  • Patent number: 11782066
    Abstract: A reagent storage device of the present disclosure includes a shutter and a moving mechanism. The shutter is configured to open and close an opening in a reagent compartment for housing a reagent container, the reagent compartment being provided with the opening for insertion and removal of a probe used to extract a reagent from inside the reagent container housed in the reagent compartment. The moving mechanism is configured to move the shutter to an overlay position opposing the opening and separated from the opening before moving the shutter downward so as to close off the opening, and is also configured to move the shutter that is closing off the opening upward to open up the opening before withdrawing the shutter from the overlay position over the opening.
    Type: Grant
    Filed: March 19, 2019
    Date of Patent: October 10, 2023
    Inventors: Isao Yamaguchi, Takaaki Mori
  • Patent number: 11761970
    Abstract: Systems and methods are described for preventing the release of metal particles from an autosampler that could otherwise be detected within a sample during sample analysis. In an example implementation, an autosampler systems includes, but is not limited to, a sample probe support structure; a z-axis support; an outer shuttle coupled with an outer surface of the z-axis support; and an inner shuttle linearly moveable within an interior volume of the z-axis support, the inner shuttle magnetically coupled with the outer shuttle to translate linear motion of the inner shuttle to the outer shuttle.
    Type: Grant
    Filed: March 22, 2021
    Date of Patent: September 19, 2023
    Assignee: Elemental Scientific, Inc.
    Inventors: Beau A. Marth, Tyler Yost
  • Patent number: 11754582
    Abstract: An automated analyzer that receives samples prepared for analysis in an automated pre-analytical module and a method of operation of such automated analyzer. The automated analyzer includes a shuttle transfer station that receives a shuttle carrier from the automated pre-analytical system. The shuttle transfer station has a clamping assembly for the shuttle. The clamping assembly has jaws that advance engagement members into contact with a bottom portion of sample containers disposed in the shuttle. The clamping assembly secures the sample containers in the shuttle when sample is aspirated from the sample containers. The automated analyzer also has a multichannel puncture tool that is adapted to be carried by a robotic gripper mechanism. The multichannel puncture tool has multiple puncture members that each defines a channel Each channel is in communication with a different trough in the consumable. A pipette can pass through the channel in the puncture tool.
    Type: Grant
    Filed: November 10, 2021
    Date of Patent: September 12, 2023
    Assignee: BECTON DICKINSON AND COMPANY
    Inventors: Michael T. VanSickler, Neil G. Terry, Brian Bell, Steven C. Rotundo, Stephen Robert LaChance, Alyssa Shedlosky
  • Patent number: 11754558
    Abstract: Systems and methods for use in an in vitro diagnostics setting incorporating magnetic shielding to reduce exposure of any of samples, reactants, devices or people from exposure or prolonged exposure to magnetic or electromagnetic fields generated with the system.
    Type: Grant
    Filed: March 9, 2022
    Date of Patent: September 12, 2023
    Inventors: Kung-Le Chang, Manuel Lavin, Baris Yagci
  • Patent number: 11747354
    Abstract: The present disclosure relates to a method to re-identify a carrier on a laboratory transport system after a system failure. The carrier is associated with an identity and is configured to move over a transport plane of the laboratory transport system. The laboratory transport system comprises a monitoring system configured to monitor motion positions of the carrier on the transport plane when the laboratory transport system is activated. After a system failure, the identity dissociates from the carrier and the carrier keeps moving on the transport plane. After reactivation of the laboratory transport system, a predicted position of the identity is compared to an actual position of the carrier by a control unit of the laboratory transport system. The control unit assigns the identity to the carrier if the predicted position of the identity matches with the actual position of the carrier.
    Type: Grant
    Filed: March 24, 2021
    Date of Patent: September 5, 2023
    Assignee: Roche Diagnostics Operations, Inc.
    Inventor: Goran Savatic
  • Patent number: 11719714
    Abstract: The automatic analyzer includes: a liquid dispensing mechanism that performs suction of a liquid; a pressure sensor that measures a change of an internal pressure of a probe provided at the liquid dispensing mechanism; a determination section that determines whether the suction of the liquid by the probe is normal suction or air suction abnormality; an analysis section; a storage section that stores a cumulative number of times of air suction abnormality per liquid and an allowable cumulative number for the cumulative number of times of air suction abnormality; and a controller that exercises operation control over the liquid dispensing mechanism, the determination section, and the analysis section. The controller exercises control such that the cumulative number of times of air suction abnormality is updated and the updated cumulative number is stored in the storage section even if the air suction abnormality occurs non-consecutively.
    Type: Grant
    Filed: March 19, 2019
    Date of Patent: August 8, 2023
    Assignees: HITACHI HIGH-TECH CORPORATION, ROCHE DIAGNOSTICS OPERATIONS, INC.
    Inventors: Sayaka Sarwar, Masaharu Nishida, Yoko Inoue, Masafumi Shimada, Kenichi Yagi, Naohiko Fukaya, Andrew McCaughey
  • Patent number: 11717273
    Abstract: A kit for testing for a virus and interacting with a sensor are disclosed. For example, the kit can include a first container having a first media for conditioning, catalyst formation and rinsing of the sensor. The first media can comprise V mL of 1 M KOH. The kit can have a second container with a second media for negative control (baseline solution) for the sensor. The second media can comprise W ML of 0.01 M KOH. The kit can further include a third container having a third media for sample testing with the sensor. The third media can comprise X mL of 0.01 M KOH. The third container can receive Y mL of saliva to complete a Z mL total volume in the third container prior to sample testing. In some versions, a ratio V: W: X: Y: Z=1.0: 1.0: 0.9: 0.1: 1.0 can be used.
    Type: Grant
    Filed: May 3, 2022
    Date of Patent: August 8, 2023
    Assignee: Texas Tech University System
    Inventor: Gerardine G. Botte
  • Patent number: 11714096
    Abstract: An automated carousel and system configured for translationally moving a plurality of biological production units in unison along a vertical frame while maintaining a precise alignment of each of the biological production units relative to gravity, and simultaneously providing independent dynamic adjustment of the axial orientation of each of the plurality of biological production units relative to gravity. The automated carousel may be adapted for use with a variety of biological production units supporting cell culture and/or tissue engineering systems in various clinical and laboratory settings and provides for ergonomic use thereof.
    Type: Grant
    Filed: December 18, 2019
    Date of Patent: August 1, 2023
    Assignee: OCTANE BIOTECH INC.
    Inventors: Timothy Smith, Ian Grant, Guy Oram, Chase McRobie, Raelyn Daniels, Taylor Plant
  • Patent number: 11709171
    Abstract: A laboratory system for a laboratory automation system is presented. The laboratory system comprises a sample container carrier. The sample container carrier is configured to carry a laboratory sample container and comprises a removal detector. The removal detector is configured to interact with the laboratory sample container to detect a removal of the carried laboratory sample container from the sample container carrier. Furthermore, the laboratory system is configured to determine based on the detected removal that a before valid logic assignment of the sample container carrier to the carried laboratory sample container is invalid.
    Type: Grant
    Filed: March 4, 2019
    Date of Patent: July 25, 2023
    Assignee: ROCHE DIAGNOSTICS OPERATIONS, INC.
    Inventors: Martin Kopp, Oliver Gutmann, Norbert Schmitt
  • Patent number: 11709173
    Abstract: Disclosed are high-throughput vessel supply systems and methods of supplying sample vessels, such as samples stored in test tubes. A system for supplying a plurality of individual vessels that each contains a sample is disclosed.
    Type: Grant
    Filed: October 26, 2021
    Date of Patent: July 25, 2023
    Assignee: Laboratory Corporation of America Holdings
    Inventors: David Wilson, Jay Krajewski, Kevin Meyer
  • Patent number: 11709174
    Abstract: Disclosed are high-throughput vessel sorting systems and methods of sorting sample vessels, such as samples stored in test tubes. A system for sorting a plurality of individual vessels that each contains a sample is disclosed.
    Type: Grant
    Filed: April 29, 2022
    Date of Patent: July 25, 2023
    Assignee: Laboratory Corporation of America Holdings
    Inventors: David Wilson, Jay Krajewski, Kevin Meyer
  • Patent number: 11703518
    Abstract: A sample analysis system is available that can include a remote sampling system, at least one analyzer, and a controller. The remote sampling system can include a plurality of sample sources for providing a corresponding sample therefrom; and a plurality of sample collection devices selectively coupled to any of the plurality of sample sources for receiving at least one of the samples therefrom. The at least one analyzer can be coupled to the plurality of the sample collection devices for receiving at least one of the samples therefrom. The controller can be coupled with the remote sampling system and the at least one analyzer, the controller configured to control which of the sample sources is actively coupled to a given sample collection device at a given time.
    Type: Grant
    Filed: September 29, 2020
    Date of Patent: July 18, 2023
    Assignee: Elemental Scientific, Inc.
    Inventors: Tyler Yost, Jonathan Hein, Jae Seok Lee, Dong Cherl Park
  • Patent number: 11686741
    Abstract: The object of the invention is to realize an automatic analyzer capable of suppressing an increase in cost without greatly changing the configuration even when the configuration of an inspection system is changed, and reducing burden of an operator. A pin to be fitted into a hole formed in a specimen container conveying unit is formed on a specimen container conveying unit mounting surface at a position below a specimen suction position, and it is possible to make relative positions between components of a specimen dispensing unit and the specimen container conveying unit at the time of a specimen dispensing operation, as well as driving conditions when moving each axis of the specimen dispensing unit identical even when the types of the specimen container conveying unit are different, and it is possible to ensure stability of the same specimen dispensing operation before and after changing the specimen container conveying unit.
    Type: Grant
    Filed: July 6, 2018
    Date of Patent: June 27, 2023
    Assignee: Hitachi High-Tech Corporation
    Inventors: Takenori Okusa, Susumu Sakairi