Patents Examined by John Rollins
  • Patent number: 4745099
    Abstract: A pharmaceutical composition for the treatment of the anemia of malignant tumors comprising a therapeutically effective amount of human erythropoietin (EPO) in a parenterally acceptable vehicle is disclosed. Human EPO may be extracted from human urine or also be prepared by expressing in a host cell the gene coding for the amino acid sequence of human EPO.
    Type: Grant
    Filed: February 3, 1986
    Date of Patent: May 17, 1988
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Ken-ichi Akamatsu, Masayoshi Ono
  • Patent number: 4745107
    Abstract: Heparin derivatives containing hydrophobic groups and exhibiting improved permeability are disclosed. Said derivatives exhibit anticoagulant activity and improved solubility in organic solvents.
    Type: Grant
    Filed: August 20, 1986
    Date of Patent: May 17, 1988
    Inventors: Kevin M. Foley, Charles C. Griffin, Eduardo Amaya
  • Patent number: 4745106
    Abstract: Acetyl ester derivatives of heparin are disclosed. These derivatives exhibit improved Anti-Xa activity in relation to their global anticlotting activity.
    Type: Grant
    Filed: August 20, 1986
    Date of Patent: May 17, 1988
    Inventors: Charles C. Griffin, Kevin M. Foley, Eduardo Amaya
  • Patent number: 4745108
    Abstract: Ester derivatives of heparin are disclosed. These derivatives exhibit low anti-Xa activity in relation to global anticlotting activity.
    Type: Grant
    Filed: August 20, 1986
    Date of Patent: May 17, 1988
    Inventors: Kevin M. Foley, Charles C. Griffin, Eduardo Amaya
  • Patent number: 4744984
    Abstract: The present invention relates to an immunotherapeutic agent that is effective in treating a wide variety of ongoing viral infections in animals and man. The present invention is a preparation of modified mycobacterial cell walls that is capable of stimulating the immune system of an animal or man in such a way as to cause the body to neutralize, abort or eliminate an virus infection.
    Type: Grant
    Filed: October 8, 1985
    Date of Patent: May 17, 1988
    Assignee: Vetrepharm Research, Inc.
    Inventor: William L. Ragland
  • Patent number: 4737364
    Abstract: A highly nutritional dry food concentrate consisting entirely of plant and other non-animal natural components having a low caloric content and containing no added simple sugars. The nutritional dry food concentrate consisting entirely of natural ingredients is useful as a food supplement and in a weight reduction program.
    Type: Grant
    Filed: February 4, 1987
    Date of Patent: April 12, 1988
    Inventor: Theodore P. Kalogris
  • Patent number: 4551331
    Abstract: A modified dry dietary fiber product which is readily dispersible in liquids such as water, comprises a dry dietary fiber product coated with from 0.05 to 20% by weight of the food grade emulsifier. Process for producing coated dietary fiber products comprises blending these dietary fiber product materials with the mixture of a non-toxic solvent in a food grade emulsifier followed by removing the solvent.
    Type: Grant
    Filed: June 2, 1983
    Date of Patent: November 5, 1985
    Assignee: S. C. Johnson & Son, Inc.
    Inventor: Richard E. Rudin
  • Patent number: 4473561
    Abstract: A fungicidal composition which comprises as an active ingredient a fungicidally effective amount of a compound of the formula: ##STR1## wherein X is a hydroxyl group or a hydroxyamino group, or its salt and an inert carrier or diluent.
    Type: Grant
    Filed: April 6, 1982
    Date of Patent: September 25, 1984
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Yukio Ishiguri, Yoshimi Yamada, Toshiro Kato, Mitsuru Sasaki, Kunio Mukai
  • Patent number: 4473559
    Abstract: A mixture of compositions for reducing red blood cell sickling is disclosed. This process utilizes porphyrinic and chlorophyllic compounds derived from dehydrated legumes and cereal grasses. After processing, the product of interest is a free flowing crystalline solid and has a purple color when dissolved in methanol. It is yellow when dissolved in water, has a strong absorption band near 400 millimicrons when dissolved in either water or methanol and has lesser absorption bands at other wavelengths, is free of esters or ketones and is believed to be an alkali metal salt, the preferred salt being potassium carboxylic acid salt, and wherein the active agent is substantially free of magnesium and includes a trace amount of paramagnetic impurities.
    Type: Grant
    Filed: March 18, 1983
    Date of Patent: September 25, 1984
    Inventor: Larry H. Robinson
  • Patent number: 4470927
    Abstract: A process for recovering flavoring substances from the vanilla capsule with carbon dioxide under fluid conditions is described, which consists in performing the extraction at temperatures between 10.degree. and 30.degree. C. and pressures of 80 to 350 bar, and producing the separation of the extract at temperatures of 0.degree. to 30.degree. C. and pressures of 30 to 60 bar. In this manner it is possible by a one-step process to extract all of the flavoring substances of the vanilla capsule with the recovery of a highly concentrated vanilla flavoring, and to obtain a material which is considerably superior to the products obtained by conventional extraction with organic solvents.
    Type: Grant
    Filed: September 10, 1982
    Date of Patent: September 11, 1984
    Assignees: SKW Trostberg Aktiengesellschaft, Haarmann & Reiner
    Inventors: Erwin Sch/u/ tz, Heinz-R/u/ diger Vollbrecht, Klaus Sandner, Theodor Sand, Peter M/u/ hlnickel
  • Patent number: 4470966
    Abstract: An emulsifiable concentrate of Imidan, an acrylic resin, a surfactant and a common organic solvent functions as a controlled release insecticide when applied to plant foliage.
    Type: Grant
    Filed: March 15, 1982
    Date of Patent: September 11, 1984
    Assignee: Celanese Corporation
    Inventors: John R. Costanza, Henry A. Terwedow, Jr.
  • Patent number: 4466961
    Abstract: A new pharmaceutical composition suitable for the treatment of injuries to the skin, particularly burns, a process for the preparation thereof and a method of treatment for skin injuries is disclosed. The new composition relieves pain and promotes healing and is locally administered to the injury. The composition contains 5 to 20 mg of a tannic material, 5 to 15 mg of a carbohydrate, 0.5 to 6 mg of an anthocyane and/or a flavonone compound and/or pectin, 0.5 to 6 mg of plant wax, and 0.01 to 0.1 mg of volatile oil, balance a C.sub.2 to C.sub.4 alkanol, to yield 100 ml of composition.
    Type: Grant
    Filed: March 16, 1982
    Date of Patent: August 21, 1984
    Assignee: Human Oltoanyagtermeloo es Kutato Intezet
    Inventors: Emilia Szijjarto nee Auber, Magda Raskai
  • Patent number: 4455306
    Abstract: The present invention relates to a method for concentrating a dilute aqueous solution of a .beta.-lactam antibiotic which is readily susceptible to heat, by subjecting a dilute aqueous solution of a .beta.-lactam antibiotic, said solution containing 2 to 20% (v/v) of a lower alcohol, to concentration by means of a permeable membrane made of poly(ether/amide) or polybenzimidazolone.
    Type: Grant
    Filed: December 21, 1981
    Date of Patent: June 19, 1984
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Kiyoshi Nara, Kazuyoshi Katamoto, Sadao Ohkido, Isao Yamamoto, Hiroshi Yanome
  • Patent number: 4405643
    Abstract: Pharmaceutical compositions for use in the relief of acute pulmonary edema, different types of shock including anaphylactic shock, shock induced by bacterial endotoxins, and hyperfibrinolysis induced by substances which activate plasminogen, consist of solutions of an ester of L-arginine with an aliphatic alcohol in water at a pH between 5.5 and 8.5. The compositions may be provided in unit dosage form containing 0.25-100 mg of active substance per kilogram of body weight of the subject in need of treatment and are administered through the parenteral route. The esters may be provided in the form of a salt with a pharmaceutically acceptable organic or inorganic acid. The esters may be with methyl or ethyl alcohol. The compositions are more effective than aspirin and aprotinin.
    Type: Grant
    Filed: August 27, 1981
    Date of Patent: September 20, 1983
    Assignee: Italfarmaco S.p.A.
    Inventors: Giancarlo Sportoletti, Alessandro Baglioni