Patents Examined by John Rollins
  • Patent number: 4777043
    Abstract: Disclosed are novel, stable pharmaceutically acceptable compositions containing human tissue plasminogen activator, featuring, for example, an argininum ion containing buffer as a component. Also disclosed are associated means and methods for preparing and using such compositions in various forms.
    Type: Grant
    Filed: December 17, 1985
    Date of Patent: October 11, 1988
    Assignee: Genentech, Inc.
    Inventors: William F. Bennett, Stuart E. Builder, Larry A. Gatlin
  • Patent number: 4775532
    Abstract: An animal repellent composition comprising an animal repellent proportion of an olfactory animal repellent carried by a vehicle comprising a di(alkhyl) adipate and a method of repelling animals.
    Type: Grant
    Filed: October 24, 1984
    Date of Patent: October 4, 1988
    Assignee: Mobil Oil Corporation
    Inventor: William J. Clayton
  • Patent number: 4774229
    Abstract: A mixture of an extract from a plant belonging to the Zygophyllaceae family containing phenolic compositions and a nonalkali metal salt is useful as a pharmaceutical agent, for example, in the treatment of cancer, nonmalignant tumors, osteomyelitis, psoriasis and warts.
    Type: Grant
    Filed: May 7, 1986
    Date of Patent: September 27, 1988
    Assignee: Chemex Pharmaceuticals, Inc.
    Inventor: Russell T. Jordan
  • Patent number: 4772467
    Abstract: A process for dietary calcium supplementation. Oral dosage of a composition comprising calcium citrate is utilized to provide an efficiently absorbable chemical form of calcium, while raising urinary level of citrate. Because of improved absorption of calcium, osteoporosis development is precluded. Since citrate retards precipitation of stone-forming calcium stones, the risk of calcium nephrolithiasis (resulting from calcium supplementation) is reduced.
    Type: Grant
    Filed: December 11, 1985
    Date of Patent: September 20, 1988
    Assignee: Board of Regents, U T Systems
    Inventor: Charles Y. C. Pak
  • Patent number: 4771039
    Abstract: A botulinus toxin neutralizer comprising heat-treated fat globule membranes of animal milk or gangliosides isolated from fat globule membranes of animal milk. The neutralizer of the former nature is prepared from a material containing fat globules of animal milk by fractionating the material for separating the membranes of the fat globules from the rest of the material, and subjecting the separated fat globule membranes to heat treatment. The neutralizer of the former nature is prepared from a material containing fat globules by fractionating the material for separating the membranes of the fat globules from the rest of the material, and isolating gangliosides from the globule membranes.
    Type: Grant
    Filed: March 25, 1986
    Date of Patent: September 13, 1988
    Assignee: Kabushiki Kaisha Yakult Honsha
    Inventors: Ryuichiro Tanaka, Koutaro Takamizawa, Hiroo Takayama, Toshizo Sakurai, Mitsuo Mada, Masahiko Mutai
  • Patent number: 4767624
    Abstract: A decubital remedy suitable for cutaneous administration contains ubidecarenone as an effective ingredient. The decubital remedy, which may preferably take the form of a cream, lotion or ointment, is effective in reducing decubitus-related severe pain and restoring the tissue damaged by decubitus. It is applicable even to patients who are unable to take drugs orally by themselves due to dyscrasia or cranial nerve disorders. It is also free of such cumbersomeness and body-wide influence as injection.
    Type: Grant
    Filed: March 11, 1986
    Date of Patent: August 30, 1988
    Inventors: Shinichi Okuyama, Kazumaro Furuse, Shigemitsu Ohsawa
  • Patent number: 4767626
    Abstract: A method for the treatment of anemia associated with viral and bacterial infection in a patient wherein symptoms of rheumatoid arthritis are present, by administering to the patient an effective amount of a composition capable of increasing thyroxine in the blood stream of said patient and thereby increasing stem cells in the blood stream. The composition preferably comprises fat soluble alkaloid extracts from the root of Zanthoxylum Simulans.
    Type: Grant
    Filed: February 27, 1986
    Date of Patent: August 30, 1988
    Inventor: Theodore Cheng
  • Patent number: 4767746
    Abstract: Omental lipid fractions accelerate wound healing especially as to epithelialization in mammals.
    Type: Grant
    Filed: December 4, 1985
    Date of Patent: August 30, 1988
    Assignees: Trustees of Boston University, Angio-Medical Corporation
    Inventors: Nicholas Catsimpoolas, Robert S. Sinn
  • Patent number: 4766111
    Abstract: Plasmin inhibitory substances have been found in mammalian omental extracts. The substances all contain lipid components. In addition, related commercially available lipid containing molecules, such as mono-, di-, and trisialogangliosides are found to possess unexpected plasmin inhibitory properties. This suggests methods of therapy for diseases and conditions where blood clotting and fibrin degradation products, are implicated.
    Type: Grant
    Filed: March 23, 1987
    Date of Patent: August 23, 1988
    Assignee: Trustees of Boston University
    Inventor: Nicholas Catsimpoolas
  • Patent number: 4764502
    Abstract: A protein having a molecular weight of from about 10,000 to 18,000 daltons, isoelectric points of from about pH 4.0 to 6.5 and having the reversible biological effect of inhibiting aromatase activity in a biological system, and antibodies to the protein, modulate follicular development and spermatogenesis and provide for diagnostic tests of gonadal functions.
    Type: Grant
    Filed: September 25, 1986
    Date of Patent: August 16, 1988
    Assignee: University of Southern California
    Inventor: Gere S. diZerega
  • Patent number: 4762822
    Abstract: The present invention discloses mother's milk substitutes containing sialic acid or a ganglioside that reduce the number of gastrointestinal disease-producing organisms in a young mammal's food and gastrointestinal tract. The invention also discloses dietary supplements and methods for reducing the number of gastrointestinal disease-producing organisms.
    Type: Grant
    Filed: August 8, 1985
    Date of Patent: August 9, 1988
    Inventor: Anna C. Ettinger
  • Patent number: 4762716
    Abstract: Annonin, a substantially pure insecticidally active compound obtained by extracting comminuted Annona squamosa parts to remove the petroleum ether solubles, then optionally extracting with alcohol to dissolve the desired material, then extracting either the petroleum ether-residue or the alcohol extract with an aliphatic halogenohydrocarbon, an aliphatic ether and/or an ester, and discarding the residue, and evaporating off the solvent. It has the 1R spectrum shown in the drawing.
    Type: Grant
    Filed: June 22, 1987
    Date of Patent: August 9, 1988
    Assignee: Bayer Aktiengesellschaft
    Inventors: Heinrich F. Moeschler, Wolfgang Pfluger, Detlef Wendisch
  • Patent number: 4761285
    Abstract: A composition comprising Leptandra Culver's root, chick-peas and grape seeds. The composition can be enhanced with honey, cinnamon and/or oil. The composition is useful for the relief and treatment of hemorrhoids and hemorrhoidal symptoms. The composition can also be used as an herbal food supplement for dietary and nutritional purposes.
    Type: Grant
    Filed: October 28, 1986
    Date of Patent: August 2, 1988
    Assignee: Athanasios Vasiliou
    Inventors: Anna Vasiliou, Athanasios Vasiliou
  • Patent number: 4761286
    Abstract: Gymnema sylvestre is added to glucose for inhibiting absorption of the glucose through intestine, whereby the increase in calorie intake which usually arises from taking of glucose-containing foodstuffs can be restrained at a low level.
    Type: Grant
    Filed: January 27, 1987
    Date of Patent: August 2, 1988
    Inventor: Yasutake Hiji
  • Patent number: 4755383
    Abstract: A pharmaceutical composition is disclosed which comprises a physiologically active substance possessing peptide bonds in its structure and being inactivable by digestive enzymes, the active substances being other than insulin, and a synthetic chymotrypsin inhibitor. The composition is particularly suitable for intestinal absorption of the active substance.
    Type: Grant
    Filed: June 30, 1986
    Date of Patent: July 5, 1988
    Assignee: Kowa Co., Ltd.
    Inventors: Setsuro Fujii, Touru Yokoyama, Kouji Ikegaya, Nobuo Yokoo, Masahiko Nagakura
  • Patent number: 4755379
    Abstract: Anticoagulant products are constituted by polymers (homopolymers or copolymers) including in their chain substitutable groups on which are fixed statistically, groups X and/or Y and/or V, where X denotes the group --SO.sub.3 R.sub.1 or --R.sub.3 --SO.sub.3 R.sub.1, R.sub.1 being a hydrogen atom or a physiologically compatible metal, R.sub.3 being a --CH.sub.2 --CO--NH--R.sub.4 group in which R.sub.4 represensts an alkyl aryl or alkylaryl radical, which may or may not be substituted, or substituted or unsubstituted --CH.sub.2 --; Y denotes the group --SO.sub.2 --R.sub.2 or --R.sub.3 --SO.sub.2 --R.sub.2, R.sub.2 being the residue of an amino acid connected to the --SO.sub.2 bridge through its amine function and V denotes the group --CH.sub.2 --CO--NH--CHR--COOH, R being the side chain of an amino acid it being understood that: (a) if X is --SO.sub.3 R.sub.1 it is necessarily accompanied by Y and/or by V, and (b) V is always accompanied by X and/by Y.
    Type: Grant
    Filed: September 27, 1985
    Date of Patent: July 5, 1988
    Assignees: Jacqueline Jozefonvicz, Marcel Jozefonvicz, Christine Fougnot
    Inventors: Marcel Jozefonvicz, Jacqueline Jozefonvicz, Christine Fougnot, Monique Mauzac
  • Patent number: 4752476
    Abstract: A composition to be ingested after boiling by an individual for the purpose of inducing sleep in the individual comprising ingredients mixed in the following ratios: seven ounces of water, one and one-half tablespoons of rose water, two teaspoons of nutmeg, nine bay leaves, and two and one-half tablespoons of spearmint.
    Type: Grant
    Filed: February 18, 1986
    Date of Patent: June 21, 1988
    Inventor: Claudette V. Copney
  • Patent number: 4751218
    Abstract: An acylglycan extract of Klebsiella consisting essentially of about 80% of neutral oses, about 20% of lipids and less than 2% of proteins and having a molecular weight of approximately 12,500 and a process for obtining them which have antiallergic and immunomodulating properties.
    Type: Grant
    Filed: December 4, 1985
    Date of Patent: June 14, 1988
    Assignee: Roussel Uclaf
    Inventors: Pierre Smets, Rene Zalisz
  • Patent number: 4749522
    Abstract: Supercritical fluids (SCF) are found to be useful in extracting desired materials from animal tissues, cells, and organs. By varying the choice of SCF, experimental conditions, and animal source material, one may obtain lipids, proteins, nucleotides, saccharids, and other desirable components or remove undesirable components.
    Type: Grant
    Filed: October 31, 1985
    Date of Patent: June 7, 1988
    Assignee: Angio-Medical Corporation
    Inventor: Ahmad R. Kamarei
  • Patent number: 4746675
    Abstract: A pharmaceutical composition for external use with the enhanced penetration of a pharmacologically active agent through the skin or mucosa of a warm-blooded animal, said composition comprising(A) a pharmaceutically effective amount of the pharmacologically active agent such as antiinflammatory agent, etc., and(B) a penetration enhancer of the following formula (1) ##STR1## wherein R.sub.1 and R.sub.2 are identical or different and each represents H, a C.sub.1-25 alkyl, C.sub.2-25 alkenyl, a (C.sub.1-24 alkyl)carbonyl or a (C2-24 alkenyl)carbonyl, provided that R.sub.1 and R.sub.2 are not H at the same time, or R.sub.1 and R.sub.2, taken together, may form a group of the following formula (a) ##STR2## in which R.sub.3 and R.sub.4 are identical or different and each represents H, C.sub.1-24 alkyl or C.sub.1-24 alkenyl.
    Type: Grant
    Filed: October 27, 1986
    Date of Patent: May 24, 1988
    Assignee: Teijin Limited
    Inventors: Yuji Makino, Yoshiki Suzuki