Abstract: Disclosed are novel, stable pharmaceutically acceptable compositions containing human tissue plasminogen activator, featuring, for example, an argininum ion containing buffer as a component. Also disclosed are associated means and methods for preparing and using such compositions in various forms.
Type:
Grant
Filed:
December 17, 1985
Date of Patent:
October 11, 1988
Assignee:
Genentech, Inc.
Inventors:
William F. Bennett, Stuart E. Builder, Larry A. Gatlin
Abstract: An animal repellent composition comprising an animal repellent proportion of an olfactory animal repellent carried by a vehicle comprising a di(alkhyl) adipate and a method of repelling animals.
Abstract: A mixture of an extract from a plant belonging to the Zygophyllaceae family containing phenolic compositions and a nonalkali metal salt is useful as a pharmaceutical agent, for example, in the treatment of cancer, nonmalignant tumors, osteomyelitis, psoriasis and warts.
Abstract: A process for dietary calcium supplementation. Oral dosage of a composition comprising calcium citrate is utilized to provide an efficiently absorbable chemical form of calcium, while raising urinary level of citrate. Because of improved absorption of calcium, osteoporosis development is precluded. Since citrate retards precipitation of stone-forming calcium stones, the risk of calcium nephrolithiasis (resulting from calcium supplementation) is reduced.
Abstract: A botulinus toxin neutralizer comprising heat-treated fat globule membranes of animal milk or gangliosides isolated from fat globule membranes of animal milk. The neutralizer of the former nature is prepared from a material containing fat globules of animal milk by fractionating the material for separating the membranes of the fat globules from the rest of the material, and subjecting the separated fat globule membranes to heat treatment. The neutralizer of the former nature is prepared from a material containing fat globules by fractionating the material for separating the membranes of the fat globules from the rest of the material, and isolating gangliosides from the globule membranes.
Abstract: A decubital remedy suitable for cutaneous administration contains ubidecarenone as an effective ingredient. The decubital remedy, which may preferably take the form of a cream, lotion or ointment, is effective in reducing decubitus-related severe pain and restoring the tissue damaged by decubitus. It is applicable even to patients who are unable to take drugs orally by themselves due to dyscrasia or cranial nerve disorders. It is also free of such cumbersomeness and body-wide influence as injection.
Abstract: A method for the treatment of anemia associated with viral and bacterial infection in a patient wherein symptoms of rheumatoid arthritis are present, by administering to the patient an effective amount of a composition capable of increasing thyroxine in the blood stream of said patient and thereby increasing stem cells in the blood stream. The composition preferably comprises fat soluble alkaloid extracts from the root of Zanthoxylum Simulans.
Abstract: Plasmin inhibitory substances have been found in mammalian omental extracts. The substances all contain lipid components. In addition, related commercially available lipid containing molecules, such as mono-, di-, and trisialogangliosides are found to possess unexpected plasmin inhibitory properties. This suggests methods of therapy for diseases and conditions where blood clotting and fibrin degradation products, are implicated.
Abstract: A protein having a molecular weight of from about 10,000 to 18,000 daltons, isoelectric points of from about pH 4.0 to 6.5 and having the reversible biological effect of inhibiting aromatase activity in a biological system, and antibodies to the protein, modulate follicular development and spermatogenesis and provide for diagnostic tests of gonadal functions.
Abstract: The present invention discloses mother's milk substitutes containing sialic acid or a ganglioside that reduce the number of gastrointestinal disease-producing organisms in a young mammal's food and gastrointestinal tract. The invention also discloses dietary supplements and methods for reducing the number of gastrointestinal disease-producing organisms.
Abstract: Annonin, a substantially pure insecticidally active compound obtained by extracting comminuted Annona squamosa parts to remove the petroleum ether solubles, then optionally extracting with alcohol to dissolve the desired material, then extracting either the petroleum ether-residue or the alcohol extract with an aliphatic halogenohydrocarbon, an aliphatic ether and/or an ester, and discarding the residue, and evaporating off the solvent. It has the 1R spectrum shown in the drawing.
Type:
Grant
Filed:
June 22, 1987
Date of Patent:
August 9, 1988
Assignee:
Bayer Aktiengesellschaft
Inventors:
Heinrich F. Moeschler, Wolfgang Pfluger, Detlef Wendisch
Abstract: A composition comprising Leptandra Culver's root, chick-peas and grape seeds. The composition can be enhanced with honey, cinnamon and/or oil. The composition is useful for the relief and treatment of hemorrhoids and hemorrhoidal symptoms. The composition can also be used as an herbal food supplement for dietary and nutritional purposes.
Abstract: Gymnema sylvestre is added to glucose for inhibiting absorption of the glucose through intestine, whereby the increase in calorie intake which usually arises from taking of glucose-containing foodstuffs can be restrained at a low level.
Abstract: A pharmaceutical composition is disclosed which comprises a physiologically active substance possessing peptide bonds in its structure and being inactivable by digestive enzymes, the active substances being other than insulin, and a synthetic chymotrypsin inhibitor. The composition is particularly suitable for intestinal absorption of the active substance.
Abstract: Anticoagulant products are constituted by polymers (homopolymers or copolymers) including in their chain substitutable groups on which are fixed statistically, groups X and/or Y and/or V, where X denotes the group --SO.sub.3 R.sub.1 or --R.sub.3 --SO.sub.3 R.sub.1, R.sub.1 being a hydrogen atom or a physiologically compatible metal, R.sub.3 being a --CH.sub.2 --CO--NH--R.sub.4 group in which R.sub.4 represensts an alkyl aryl or alkylaryl radical, which may or may not be substituted, or substituted or unsubstituted --CH.sub.2 --; Y denotes the group --SO.sub.2 --R.sub.2 or --R.sub.3 --SO.sub.2 --R.sub.2, R.sub.2 being the residue of an amino acid connected to the --SO.sub.2 bridge through its amine function and V denotes the group --CH.sub.2 --CO--NH--CHR--COOH, R being the side chain of an amino acid it being understood that: (a) if X is --SO.sub.3 R.sub.1 it is necessarily accompanied by Y and/or by V, and (b) V is always accompanied by X and/by Y.
Abstract: A composition to be ingested after boiling by an individual for the purpose of inducing sleep in the individual comprising ingredients mixed in the following ratios: seven ounces of water, one and one-half tablespoons of rose water, two teaspoons of nutmeg, nine bay leaves, and two and one-half tablespoons of spearmint.
Abstract: An acylglycan extract of Klebsiella consisting essentially of about 80% of neutral oses, about 20% of lipids and less than 2% of proteins and having a molecular weight of approximately 12,500 and a process for obtining them which have antiallergic and immunomodulating properties.
Abstract: Supercritical fluids (SCF) are found to be useful in extracting desired materials from animal tissues, cells, and organs. By varying the choice of SCF, experimental conditions, and animal source material, one may obtain lipids, proteins, nucleotides, saccharids, and other desirable components or remove undesirable components.
Abstract: A pharmaceutical composition for external use with the enhanced penetration of a pharmacologically active agent through the skin or mucosa of a warm-blooded animal, said composition comprising(A) a pharmaceutically effective amount of the pharmacologically active agent such as antiinflammatory agent, etc., and(B) a penetration enhancer of the following formula (1) ##STR1## wherein R.sub.1 and R.sub.2 are identical or different and each represents H, a C.sub.1-25 alkyl, C.sub.2-25 alkenyl, a (C.sub.1-24 alkyl)carbonyl or a (C2-24 alkenyl)carbonyl, provided that R.sub.1 and R.sub.2 are not H at the same time, or R.sub.1 and R.sub.2, taken together, may form a group of the following formula (a) ##STR2## in which R.sub.3 and R.sub.4 are identical or different and each represents H, C.sub.1-24 alkyl or C.sub.1-24 alkenyl.