Abstract: This invention provides several ways of managing GC bias that occurs during seequencing and analysis of genomic DNA. Maternal plasma can be used as a source of fetal DNA for analysis. DNA segments or tags obtained from the plasma can be aligned with a chromosomal region of interest and with an artificial reference chromosome assembled from regions of the genome having matching GC content. This technology can be used, for example, to detect and evaluate aneuploidy and other chromosomal abnormalities.

Abstract: The microorganism-containing biocatalysts disclosed have a large population of the microorganisms irreversibly retained in the interior of the biocatalysts. The biocatalysts possess a surprisingly stable population of microorganisms and have an essential absence of debris generation from metabolic activity of the microorganisms. The biocatalysts are composed of highly hydrophilic polymer and have an internal, open, porous structure that promotes community phenotypic changes.

Abstract: A method of analyzing RNA extracted from a tissue or cell(s) fixed with a fixative, said method comprising a determining step of whether said RNA satisfies: B/A?1 wherein A represents the weight ratio (%) of RNA within the range of 1000 to 4000 nucleotides with respect to the total weight of RNA as determined by electrophoresis; and B represents the weight ratio (%) of RNA within the range of more than 4000 nucleotides with respect to the total weight of RNA as determined by electrophoresis.

Abstract: Oligosaccharides from bovine milk, whey and dairy products, and methods of producing bovine milk oligosaccharides are provided.

Abstract: A process is provided that is effective for allowing bacteria to be cultured in a selected substrate. Bacteria are sporulated and then germinated in the presence of a selected substrate and medium.

Abstract: The invention is directed to methods for preventing and/or treating necrotizing enterocolitis. The invention is further directed to reducing inflammation of the intestinal mucosa associated with necrotizing enterocolitis. The invention is further directed to methods for preventing and/or treating necrotizing enterocolitis and/or inflammation of the intestinal mucosa associated with necrotizing enterocolitis by administering to a subject suffering from such conditions, or at risk of developing such conditions, cellular factor-containing solution compositions (referred to herein as “CFS” compositions), including sustained-release cellular factor-containing solution compositions (referred to herein as “SR-CFS” compositions).

Abstract: The present invention relates to a method for producing hydrocarbons from biomass or organic waste. The present invention provides: a method for effectively producing diverse hydrocarbons by using a raw material comprising mixed organic acids that can be obtained by anaerobic fermentation which is a fermentation process in biogasification technology; and a method for producing diverse products such as fuel, lube base oil and aromatics by using a raw material comprising mixed organic acids.

Abstract: A computer-implemented method for processing and/or analyzing nucleic acid sequencing data comprises receiving a first data input and a second data input. The first data input comprises untargeted sequencing data generated from a first nucleic acid sample obtained from a subject. The second data input comprises target-specific sequencing data generated from a second nucleic acid sample obtained from the subject. Next, with the aid of a computer processor, the first data input and the second data input are combined to produce a combined data set. Next, an output derived from the combined data set is generated. The output is indicative of the presence or absence of one or more polymorphisms of the first nucleic acid sample and/or the second nucleic acid sample.

Abstract: The present invention includes a stabilized curcumin composition. The composition includes a curcumin composition and a phosphate composition, wherein the phosphate composition is non-buffering and is provided in an amount sufficient to stabilize and/or prevent the degradation of curcumin and/or a curcuminoid in a biological sample.

Abstract: Computer implemented methods, and systems performing such methods for processing signal data from analytical operations and systems, and particularly in processing signal data from sequence-by-incorporation processes to identify nucleotide sequences of template nucleic acids and larger nucleic acid molecules, e.g., genomes or fragments thereof. In particularly preferred embodiments, nucleic acid sequences generated by such methods are subjected to de novo assembly and/or consensus sequence determination.

Abstract: A method for determining the presence or absence of a genetic segment of interest, such as an exon, an intron or a promoter, in a DNA-containing sample, and probe sets for use in such methods, including probe sets comprising oligonucleotide probes having nucleotides sequences selected from those of SEQ ID NOS: 1-101.

Abstract: Method and device for detection and quantitative and qualitative analysis of components in a gaseous mixture distinguished by high selectivity and high resolution. Method allows to distinguish the influence of individual gases, by themselves or in a mixture, on the microstructure of a sensor's sensitive layer and utilizing the variations of measured parameters to analyze and derive the characteristics of gases, for example, the concentration of a gas or multiple gases in a mixture. As an example, the method could be utilized in medicine for non-invasive detection of the blood glucose level in diabetics. Device realizing the method is described.

Abstract: An object of the present invention is to provide a means for conveniently producing ethanol with high efficiency from a carbon source derived from a plant biomass resource or the like. The present invention relates to a method for producing ethanol, comprising a step of generating ethanol by culturing basidiomycetes belonging to the genus Phlebia with a carbon source. As carbon sources, cellulose, hemicellulose, glucose, xylose, and the like or plant biomass resources containing the same can be used.

Abstract: Methods and algorithms for automated allele assignments within an integrated software environment are provided. These methods and algorithms offer a multiplicity of functionalities including: data management; system configuration including user authorization, training set analysis and probe masking; pattern analysis including string matching and probe flipping; and interactive redaction of data. The methods and algorithms further include methods of setting thresholds, refining thresholds, and probe masking of signals produced by probes which do not contribute significantly to discriminating among alleles.

Abstract: The present invention provides a device, method and program for selecting genes or proteins from a set of candidate genes or proteins so that the selected genes or proteins have a stronger relevance to a specific subject. The device of the present invention contains a storage device, an input device and a processor. The storage device stores a data warehouse that contains a data about a collection of genes or proteins, with which annotations are associated. The input device receives an input of the set of candidate genes or proteins. The processor (a) gathers annotations that are associated with the candidate genes or proteins, (b) chooses annotations that are associated with the candidate genes or proteins more than a threshold number of times or frequencies, and (c) selects genes or proteins, with which at least one of the chosen annotations is associated.

Abstract: Provided is a cell culture apparatus, an apparatus for long-term observation of cell culture, a method for long-term cell culture, and a method for long-term observation of cell culture, which are capable of continuously culturing and observing cells under uniform environmental conditions without aging of the cultured cells' physiological state, and also tracing the history of a cell. The cell culture apparatus comprises a cell culture substrate, a semipermeable membrane, and a culture solution supplier. The cell culture substrate has on a surface a narrow culture groove for holding and culturing cells and wide flow grooves for discarding the cells held and cultured in the culture groove. Both ends of the culture groove are connected to the flow grooves being larger in width and depth than the culture groove. The semipermeable membrane covers the culture groove and the flow grooves. Finally, the culture solution supplier continuously supplies culture solution.

Abstract: A method of detecting in a sample an analyte (A) having a molecularly recognizable portion thereon, which comprises: providing (B) a molecular bridging entity having thereon: (i) a portion capable of recognizing the molecularly recognizable portion on the analyte; and (ii) a portion comprising a polynucleotide sequence; and (C) a signalling entity having thereon: (i) a polynucleotide portion capable of annealing to the polynucleotide portion of the bridging entity, thereby to form a stable polynucleotide hybrid, and (ii) a signal generating portion; forming a complex comprising: (1) the analyte (A) complexed through its molecularly recognizable portion to (2) the recognizing portion of the entity (B); the entity (B) being complexed through the polynucleotide portion thereon to (3) the polynucleotide portion of the signalling entity; and detecting a signal by means of the signal generating portion present in the complex.

Abstract: Methods, computer readable storage media and systems which can be used for analyzing labeled biological samples, identifying chromosomal aberrations, identifying genetically abnormal cells and/or computationally scanning the samples using randomly or randomized scanning methods are provided. Specifically, the present invention can be used to analyze FISH-stained samples and automatically identify chromosomal aberrations associated with abnormal intensity ratio of stained occurrences in the sample.

Abstract: This disclosure describes novel probiotics, and also describes novel methods by which such probiotics can be obtained.

Abstract: This invention discloses an immunosuppressive cell-capturing material comprising a molded body that includes: a readily hydrolyzable condensation polymer having an amino group; a poorly hydrolyzable polymer coating the readily hydrolyzable condensation polymer; and a ligand-conjugated poorly hydrolyzable polymer coating the poorly hydrolyzable polymer, wherein the ligand is at least one selected from the group consisting of a NH2 group, a secondary amino group, a tertiary amino group, a polyamine residue, a basic cyclic polypeptide residue, an aminoglycosidic compound residue, chloroquine, primaquine, mefloquine, imiquimod, and nystatin, and wherein the content of the amino group in the molded body is 150 ?mol/g or less. The invention also discloses an immunosuppressive cell-capturing column filled with the capturing material.