Patents Examined by John S. Brusca
  • Independently removable nucleic acid sequencing system and method
    Patent number: 9121063
    Abstract: A system for sequencing nucleic acids, that includes (a) a table having an arrangement of sites, including a site for receiving a first substrate, and a site for receiving a second substrate, the substrates each having an array for providing sequencing data for a plurality of different nucleic acids in parallel; (b) a plurality of stations configured to carry out manipulations in a sequencing procedure; and (c) a system control interface configured to direct relative movement between the table and the plurality of stations, and to direct different steps of the sequencing procedure to occur at the sites for receiving the different substrates, wherein the first substrate can be removed from the system independently of the second substrate such that the second substrate can be processed to obtain sequencing data independently of the first substrate.
    Type: Grant
    Filed: October 17, 2012
    Date of Patent: September 1, 2015
    Assignee: Illumina, Inc.
    Inventors: Robert C. Kain, David L. Heiner, Chanfeng Zhao, Kevin Gunderson
  • Plant growth promoting rhizobacterium
    Patent number: 9101144
    Abstract: The present invention is directed to the Pseudomonas fluorescens strain GM30 deposited under ATCC Accession No. PTA-13340, compositions containing the GM30 strain, and methods of using the GM30 strain to enhance plant growth and/or enhance plant resistance to pathogens.
    Type: Grant
    Filed: January 23, 2013
    Date of Patent: August 11, 2015
    Assignee: UT-BATTELLE, LLC.
    Inventors: Mitchel John Doktycz, Dale A. Pelletier, Christopher Warren Schadt, Gerald A. Tuskan, David Weston
  • Composition for preventing inflammations
    Patent number: 9095604
    Abstract: The purpose of the present invention is to provide a probiotic(s) which can activate an aromatic hydrocarbon receptor (AhR) and can consequently prevent inflammatory damage in the digestive tract. The present invention relates to; a probiotic(s) capable of activating an AhR; an anti-inflammatory agent comprising the probiotic(s); an orally ingestible composition containing the anti-inflammatory agent; and a method for screening for the probiotic(s).
    Type: Grant
    Filed: September 8, 2011
    Date of Patent: August 4, 2015
    Assignee: Meiji Co, Ltd.
    Inventors: Shuji Ikegami, Seiya Makino, Takayuki Toshimitsu, Hiroyuki Itoh, Atsuhito Nakao
  • Cancer stem cell survivor lines
    Patent number: 9080154
    Abstract: A method of determining the relative effectiveness of potential chemotherapeutic agents designed to inhibit neoplasm, growth or metastasis is described. The chemotherapeutic agent may be curcumin. The invention also relates to kits designed to aid in determining the relative effectiveness of potential chemotherapeutic agents. The invention also relates to cancer stem cell survivor lines that can be included in the kits and used in the method.
    Type: Grant
    Filed: April 2, 2013
    Date of Patent: July 14, 2015
    Assignee: Bowling Green State University
    Inventors: Roudabeh J. Jamasbi, Taghreed N. Almanaa, Michael E. Geusz
  • Method of quality control testing a Factor XIII containing sample
    Patent number: 9080200
    Abstract: The invention relates to a method of quality control testing a Factor XIII (FXIII) containing sample which comprises the step of detecting the presence of and/or measuring the concentration of pre-activated FXIII (FXIIIao) in said sample and to a quality control kit for determining the quality of a Factor XIII (FXIII) containing sample. Preferably, an anion-exchange chromatographic column is used, as well as the fluorescent substrate Abz-NE (Cad-Dnp) EQVS PLTLLK-OH.
    Type: Grant
    Filed: October 23, 2009
    Date of Patent: July 14, 2015
    Assignee: Novo Nordisk Healthcare A/G
    Inventors: Mette Dahl Andersen, Gunhild K. Kristiansen, Pernille Charlotte Svane, Lene Hørlyck, Mette Schrøder
  • Sample analyzer, sample information processing apparatus, and sample analysis method
    Patent number: 9075043
    Abstract: A sample analyzer includes: a first measurement part which performs measurement on a sample for a first measurement item; a second measurement part which performs a measurement on the sample for a second measurement item; an output section; and a controller configured to control the output section to output, when a time difference between a measurement on a sample performed by the first measurement part and a measurement on the sample performed by the second measurement part exceeds a predetermined time period, information based on an excess of the time difference.
    Type: Grant
    Filed: September 24, 2013
    Date of Patent: July 7, 2015
    Assignee: SYSMEX CORPORATION
    Inventors: Toru Mizumoto, Fumio Inoue
  • Method for myceliating coffee
    Patent number: 9068171
    Abstract: A method of creating an extract of myceliated agricultural product for human consumption includes providing an agricultural substrate such as rice, where the agricultural substrate has been inoculated by liquid media comprising an aliquot of culture derived from liquid-state fermentation. The culture being selected from the group consisting of Basidiomycota and Ascomycota fungi. Next, the step of enabling mycelium growth on the substrate by controlling temperature, humidity and sterility of the environment. After mycelium growth on the substrate reaches a desired stage, then the step of boiling the substrate in water and separating the water-substrate mixture into aqueous component and non-aqueous components creates an extraction.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: June 30, 2015
    Assignee: Mycotechnology, Inc.
    Inventors: Brooks John Kelly, James Patrick Langan
  • Three dimensional lignocellulosic detection device
    Patent number: 9063128
    Abstract: A three dimensional lignocellulosic detection device includes a first lignocellulosic substrate and a second lignocellulosic substrate. When the first lignocellulosic substrate is in contact with a liquid specimen through capillary effect, the sample is absorbed into the second lignocellulosic substrate through the first lignocellulosic substrate, reacts with the detecting reagent on the second lignocellulosic substrate and makes a detection test. The three dimensional lignocellulosic detection device of the present invention has the inherent advantages of a lignocellulosic material such as natural material, low cost, easy manipulation and capillary effect and results in a good preventive diagnostic platform. Also, users may achieve preventive disease diagnostic without spending additional time and/or money.
    Type: Grant
    Filed: July 18, 2013
    Date of Patent: June 23, 2015
    Assignee: NATIONAL TSING HUA UNIVERSITY
    Inventors: Chen-Meng Kuan, Robert S. Langer, Chao-Min Cheng
  • Method and apparatus for treatment of biomass substrates
    Patent number: 9056893
    Abstract: A system and method for the treatment of biomass comprising mixing a biomass with an ionic liquid (IL) to swell the biomass and electromagnetic (EM) heating, preferably radiofrequency (RF) heating, said biomass. Additionally, a method of acidolysis of biomass comprising mixing biomass in an ionic liquid (IL) to swell the biomass; adding an acid, to lower the pH of the biomass below pH 7; applying radio frequency (RF) heating to the biomass to heat to a target temperature range; applying ultrasonic heating, electromagnetic (EM) heating, convective heating, conductive heating, or combinations thereof, to the biomass to maintain the biomass at a target temperature range; washing the treated biomass; and recovering sugars and released lignin.
    Type: Grant
    Filed: June 21, 2013
    Date of Patent: June 16, 2015
    Assignee: Suganit Systems, Inc.
    Inventors: Praveen Paripati, Anantharam Dadi
  • MRI-compatible bioreactors and methods of using
    Patent number: 9051541
    Abstract: This disclosure describes a MRI-compatible bioreactor that allows a biological sample to be imaged in culture without disrupting or compromising the culture.
    Type: Grant
    Filed: July 30, 2013
    Date of Patent: June 9, 2015
    Assignee: NUtech Ventures
    Inventors: Shadi Othman, Huihui Xu, Karin Wartella, Vahid Khalilzad-Sharghi, Ian Bargar
  • Eicosapentaenoic acid-producing microorganisms, fatty acid compositions, and methods of making and uses thereof
    Patent number: 9045785
    Abstract: The present invention is directed to isolated microorganisms as well as strains and mutants thereof, biomasses, microbial oils, compositions, and cultures; methods of producing the microbial oils, biomasses, and mutants; and methods of using the isolated microorganisms, biomasses, and microbial oils.
    Type: Grant
    Filed: July 20, 2012
    Date of Patent: June 2, 2015
    Assignee: DSM IP Assets B.V.
    Inventors: Joseph W. Pfeifer, III, Jon Milton Hansen, Jose R. Garcia, Xiao Daniel Dong, Paul Warren Behrens, Kirk E. Apt
  • Method to quantify and measure excess colipase in a pancreatin active pharmaceutical ingredient
    Patent number: 9046524
    Abstract: A method for determining the amount of colipase in a pancreatin active pharmaceutical ingredient sample is provided, the method being a titrimetric method with a constant pH and temperature.
    Type: Grant
    Filed: February 27, 2013
    Date of Patent: June 2, 2015
    Assignee: Scientific Protein Laboratories, LLC
    Inventors: Anisha Akula, Yan Wang
  • Three-dimensional, prevascularized, engineered tissue constructs, methods of making and methods of using the tissue constructs
    Patent number: 9034571
    Abstract: Three-dimensional (3D), prevascularized, engineered tissue constructs, 3D prevascularized engineered tissue models of cancer, and bioreactors and bioreactor arrays including the tissue constructs are disclosed. Methods of making the tissue constructs, methods of using the tissue constructs, methods of drug discovery using the tissue constructs and/or cancer models, and the like are also disclosed.
    Type: Grant
    Filed: March 6, 2013
    Date of Patent: May 19, 2015
    Assignees: THE UAB RESEARCH FOUNDATION, SOUTHERN RESEARCH INSTITUTE
    Inventors: Joel L. Berry, Timothy M. Wick, Joanne Murphy-Ullrich, Andrew D. Penman, Andrew W. Cain, Andra Rixse Frost
  • Microfluidic vortex-assisted electroporation system and method
    Patent number: 9029109
    Abstract: A system and method include delivering cells of interest to multiple traps via a channel connecting the traps, maintaining a vortex flow in the traps to trap the cells of interest in the traps, providing first molecules of interest to the traps, and providing an electric field across the traps to perform electroporation of the first molecules of interest into the cells of interest in the traps.
    Type: Grant
    Filed: August 7, 2013
    Date of Patent: May 12, 2015
    Assignee: President and Fellows of Harvard College
    Inventors: Soojung Claire Hur, Hoyoung Yun
  • Microplate reader with lid lifter for microplates
    Patent number: 9029101
    Abstract: Microplate reader with optical measuring/detection device has housing, a microplate support and a moving unit. The moving unit moves the microplate support out and into the housing and horizontally within the housing. The reader has an integrated lid holding apparatus within the housing for lifting and placing a microplate lid on the microplate. The lid holding apparatus moves the microplate lid and/or the microplate support for moving the microplate in one respective vertical direction. A method for optically measuring a microplate in such a microplate reader places a covered microplate on the microplate support, retracts it into the housing, lifts the lid from the microplate, measures the microplate with the lifted lid, replaces the lid, and extends the support and the covered microplate out of the housing.
    Type: Grant
    Filed: August 1, 2013
    Date of Patent: May 12, 2015
    Assignee: Tecan Trading AG
    Inventors: Friedrich Menges, Harald Gebetsroither, Gyoergy Wenczel
  • Broccoli based nutritional supplements
    Patent number: 9017666
    Abstract: A nutritional supplement is provided containing two broccoli based components that are combined and, when ingested, react in the intestines to provide sulforaphane. Processes for producing the broccoli components of the nutritional supplement are also provided. The broccoli components are treated separately using supercritical fluid extraction to remove oils. The temperature and pressure of the supercritical extraction processes are controlled to provide broccoli components having the desired properties for the nutritional supplement.
    Type: Grant
    Filed: June 5, 2013
    Date of Patent: April 28, 2015
    Assignee: Jarrow Formulas, Inc.
    Inventor: Kean Ashurst
  • Method and apparatus for providing data processing and control in medical communication system
    Patent number: 9008743
    Abstract: Methods and apparatus for providing data processing and control for use in a medical communication system are provided.
    Type: Grant
    Filed: April 14, 2008
    Date of Patent: April 14, 2015
    Assignee: Abbott Diabetes Care Inc.
    Inventors: Gary Hayter, Benjamin J. Feldman
  • Method for obtaining a lipid-containing composition from microbial biomass
    Patent number: 8999663
    Abstract: Methods are provided for pelletizing a microbial biomass, extracting a refined lipid composition from the pelletized biomass under supercritical conditions and distilling the refined lipid composition, at least once under short path distillation conditions, to obtain a lipid-containing fraction. Also disclosed are methods of making lipid-containing oil concentrates therefrom, by transesterifying and enriching the lipid-containing fraction.
    Type: Grant
    Filed: February 10, 2012
    Date of Patent: April 7, 2015
    Assignee: E l du Pont de Nemours and Company
    Inventors: Marios Avgousti, Timothy Allan Bell, Richard E. Bockrath, Oliver Walter Gutsche, Keith W. Hutchenson, Shu-Chien Liang, Robert D. Orlandi
  • Using oligonucleotide microarrays to analyze genomic differences for the prediction of heterosis
    Patent number: 8996318
    Abstract: A novel method for prediction of the degree of heterotic phenotypes in plants is disclosed. Structural variation analyzes of the genome are used to predict the degree of a heterotic phenotype in plants. In some examples, copy number variation is used to predict the degree of heterotic phenotype. In some methods copy number variation is detected using competitive genomic hybridization arrays. Further, methods for optimizing the arrays are disclosed, together with kits for producing such arrays, as well as hybrid plants selected for development based on the predicted results.
    Type: Grant
    Filed: December 29, 2008
    Date of Patent: March 31, 2015
    Assignees: Pioneer Hi-Bred International, Inc., E. I. du Pont de Nemours and Company
    Inventors: Mary Beatty, James A. Janni, Jonathan E. Lightner, J. Antoni Rafalski
  • Production of sulfur-free nanoparticles by yeast
    Patent number: 8986975
    Abstract: A method of producing sulfur-free nanoparticles involves growing yeast in a growth medium containing a source of an element in a bio-reducible oxidation state (e.g. Se(Vl), and, precipitating nanoparticles containing the element in a lower oxidation state (e.g. Se(O)) than the oxidation state of the element in the source. The method advantageously can provide substantially spherical nanoparticles at high production efficiencies.
    Type: Grant
    Filed: August 17, 2009
    Date of Patent: March 24, 2015
    Assignee: National Research Council of Canada
    Inventors: Zoltan Mester, Laurent Ouerdane