Abstract: A multiple degree of freedom sample stage or testing assembly including a multiple degree of freedom sample stage. The multiple degree of freedom sample stage includes a plurality of stages including linear, and one or more of rotation or tilt stages configured to position a sample in a plurality of orientations for access or observation by multiple instruments in a clustered volume that confines movement of the multiple degree of freedom sample stage. The multiple degree of freedom sample stage includes one or more clamping assemblies to statically hold the sample in place throughout observation and with the application of force to the sample, for instance by a mechanical testing instrument. Further, the multiple degree of freedom sample stage includes one or more cross roller bearing assemblies that substantially eliminate mechanical tolerance between elements of one or more stages in directions orthogonal to a moving axis of the respective stages.

Abstract: A mass spectrometer is provided that includes a precursor ion candidate selector, a product ion scan measurement condition setter, a product ion spectral data obtainer, a compound database file generator, and an MRM measurement condition candidate generator. The precursor ion candidate selector selects precursor ion candidates from mass spectrometric data. The product ion scan measurement condition setter combines the precursor ion candidates with a plurality of candidate values of cleavage energy to set a product ion scan measurement condition. The product ion spectral data obtainer carries out MS/MS measurement to obtain product ion spectral data. The compound database file generator generates a compound database file in which the product ion scan measurement condition and the product ion spectral data are associated with each other.

Abstract: Embodiments include identifying unusual activity in an IT system based on user configurable message anomaly scoring. Aspects include receiving a message stream for the IT system and dividing the message stream into a plurality of intervals, wherein each interval corresponds to a time period. Aspects also include identifying and removing one or more intervals from the plurality of intervals that include a startup or a shutdown of an element of the IT system, identifying and removing one or more intervals from the plurality of intervals that correspond to a standard level of command activity and an elevated level of user complaint activity, and identifying and removing one or more intervals from the plurality of intervals that correspond to an elevated level of command activity and an standard level of user complaint activity. Aspects further include creating a training set of intervals that consists of the remaining labelled intervals.

Abstract: To provide a lightweight and highly rigid stage device that can move in X and Y directions and a Z direction, and a charged particle beam device including the stage device. A stage device includes a chuck that is loaded with a sample, an XY stage that moves in X and Y directions, and a Z stage that moves in a Z direction. The Z stage includes: an inclined part that is fixed to the XY stage and includes an inclined surface inclined with respect to an XY plane; a movement part that moves on the inclined surface; and a table that is fixed to the movement part and is provided with the a plane parallel to the XY plane.

Abstract: A method for qualitative and quantitative multiplexing of drug analytes from dried blood samples includes the steps of mixing an Internal Standard solution with a first diluent in a vessel, adding the dried blood sample to the vessel, sonicating the vessel containing the Internal Standard solution, the first diluent and the dried blood sample, removing the dried blood sample from the vessel so that a final sample can be attained, and analyzing at least a portion of the final sample using one of LC-MS and LC-MS/MS to simultaneously determine the presence or absence of a plurality of different analytes in the dried blood sample. The Internal Standard solution can include at least 8, 15, 25 or 50 Internal Standards. The dried blood sample is generated using less than 50 ?L, 20 ?L or 10 ?L of blood. The step of analyzing includes simultaneously determining the presence or absence of at least 15, 60, 90 or 130 different analytes.