Patents Examined by Jonathan S Lau
  • Patent number: 12274707
    Abstract: The present disclosure is directed to methods of treating patients with chronic kidney disease (CKD), with and without Type 2 diabetes, with an SGLT2 inhibitor, such as dapagliflozin.
    Type: Grant
    Filed: April 1, 2021
    Date of Patent: April 15, 2025
    Assignee: AstraZeneca AB
    Inventor: Anna Maria Langkilde
  • Patent number: 12268706
    Abstract: The invention concerns a method for relieving idiopathic ocular pain by administering an effective amount of a fluid composition comprising hyaluronic acid, a hyaluronic acid analogue, or a combination thereof, to the eye of a human or non-human animal subject, wherein the fluid composition is administered after onset of the idiopathic ocular pain and in the absence of detectable signs known to cause ocular pain.
    Type: Grant
    Filed: January 31, 2020
    Date of Patent: April 8, 2025
    Assignee: I.COM MEDICAL GMBH
    Inventors: Wolfgang Georg Konrad Müller-Lierheim, Gysbert-Botho Van Setten
  • Patent number: 12269903
    Abstract: Provided herein are purified hemicellulose compositions, sweetener compositions including purified hemicellulose compositions, as well as methods for making the same. Also provided are uses of the compositions.
    Type: Grant
    Filed: November 11, 2022
    Date of Patent: April 8, 2025
    Assignee: Comet Biorefining Inc.
    Inventors: Andrew Richard, Dennis D'Agostino, Richard Lloyd Troyer, Jr.
  • Patent number: 12264174
    Abstract: The present invention relates to a process for preparing the telomerase inhibitor imetelstat using a 3 steps per cycle solid-phase support bound process comprising the steps of deprotection of the 3?-amino group of the support-bound oligonucleotide, coupling with a 5?-phosphoramidite, and sulfurization with an acyl disulfide, characterized by the absence of an additional capping step in each cycle that is used to prevent unreacted 3?-amino oligonucleotide groups from reacting during subsequent cycles. Imetelstat has formula below.
    Type: Grant
    Filed: February 7, 2024
    Date of Patent: April 1, 2025
    Assignee: Geron Corporation
    Inventors: Jale Muslehiddinoglu, Dinesh Gala, Jennifer Elizabeth Albaneze-Walker
  • Patent number: 12263186
    Abstract: This disclosure provides a method of administrating to a subject a two-portion solution system in a specific ingesting order to yield a water-insoluble cross-linked hydrogel mass in the stomach. The volume of the formed water-insoluble cross-linked hydrogel mass is at least 50% v/v of the total volume of the two-portion solution system. The method is useful for preventing and treating overweight and obesity.
    Type: Grant
    Filed: September 23, 2020
    Date of Patent: April 1, 2025
    Assignee: Brillian Pharma Inc.
    Inventors: Nuo Wang, Shaohui Lin, Xuening Hu
  • Patent number: 12257292
    Abstract: The present disclosure generally relates to methods and formulations for treating central nervous system (CNS) disorders. The present disclosure involves intranasal delivery of at least one antioxidant compound, allowing for effective treatment of a central nervous system disorder such as traumatic brain injury or stroke.
    Type: Grant
    Filed: December 15, 2022
    Date of Patent: March 25, 2025
    Assignee: BEYOND BARRIERS THERAPEUTICS, INC.
    Inventors: Ryan Kole, John Marshall, Meriel Owen
  • Patent number: 12257227
    Abstract: The use of a pharmaceutical composition in treating cancer in a subject comprising a therapeutically effective amount of a compound of formula (I), a therapeutically effective amount of paclitaxel and a low dose of gemcitabine, and a kit included above composition thereof.
    Type: Grant
    Filed: October 12, 2019
    Date of Patent: March 25, 2025
    Assignee: 1GLOBE BIOMEDICAL CO., LTD.
    Inventor: Chiang J. Li
  • Patent number: 12257231
    Abstract: A method and composition for treating viral infections using a combination of naturally occurring compounds is provided. The method includes administering to a patient at risk of or diagnosed with a viral infection a composition including therapeutically effective amounts of a myricetin and hesperitin to treat viral infections include coronavirus.
    Type: Grant
    Filed: June 14, 2021
    Date of Patent: March 25, 2025
    Assignee: Global BioLife Inc.
    Inventor: Daryl L. Thompson
  • Patent number: 12252505
    Abstract: Provided herein are methods and compositions for preventing or treating aging, or an aging-related disorder, a disorder associated with inflammation, or for modulating an immune response in a subject in need thereof. In some embodiments, the methods comprise administering to the subject an effective amount of a compound of Formulas I-XIII.
    Type: Grant
    Filed: October 16, 2019
    Date of Patent: March 18, 2025
    Assignee: President and Fellows of Harvard College
    Inventors: David A. Sinclair, Conrad Rinaldi
  • Patent number: 12251397
    Abstract: The invention provides a new method of synthesizing cross-linked hyaluronic acids, compositions thereof, tubes and syringes containing such compositions alone or in combination with PRP/BMC, new devices for PRP/BMC preparation, and uses thereof in cell culture, skincare and joint preservation. The invention provides a method for the production of a crosslinked gel (preferably of desired molecular weight and/or concentration) from at least one first polymer (preferably hyaluronic acid), comprising the steps of: homogenizing said first polymer, hydrating said first polymer in a basic solution, crosslinking said basic solution by adding at the least one crosslinking agent at a higher temperature than room temperature, neutralizing said basic solution in an acidic solution, homogenizing said solution, mixing said solution with a supplemental quantity of a second polymer (preferably a second polymer of substantially the same molecular weight and/or concentration as said first polymer), and purifying said solution.
    Type: Grant
    Filed: February 7, 2019
    Date of Patent: March 18, 2025
    Assignee: REGEN LAB SA
    Inventors: Antoine Turzi, Marta Mameli
  • Patent number: 12247047
    Abstract: This invention generally relates to the field of compounds and methods for enhanced cellular uptake. In particular, the invention relates to N-acetylgalactosamine compounds and their conjugates. Also provided are methods for the preparation of these molecules and possible uses thereof, in particular in medicine.
    Type: Grant
    Filed: August 1, 2024
    Date of Patent: March 11, 2025
    Assignee: ARNATAR THERAPEUTICS, INC
    Inventors: Derek Steiner, Xuehai Liang, Yangfeng Wang
  • Patent number: 12240922
    Abstract: The present disclosure relates to an improvement in the process of hydrolysis of cellulose to produce nanocellulose using imidazolium-based ionic liquids with short alkyl chains in the presence of transition metal complex and an oxidizing agent.
    Type: Grant
    Filed: May 23, 2024
    Date of Patent: March 4, 2025
    Assignee: UNITED ARAB EMIRATES UNIVERSITY
    Inventors: Mohsin Raza, Basim Abu-Jdayil
  • Patent number: 12233081
    Abstract: This invention provides, among other things, compounds useful for treating spirochete diseases such as Lyme disease, as well as pharmaceutical formulations and/or environmental baits containing such compounds.
    Type: Grant
    Filed: August 19, 2019
    Date of Patent: February 25, 2025
    Assignee: NORTHEASTERN UNIVERSITY
    Inventors: Kim Lewis, Yu Imai, Xiaoqian (Wendy) Wu, Anthony D'Onofrio, Nadja Leimer, Akira Iinishi
  • Patent number: 12202913
    Abstract: A preparation method of a Lentinula edodes polysaccharide rich in ?-glucan includes: (1) extracting the Lentinula edodes polysaccharide to obtain a filtrate; (2) concentrating the filtrate to obtain a supernatant; (3) precipitating a crude Lentinula edodes polysaccharide from the supernatant using anhydrous ethanol to obtain a first precipitate; and (4) purifying the first precipitate to obtain the Lentinula edodes polysaccharide. The Lentinula edodes polysaccharide rich in the ?-glucan has stable quality, and its yield, polysaccharide content and ?-glucan content are significantly improved compared with water extraction and alcohol precipitation methods in the related art. In vitro pharmacological experiments prove that the Lentinula edodes polysaccharide rich in the ?-glucan has good anti-inflammatory activity and can be applied to preparation of drugs or health foods.
    Type: Grant
    Filed: August 23, 2024
    Date of Patent: January 21, 2025
    Assignee: SHANGHAI ACADEMY OF AGRICULTURAL SCIENCES
    Inventors: Yanfang Liu, Jia Luo, Liping Liu, Jie Feng, Jingsong Zhang, Shuai Zhou
  • Patent number: 12187762
    Abstract: There are provided, inter alia, methods for decreasing mucus elasticity or decreasing mucus viscosity in a subject in need thereof, the methods including administering to the subject an effective amount of a dithiolsaccharide mucolytic agent, and compounds and pharmaceutical compositions useful for the methods.
    Type: Grant
    Filed: September 10, 2019
    Date of Patent: January 7, 2025
    Assignees: The Regents of the University of California, University College Dublin
    Inventors: Stefan Oscarson, John Vincent Fahy, Irina Gitlin, Wilfred Raymond
  • Patent number: 12185721
    Abstract: A glycoside compound of fatty acids that includes the general formula: GalNAc-GalNAc-Glc-O—R, where GalNAc is ?- or ?-D-N-acetylgalactosamine, Glc-O—R is a molecule of ?- or ?-D-glucose esterified to a monounsaturated fatty acid (R), where R is selected from 12:1(n) and where n is an integer between 2 and 11; 11:1(n) and where n is an integer between 2 and 10; 10:1(n), and where n is an integer between 2 and 9; 9:1(n), and where n is an integer between 2 and 8; 8:1(n), and where n is an integer between 2 and 8; 7:1(n) and where n is an integer between 2 and 7; and 6:1(n), and where n is an integer between 2 and 6. The compound has activity against plant pathogens, and induces the defense, and promotes the growth, of plants.
    Type: Grant
    Filed: February 27, 2023
    Date of Patent: January 7, 2025
    Assignees: Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), ESTACION, EXPERIMENTAL AGROINDUSTRIAL OBISPO COLOMBRES
    Inventors: Atilio Pedro Castagnaro, Maria Paula Filippone, Bjorn Gunnar Viking Welin, Carlos Froilan Grellet Bournonville, Alicia Ines de Fatima Mamaní, Pía de los Angeles Di Peto
  • Patent number: 12173026
    Abstract: The present invention provides a compound of Formula (I) and the pharmaceutically acceptable salts, esters, and prodrugs thereof, which are PRMT5 inhibitors. Also provided are methods of making compounds of Formula I, pharmaceutical compositions comprising compounds of Formula I, and methods of using these compounds to treat cancer, sickle cell, and hereditary persistence of foetal hemoglobin (HPFH) mutations.
    Type: Grant
    Filed: August 5, 2019
    Date of Patent: December 24, 2024
    Assignees: Merck Sharp & Dohme LLC, MSD International GmbH
    Inventors: Michelle Machacek, David Witter, Craig Gibeau, Chunhui Huang, Shuhei Kawamura, David L. Sloman, Phieng Siliphaivanh, Ryan Quiroz, Murray Wan, Sebastian Schneider, Charles S. Yeung, Michael H. Reutershan, Timothy J. Henderson, Jean-Laurent Paparin, Houcine Rahali, Jonathan M. E. Hughes, Sulagna Sanyal, Yingchun Ye, David A. Candito, Patrick S. Fier, Steven M. Silverman
  • Patent number: 12168674
    Abstract: The present disclosure provides reagent compounds, reactive biopolymeric compounds, and methods of making and using these materials for the rapid and efficient synthesis and purification of biopolymeric compounds at low cost. The materials and methods yield highly pure synthetic biopolymeric compounds, including synthetic oligonucleotides and polypeptides, and reduce or eliminate the need for toxic solvents in the synthetic process.
    Type: Grant
    Filed: December 8, 2023
    Date of Patent: December 17, 2024
    Assignee: Oligo Foundry, Inc.
    Inventors: David A. Schwartz, Jimmy H. Williams
  • Patent number: 12168024
    Abstract: The invention discloses a functionalised chitosan, or a salt thereof, used in the treatment of pathologies of the respiratory tract or hepatic pathologies, preferably caused by viral infections. It was indeed observed that said functionalised chitosan or salt thereof was able to act as galectin-modulator, modulating in particular galectin-3, and therefore determining a marked reduction in the inflammatory and fibrotic cascade generated by these viral infections. The invention moreover discloses a pharmaceutical composition, as well as a biomaterial, comprising this functionalised chitosan, or a salt thereof.
    Type: Grant
    Filed: April 19, 2022
    Date of Patent: December 17, 2024
    Assignee: GLYCOCORE PHARMA
    Inventors: Lanfranco Callegaro, Giulio Bianchini
  • Patent number: 12162963
    Abstract: Disclosed are compounds, in particular based on polysaccharides, that are adsorbed on a cellulosic material, and relates in particular to the application of such compounds as reinforcing agent for cellulosic materials, in the wet and/or dry state. The compounds include a combination of at least one polysaccharide adsorbed on a cellulosic material, the polysaccharide including at least two different monosaccharide units, forming first and second monosaccharide units, the second monosaccharide units being branched on a chain including at least the first monosaccharide units, at least some of the second monosaccharide units being non-cyclic and bearing aldehyde functions, the aldehyde functions possibly forming hemiacetal functions with hydroxy functions of the cellulosic material.
    Type: Grant
    Filed: September 5, 2019
    Date of Patent: December 10, 2024
    Assignee: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Lauric Gaffiot, Laurent Heux