Abstract: The invention provides for exposing an extraocular (i.e., non-ocular) region of a human to light during sleep which enhances REM sleep. Also provided are devices to carry out the methods. Key timing parameters ensure effective REM enhancement without adversely impacting a subject's circadian clock. The invention provides for improving cognitive function and performance in healthy individuals, and in individuals suffering from a disease or disorder in which mental status is compromised. One embodiment of the invention (100) includes a fiber optics pad (160) attached to a power source, and lamp housing (120) by a fiber optics cable (140).

Abstract: The invention relates to a method and device for treating urinary incontinence in women.

Abstract: A stepped centering catheter for delivery of intravascular radiation therapy including a central segment of a first effective diameter and smaller, offset segments of second effective diameters to each side of the central segment. The first effective diameter of the central segment substantially centers a portion of a radiation source within the lumen of a vessel along a therapeutic treatment length. The second effective diameters of the offset segments constrain portions of the radioactive source that extend beyond the therapeutic treatment length within a region having a minimum offset distance from the vessel wall. The first effective diameter of the central segment is gradually tapered to the second effective diameter of the offset segments across first steps. The second effective diameters of the offset segments are gradually tapered to the diameter of the catheter shaft across second steps.

Abstract: A loading clip for low dose radioisotope seeds has a body having a channel defined therein. The channel has a cavity adapted for receiving a radioisotope seed at a distal end. A slider member slidably positionable within the channel has a spring biased tooth at a distal end. A constant force spring member is slidably positioned within the channel between the slider member and the body. Radioisotope seeds are magazined into the loading clip biased against the constant force spring member by operation of the slider member extending the tooth over the cavity and retracting a radioisotope seed in the cavity into the channel. In one embodiment, radioisotope seeds are magazined into the loading clip that is then used to load an automated seed cartridge. In this embodiment, the loading clip has structure for mating with an aperture in the automated seed cartridge so as to introduce radioisotope seeds into the seed cartridge one at a time.

Abstract: A method and apparatus for improving hearing by preventing acoustic feedback from the ossicular chain into a middle ear-implanted microphone of an implantable hearing assistance system. Mechanical sound vibrations are received with an acoustic microphone implanted in the middle ear. The mechanical sound vibrations are converted to an amplified electrical signal and the amplified electrical signal is delivered to the inner ear with a transducer operatively coupled between the microphone and the inner ear. A mechanical feedback barrier is established by removing or separating a portion of the hearing-impaired person's ossicular chain (e.g., malleus or incus) to prevent transmission of sound feedback into the microphone from the tympanic membrane via the ossicular chain. Implanting an acoustic microphone permits alternative implantation methods other than a mastoidectomy.

Abstract: A process and apparatus for selecting or designing a product, such as a muffler, having a sound output which is less stressful or more pleasing. The process includes the steps of sensing at least one physiological response of a subject (21) while the subject listens to an initial sound output, repeating the sensing step for the new sound output, comparing the physiological responses, and selecting the sound output for use in selecting or designing the product which output produces the physiological response that is the least stressful or most pleasing to the subject. The apparatus includes an audio playback device (15), a sound recording (16) of the initial sound, a sound recording (16) of the new sound, and physiological monitoring apparatus (17) suitable for attachment to and monitoring of the physiological responses of the test subject (21) to the playback of the sound recordings.

Abstract: A system and method for implanting a wrap on a patient's heart or other organ provides a wrap having finger-engagement members typically defining loops that encompass all or a substantial portion of the fingers of a surgeon's treatment hand. The loops retain the fingers to the wrap during implant, and enable the fingers to be detached after the procedure is complete. The loops can be detachable from the wrap after the procedure is completed or can be formed to remain with the wrap.

Abstract: A treating element source train that comprises a plurality of treating elements, with each treating element comprising a hollow outer housing closed on each end and a radiation emitting substance encapsulated therein. The treating elements are aligned end-to-end, and a wire is wound around the exterior of the treating elements to maintain the treating elements in their end-to-end relationship. The wire may be helically coiled about the treating elements, or braided around them. Also, the wire may be secured to the proximal and distal treating elements, or to each individual treating element. Preferably, the wire is made of a radiopaque material such as gold, platinum, platinum iridium, tungsten and tantalum. In an alternate embodiment, the source train may be provided with an end cap at either end, with the wire jacket being secured to each endcap.

Abstract: An interstitial brachytherapy device includes an applicator having an elongate barrel and a plurality of radioactive seed-containing cartridges releasably connected to the elongate barrel along its longitudinal extent. Each cartridge includes a handle, a hollow housing within which is stacked the seeds, and a neck formed integrally with the handle. The neck is slideably received within the hollow housing and its free end abuts the top of the stack of seeds. A plurality of seed-discharging chambers is formed in the elongate barrel at longitudinally spaced intervals along the extent of the elongate barrel and each chamber is in alignment with each cartridge. The seeds in each hollow housing are urged toward their associated seed-discharging chamber by a bias member having a leading end connected to the hollow housing and a trailing end connected to the handle.

Abstract: A method for stimulating growth in biological tissue or sprouts, an apparatus and a use thereof employs fluctuating magnetic fields. The apparatus includes a pulse generator and a plurality of coils in which pulsed currents will cause fluctuating magnetic fields in a predetermined region holding the material to be stimulated. The fluctuating magnetic fields will induce an electric field in the material. An enhanced effect has been detected in the regions where the electric fields are largest. The coils include a number of pairs of coils having, during a given pulse, magnetic fields in opposite directions in order to provide field gradients in the cells, micro organisms or tissue. Selecting a suitable number, size and positioning of coils will provide a homogeneous electric field in the predetermined region, which does not have any undesirable peaked maxima.

Abstract: This relates to flextensional microphones which are made up of a piezoelectric substrate having opposing surfaces, typically parallel surfaces when the substrate is crystalline or ceramic, and at least one sound receiving surface physically tied to the piezoelectric substrate. The microphones are at least partially isolated via a biocompatible material, e.g., by a covering or a coating. The inventive microphones may be subcutaneously implanted. The microphones may be used as components of surgically implanted hearing aid systems or as components of hearing devices known as cochlear implants. Preferably the microphones are used in arrays and when used as a component of a hearing assistance or replacement device, are used in conjunction with a source of feedback information, usually another microphone. The feedback information usually relates to sound re-emitted from physical portions of the ear, e.g.

Abstract: A graft vessel preparation device and a method for using the graft vessel preparation device is provided. The graft vessel preparation device establishes and maintains a critical dimension on a graft vessel which corresponds to a dimension of an anastomosis site on a target vessel. One example of a graft vessel preparation device which prepares a graft vessel for a vascular anastomosis procedure includes a parallelogram linkage, a first spreader arm and a second spreader arm. The first spreader arm and the second spreader arm mount on opposing members of the parallelogram linkage in a parallel configuration. The spreader arms are configured in order to allow the placement of an end of a graft vessel over the spreader arms. The spreader arms are also configured to separate within an interior of the graft vessel once the graft vessel is placed over the spreader arms in order to establish a critical dimension. The critical dimension is established using a critical dimension locator.

Abstract: An artificial insemination device for breeding animals, such as sows, including a catheter suitable for being introduced into the genital system so as to enable sperm to be discharged therefrom and a reservoir of sperm connected to the catheter. The catheter has a conduit with an end piece at a distal end thereof. The conduit is suitable for lodging in the neck of the animal's uterus. A ring is provided so as to form a tight seal between the reservoir and the catheter.

Abstract: The present invention discloses a methodology for the characterization and determination of mixed-field dosimetry for 252Cf Applicator Tube (AT)-type medical sources, utilizing ionization chambers, GM counters, and Monte Carlo methods. Unlike the previous methodologies, the present invention discloses a specification of dose to muscle, rather than dose to water, for clinical dosimetry of 252Cf medical sources. A dosimetry protocol, similar to that utilized for ICRU-45, with parameters determined specifically for 252Cf brachytherapy is disclosed. Neutron isodose distributions and data necessary for clinical implementation of 252Cf AT sources are also disclosed herein. Additionally, novel methods for the encapsulation, storage, and delivery/implantation of 252Cf radionuclide sources are disclosed.

Abstract: Implantable arrangement for mechanical coupling of an output-side driver part of an active or passive hearing system, the driver part having a capacity to be excited to mechanical vibrations, to a preselected coupling site on the ossicular chain, the footplate of the stapes or a membrane which closes the round window or an artificial window in the cochlea, in the vestibulum or in the labyrinth (equilibrium organ), via a coupling arrangement which has a coupling element adapted to be connected to a preselected coupling site. The coupling element is provided with a positioning device for selective movement of the coupling element between an open position in which the coupling element is adapted to be engaged with and disengaged from the coupling site, and a closed position in which the coupling element in the implanted state is joined by force fit and/or form fit to the coupling site.

Abstract: Human infertility can be treated by in vitro methods that actively arrest the human oocyte in prophase of first meiotic division and subsequently actively reverse this meiotic blockage by either adding at least one meiosis-stimulating compound or by culture conditions leading to endogenous formation of meiotic stimulating molecules in the oocyte-cumulus complex.

Abstract: A miniaturized x-ray apparatus for delivering x-rays to a selected site within a body cavity includes a catheter having at least one lumen and an x-ray transparent window at a distal end thereof; an x-ray source in the lumen adjacent said x-ray transparent window; a movable x-ray shield positioned to direct x-rays from the source through the x-ray transparent window to the selected site.

Abstract: A sexual assistance device and methods which may be used as a marital aid are disclosed which include two elongate members secured by a pivotal connection. A biasing element, such as a spring coil, is disposed at or adjacent the pivotal connection for biasing the opposite ends of the two elongate members away from each other. Respective supports are provided at the two opposite ends of the two elongate members which are engageable with the operator's legs. A sexually stimulating element, such as a vibrator or the like, is preferably removably attached to the pivotal connection. Thus, the operator may produce reciprocal longitudinal movement inwardly and outwardly, relative to the operator's body, by compressing and uncompressing the two elongate members with the legs of the operator thereby fully controlling movement of the sexually stimulating element by the legs of the operator.

Abstract: The invention relates to methods of improving the bodily appearance in the case of cellulite. In order to achieve an effective improvement without the direct contact of sound heads, electrodes or winding foils on the skin the invention suggests that the body or a part of the body of a person is received by a known chamber provided with at least one pump which chamber is subsequently sealed in a gas-tight manner and exposed to the action of an alternating pressure. If the pressure in the chamber is lowered (negative pressure) relative to the atmospheric ambient pressure the lymph vessels widen and receive tissue fluid and residual metabolic products associated with the lymph. The subsequent raising of the pressure in the chamber either to the atmospheric ambient pressure or an excess pressure [superpressure] in the range of a maximum of 20-60 mbar produces a directed flow of lymph and a removal of the residual metabolic products to the filtering organs.

Abstract: An automated system for loading low dose radioisotope seeds into a plurality of implant needles includes a loading station into which a replaceable cartridge may be positioned. The cartridge is preloaded with a plurality of radioisotope seeds and a plurality of spacers. The cartridge has at least one aperture and preferably the radioisotope seeds and spacers are loaded around the periphery of a rotatable drum within the cartridge. The loading station has a cartridge receiving structure and an automated motion control system. When the cartridge is positioned in the cartridge receiving structure, the automated motion control system preferably drives a pair of stepper motors within the cartridge, one for rotating the rotatable drum and one for sliding a pushrod to selectively eject radioisotope seeds and spacers from the cartridge into each of a plurality of implant needles positioned so as to receive the radioisotopes seeds and spacers within the implant needle.