Abstract: A process is described for the preparation of a functionalized hybrid solid with an organic-inorganic matrix, crystallized, bearing at least one reactive group based on a triazole ring, from a hybrid solid with an organic-inorganic matrix, MOF—NH2, comprising: i/ introduction, in a polar solvent S1, of said crystallized hybrid solid MOF—NH2, of at least one organic compound Q containing a nitride function N3 and at least one intermediate reagent R containing a nitrite function NO2, ii/ reaction of said reaction mixture, iii/ introduction in the reaction mixture of at least one reagent A bearing an alkyne function or an activated cyanide function, at least one Cu-based catalyst C and at least one polar solvent S2, iv/ reaction of said reaction mixture, v/ filtration and then washing and vi/ drying of said crystallized functionalized hybrid solid.
Type:
Grant
Filed:
October 6, 2010
Date of Patent:
January 27, 2015
Assignees:
CNRS, IFP Energies Nouvelles
Inventors:
Marie Savonnet, David Farrusseng, Catherine Pinel, Delphine Bazer-Bachi, Nicolas Bats, Vincent Lecocq
Abstract: Methods and systems are provided for converting methane in a feed stream to acetylene. The method includes removing at least a portion of acids from a hydrocarbon stream. The hydrocarbon stream is introduced into a supersonic reactor and pyrolyzed to convert at least a portion of the methane to acetylene. The reactor effluent stream may be treated to convert acetylene to another hydrocarbon process. The method according to certain aspects includes controlling the level of acids in the hydrocarbon stream by use of adsorbents or basic solutions.
Abstract: Compositions comprising ergothioneine and a trimethylamine absorber are provided. Also provided are methods for preventing, reducing or minimizing the fishy, amine odor, due to trimethylamine, that is associated with the processing and/or storage of a preparation containing ergothioneine, by combining with the ergothioneine, during processing or prior to storage, a trimethylamine absorber in an amount sufficient to prevent the detection of any trimethylamine odor by the human nose. A method is further provided for ameliorating the methylamine odor associated with an aqueous ergothioneine-containing preparation after it has developed a fishy trimethylamine odor.
Abstract: The present invention relates to aryloxy substituted phenylamidine derivatives of formula (I) wherein the substituents are as in the description, their process of preparation, their use as fungicide or insecticide active agents, particularly in the form of fungicide or insecticide compositions, and methods for the control of phytopathogenic fungi or damaging insects, notably of plants, using these compounds or compositions (I).
Type:
Grant
Filed:
September 12, 2006
Date of Patent:
January 13, 2015
Assignee:
Bayer Cropscience AG
Inventors:
Klaus Kunz, Jörg Greul, Oliver Guth, Benoît Hartmann, Kerstin Ilg, Wahed Ahmed Moradi, Thomas Seitz, Peter Dahmen, Arnd Voerste, Ulrike Wachendorff-Neumann, Ralf Dunkel, Ronald Ebbert, Eva-Maria Franken, Olga Malsam
Abstract: A method for producing high-purity olmesartan medoxomil is provided in which a solvent containing water is used in steps of tritylation and DMDO esterification of olmesartan.
Abstract: The invention provides compounds and methods for inhibiting proteases. One aspect of the invention features pro-soft inhibitors which react with an activating protease to release an active inhibitor moiety in proximity to a target protease. In certain instances, compounds inhibit proteasomes and/or post-proline cleaving enzymes (PPCE), such as dipeptidyl peptidase IV. The compounds of the invention provide a better therapeutic index, owing in part to reduced toxicity and/or improved specificity for the targeted protease.
Type:
Grant
Filed:
September 30, 2013
Date of Patent:
January 13, 2015
Assignee:
Trustees of Tufts College
Inventors:
William W. Bachovchin, Hung-sen Lai, Wengen Wu
Abstract: The present invention relates to a process for producing 2-cyanoacetic acid anhydride, comprising the steps of a) preparing a reaction mixture, containing as reactants 2-cyanoacetic acid, and at least one C4-20 carboxylic acid anhydride in at least one organic solvent, wherein the molar ratio of 2-cyanoacetic acid to C4-20 carboxylic acid anhydride in said reaction mixture is greater than 1.5:1, and b) subjecting the reaction mixture to a temperature of 0° C. to 100° C. to form 2-cyanoacetic acid anhydride. The present invention also relates to process for producing 2-cyanoacetic acid esters, 2-cyanoacetic acid amides and/or 2-cyanoacetic acid thioesters from 2-cyanoacetic acid anhydride.
Abstract: The invention relates to a process for the preparation of salts having perfluoroalkyltricyano- or perfluoroalkylcyanofluoroborate anions, ((per)fluoro)phenyltricyano- or ((per)fluoro)phenylcyanofluoroborate anions, phenyltricyanoborate anions which are mono- or disubstituted by perfluoroalkyl groups having 1 to 4C atoms or phenylcyanofluoroborate anions which are mono- or disubstituted by perfluoroalkyl groups having 1 to 4C atoms, by reaction of alkali metal trifluoroperfluoroalkylborate with trialkylsilyl cyanide and a subsequent salt-exchange reaction or by direct reaction of an organic trifluoroperfluoroalkyl borate with trialkylsilyl cyanide.
Type:
Grant
Filed:
January 12, 2011
Date of Patent:
January 6, 2015
Assignee:
Merck Patent GmbH
Inventors:
Nikolai (Mykola) Ignatyev, Michael Schulte, Jan Sprenger, Maik Finze, Walter Frank
Abstract: The present teachings provide methods that enable the preparation and purification of radioiodinated vectors without the need for HPLC purification, as well as novel precursors which include biotin-like substituents useful in such methods.
Type:
Grant
Filed:
March 30, 2012
Date of Patent:
January 6, 2015
Assignee:
General Electric Company
Inventors:
Randall Lee Carter, Bruce Fletcher Johnson, Anup Sood, Michael James Rishel, John Fitzmaurice Valliant, Karin Ann Stephenson, Tao Wu, Yang Yang
Abstract: Phosphonium-based room temperature ionic liquids (“RTILs”) were prepared. They were used as matrices for Matrix-Assisted Laser Desorption Ionization (MALDI) mass spectrometry and also for preparing samples of dyes for analysis.
Type:
Grant
Filed:
December 2, 2010
Date of Patent:
December 30, 2014
Assignee:
Los Alamos National Security, LLC
Inventors:
Rico E. Del Sesto, Andrew T. Koppisch, Katherine S. Lovejoy, Geraldine M. Purdy
Abstract: A process for the epoxidation of an olefin comprising contacting a reactor feed comprising an olefin, oxygen, and carbon dioxide, with a catalyst comprising a carrier and, deposited on the carrier, silver, a rhenium promoter, and a potassium promoter; wherein the carbon dioxide is present in the reactor feed in a quantity of at most 3 mole percent based on the total epoxidation reactor feed; the potassium promoter is deposited on the carrier in a quantity of at least 0.5 mmole/kg, relative to the weight of the catalyst; and the carrier contains water leachable potassium in a quantity of less than 55 parts per million by weight, relative to the weight of the carrier; a process for preparing a 1,2-diol, a 1,2-diol ether, a 1,2-carbonate, or an alkanolamine.
Abstract: The present invention relates to electrolyte formulations comprising at least one imidazolium fluorotricyanoborate or pyrrolidinium fluorotricyanoborate and their use in an electrochemical and/or optoelectronic device such as a photovoltaic cell, a light emitting device, an electrochromic or photo-electrochromic device, an electrochemical sensor and/or biosensor, preferably their use in a dye or quantum dot sensitized solar cell.
Type:
Grant
Filed:
September 1, 2011
Date of Patent:
December 30, 2014
Assignee:
Merck Patent GmbH
Inventors:
Kentaro Kawata, Nikolai Mykola Ignatyev, Michael Schulte, Hiroki Yoshizaki
Abstract: The present invention relates to compounds of the formula in which the variables G, W, Q, X, Y, B1, B2, Z1, Z2, and R1-R7 are as defined herein, methods for the preparation of the derivatives and intermediates thereof.
Type:
Grant
Filed:
August 14, 2013
Date of Patent:
December 30, 2014
Assignee:
Bristol-Myers Squibb Company
Inventors:
Soong-Hoon Kim, Robert M. Borzilleri, Gregory D. Vite, James A. Johnson
Abstract: The present invention provides compositions and methods for cytoprotection. In particular, it provides zinc chelate compositions comprising at least one zinc ion and at least one aminothiol ligand.
Type:
Grant
Filed:
February 6, 2014
Date of Patent:
December 23, 2014
Assignee:
The Board of Trustees of the University of Arkansas
Inventors:
Alexei G. Basnakian, Richard B. Walker, John R. J. Sorenson
Abstract: An improved and efficient process for the preparation of 2-[3-cyano-4-(2-methylpropoxy)phenyl]-4-methylthiazole-5-carboxylic acid (febuxostat) that is substantially free from amide by-product is provided.
Abstract: This invention provides new compounds having NPY Y5 antagonistic activity. The present inventors found that a compound of the formula (I): wherein R1 is substituted or unsubstituted alkyl or the like; p, q and r are each independently 0 or 1; ring A is oxadiazole; and R2 is substituted or unsubstituted alkyl or the like, has NPY Y5 antagonistic activity.
Abstract: Use of transition metal complexes of the formula (I) in organic light-emitting diodes where: M1 is a metal atom; carbene is a carbene ligand; L is a monoanionic or dianionic ligand; K is an uncharged monodentate or bidentate ligand selected from the group consisting of phosphines; CO; pyridines; nitriles and conjugated dienes which form a ? complex with M1; n is the number of carbene ligands and is at least 1; m is the number of ligands L, where m can be 0 or ?1; o is the number of ligands K, where o can be 0 or ?1; where the sum n+m+o is dependent on the oxidation state and coordination number of the metal atom and on the denticity of the ligands carbene, L and K and also on the charge on the ligands carbene and L, with the proviso that n is at least 1, and also an OLED comprising these transition metal complexes, a light-emitting layer comprising these transition metal complexes, OLEDs comprising this light-emitting layer, devices comprising an OLED according to the present invention, and specific tr
Type:
Grant
Filed:
October 15, 2010
Date of Patent:
December 23, 2014
Assignee:
BASF SE
Inventors:
Markus Bold, Christian Lennartz, Martina Prinz, Hans-Werner Schmidt, Mukundan Thelakkat, Markus Baete, Christian Neuber, Wolfgang Kowalsky, Christian Schildknecht, Hans-Hermann Johannes
Abstract: The present invention relates to a process for the preparation of compounds with (perfluoroalkyl)fluorohydrogenphosphate anion, and to compounds containing (perfluoroalkyl)fluorohydrogenphosphate anion and to the use thereof.
Type:
Grant
Filed:
December 6, 2010
Date of Patent:
December 23, 2014
Assignee:
Merck Patent GmbH
Inventors:
Nikolai (Mykola) Ignatyev, Michael Schulte, Anne Julia Bader, Berthhold Theo Hoge
Abstract: Disclosed in the present invention is a method for preparing a (?)-clausenamide compound of formula (I), comprising: firstly, catalyzing the asymmetrical epoxidation of trans-cinnamate using a chiral ketone derived from fructose or a hydrate thereof as a catalyst, and then subjecting the product to amidation, oxidation, cyclization and reduction successively to finally obtain the optically pure (?)-clausenamide compound of formula (I).
Type:
Grant
Filed:
November 4, 2011
Date of Patent:
December 16, 2014
Assignee:
Institute of Chemistry Chinese Academy of Sciences