Abstract: A compound of formula (I) is described in which each A, which may be the same or different, is a halide selected from fluoride, chloride, bromide and iodide, or is O—Y, wherein Y is a substituted or unsubstituted, saturated or unsaturated, straight or branched chain alkyl moiety. R1, R2, R3, R6, R7, and R8 are each independently H, OH, NO2 or O-L-X, wherein L is a spacer group, and X is a conjugation group or a water-solubilizing group. At least one of R1, R2, R3 is OH or O-L-X and at least one of R6, R7, and R8 is OH or O-L-X. R4 and R5, which may be the same or different, are each independently H; or are a substituted or unsubstituted, saturated or unsaturated, cyclic moiety; a substituted or unsubstituted, saturated or unsaturated heterocyclic moiety; or a substituted or unsubstituted, saturated or unsaturated, straight or branched chain alkyl moiety. Also described are dye conjugates comprising a compound of the invention.
Abstract: The present invention relates to compounds containing perfluoroalkyl-cyano-alkoxy-borate anions or perfluoroalkyl-cyano-alkoxy-fluoro-borate anions, ((per)fluoro)phenyl-cyano-alkoxy-borate anions or ((per)fluoro)phenyl-cyano-alkoxy-fluoro-borate anions or phenyl-cyano-alkoxy-borate anions which are monosubstituted or disubstituted with perfluoroalkyl groups having 1 to 4 C atoms or phenyl-cyano-alkoxy-fluoro-borate anions which are monosubstituted or disubstituted with perfluoroalkyl groups having 1 to 4 C atoms, the preparation thereof and the use thereof, in particular as part of electrolyte formulations for dye sensitized solar cells.
Type:
Grant
Filed:
January 12, 2011
Date of Patent:
December 2, 2014
Assignee:
Merck Patent GmbH
Inventors:
Hiromi Shinohara, Kentaro Kawata, Hiroki Yoshizaki, Peer Kirsch, Nikolai (Mykola) Ignatyev, William Robert Pitner, Michael Schulte, Jan Sprener, Maik Finze, Walter Frank
Abstract: The present invention relates to a process for preparing heterocyclic fluoroalkenyl sulfones and fluoroalkenyl sulfoxides by allowing the corresponding fluoroalkenyl thioethers to react with a salt of peroxomonosulfuric acid (H2SO5), optionally in the presence of a reaction assistant and optionally in the presence of a diluent.
Abstract: The invention is directed to methods of making organic compounds by metathesis and hydrocyanation. The method of the invention may be used, for example, to make industrial important organic compounds such as diacids, diesters, acid-amines, acid-alcohols, acid-nitriles, ester-amines, ester-alcohols, and ester-nitriles.
Type:
Grant
Filed:
April 10, 2009
Date of Patent:
November 25, 2014
Assignee:
Elevance Renewable Sciences, Inc.
Inventors:
Timothy W. Abraham, Hiroki Kaido, Choon Woo Lee, Richard L. Pederson, Yann Schrodi, Michael John Tupy, Alexandre A. Pletnev
Abstract: The present invention provides a compound represented by the formula which is useful as an agent for the prophylaxis or treatment of diseases related to the action of melatonin, or a salt thereof and the like.
Abstract: The present invention is directed to a fluorescence compound represented by structural Formula (I), with specificity to neural stem cells: I or a pharmaceutically acceptable salt thereof. The variables for structural Formula (I) are defined herein. Also described are methods for detection of neural stem cells, comprising using a compound of structural Formula (I) or pharmaceutically acceptable salts thereof. Compounds of structural Formula (I) can detect and separate neural stem cells without immunostaining, providing a much shorter and more convenient method for detection of neural stem cells.
Type:
Grant
Filed:
November 22, 2011
Date of Patent:
November 18, 2014
Assignees:
National University of Singapore, Agency for Science, Technology and Research
Abstract: A photoacid generator represented by the following formula (1), a method for producing the photoacid generator, and a resist composition containing the photoacid generator are provided. wherein in the formula (1), Y, X, R1, R2, n1, n2 and A+ have the same meanings as defined in the detailed description of the invention. The photoacid generator can maintain an appropriate contact angle at the time of ArF liquid immersion lithography, can reduce defects occurring during liquid immersion lithography, and has excellent solubility in resist solvents and excellent compatibility with resins. Furthermore, the photoacid generator can be produced by an efficient and simple method using an epoxy compound that is industrially easily available.
Abstract: The invention relates to substituted benzothiazoles, benzoxazoles—and their counterparts having pyridine and pyrimidine rings replacing the benzene ring—that are PDE4 inhibitors useful for treating stroke, myocardial infarct, and cardiovascular inflammatory conditions, to pharmaceutical compositions comprising these compounds, and to methods for the treatment of stroke, myocardial infarct, and cardiovascular inflammatory conditions in a mammal. The compounds have general formula I: in which A and B are carbocycles or heterocycles.
Type:
Grant
Filed:
November 20, 2008
Date of Patent:
November 11, 2014
Assignee:
Decode Genetics EHF
Inventors:
Jasbir Singh, Mark E. Gurney, Alex Burgin, Vincent Sandanayaka, Alexander Kiselyov, Munagala Rao
Abstract: The present invention relates to novel compounds of formula I wherein W, n, X and W? are defined in the description; invention compounds are modulators of metabotropic glutamate receptors—subtype 5 (“mGluR5”) which are useful for the treatment of central nervous system disorders as well as other disorders modulated by mGluR5 receptors.
Type:
Grant
Filed:
December 20, 2011
Date of Patent:
November 11, 2014
Assignee:
Addex Pharma SA
Inventors:
Anne-Sophie Bessis, Christelle Bolea, Beatrice Bonnet, Mark Epping-Jordan, Nicolas Poirier, Sonia-Maria Poli, Jean-Philippe Rocher, Yves Thollon
Abstract: Process for preparing cyclometallated transition metal-carbene complexes comprising at least one carbene ligand, which comprises reacting a ligand precursor with a base, an auxiliary reagent and a metal complex comprising at least one metal M1 (route A) or reacting the ligand precursor with a basic auxiliary reagent and a metal complex comprising at least one metal M1 (route B). The present invention further relates to the use of an auxiliary reagent selected from among salts comprising at least one metal selected from the group consisting of Ag, Hg, Sb, Mg, B and Al together with a base in a process for preparing cyclometallated metal complexes.
Type:
Grant
Filed:
February 27, 2013
Date of Patent:
November 4, 2014
Assignee:
BASF SE
Inventors:
Oliver Molt, Evelyn Fuchs, Martina Egen, Klaus Kahle, Christian Lennartz
Abstract: A copper catalyzed click chemistry ligation process is employed to bind azides and terminal acetylenes to provide 1,4-disubstituted 1,2,3-triazole triazoles. The process comprises contacting an organic azide and a terminal alkyne with a source of reactive Cu(I) ion in human blood plasma to form by cycloaddition a 1,4-disubstituted 1,2,3-triazole. The source of reactive Cu(I) ion can be, for example, a Cu(I) salt, Cu(II) ion in the presence of a reducing agent, or copper metal.
Type:
Grant
Filed:
November 12, 2013
Date of Patent:
November 4, 2014
Assignee:
The Scripps Research Institute
Inventors:
K. Barry Sharpless, Valery Fokin, Vsevold A. Rostovtsev, Luke Green, Fahmi Himo
Abstract: This invention relates generally to olefin metathesis, more particularly, to tri- or tetra-substituted imidazolinium salts which are precursors to N-heterocyclic carbene (NHC) ligands with tri- or tetra-substituted imidazolinium rings, organometallic ruthenium complexes comprising gem di-substituted imidazolinium NHC ligands, organometallic ruthenium complexes comprising tri- or tetra-substituted imidazolinium NHC ligands, and to olefin metathesis methods using them. The catalysts and methods of the invention have utility in the fields of catalysis, organic synthesis, and industrial chemistry.
Type:
Grant
Filed:
April 9, 2009
Date of Patent:
November 4, 2014
Assignee:
California Institute of Technology
Inventors:
Robert H. Grubbs, Cheol Keun Chung, Jean-Baptiste Bourg, Kevin Kuhn
Abstract: The invention provides a novel immobilized Lewis acid catalyst which exhibits high catalytic activity in an aqueous solution and which permits recovery and reuse or long-term continuous use. The invention relates to an immobilized Lewis acid catalyst comprising a solid substance and a Lewis acid supported on the surface of the solid substance by chemical bonding, wherein the surface of the solid substance and the peripheries of the Lewis acid are coated with an ionic liquid, more specifically, an immobilized Lewis acid catalyst comprising a solid substance such as silica gel or an organic polymer and a Lewis acid stable even in water which is supported on the surface of the solid substance by chemical bonding, wherein the surface of the solid substance and the peripheries of the Lewis acid are completely or partially coated with a hydrophobic ionic liquid; a process for the production of the catalyst; use thereof; and a process for the preparation of compounds with the catalyst.
Type:
Grant
Filed:
March 12, 2007
Date of Patent:
October 28, 2014
Assignee:
Japan Science and Technology Agency
Inventors:
Shu Kobayashi, Yuichiro Mori, Gu Yanlong
Abstract: The invention relates to new compounds containing alkyl-alkoxy-cyano-borate anions, their preparation and their use, in particular as part of electrolyte formulations for electrochemical or optoelectronic devices.
Type:
Grant
Filed:
July 6, 2012
Date of Patent:
October 14, 2014
Assignee:
Merck Patent GmbH
Inventors:
Nikolai (Mykola) Ignatyev, Michael Schulte, Kentaro Kawata, Tomohisa Goto, Jan Sprenger, Maik Finze, Walter Frank
Abstract: The present invention relates to crystalline complexes comprising at least one agriculturally active organic compound A having at least one functional moiety which is capable as serving as a hydrogen acceptor in a hydrogen bond and thiophanate-methyl.
Type:
Grant
Filed:
February 8, 2008
Date of Patent:
October 14, 2014
Assignee:
BASF SE
Inventors:
Rafel Israels, Heidi Emilia Saxell, Matthias Bratz, Marco Kuhns, Peter Erk
Abstract: The invention relates to biaryl substituted azabicyclic alkane derivatives, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.
Type:
Grant
Filed:
January 27, 2011
Date of Patent:
October 7, 2014
Assignee:
AbbVie Inc.
Inventors:
Jianguo Ji, Tao Li, Kevin B. Sippy, Chih-Hung Lee, Murali Gopalakrishnan
Abstract: This invention provides novel compounds, methods of using the compounds, and pharmaceutical formulations comprising the compounds.
Type:
Grant
Filed:
November 16, 2012
Date of Patent:
October 7, 2014
Assignee:
Anacor Pharmaceuticals, Inc.
Inventors:
Tsutomu Akama, Terry William Balko, Jean Marie Defauw, Jacob J. Plattner, William Hunter White, Joseph Raymond Winkle, Yong-Kang Zhang, Yasheen Zhou
Abstract: Synthesis of platinum(II) di(2-pyrazolyl)benzene chloride and analogs includes forming a 1,3-di-substituted benzene including two aromatic five-membered heterocycles, and reacting the 1,3-di-substituted benzene with an acidic platinum-containing solution to form a luminescent platinum(II) complex. The luminescent platinum(II) complex is capable of emitting blue and white light and can be used as an emitter in a light emitting device.
Type:
Grant
Filed:
October 25, 2013
Date of Patent:
September 30, 2014
Assignee:
Arizona Board of Regents for and on behalf of Arizona State University
Abstract: This document relates to functionalized (e.g., mono- or bi-functional) polymers (e.g., polyethylene glycol and related polymers) as well as methods and materials for making and using such functionalized polymers.