Patents Examined by Joseph Murray
-
Patent number: 5827863Abstract: Compounds of general formula I and their salts and solvates are angiotensin II receptor antagonists and as such are useful in the treatment of hypertension, congestive heart failure and elevated intraocular pressure. Pharmaceutical compositions including these compounds and processes for their preparation are also provided.Type: GrantFiled: June 20, 1996Date of Patent: October 27, 1998Assignee: J. Uriach & Cia, S.A.Inventors: Carmen Almansa, Concepcion Gonzalez, M. Carmen Torres, Elena Carceller, Javier Batroli
-
Patent number: 5827938Abstract: A process for the coproduction of 6-aminocapronitrile (ACN) and hexamethylenediamine (HMD) by treatment of adiponitrile (ADN) with hydrogen in the presence of a nickel-containing catalyst at temperatures not below room temperature and elevated hydrogen partial pressure in the presence or absence of a solvent comprises, after the conversion based on ADN and/or the selectivity based on ACN has or have dropped below a defined value(a) interrupting the treatment of ADN with hydrogen by stopping the feed of ADN and of the solvent, if used,(b) treating the catalyst at from 150.degree. to 400.degree. C. with hydrogen using a hydrogen pressure within the range from 0.1 to 30 MPa and a treatment time within the range from 2 to 48 h, and(c) then continuing the hydrogenation of ADN with the treated catalyst of stage (b).Type: GrantFiled: April 22, 1996Date of Patent: October 27, 1998Assignee: BASF AktiengesellschaftInventors: Werner Schnurr, Guido Voit, Klemens Flick, Johann-Peter Melder, Rolf-Hartmuth Fischer, Wolfgang Harder
-
Patent number: 5817827Abstract: The present invention relates to a process for the dehydration of amides to nitrites which comprises carrying out the dehydration in the presence of an adduct of sulphur trioxide and an amine as the dehydrating reagent in a basic reaction mixture. Thereby, for example, aliphatic, aromatic and heteroaromatic amides are dehydrated to the corresponding nitrites, such as 5-carbamoyl-4-methyl-oxazole to 5-cyano-4-methyl-oxazole, a valuable intermediate in the synthesis of pyridoxine.Type: GrantFiled: October 22, 1996Date of Patent: October 6, 1998Assignee: Hoffmann-La Roche Inc.Inventors: Werner Bonrath, Horst Pauling
-
Patent number: 5817651Abstract: 2-R.sub.2 --R.sub.4 -substituted-3-R.sub.3 --CO-1-?(C-attached-N-heteryl)-(Alk) .sub.n !-1H-indoles useful as analgesic, anti-rheumatic, anti-inflammatory or anti-glaucoma agents.Type: GrantFiled: January 14, 1997Date of Patent: October 6, 1998Assignee: SanofiInventors: Thomas Edward D'Ambra, Edward Richard Bacon, Malcolm Rice Bell, Philip Michael Carabateas, Michael Allen Eissenstat, Virendra Kumar, John Peter Mallamo, Susan Jean Ward
-
Patent number: 5817286Abstract: Processes for the production of hydrogen cyanide from the reaction of methane with ammonia at temperatures above about 800.degree. C. where the reactor contains a matrix bed of heat resistant materials. The product stream produced within the reactor is preferably routed in a countercurrent fashion to the feed stream entering the reactor to preheat the feed stream and to lower the exit temperature of the product stream. Reactors capable of being used to practice such processes are also provided by the invention.Type: GrantFiled: July 25, 1997Date of Patent: October 6, 1998Assignee: Thermatrix Inc.Inventors: Richard J. Martin, John D. Stilger, John D. Young
-
Patent number: 5811584Abstract: Process for the production of TMEDA in high yield by reducing 2,3-dimethyl-2,3-dinitrobutane with hydrogen in the presence of a chromium promoted Raney cobalt catalyst. A solution of 2,3-dimethyl-2,3-dinitrobutane in a suitable solvent is fed to a reactor while avoiding the accumulation of 2,3-dimethyl-2,3-dinitrobutane in the reaction medium, such as by feeding it at a rate no greater than its rate of reaction with hydrogen. In a preferred embodiment, the resulting TMEDA is recovered by converting it to an amine salt by sparging carbon dioxide through the solution.Type: GrantFiled: July 29, 1997Date of Patent: September 22, 1998Assignee: Hampshire Chemical Corp.Inventors: Gerald J. O'Neill, Albert H. Levesque, Robert J. Bulka
-
Patent number: 5804532Abstract: Herbicides derived from 2-cyano-1,3-diones have the formula: ##STR1## wherein R, R.sup.1, R.sup.2 R.sup.3, R.sup.4 and R.sup.5 are as defined in the description. The compounds are intended for use pre- and post-emergence as selective herbicides in maize and a large number of other monocotyledon crops.Type: GrantFiled: June 2, 1995Date of Patent: September 8, 1998Assignee: Rhone-Poulenc Agriculture LimitedInventors: Paul Alfred Cain, Susan Mary Cramp, Claude Lambert, Derek Ian Wallis, Thomas David Yarwood, Gillian Mary Little, John Morris, Tibor Musil, Simon Neil Pettit, Philip Henry Gaunt Smith
-
Patent number: 5801266Abstract: The present invention relates to a method for producing acrylonitrile comprising the steps of reacting propylene and/or propane, ammonia and molecular oxygen in the presence of a catalyst to form a reacted gas, contacting the reacted gas with a liquid containing water and an acid in a multi-stage quenching tower having three or more chambers and transferring the liquid contacted with the reacted gas in the second quenching chamber to the first quenching chamber. According to the present invention, high boiling point compounds are efficiently removed and clogging is prevented in an acrylonitrile recovery process so that the productivity of acrylonitrile is enhanced.Type: GrantFiled: August 27, 1997Date of Patent: September 1, 1998Assignee: Asahi Kasei Kogyo Kabushiki KaishaInventor: Kanji Ishii
-
Patent number: 5795918Abstract: This invention relates to certain 1,3,3-(trisubstituted)cyclohex-1-ene dimers and related compounds which are useful in treating allergic and inflammatory diseases and for inhibiting the production of Tumor Necrosis Factor (TNF).Type: GrantFiled: February 27, 1996Date of Patent: August 18, 1998Assignee: SmithKline Beecham CorporationInventors: Siegfried B. Christensen, IV, Joseph M. Karpinski
-
Patent number: 5789582Abstract: A nuclear halogenated aromatic compound possessing cyano groups is produced by a method using as a raw material an aromatic compound which possesses cyano groups and assumes a solid state at room temperature and subjecting the raw material to a procedure comprising a step of melting and transporting the compound by a means transport-melting, a step of vaporizing the compound, a step of mixing the compound with a halogen gas, and a step of causing the vapor of the compound to react with the halogen gas in vapor phase in the presence of a catalyst sequentially in the order mentioned, which comprises maintaining a content of a self-condensate of the aromatic compound possessing cyano groups which arise during the melting of the aromatic compound possessing cyano groups in a gas of the compound which reacts with the halogen gas to a level of not more than 2.5 mol % based on the compound.Type: GrantFiled: March 7, 1997Date of Patent: August 4, 1998Assignee: Nippon Shokubai Co., Ltd.Inventors: Osamu Kaieda, Koichi Hirota, Teruhisa Kajiwara, Norimasa Okuda, Hisakazu Shindo, Yoshiro Hanayama, Yujin Shoda, Toyohiko Kohno, deceased, Takashi Yodoshi, Masaru Awashima
-
Patent number: 5789409Abstract: This invention provides a benzylpiperazine derivative of formula (I) and a pharmacologically acceptable salt thereof ##STR1## wherein R.sub.1 represents a pyridine ring or a group of either formula (IV) or formula (V); R.sub.2 represents hydrogen or lower alkyl ##STR2## wherein R.sub.3 represents hydrogen, lower alkyl, a pyridine ring or a benzene ring which may be substituted by halogen; X represents halogen ##STR3## wherein R.sub.4 and R.sub.5 may be the same or different and each represents hydrogen, lower alkyl, lower alkoxy, halogen or carboxy.Type: GrantFiled: July 9, 1996Date of Patent: August 4, 1998Assignee: Senju Pharmaceutical Co., Ltd.Inventors: Kazumi Ogata, Kazuhiko Ito, Takahiro Sakaue, Shinya Ogino
-
Patent number: 5786483Abstract: .alpha.- and .beta.-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.Type: GrantFiled: June 7, 1995Date of Patent: July 28, 1998Assignees: G. D. Searle & Co., Monsanto CompanyInventors: Michael L. Vazquez, Richard A. Mueller, John J. Talley, Daniel Getman, Gary A. DeCrescenzo, John N. Freskos
-
Patent number: 5786498Abstract: A process for resolving the racemates of phenylacetonitriles of the formula I ##STR1## where R.sup.1, R.sup.2, R.sup.3 and m have the meanings stated in the description is described. The process comprises dissolving the racemates I in a polar solvent, adding from 0.5 to 1.0 mol of optically active camphorsulfonic acid per mol of compound I, heating to 40.degree.-100.degree. C., allowing to cool and liberating the optically active phenylacetonitrile I from the salt obtained in this way.Type: GrantFiled: July 7, 1997Date of Patent: July 28, 1998Assignee: BASF AktiengesellschaftInventors: Ulrich Karl, Werner Seitz
-
Patent number: 5780644Abstract: Branched, dendrimeric-type macromolecules composed essentially of a central nucleus and of a series of polyoxaalkyl chains that depart from said nucleus and spread into the surrounding space branching in a cascade fashion useful as carriers of drugs, contrast agents, etc.Type: GrantFiled: March 15, 1995Date of Patent: July 14, 1998Assignee: Dibra S.p.A.Inventors: Luigia Gozzini, Monica Muttoni, Christoph DeHaen
-
Patent number: 5780542Abstract: Water-emulsifiable polyisocyanates containinga) aliphatic, cycloaliphatic and aromatic polyisocyanates andb) reaction products of the abovementioned polyisocyanates with polyvinylpyrrolidones which have at least one group which is reactive with isocyanate.Type: GrantFiled: July 12, 1996Date of Patent: July 14, 1998Assignee: BASF AktiengesellschaftInventors: Brigitta Huckestein, Hans Renz, Stephan Kothrade, Karl Haberle
-
Patent number: 5780674Abstract: Sulfonated phosphines of the formula ##STR1## in which R is cyclohexyl or alkyl having 1 to 4 carbon atoms, M is hydrogen, alkyl substituted ammonium, aryl substituted-ammonium, monovalent metal, or the chemical equivalent of a polyvalent metal, x is 1, 2, or 3 and n is 0 or 1. These compounds are obtained by sulfonation of the non-sulfonated parent substances with oleum or an anhydrous mixture of sulfuric acid and orthoboric acid.Type: GrantFiled: February 18, 1997Date of Patent: July 14, 1998Assignee: Hoechst AktiengesellschaftInventors: Guido Albanese, Rainer Manetsberger, Wolfgang A. Herrmann
-
Patent number: 5776865Abstract: Emulsifiable oil, suitable for use as oil phase in oil-based drilling fluids, having one or more ketones with a flashpoint of at least 55.degree. C., in particular oligoketones obtainable by co-oligomerization of carbon monoxide and olefins.Type: GrantFiled: May 17, 1995Date of Patent: July 7, 1998Assignee: Shell Oil CompanyInventors: Maria Manuel De Castro Loureiro Barreto Rosa, Arend Kuindert Van Helden, Herman Mathieu Muijs
-
Patent number: 5773618Abstract: Compounds of formula (I): ##STR1## ?wherein: R.sup.1 represents halogen, alkyl, haloalkyl, alkoxy, haloalkoxy, cycloalkyl, or cycloalkyloxy; R.sup.2 represents hydrogen or halogen; R.sup.3 represents hydrogen, alkyl, or cycloalkyl; and the dotted line represents a single or double carbon--carbon bond!; and salts thereof have valuable fungicidal activities which make them of considerable value in agriculture and horticulture.Type: GrantFiled: May 14, 1997Date of Patent: June 30, 1998Assignee: Sankyo Company, LimitedInventors: Hideo Takeshiba, Chiaki Imai, Hiroshi Ohta, Shigehiro Kato, Hiroyuki Itoh
-
Patent number: 5760274Abstract: Disclosed is a method of making an aromatic nitrile by reacting a benzotrichloride having the formula ##STR1## with a source of ammonia, where Z is R, X, ##STR2## --ROR, or --OR, R is alkyl from C.sub.1 to C.sub.20 or aryl from C.sub.1 to C.sub.25, X is halogen and n is 0 to 5. The reaction is performed in the presence of 0.01 to about 5 wt % of a catalyst having the general formula M.sub.P/2 O or MX.sub.p .cndot.mH.sub.2 O and about 0.01 to about 5 wt % water, as free water or water of hydration, based on the weight of the benzotrichloride, where M is beryllium, magnesium, calcium, strontium, or barium, m is 0 to 6, and p is the valence of M.Type: GrantFiled: July 29, 1997Date of Patent: June 2, 1998Assignee: Occidental Chemical CorporationInventors: Ronald F. Spohn, Robert L. Bell
-
Patent number: RE35886Abstract: A phosphonic acid derivative compound represented by formula ?I ! or a pharmaceutically acceptable salt thereof: ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 each represent hydrocarbon groups which may be substituted, except cases in which (1) R.sub.2 is unsubstituted methyl, ( 2 ) R.sub.3 is an unsubstituted hydrocarbon group having 1 to 3 carbon atoms, and (3) R.sub.1 is benzyloxycarbonylaminomethyl, R.sub.2 is isobutyl and R.sub.3 is isobutyl or phenylmethyl, which has endothelin-converting enzyme inhibiting activity and is useful as pharmaceutical drugs such as therapeutic agents for hypertension, cardiac or cerebral circulatory diseases and renal diseases.This is a Reissue of a Patent which was the subject of a Reexamination Certificate No. B1 5,330,978, dated Jun. 18, 1996, Request No. 90/00400, Oct. 18, 1995.Type: GrantFiled: July 12, 1996Date of Patent: September 1, 1998Assignee: Takeda Chemical Industries, Ltd.Inventors: Mitsuhiro Wakimasu, Masaaki Mori, Akira Kawada