Patents Examined by Joseph P. Brust
  • Patent number: 5077306
    Abstract: Fungicidal N,N'-diacylaminals of the formula ##STR1## in which R.sup.1 is optionally substituted alkyl, alkenyl, alkinyl, cycloalkyl or cycloalkenyl,R.sup.2 and R.sup.3 are hydrogen or various organic radicals, andX is oxygen or sulphur.
    Type: Grant
    Filed: April 18, 1990
    Date of Patent: December 31, 1991
    Assignee: Bayer Aktiengesellschaft
    Inventors: Winfried Lunkenheimer, Dieter Berg, Wilhelm Brandes
  • Patent number: 5049578
    Abstract: Antihypercholesterolemic activity is exhibited by novel compounds of the formula ##STR1## wherein: Z is ##STR2## X is lower alkyl or lower alenyl; R.sup.1 is aryl or alkyl;R.sup.2 and R.sup.3 are the same or different and are hydrogen, or lower alkyl or aryl, or R.sup.2 and R.sup.3 taken together to form a cycloalkyl group; andR.sup.4 is hydrogen, lower alkyl, or alkali metal (such as sodium, lithium, or potassium) or a radical such as ammonium.Methods of use and novel intermediates of these compounds are also provided.
    Type: Grant
    Filed: March 9, 1990
    Date of Patent: September 17, 1991
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Ravi K. Varma, Eric M. Gordon
  • Patent number: 5043451
    Abstract: There are provided compounds of the formula: ##STR1## wherein R.sub.1 is a hydrogen or C.sub.1 -C.sub.5 alkyl; R.sub.2 is an C.sub.1 -C.sub.10 alkyl, aryl, aralkyl, or pyridyl, where the aryl, aralkyl, or pyridyl are unsubstituted or are substituted by C.sub.1 -C.sub.5 alkyl, C.sub.1 -C.sub.5 alkoxy, nitro, hydroxy, carboxy, amino, C.sub.1 -C.sub.5 alkylamino, C.sub.1 -C.sub.5 dialkylamino whose two alkyl groups may be different from each other, C.sub.2 -C.sub.3 alkanoylamino, or halogen and X is an C.sub.1 -C.sub.7 alkylene, C.sub.2 -C.sub.7 alkenylene, --CH(F)CH.dbd.CH(CH.sub.2).sub.3 --, --(CH.sub.2).sub.3 --S--(CH.sub.2).sub.2 --, --CH.sub.2).sub.2 --S--(CH.sub.2).sub.3 --, --C.sub.6 H.sub.4 --O--CH.sub.2 --or --CH.sub.2 CH.dbd.CH--m--C.sub.6 H.sub.4 --, or their pharmaceutically acceptable salts. The compounds are useful as antithrombotic, anti-vasoconstricting and anti-bronchoconstricting drugs.
    Type: Grant
    Filed: April 27, 1990
    Date of Patent: August 27, 1991
    Assignee: Shionogi & Co., Ltd.
    Inventors: Mitsuaki Ohtani, Fumihiko Watanabe, Tadadiko Tsushima, Kenji Kawada, Susumu Kamata
  • Patent number: 5041605
    Abstract: Phenolic cyan-dye-forming couplers characterized by a p-cyanophenylureido group in the 2-position of the phenol are synthesized in high yield by a process comprising the steps of contacting, in a reaction solvent in the presence of a transition metal catalyst at moderate temperature and atmospheric pressure, a coupler intermediate having a nitro group in the 5-position with a hydrogen donor, such as, for example, ammonium formate, to thereby form the corresponding 2-(p-cyanophenylureido)-5-aminophenol and reacting the 2-(p-cyanophenylureido)-5-aminophenol with an acylating agent to form the phenolic cyan-dye-forming coupler.
    Type: Grant
    Filed: November 20, 1989
    Date of Patent: August 20, 1991
    Assignee: Eastman Kodak Company
    Inventors: James J. Huson, Louis F. Valente
  • Patent number: 5041635
    Abstract: There is provided 5(Z)-7-(endo-3-benzenesulfonamidobicyclo[2.2.1]hept-exo-2-yl)-5-heptenoic acid, sodium salt which is useful as an antithrombotic, anti-vasoconstricting and anti-bronchoconstricting agent.
    Type: Grant
    Filed: June 20, 1990
    Date of Patent: August 20, 1991
    Assignee: Shionogi & Co., Ltd.
    Inventors: Masayuki Narisada, Mitsuaki Ohtani
  • Patent number: 5030748
    Abstract: New composition of monomers and polymers and their methods of use are disclosed. The polymers are water soluble and are composed of repeat units formed from an ethylenically unsaturated compound, and repeat units formed from substituted allyloxy alkylenes.
    Type: Grant
    Filed: October 27, 1989
    Date of Patent: July 9, 1991
    Assignee: Betz Laboratories, Inc.
    Inventors: Fu Chen, William Carey
  • Patent number: 5019588
    Abstract: Novel 1,2-cyclohexylaminoaryl amides useful as analgesic agents having very high kappa-opioid affinity and selectivity and potency and useful as analgesics, diuretics, antiinflammatory and psychotherapeutic agents are disclosed. Methods for making the compounds and pharmaceutical compositions containing them are also disclosed.
    Type: Grant
    Filed: October 10, 1989
    Date of Patent: May 28, 1991
    Assignee: Warner-Lambert Company
    Inventors: David C. Horwell, David C. Rees
  • Patent number: 4990647
    Abstract: Unsymmetric biaryl compounds are prepared by coupling two different halogenoaromatics by reaction with a metal and carrying out the reaction in the presence of catalytic amounts of a nickel compound, a promoter and a phosphorus-containing ligand.
    Type: Grant
    Filed: April 24, 1989
    Date of Patent: February 5, 1991
    Assignee: Bayer Aktiengesellschaft
    Inventors: Thomas Himmler, Rudolf Braden
  • Patent number: 4990646
    Type: Grant
    Filed: January 19, 1990
    Date of Patent: February 5, 1991
    Assignee: Bayer Aktiengesellschaft
    Inventor: Klaus Grohe
  • Patent number: 4983624
    Abstract: A novel prolinal derivative of general formula: ##STR1## [whereinA represents a group of the general formula: ##STR2## (wherein one of R.sup.1 and R.sup.2 represents hydrogen atom and the other represents alkyl group of from 2 to 5 carbon atoms, alkoxy group of from 1 to 5 carbon atom(s), phenyl group, benzyl group, cycloalkyl group of from 4 to 6 carbon atoms or (cycloalkyl group of from 4 to 6 carbon atoms) - methyl group or R.sup.1 and R.sup.2 each represents, same or different, alkyl group of from 1 to 4 carbon atom(s).)or a group of the general formula: ##STR3## (wherein m represents an integer of from 3 to 6.) n represents an integer of from 3 to 10.D represents carbocyclic or heterocyclic ring unsubstituted or substituted by from one to three of halogen atom, nitro group, trifluoromethyl group, alkyl or akloxy group of from 1 to 4 carbon atom(s).]possess inhibitory activity on prolyl endopeptidase, and therefore be useful for treating and/or preventing agent for amnesia.
    Type: Grant
    Filed: December 29, 1987
    Date of Patent: January 8, 1991
    Assignee: Ono Pharmaceutical Co., Ltd
    Inventors: Masaaki Toda, Shuichi Ohuchida, Hiroyuki Ohno
  • Patent number: 4980494
    Abstract: Novel 2-(4-(2'-fluoro-4'-cyanophenoxy)-phenoxy)alkanoic acids and agriculturally acceptable derivatives thereof are selective postemergent herbicides for the control of grassy weeds in valuable crops. The novel herbicides are surprisingly selective, i.e., exhibit little or no phytotoxic effects, to wheat, barley and especially rice at concentrations that control undesired weed grasses.
    Type: Grant
    Filed: December 8, 1989
    Date of Patent: December 25, 1990
    Assignee: The Dow Chemical Company
    Inventors: R. Garth Pews, Lucinda A. Jackson, Chrislyn M. Carson
  • Patent number: 4980158
    Abstract: The novel dye compound ##STR1## wherein R.sub.1 and R.sub.2, which may be the same or different except that R.sub.1 and R.sub.2 are not simultaneously hydrogen, are hydrogen, alkyl, hydroxyalkyl polyhydroxyalkyl, alkoxyalkyl, hydroxyalkoxyalkyl and amino alkyl, the alkyl group and the alkoxy group having from 1 to 6 carbons, and R.sub.3 is a compatible substituent group, for example, hydrogen, alkyl, hydroxy hydroxyalkyl and halogen. The dye compound is especially useful in hair dye compositions containing same.
    Type: Grant
    Filed: April 4, 1989
    Date of Patent: December 25, 1990
    Assignee: Clairol Incorporated
    Inventors: Yuh-Guo Pan, Lana Hochman
  • Patent number: 4978765
    Abstract: A process for the production of acrylonitrile by vapor phase catalytic ammoxidation of propylene in a fluidized bed at high yield with the use of a multicompenent fluidized bed catalyst comprising molybdenum, bismuth, iron, antimony, nickel and alkali metal(s) each carried by silica, which has a high catalytic activity and a high attrition resistance and which does not require any expensive cobalt catalytic component.
    Type: Grant
    Filed: April 14, 1989
    Date of Patent: December 18, 1990
    Assignee: Nitto Chemical Industry Co., Ltd
    Inventors: Yutaka Sasaki, Kunio Mori, Kiyoshi Moriya
  • Patent number: 4977180
    Abstract: A novel prolinal derivative of general formula: ##STR1## wherein A represents alkylene group of from 1 to 4 carbon atom(s) or saturated hydrocarbon ring of from 3 to 7 carbon atoms, n represents a number 2, 3 or 4, D represents carbocyclic or heterocyclic ring unsubstituted or substituted by from one to three of halogen atom, alkyl or alkoxy group of from 1 to 4 carbon atom(s), nitro group or trifluromethyl group posses inhibitory activity on prolyl endopeptidase, and therefore are useful for treating and/or preventing agent for amnesia.
    Type: Grant
    Filed: February 3, 1988
    Date of Patent: December 11, 1990
    Assignee: Ono Pharmaceutical Co., Ltd.
    Inventors: Masaaki Toda, Shuichi Ohuchida, Hiroyuki Ohno
  • Patent number: 4971959
    Abstract: Novel trisubstituted phenyl analogs are now found to have activity as for the treatment of congestive heart failure.
    Type: Grant
    Filed: December 30, 1988
    Date of Patent: November 20, 1990
    Assignee: Warner-Lambert Company
    Inventor: Lynn D. Hawkins
  • Patent number: 4959487
    Abstract: A process for producing aromatic nitrile, comprising reacting aromatic halide substituted by a nitro group in the ortho position relative to the halogen atom with 0.1 to 0.99 mol of cuprous cyanide and 0.1 to 2.0 mol of alkali cyanide, both being per mol of said aromatic halide, in a polar solvent, the amount of said aprotic solvent being 0.1 to 30 parts by weight per 100 parts by weight of said aromatic halide.
    Type: Grant
    Filed: March 2, 1989
    Date of Patent: September 25, 1990
    Assignee: Idemitsu Kosan Co., Ltd.
    Inventors: Hirotaka Yamasaki, Yoshio Hironaka
  • Patent number: 4936906
    Abstract: Agents for regulating plant growth containing an effective amount of at least one cyclohexanone derivative of the formula I ##STR1## where A, X, n, Y, Z and R have the meanings given in the disclosure, or salts of these compounds, and a process for regulating plant growth.
    Type: Grant
    Filed: July 2, 1986
    Date of Patent: June 26, 1990
    Assignee: BASF Aktiengesellschaft
    Inventors: Dieter Jahn, Michael Keil, Dieter Kolassa, Ulrich Schirmer, Rainer Becker, Johann Jung, Wilhelm Rademacher
  • Patent number: 4933484
    Abstract: The present invention relates to a process for reducing the concentration of acrylontrile in an aqueous-acrylonitrile vapor stream. The process involves feeding the aqueous-acrylontrile vapor stream to a primary condenser maintained at a temperature and pressure so that a substantial amount of the water is condensed and the acrylonitrile is maintained in the vapor phase. The vapor containing the acrylonitrile from the first condenser is introduced to a secondary condenser maintained at a temperature and pressure so that substantially all the vapor is condensed. The condensate exiting the secondary condenser is introduced to a decanter where the acrylonitrile containing organic phase of the condensate is separated and recovered from the aqueous phase. The aqueous phase is recycled to the primary condenser to significantly reduce the acrylonitrile level in the aqueous phase and enhanced the separation.
    Type: Grant
    Filed: January 30, 1989
    Date of Patent: June 12, 1990
    Assignee: The Goodyear Tire & Rubber Company
    Inventors: Ramesh N. Gujarathi, Carole I. Wendt, Edward K. Kazanjian, Ann M. Jones
  • Patent number: 4908452
    Abstract: A facile and mild process for the preparation of nitriles from reagent sensitive primary carboxamides is described. The process utilizes a (carboxysulfamoyl)ammonium hydroxide compound as the dehydrating agent. It is useful for preparing nitriles which have present other groups which are sensitive to the more conventional methods of dehydration or to other methods of nitrile synthesis. Some novel nitriles prepared by the new method are also described.
    Type: Grant
    Filed: December 21, 1987
    Date of Patent: March 13, 1990
    Assignee: Merck & Co., Inc.
    Inventor: David A. Claremon
  • Patent number: 4906642
    Abstract: New Pyridine derivatives of the formula ##STR1## wherein group Y or one of the groups Z is N and the others of these groups being in each case CH;n is 1, 2 or 3;R is ##STR2## R.sup.1 and R.sup.2 are in each case phenyl or 2- or 3-thienyl radicals which are unsubstituted or mono- or di-substituted by an alkyl and/or alkoxy having 1-4 C atoms, F, Cl, Br, OH and/or CF.sub.3 ; andR.sup.3 and R.sup.4 are in each case H, alkyl or alkoxy having 1-4 C atoms, F, Cl, Br, OH or CF.sub.
    Type: Grant
    Filed: March 18, 1987
    Date of Patent: March 6, 1990
    Assignee: Merck Patent Gesellschaft Mit Beschrankter Haftung
    Inventors: Henning Bottcher, Christoph Seyfried, Klaus-Otto Minck