Abstract: An auto-injector device comprising an injector body having a proximal end and a distal end; a syringe received in the injector body; a needle disposed in a first end of the syringe to extend toward an opening in the distal end of the injector body; and a sealing element disposed at the distal end of the injector body for making a seal against a patient's skin. The auto-injector is configured to generate a reduced pressure to draw the auto-injector device against the patient's skin. The auto-injector device comprises a pressure-reducing mechanism configured to generate the reduced pressure within the injector body during an injection process. The pressure reducing mechanism comprises a moveable member configured such that movement of the moveable member from a first position to a second position enlarges a closed volume within the injector body to generate the reduced pressure within the closed volume.

Abstract: Described herein are specialized needle assemblies for injection systems. One example injection system includes a needle assembly configured to removably attach to a drug delivery device and a housing configured to receive a drug cartridge. The needle assembly includes a needle configured to extend through an outlet port of the drug delivery device and establish fluid communication with the drug cartridge within the housing of the drug delivery device. The needle assembly may include a fluid flow sensor monitoring the fluid flow and/or occlusions within the needle assembly, and provide indications of an occluded or clogged needle and/or one or more indications of proper flow through the needle, e.g., non-occlusion of the needle. In some examples, the arrangement of the needle assembly includes sensors to detect an occlusion within a portion of a needle.

Abstract: This disclosure provides a method of determining a cartridge type of a cartridge used with a fluid drug injection system having a pump that receives a fluid drug cartridge. The fluid drug cartridge has a barrel filled with a fluid drug solution and a plunger within the barrel that forces the fluid drug solution through an outlet. An actuator of the pump is moved to contact or to move the plunger and a force sensor is used to measure force data during the movement. The force data is descriptive of the force applied to the plunger. A feature signal is determined from the force data. The feature signal can be a force modulation amplitude, a force modulation duration or a force modulation number. The cartridge type is assigned using the feature signal. Also disclosed is a fluid drug injection system and a cartridge for use therewith.

Abstract: A method of manufacturing a needle-equipped outer tube includes a preheating step comprising heating a distal end connecting section to a temperature at or below a softening point of a material forming an outer tube member with a joint member inserted in a distal end connecting section of the outer tube member, and with a needle being inserted or inserted and fixed in the needle insertion hole; and a joint member welding step, performed after the preheating step, comprising thermally welding the joint member to the distal end connecting section of the outer tube member with a distal end portion of the joint member pressed toward the proximal end of the joint member by a pushing member with a pressing force in a range of 4 N to 30 N.

Abstract: A medical vaporizer includes a liquid drug reservoir configured to receive and hold a liquid drug. A low power graphical display is configured to intermittently receive power. The low power graphical display is operable to visually present information and maintain the visual presentation of information in the absence of power. A controller is configured to intermittently receive power and upon receiving power the controller operates to determine a status of a medical vaporizer. The controller operates the low power graphical display to present the status of the medical vaporizer as visually presented information.

Abstract: A medicament delivery device is presented having a second housing part, a plunger rod arranged in the second housing part and configured to act on a stopper arranged inside a multi-chamber container. A first housing part contains the multi-chamber container, where the first housing part is arranged to be manually displaced into the second housing part by relative rotation between the first and the second housing parts for mixing at least two substances arranged inside the multi-chamber container. The delivery device further has a rotating contact element arranged between said plunger rod and said stopper capable of rotating in relation to said plunger rod.

Abstract: A system for managing a patient's glucose level includes a glucose sensor to generate and store data signals for measurements of the patient's glucose level made by the glucose sensor; an insulin pump; and sensor electronics operatively coupled to the glucose sensor, the sensor electronics comprising a memory storing one or more predetermined characteristics associated with the sensor electronics; and a computing device in electronic communication with the sensor electronics. The computing device comprises a processor configured to operate the sensor electronics to (i) receive the generated data signals, (ii) obtain the one or more predetermined sensor characteristics from the memory and (iii) execute a closed-loop algorithm to provide insulin delivery instructions to an insulin pump by at least using the data signals and predetermined characteristics.

Abstract: The present invention relates to an innovative system which definitively prevents the re-use of syringes with retractable needles, allowing at the same time to fill the tank by means of a mechanical system installed inside the piston. The operation that aims at preventing the re-use of the device takes place through a mechanical system that prevents the return of the piston towards the initial position of aspiration and restricts, therefore, its action in a single direction and prevents the return of the plunger to the initial position of injection and therefore restricts its action in a single direction. Moreover a rotating mechanical transition system prevents the repositioning of the piston in the previously used position. The filling of the container, instead, takes place through the use of a system via a flexible cannula placed inside the piston.

Abstract: Variations of integral navigation controls may be used in conjunction with a medical instrument to provide navigation functions for an image guided surgery (IGS) system that is in communication with the integral navigation controls. In some variations, a medical instrument with integrated navigation wheels allows movement of a cursor of the IGS system along the x and y axis by scrolling the wheel, or allows selection, zooming, or other controls by combined clicking and/or scrolling of wheels, and may be sterilized or discarded along with the device. In some other variations, a control overlay may be temporarily attached to the medical instrument to provide additional controls, such as buttons or a pointing stick, and then removed and sterilized or discarded after a procedure. In each variation, inputs may be communicated via wire or wirelessly to an IGS system to provide navigation of images during a surgical procedure.

Abstract: A system for injecting includes a syringe body having proximal and distal ends, a syringe interior, and a syringe flange at the proximal end thereof. The system also includes a stopper member disposed in the syringe interior. The system further includes a plunger member coupled to the stopper member. The plunger member includes a rotatable member configured to insert the stopper member distally in the syringe interior relative to the syringe body with rotation of the rotatable member. The plunger member further includes a proximal portion proximal of the rotatable member configured to be moved distally to also insert the stopper member distally in the syringe interior relative to the syringe body to eject about microliters of fluid from the syringe interior.

Abstract: The present disclosure relates to a cap assembly for a medicament delivery device, having a cap containing a tubular body provided with a distal opening, the cap being configured to be mounted to a proximal end of a medicament delivery device, a tubular remover configured to be received in the distal opening of the cap, the remover having flexible radially inwards extending grippers configured to engage with a delivery member shield, and a tubular remover insert configured to be received by the remover and configured to be fixedly attached to the cap to prevent axial displacement of the remover insert relative to the cap, wherein the remover is axially displaceable relative to the cap and relative to the remover insert, from a first position in which the grippers are pressed radially outwards by an outer surface of the remover insert, to a second position located distally relative to the first position, in which second position the grippers are arranged distally beyond the outer surface of the remover insert,

Abstract: An injection device comprising: a housing arranged to contain a medicament cartridge; a needle holder holding an injection needle; a generally tubular needle sleeve fixed with respect to the needle holder and axially movable with respect to the housing; and a gear assembly comprising a rotary gear fixed to the needle holder, a first gear rack disposed on the needle sleeve and a second gear rack disposed on the housing, wherein the gear assembly is arranged so that movement of the needle sleeve in a proximal axial direction causes movement of the needle holder in the proximal axial direction.

Abstract: The disposable protective cover for ear washing machines is designed to protect a patient's ear from bacteria or infection during use of the machine. The cover is a flexible, resilient tube having an open end and a reinforced ring about the open end. The opposite end of the tube is hemispherical and closed, but having a central, circular opening for ear washing solution from the ear washing machine to exit the cover and enter the ear. To place the cover on the ear washing machine's nozzle, the cover is first rolled up to form a disc and the protective cover is placed against the nozzle with the central opening aligned with the nozzle's circular outlet port. It is then unrolled as much as possible over the outer surface of the nozzle. The protective cover is disposed of after each use to prevent the spread of bacteria or infection between patients.

Abstract: A syringe assembly includes a syringe barrel having a first end, a second end, and a sidewall extending between the first end and the second end. The syringe assembly further includes a stopper disposed within a chamber of the syringe barrel, a plunger adapter engaged with the stopper, and a plunger rod having first and second ends. The first end of the plunger rod is pivotally secured to the plunger adapter. The plunger rod has a pre-use position where the second end of the plunger rod is positioned adjacent to the syringe barrel, and a use position where the plunger rod is configured to displace the stopper relative to the syringe barrel. A recessed portion of the plunger adapter receives a portion of the first end of the plunger rod when the plunger rod is in the pre-use position and the use position.

Abstract: A tamper evident closure assembly for a fitting including, but not limited to, use in combination with a female fixture or an enteral fixture. A cap is connectable in flow restricting relation to the fitting and includes an indicator member removably connected to an exterior thereof. A housing is dimensioned to removably contain the cap and the connected indicator member. Subsequent to the fixture being connected to the cap, a removal thereof results in the indicator member being detached from the cap and movably disposed in a captured, detached orientation within the housing. Tampering may be evidenced by the indicator member remaining captivated within the housing which may be determined by visual observation or the generation of sound caused resulting from the housing being shaken.

Abstract: A closure assembly for a medical device such as a syringe comprises a housing having an open end and a hollow interior. A tip cap is removably disposed within the housing and includes a cover connected to the open end by a snap-fit connection. An indicator ring includes an access opening and is removably connected to the cover in interruptive, removable restricting relation to said tip cap. The access opening is dimensioned to facilitate passage of the syringe therethrough into attachment with the tip cap, with the tip cap disposed into disconnecting engagement with said indicator ring concurrent to removal of said tip cap and attached syringe through said open end. Upon removal of the tip cap and attached syringe through the open end of the housing, the indicator ring will be disposed in a surrounding captured disposition on the syringe, thereby providing a clear indication of tampering or use.

Abstract: A sterile fluid pathway connector includes a piercing member, a connector hub, and a pierceable seal; wherein at least a portion of the pierceable seal is configured to move from a first position in which the piercing member is retained within a sterile cavity between the pierceable seal and the connector hub, to a second position in which the pierceable seal has been penetrated by the piercing member. A filter may be utilized to enclose the sterile cavity from the outside environment. Such fluid pathway connections may be integrated into a fluid container having a barrel and a plunger seal. The components of the fluid pathway connector may further be capable of transmitting a signal to the user upon completion of fluid delivery, for example, upon contact between the plunger seal and the pierceable seal. A fluid delivery pump includes such integrated fluid pathway connectors and fluid containers.

Abstract: A plunger assembly (200) for use in a syringe apparatus (100). The plunger assembly (200) includes a movable tip (280) that can be removably secured to a plunger rod (210). By positioning the movable tip (280) in a barrel (300) while air (70) can still pass through a hole (282) in the movable tip (280), a user (90) can use the plunger assembly (200) to easily remove air (70) from a syringe apparatus (100) that has been loaded with the desired liquid (80).

Abstract: An infusion device (50) incl. a preferably soft cannula (1) configured to be inserted by means of an insertion needle. The cannula has a tubular body member having a proximal end and a subcutaneously placed distal portion having a distal end where the distal portion is provided with an opening (2) allowing a portion of a drug conveyed through the tubular body member to discharge. The cannula further comprise, in the distal portion, a radial opening allowing a portion of a drug conveyed through the tubular body member to discharge.

Abstract: A device and method for dilating a Eustachian tube of a patient is disclosed. The device includes a guide catheter and a balloon dilation catheter. The balloon dilation catheter has an actuator that prevents injury to the middle ear. The balloon dilation catheter is slidably coupled with the guide catheter through the guide catheter lumen and is fully inserted into the guide catheter lumen when the distal side of the actuator is adjacent to the proximal end of the guide catheter. The method involves advancing the guide catheter and balloon dilation catheter through a nasal passage of the patient to dilate a portion of the Eustachian tube.