Abstract: This document describes rotational atherectomy devices and systems for removing or reducing stenotic lesions in blood vessels by rotating an abrasive element within the vessel to partially or completely remove the stenotic lesion material.

Abstract: Systems and methods can remove material of interest, including blood clots, from a body region, including but not limited to the circulatory system for the treatment of pulmonary embolism, deep vein thrombosis, cerebrovascular embolism, and other vascular occlusions. The capture system can include a tubular body comprising a first end, a second end, and an axial length therebetween, the first end having an opening and a capture guide. The capture system can include one or more tensioners coupled to the capture guide. The tubular body has a first configuration in which the first end and the capture guide are expanded while the second end and a majority of the tubular body remains compressed. The tubular body is transformable to a second configuration by application of tension by the tensioners. The catheter can remove a large volume of clot.

Abstract: Provided is a surgical instrument, in more detail, a surgical instrument that may be manually operated to be used in laparoscopic surgery or various other kinds of surgery. To this end, the present invention provides a surgical instrument including an end tool configured to be rotatable in at least two directions; and a manipulator including a pitch operator controlling a pitch movement of the end tool, a yaw operator controlling a yaw movement of the end tool, and an actuation operator controlling an actuation movement of the end tool.

Abstract: A fiber-reinforced device, such as an inflatable medical balloon, includes a cylindrical central portion. The balloon includes first and second tapered portions connected to the cylindrical central portion along a longitudinal axis extending from a first end of the balloon to a second end of the balloon. In one embodiment, the balloon includes at least one zone free of fibers extending in a longitudinal direction, such that each longitudinal fiber is discontinuous in a circumferential direction around the balloon. In another embodiment, the balloon includes alternating discontinuous and continuous longitudinal fibers. In yet another embodiment, the balloon includes discontinuous longitudinal fibers, with every other longitudinal fiber having a discontinuity aligned in a circumferential direction. Related methods are also disclosed.

Abstract: Disclosed herein is a rotary embolectomy device. The device includes a rotatable bit which contacts a blood clot within a cannula, thereby disintegrating the clot. The clot can be removed by means of suction, complete disintegration, or a collecting basket.

Abstract: A medical device includes a handle with a proximal arm and a distal arm. The proximal arm and the distal arm are pivotable via a joint. The medical device also includes a tube coupled to the distal arm and a drive wire. A distal portion of the drive wire includes an expandable end effector. A portion of the drive wire is positioned within the tube, and a different portion of the drive wire extends proximally of the distal arm and is coupled to the proximal arm.

Abstract: Disclosed herein are devices and methods for providing embolic protection in a patient's vascular system. In particular, the devices detailed herein are supported by a flexible scaffold that is coupled to a filter. When deployed into the peripheral or coronary vasculature of a patient, the embolic protection devices of the present disclosure collect and remove embolic debris as a prophylactic measure to lessen the risk of embolic associated complications.

Abstract: Methods and devices for catheter-based removal of unwanted tissue or occlusive matter from blood vessels and other body lumens rely on a wire advanced from a tube to deploy a capture net that can be drawn over the clot. Apparatus include simple and reliable mechanisms for deployment of nets, funnels, and other clot capturing mechanisms for retrieving clot material from inside a blood vessel.

Abstract: A device for removing a clot from a vessel can have dual layers where an inner expandable member runs within an outer expandable member. The inner expandable member can be divided into one or more sections, with a proximal section having a clot pinching structure configured to pinch the clot between the pinching structure and an outer catheter. A distal flow channel section of the inner member can be configured to create a flow channel through the clot to restore blood to the downstream vasculature. The struts of the outer expandable member can form closed cells that are not fully circumferential in a proximal portion to allow a clot to pass inside and engage the pinching structure, and fully circumferential in a distal portion to scaffold the vessel for dislodging the clot. A protective element at the distal end of the device can prevent the escape of clot fragments.

Abstract: A stent graft system and method for implanting a stent graft prosthesis having a plurality of suture loops along a flexible wall of a stent graft and at least one ligature that extends through the suture loops. The sutures through which the ligature extends are spaced relative to each other. Tension or stiffness of the ligature aligns the suture loops substantially longitudinally, thereby radially collapsing the stent graft.

Abstract: A specimen retrieval device includes a tubular body defining a longitudinal bore, an articulation shaft disposed within the longitudinal bore of the tubular body, and a specimen receptacle affixed to a support mechanism at the distal portion of the tubular body. In embodiments, the specimen receptacle has two openings which may be used to transfer a tissue specimen from within a patient's body cavity to outside of the patient's body.

Abstract: A clot removal device including an elongated member including a distal end; and an expandable frame including a proximal end, and one or more frame members including one or more pinching cells operable to be slidably and rotatably placed thereon, each of the pinching cells including a collapsed state within a microcatheter and an expanded state distal of the microcatheter configured to tweeze at least a portion of a clot.

Abstract: An obstruction removal device is configured to be inserted through a catheter and at least partially extended into a vasculature from a distal end of the catheter. The obstruction removal device includes: a base member configured to engage one or more guide stops at the distal end of the catheter; a tubular member coupled to the base member and configured to apply a suction force from the catheter to an obstruction to remove the obstruction from the vasculature; and an expandable member surrounding the tubular member. The expandable member is configured to transition from a contracted state to an expanded state after the expandable member is at least partially extended into the vasculature from the distal end of the catheter. The expandable member is further configured to at least partially surround the obstruction as the obstruction is being removed from the vasculature.

Abstract: A method for improving leaflet prolapse and/or valve regurgitation associated with a heart valve involves delivering a spacer device into a ventricle of a heart using a delivery system comprising a catheter, fixing the spacer device to a wall of the ventricle, expanding the spacer device to reposition a papillary muscle disposed in the ventricle away from the wall, the papillary muscle being connected to a leaflet of an atrioventricular heart valve via chordae tendineae, and releasing the spacer device from the catheter.

Abstract: A clot removal device can include a caged portion which can include a distal end; a proximal end; an inner cage having a network of inner struts; and an outer cage having a network of outer struts. The inner cage and the outer cage can include a delivery configuration within a microcatheter and a deployed configuration distal of the microcatheter operable to retrieve at least a portion of the clot. The device can include a distal pinching portion located proximate the distal end of the caged portion, and a proximal pinching portion located proximate the proximal end of the caged portion, each pinching portion can include at least one pinching cell can include a collapsed state and an expanded state distal of the microcatheter operable to tweeze at least a portion of the clot.

Abstract: Surgical constructs and methods of use for tissue repair, in which the surgical constructs include a soft fixation device formed of flexible material, the soft fixation device having a head portion formed of a bunching material for anchoring the soft fixation device in a bone tunnel, and a tail portion for pulling the soft fixation device into the bone tunnel. The surgical constructs include one ore repair flexible strands coupled to the head portion of the soft fixation device for engaging tissue to be repaired.

Abstract: The present invention pertains to a thrombectomy device comprising a cylindrical proximal portion and one or more radiopaque segments. The cylindrical proximal portion forms a stent frame having an outer lattice network of an outer plurality of interconnecting segments. The outer plurality of interconnecting segments are configured to exert a radial force against an inner wall of a blood vessel. The radiopaque segment is formed from a plurality of radiopaque wires extending from the outer stent frame to a central axis of the thrombectomy device along a length of the stent frame. The radiopaque segment converges to a tip along with the central axis.

Abstract: A hemostatic device includes a flexible band allowed to be wrapped around a wrist in which a radial artery and an ulnar artery run, a hook and loop fastener that secures the band in a state of being wrapped around the wrist, an inflatable portion connected to the band and allowed to press a puncture site of the radial artery by being inflated in response to injection of a fluid, and a pressing member disposed at a different position from a position of the inflatable portion in a longitudinal direction of the band and allowed to press the ulnar artery. Further, a length of the pressing member along the longitudinal direction of the band is shorter than a width of the pressing member along a direction orthogonal to the longitudinal direction of the band.

Abstract: The apparatus and method for hemostasis that informs the provider as to whether the appropriate magnitude of pressure is being applied to a puncture site on a patient. A visual pulse indicator can visually convey whether or not there is proper blood flow at the puncture site based on the pulsing motion encountered by the visual pulse indicator on the puncture site. The visual pulse indicator can potentially factor in a variety of different input parameters in displaying information that is useful to providers.

Abstract: A multipurpose handle incorporated into a medical device delivery system. The multipurpose handle includes an elongate handle body, an actuation button, and a locking member. The elongate handle body has a proximal end extending to a distal end, which defines a longitudinal axis. The elongate body further includes a cutout that creates a movement space therein in which the actuation button is disposed and is connected to a medical device. The actuation button is movable within the cutout along the longitudinal axis and rotatable within the cutout. The locking member is connected to the elongate handle body and movable between a locked position and unlocked position. The locking member may be in contact with the actuation button and be configured to restrict the movement of the actuation button along the longitudinal axis when in the locked position.