Abstract: This document describes rotational atherectomy devices and systems for removing or reducing stenotic lesions in blood vessels by rotating an abrasive element within the vessel to partially or completely remove the stenotic lesion material.

Abstract: The present disclosure provides collapsible medical devices that may be introduced via a delivery device into a pre-existing patent foramen ovale or trans-septal puncture hole and left in place to provide both a sealing function on the atrial wall and a septal-access function for additional procedures. The disclosed medical devices include a penetrable and re-sealable gasket material disposed in an open lumen in the medical device. This penetrable and re-sealable material allows catheters or other medical devices to pass therethough for providing additional therapy to an individual. By allowing the access point or portal to be opened by a guidewire or another medical tool, the medical devices as disclosed herein may be particularly suitable for a variety of cardiac procedures including, for example, atrial fibrillation, mitral valve replacement or repair, left atrial appendage closures, and the like.

Abstract: The present teachings provide devices and methods of engaging, capturing, and retrieving emboli. Specifically, one aspect of the present teachings provides a device comprising a generally cylindrical body, with its proximal ends joining to a delivery system and a plurality of cells forming its luminal surface. The cylindrical body is configured to axially rotate as it radially expands. Another aspect of the present teachings provides a device comprising two elongated bodies one disposed within the other. As the device expands radially, both elongated bodies are configured to axially rotate independently.

Abstract: An injection system for an intraocular lens (IOL) utilizes a folding device for the IOL. The folding device comprises a pair of co-acting winglets pivotable between an open position and a closed position, and together defining a hinge axis and a receptacle for the IOL. Each winglet has an outwardly extending, unitary leg portion defining a base plane that includes the hinge axis and a motion limiting protuberance on each said leg portion extending from the base plane. The base planes are situated at an angle relative to one another and the protuberances abut one another when the winglets are in the open position. The base planes merge into a single plane when the winglets are in the closed position.

Abstract: A stent graft system including a component having longitudinally extending outer surface and inner surface, the inner surface defining a lumen having a longitudinal axis, a plurality of stents distributed longitudinally along the component, and a plurality of suture loops, each suture loop attached to the inner outer surface, of the stent graft, a first suture loop spaced laterally and longitudinally relative to an adjacent suture loop when the component is in an expanded configuration, the plurality of suture loops aligned longitudinally along the stent graft when the stent graft is in a radially constricted configuration, at least one ligature having a proximal end and a distal end, the ligature extending through at least some of the plurality of suture loops, whereby tension on the at least one ligature longitudinally aligns the suture loops along the longitudinal axis of the component, thereby at least partially radially constricting the stent graft.

Abstract: Systems and methods can remove material of interest, including blood clots, from a body region, including but not limited to the circulatory system for the treatment of pulmonary embolism, deep vein thrombosis, cerebrovascular embolism, and other vascular occlusions. The capture system can include a tubular body comprising a first end, a second end, and an axial length therebetween, the first end having an opening and a capture guide. The capture system can include one or more tensioners coupled to the capture guide. The tubular body has a first configuration in which the first end and the capture guide are expanded while the second end and a majority of the tubular body remains compressed. The tubular body is transformable to a second configuration by application of tension by the tensioners. The catheter can remove a large volume of clot.

Abstract: A medical device includes a handle with a proximal arm and a distal arm. The proximal arm and the distal arm are pivotable via a joint. The medical device also includes a tube coupled to the distal arm and a drive wire. A distal portion of the drive wire includes an expandable end effector. A portion of the drive wire is positioned within the tube, and a different portion of the drive wire extends proximally of the distal arm and is coupled to the proximal arm.

Abstract: There are provided ophthalmic tweezers capable of easily adjusting the strength of a gripping force depending on use conditions. Ophthalmic tweezers (10) include a tweezers section (20) which has a tubular body (21), a pair of neck portions (22), and a pair of grippers (23) located on the leading end side of the neck portions (22). The tweezers section (20) has a structure in which the grippers (23) are closed by causing the tubular body (21) to slide such that the neck portions (22) are housed in the inner cavity of the tubular body (21). The neck portions (22) each have a first curved or bent portion (22a) having a convex shape on the central axis side of the tubular body (21) and a second curved or bent portion (22b) having a concave shape on the central axis side of the tubular body (21). The first curved or bent portion (22a) is located on the tubular body side, and the second curved or bent portion (22b) is located on the gripper side.

Abstract: In one embodiment, a multi-layer suture fastener that includes a generally disc-shaped body defining a plurality of axially spaced-apart layers. Each layer can include an inner axial surface and an outer axial surface. A suture opening can extend from the inner axial surface to the outer axial surface of each layer. The suture openings can have an open configuration and a closed configuration. One or more lines of suture can be passed through the suture openings when in the open configuration. The suture openings can be placed in the closed configuration. In the closed configuration, the one or more lines of suture can be restricted by radial surfaces of the suture opening from sliding through the suture openings in at least one longitudinal direction of the one or more lines of suture.

Abstract: Surgical constructs and methods of use for tissue repair, in which the surgical constructs include a soft fixation device formed of flexible material, the soft fixation device having a head portion formed of a bunching material for anchoring the soft fixation device in a bone tunnel, and a tail portion for pulling the soft fixation device into the bone tunnel. The surgical constructs include one ore repair flexible strands coupled to the head portion of the soft fixation device for engaging tissue to be repaired.

Abstract: A clot retrieval device for removing occlusive clot from a blood vessel. The device comprises an inner elongate body having a collapsed delivery configuration and an expanded deployed configuration. An outer elongate body is at least partially overlying the inner elongate body. The outer elongate body is expandable to a radial extent which is greater than the radial extent of the inner body in the deployed configuration to define a clot reception space. The outer elongate body has a plurality of clot receiving openings and a plurality of clot engaging regions. The clot engaging regions are adapted, on engagement with clot, to urge clot towards the clot receiving openings and into the reception space between the outer elongate body and the inner elongate body, wherein the radial force profile of the device varies along the length of the device.

Abstract: A system and associated method for manipulating tissues and anatomical or other structures in medical applications for the purpose of treating diseases or disorders or other purposes. In one aspect, the system includes an expandable structure for enhancing engagement with median lobe prostate tissue.

Abstract: An apparatus for anastomosis of tubular structures includes two annular bodies. Each annular body has a first side, a second side, a central axis extending between the first and second sides, an inner wall defining a passageway that is open to the first and second sides for passing a tubular structure therethrough, and a plurality of spikes each extending from a base connected to the second side of the annular body to a pointed free end configured to pierce the tubular structure. The spikes are angled relative to the central axis such that for each of the spikes, the free end is positioned farther from the central axis in a radial direction than the base is to the central axis.

Abstract: A mechanical thrombectomy device includes several clot arrestors mounted on a support wire. The clot arrestors have rings of expandable frame cells. The frame cell rings include an open frame cell ring, having a gap between adjacent frame cells in the ring, and a closed frame cell ring, having no gap between adjacent frame cells. The gap allows clots to enter the clot arrestor for retrieval from a target anatomy. Other embodiments are also described and claimed.

Abstract: A dilation system comprising a plurality of springs axially disposed in an elastic tube.

Abstract: An epilating device for extracting hairs out of a user's skin, including hair-clamping elements that are arranged adjacent to each other and rotatable relative to a housing. A drive system rotates the hair-clamping elements which co-operate in pairs and are moveable relative to each other during rotation. On each side surface facing an adjacent hair-clamping element, there is a hair-clamping section and a hair-catching section. The hair-catching sections of adjacent hair-clamping elements define a funnel area, wherein the hair-catching sections converge towards each other for guiding hairs towards the hair-clamping sections. The hair-clamping sections of adjacent hair-clamping elements are movable relative to each other from an open position, where the hair-clamping sections are at a distance from each other, to a closed position, where the hair-clamping sections are in mutual clamping engagement in a hair-clamping area.

Abstract: A surgical fastener and a related deployment device as well as their methods of use are disclosed. In one embodiment, the deployment device includes one or more surgical fasteners including a head and a distally extending coil body attached to the head. The head includes a through hole with an internal thread. The deployment device also includes a mandrel including a threaded portion located at a distal end of the mandrel. The threaded portion is engaged with the internal thread of the one or more surgical fasteners. A rotator is associated with the one or more surgical fasteners such that the rotator can selectively rotate the one or more surgical fasteners relative to the mandrel to displace the one or more surgical fasteners in a distal direction.

Abstract: Devices and methods are described for occluding the left atrial appendage (LAA) to exclude the LAA from blood flow to prevent blood from clotting within the LAA and subsequently embolizing, particularly in patients with atrial fibrillation. An implant is delivered via transcatheter delivery into the LAA. The implant includes a conformable structure comprising a foam body and internal support. The support includes anchors that penetrate the foam body and anchor the implant to the walls of the LAA. The implant provides compliance such that it conforms to the native configuration of the LAA.

Abstract: A surgical instrument configured to be coupled to an ultrasonic oscillation mechanism for resection of tissue under suction. A tip extends from a shaft and includes teeth formed by slots. Each of the teeth includes a distal end, a distal cutting edge, and a side cutting edge. The distal cutting edge and the side cutting edge are configured to slice the tissue with the tip moving in a first direction of combined longitudinal and torsional vibration and pull the tissue with the tip moving in the second direction opposite the first direction. An intersection of an outer edge, the distal cutting edge, and the side cutting edge defines a sharp cutting point at the distal end. A sloped surface defining the slot maintains coupling of the tip with the tissue with suction during resection of the tissue with the distal cutting edge and the side cutting edge.

Abstract: Described herein are systems, devices, and methods for aspiration and mechanical thrombectomy. In some embodiments, a thrombectomy device for removing a thrombus from a vessel can include a handle assembly, a vacuum source, an aspiration catheter with an expandable distal portion, and a flexible shaft configured to rotate within the aspiration catheter.