Patents Examined by Karen Cochrane Carlson
  • ?1-antitrypsin compositions and methods of treating autoimmune diseases
    Patent number: 10781248
    Abstract: The specification provides compositions comprising chimeric proteins comprising AAT conjugated to an Fc region of an immunoglobulin. Methods for treating autoimmune disease, e.g., diabetes, e.g., Type 1 and Type 2 diabetes, are also provided.
    Type: Grant
    Filed: October 22, 2018
    Date of Patent: September 22, 2020
    Assignee: Beth Israel Deaconess Medical Center, Inc.
    Inventors: Terry B. Strom, Maria Koulmanda
  • Increasing productivity of host cells that functionally express P450 enzymes
    Patent number: 10774314
    Abstract: The present invention relates to the production of chemical species in bacterial host cells. Particularly, the present invention provides for the production of chemical species in Escherichia coli (E. coli) host cells that functionally express engineered P450 enzymes.
    Type: Grant
    Filed: August 19, 2016
    Date of Patent: September 15, 2020
    Assignee: MANUS BIO INC.
    Inventors: Jason Donald, Christopher Pirie, Liwei Li, Huey-Ming Mak, Srishti Tibrewala, Ajikumar Parayil Kumaran
  • Detergent composition comprising subtilase variants
    Patent number: 10760036
    Abstract: The present disclosure relates to detergent compositions comprising subtilase variants exhibiting improved stability and/or improved wash performance in liquid detergent and methods for obtaining such detergent compositions. The variants are suitable for use in e.g. cleaning or detergent compositions, such as laundry detergent compositions and dish wash compositions, including automatic dish wash compositions.
    Type: Grant
    Filed: December 14, 2015
    Date of Patent: September 1, 2020
    Assignee: Henkel AG & Co. KGaA
    Inventors: Timothy O'Connell, Susanne Tondera, Hendrik Hellmuth, Thomas Weber, Rolf Thomas Lenhard, Signe Eskildsen Larsen, Miguel Duarte Guilherme Pereira Toscano, Esben Peter Friis, Astrid Munch, Mikael Bauer, Bena-Marie Lue
  • Molecular rheostat for cofactor balance
    Patent number: 10760103
    Abstract: The disclosure provides a metabolic pathway for producing a metabolite, the metabolic pathway having a co-factor regulatory system for cofactor utilization in the metabolic pathway.
    Type: Grant
    Filed: October 18, 2017
    Date of Patent: September 1, 2020
    Assignee: The Regents of the University of California
    Inventors: James U. Bowie, Tyler P. Korman, Paul H. Opgenorth
  • Protease variants and polynucleotides encoding same
    Patent number: 10752890
    Abstract: The present invention relates to protease variants and methods for obtaining protease variants. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants.
    Type: Grant
    Filed: October 18, 2018
    Date of Patent: August 25, 2020
    Assignee: NOVOZYMES A/S
    Inventors: Frank Winther Rasmussen, Rolf Thomas Lenhard, Miguel Duarte Guilherme Pereira Toscano, Esben Peter Friis, Signe Eskildsen Larsen, Jurgen Carsten Franz Knotzel, Mikael Bauer
  • Alpha-hemolysin variants
    Patent number: 10752948
    Abstract: Described herein are engineered alpha-hemolysin subunits having mutated oligomerization domains for assembling into heptameric nanopores in lipid bilayers.
    Type: Grant
    Filed: January 3, 2019
    Date of Patent: August 25, 2020
    Assignee: Roche Sequencing Solutions, Inc.
    Inventors: Timothy Kellogg Craig, Cynthia Ann Cech, Michael Dorwart, Liv Elisabeth Jensen, Marshall Winston Porter, Christos Tzitzilonis, Alexander Hyun-min Yang
  • Microbial production of succinate derived products
    Patent number: 10752925
    Abstract: Microbes and methods used to convert renewable carbon sources such as glucose, sucrose, biomass hydrolysate, methanol or formate, to succinate-derived products, such as fumarate or malate, which are desirable products having many uses.
    Type: Grant
    Filed: June 21, 2018
    Date of Patent: August 25, 2020
    Assignee: William Marsh Rice University
    Inventors: Ka-Yiu San, George N. Bennett, Irene Martinez
  • Factor IX fusion proteins and methods of making and using same
    Patent number: 10745680
    Abstract: The present invention provides Factor IX (FIX) fusion proteins comprising at least one heterologous moiety, such as an XTEN. The present invention further discloses methods of making and using the FIX fusion proteins.
    Type: Grant
    Filed: August 3, 2016
    Date of Patent: August 18, 2020
    Assignee: Bioverativ Therapeutics Inc.
    Inventors: Zhiqian Liu, Arjan Van Der Flier, David R. Light, Ekta Seth Chhabra, Tongyao Liu, Robert T. Peters, John Kulman, Ayman Ismail
  • Microbial production of steviol glycosides
    Patent number: 10743567
    Abstract: The invention provides methods for making steviol glycosides, including RebM and glycosylation products that are minor products in stevia leaves, and provides enzymes, encoding polynucleotides, and host cells for use in these methods. The invention provides engineered enzymes and engineered host cells for producing steviol glycosylation products, such as RebM, at high purity and/or yield. The invention further provides methods of making products containing steviol glycosides, such as RebM, including food products, beverages, oral care products, sweeteners, and flavoring products.
    Type: Grant
    Filed: January 18, 2019
    Date of Patent: August 18, 2020
    Assignee: MANUS BIO INC.
    Inventors: Ryan Philippe, Ajikumar Parayil Kumaran, Jason Donald, Krishna Patel, Swati Gupta, Ryan Lim, Liwei Li
  • Genetically modified yeasts and fermentation processes using genetically modified yeasts
    Patent number: 10738332
    Abstract: The present invention relates to a genetically engineered yeast capable of manufacturing a fermentation product using sucrose as a fermentation substrate, and fermentation processes using such a yeast. In some embodiments, the fermentation product is ethanol.
    Type: Grant
    Filed: November 22, 2016
    Date of Patent: August 11, 2020
    Assignee: CARGILL, INCORPORATED
    Inventors: Peter Alan Jauert, Genfeng Lu, Gregory M. Poynter, Brian J. Rush
  • Cells having reduced BCAT1
    Patent number: 10738334
    Abstract: The invention relates to a method of cell culture where the cells are modified to reduce the level of synthesis of growth and/or productivity inhibitors by the cell. The invention also relates to a method of cell culture for improving cell growth and productivity, in particular in fed-batch culture of mammalian cells at high cell density. The invention further relates to a method of producing cells with improved cell growth and/or productivity in cell culture and to cells obtained or obtainable by such methods.
    Type: Grant
    Filed: September 22, 2016
    Date of Patent: August 11, 2020
    Assignee: Pfizer Inc.
    Inventors: Gregory Walter Hiller, Jeffrey Joseph Mitchell, Bhanu Chandra Mulukutla, Pamela Mary Pegman
  • Engineered microcompartment protein and related methods and systems of engineering bacterial systems for non-native protein expression and purification
    Patent number: 10738090
    Abstract: Engineered microcompartment proteins, and related engineered microcompartment, vectors, cells compositions, methods and systems configured to provide within a cell one or more proteins non-native to the cell are described, wherein the one or more proteins non-native to the cell are contained in at least one engineered microcompartment within the cell.
    Type: Grant
    Filed: December 13, 2018
    Date of Patent: August 11, 2020
    Assignees: Lawrence Livermore National Security, LLC, The Regents of the University of California
    Inventors: Mimi Cho Yung, Timothy S. Carpenter, Tek Hyung Lee, David Savage
  • Lactaldehyde reductases for the production of 1,2-propanediol
    Patent number: 10731137
    Abstract: The present invention relates to new lactaldehyde reductase (LAR) enzymes useful for the production of 1,2-propanediol and to microorganisms overexpressing said enzymes. The invention also relates to a method for producing 1,2-propanediol by converting lactaldehyde into 1,2-propanediol with said enzymes.
    Type: Grant
    Filed: September 10, 2015
    Date of Patent: August 4, 2020
    Assignee: METABOLIC EXPLORER
    Inventors: Gwénaëlle Corre, Pascale Aliprandi
  • Recombinant microorganism for improved production of fine chemicals
    Patent number: 10731188
    Abstract: The present invention relates to a recombinant nucleic acid molecule, a recombinant microorganism, to a method for producing alanine and to the use of the recombinant nucleic acid molecule or the recombinant microorganism for the fermentative production of alanine.
    Type: Grant
    Filed: December 28, 2018
    Date of Patent: August 4, 2020
    Assignee: BASF SE
    Inventors: Hartwig Schröder, Holger Hartmann, Qingzhao Wang, Shakir Siraj Ratani, Zheyuan Guo, Markus Pompejus
  • Genetically modified yeasts and fermentation processes using genetically modified yeasts
    Patent number: 10731184
    Abstract: The present invention relates to a genetically engineered yeast capable of manufacturing a fermentation product using sucrose as a fermentation substrate, and fermentation processes using such a yeast. The yeast has an exogenous invertase gene and has a deletion or disruption of the PDC activity gene. Accordingly, the yeast is useful for manufacturing fermentation products other than ethanol from fermentation substrates containing sucrose.
    Type: Grant
    Filed: November 22, 2016
    Date of Patent: August 4, 2020
    Assignee: CARGILL, INCORPORATED
    Inventors: Arlene M. Fosmer, Peter Alan Jauert, Gregory M. Poynter, Brian J. Rush
  • Use of P97 as an enzyme delivery system for the delivery of therapeutic lysosomal enzymes
    Patent number: 10716862
    Abstract: The present invention provides for compositions and methods for treating, ameliorating or preventing a lysosomal storage disease by administering to a patient suffering front a lysosomal storage disease a P97 conjugated with an enzyme which is capable of transportation into the lysosomes of cells on either sides of the blood brain barrier.
    Type: Grant
    Filed: February 28, 2017
    Date of Patent: July 21, 2020
    Assignee: BiOasis Advanced Technologies Inc.
    Inventors: Christopher M. Starr, Todd Zankel
  • Multivalent heteromultimer scaffold design and constructs
    Patent number: 10711051
    Abstract: Provided herein are multifunctional heteromer proteins. In specific embodiments is a heteromultimer that comprises: at least two monomeric proteins, wherein each monomeric protein comprises at least one cargo polypeptide, attached to a transporter polypeptide, such that said monomeric proteins associate to form the heteromultimer. These therapeutically novel molecules comprise monomers that function as scaffolds for the conjugation or fusion of therapeutic molecular entities resulting in the creation of bispecific or multivalent molecular species.
    Type: Grant
    Filed: November 5, 2018
    Date of Patent: July 14, 2020
    Assignee: ZYMEWORKS INC.
    Inventors: Surjit Bhimarao Dixit, Igor Edmondo Paolo D'Angelo, David Kai Yuen Poon
  • Methods and compositions for improving glucose metabolism
    Patent number: 10703786
    Abstract: The present invention relates to compositions, methods and kits for promoting glucose clearance in an individual. In particular, the compositions, methods and kits are particularly useful, but not limited to, the treatment of insulin resistance or type 2 diabetes. The invention provides a method of promoting blood glucose clearance in an individual, the method comprising administering SMOC1 to the individual. Preferably, the individual has an impaired ability to clear glucose from the blood. Typically, the individual displays a level of insulin resistance.
    Type: Grant
    Filed: October 28, 2016
    Date of Patent: July 7, 2020
    Assignee: THE UNIVERSITY OF MELBOURNE
    Inventors: Matthew Watt, Ruth Meex
  • CAS9 proteins including ligand-dependent inteins
    Patent number: 10704062
    Abstract: Some aspects of this disclosure provide compositions, methods, systems, and kits for controlling the activity of RNA-programmable endonucleases, such as Cas9, or for controlling the activity of proteins comprising a Cas9 variant fused to a functional effector domain, such as a nuclease, nickase, recombinase, deaminase, transcriptional activator, transcriptional repressor, or epigenetic modifying domain. For example, the inventive proteins provided comprise a ligand-dependent intein, the presence of which inhibits one or more activities of the protein (e.g., gRNA binding, enzymatic activity, target DNA binding). The binding of a ligand to the intein results in self-excision of the intein, restoring the activity of the protein.
    Type: Grant
    Filed: September 14, 2018
    Date of Patent: July 7, 2020
    Assignee: President and Fellows of Harvard College
    Inventors: David R. Liu, Kevin Davis
  • Method and system for the production of recombinant proteins by cells
    Patent number: 10696997
    Abstract: A cassette sequence for the transformation of a host cell includes at least: a first nucleotide sequence encoding a peptide or protein of interest to be produced by the host cell. The first sequence is linked to a second nucleotide sequence providing resistance to a toxin or encoding an antitoxin peptide to the toxin. The nucleotide sequences are organized in such a way that production of the peptide encoded by the second nucleotide sequence(s) is translationally coupled to production of the peptide encoded by the first nucleotide sequence.
    Type: Grant
    Filed: July 6, 2015
    Date of Patent: June 30, 2020
    Assignee: UNIVERSITE LIBRE DE BRUXELLES
    Inventors: Laurence Van Melderen, Baptiste J. S. Dumont, Thibaut Hallaert, Gilles Vanwalleghem, Philippe Goffin