Abstract: The present invention relates to methods for restoring the function of a mutated dysferlin comprising the step of preventing splicing of one or more exons which encode amino acid sequences that cause said dysferlin dysfunction. Particularly, the splicing of exon 32 is prevented. The present invention also relates to a method for treating a dysferlinopathy in a patient in need thereof, comprising the step of administering to said patient antisense oligonucleotides complementary to nucleic acid sequences that are necessary for correct splicing of one or more exons which encode amino acid sequences that cause said dysfunction. Particularly, the splicing of exon 32 is prevented.
Type:
Grant
Filed:
October 18, 2010
Date of Patent:
November 19, 2013
Assignees:
Institut National de la Sante et de la Recherche Medicale (INSERM), Universite de la Mediterranee—Aix Marseille II
Inventors:
Nicolas Levy, Martin Krahn, Marc Bartoli, Luis Garcia
Abstract: A pharmaceutical and a method for preventing and treating VHSV infection in fish with a VHSV-binding aptamer is provided. Also provided are a method for removing VHSV from an area of water and a method and kit for detecting VHSV with high sensitivity using a VHSV-binding aptamer.
Abstract: Long non-coding RNAs (lncRNAs) and methods of using them diagnostically and therapeutically for treatment of cancer, stem cell therapy, or regenerative medicine are disclosed. In particular, the invention relates to lncRNAs that play roles in regulation of genes involved in cell proliferation, differentiation, and apoptosis. Such lncRNAs can be used as biomarkers to monitor cell proliferation and differentiation during cancer progression or tissue regeneration. One of the identified lncRNAs, referred to as PANDA (a P21-Associated NcRNA, DNA damage Activated), inhibits the expression of apoptotic genes normally activated by the transcription factor NF-YA. Inhibitors of PANDA sensitize cancerous cells to chemotherapy and can be used in combination with chemotherapeutic agents for treatment of cancer.
Type:
Grant
Filed:
May 11, 2012
Date of Patent:
October 15, 2013
Assignee:
The Board of Trustees of the Leland Stanford Junior University
Inventors:
Howard Y. Chang, David J. Wong, Tiffany Hung
Abstract: The disclosure is directed to methods of treating hematologic malignancies. More particularly, the disclosure is directed to methods of treating hematologic malignancies using Rho kinase (ROCK) inhibitors and myosin light chain-specific inhibitory RNA molecules. The disclosure is further directed to methods of identifying drug candidates for inhibiting ROCK in hematologic malignancies.
Type:
Grant
Filed:
August 15, 2012
Date of Patent:
August 27, 2013
Assignee:
Indiana University Research & Technology Corporation
Abstract: TLR3 agonist compounds, compositions and methods are provided for stimulating the activity of TLR3. The compositions comprise oligonucleotide-based compounds that bind to and activate TLR3. The compositions may also comprise oligonucleotide-based compounds that bind to and activate TLR3 in combination with other therapeutic and/or prophylactic compounds and/or compositions. Methods of using these compounds and compositions for stimulation of TLR3 activity and for prevention or treatment of diseases wherein modulation of TLR3 activity would be beneficial are provided.
Type:
Grant
Filed:
June 24, 2011
Date of Patent:
July 23, 2013
Assignee:
Idera Pharmaceuticals, Inc.
Inventors:
Ekambar Kandimalla, Tao Lan, Victoria Jane Philbin, Sudhir Agrawal
Abstract: The preset invention relates to a biomarker for identifying the subgroup of early-stage lung adenocarcinoma patients in early-stage non-small cell lung cancer (NSCLC), which is T-lymphokine-activated killer cell-originated protein kinase (TOPK), and a therapeutic target for lung cancer.