Abstract: The present disclosure generally relates to a surgical instrument. In some embodiments, The surgical instrument, comprising: a distal structural body comprising a first distal structural segment and a second distal structural segment in serial arrangement; a proximal structural body comprising a first proximal structural segment and a second proximal structural segment in nested arrangement; and the first proximal structural segment and the second proximal structural segment are operable to turn the first distal structural segment and the second distal structural segment, respectively.

Abstract: A delivery system for implanting a medical device comprises a delivery catheter having an inner lumen, a mandrel received in the inner lumen of the delivery catheter and movable with respect to the delivery catheter, and an adapter piece connected to the mandrel, wherein the adapter piece, by moving the mandrel with respect to the delivery catheter, is displaceable between a first position in which the adapter piece is received within the inner lumen of the delivery catheter and a second position in which the adapter piece is arranged outside of the inner lumen of the delivery catheter. A tethering member comprises a positive-locking member adjoining a tether portion, wherein the positive-locking member in a connection state is received on the adapter piece, but is releasable from the adapter piece by displacing the adapter piece from the first position towards the second position.

Abstract: The embodiments described herein can be used in a variety of grasping, cutting, and manipulating operations. In some embodiments, an apparatus includes a shaft, a tool member, and a flexure. The shaft has a distal end portion and a proximal end portion, and defines a longitudinal axis. The distal end portion includes a ground portion. The tool member has an engagement portion and an actuation portion. The engagement portion is disposed distally from the actuation portion, and can exert an engagement force on a target structure. The actuation portion receives an actuation force. The flexure has a first end portion coupled to the ground portion of the shaft, and a second end portion coupled to the tool member. The flexure is configured to deform elastically when the actuation force is exerted on the actuation portion of the tool member such that the tool member rotates relative to the shaft.

Abstract: The present disclosure describes tissue gripping devices, systems, and methods for gripping mitral valve tissue during treatment of a mitral valve and while a tissue fixation device is implanted in the mitral valve. The tissue gripping device includes a flexible member and one or more tissue gripping members coupled to one or more arms of the flexible member. The flexible member is formed from a shape-memory material, such as nitinol, and the tissue gripping member(s) are formed from a material that is more rigid than the shape-memory material. The tissue gripping member(s) are attached to the flexible member by threading or looping suture lines around and/or through the tissue gripping member(s) and the flexible member and/or by applying a cover material to the tissue gripping device to hold the tissue gripping member(s) against the flexible member.

Abstract: A method for removing a stone from a patient comprising the steps of: providing a suction evacuation assembly which includes a sheath and one or more side arms; inserting and positioning a distal end of the sheath into a lumen or cavity of a patient's body containing a stones; connecting a tube to one of the side arms and to a collection bottle; connecting another tube to the collection bottle and a negative pressure system; visualizing the stone or foreign body using a scope inserted through the assembly; activating the negative pressure system in order to remove the stone from the cavity if the diameter of the stone is narrower than an inside diameter of the sheath and the side arm, or performing a lithotripsy on the stone to create fragments with a decreased diameter which allow the passage through the assembly; and collecting the stone in the collection bottle.

Abstract: Occlusive implants are provided with various embodiments of active and/or passive release structures. Systems for delivering the occlusive implants as well as methods for making and delivering the implants are also provided.

Abstract: A minimally invasive blood clot capturing invention made of nitinol. The nitinol is shaped into a plurality of fingers to form a frame for a basket and funnel to capture and remove blood clots. The basket and funnel being delivered to the blood clot by a catheter. The basket and funnel are capable of being collapsed within a catheter capable of being deployed into a blood vessel, and capable of being retracted into the catheter for removal from the blood vessel.

Abstract: A system and method comprising an anchor assembly including an anchor and a locking element, a tensionable fixation member (e.g., surgical suture, tape, etc.), and a release member, wherein the anchor further comprises a first end, second end and anchor body. The anchor is configured for implantation into bone. One end of a tensionable fixation member is configured for attachment to a tissue to assist with fixation of the soft tissue. Once the anchor has been seated in bone, the second end of the tensionable fixation member is pulled through a “one-way only” passage in the body of the anchor.

Abstract: A surgical instrument includes an ultrasonic transducer, an ultrasonic transmission waveguide extending from the ultrasonic transducer, and an ultrasonic blade acoustically coupled to the ultrasonic transmission waveguide. The ultrasonic blade includes a base and a curved body extending distally from the base. The curved body includes a tissue-treating surface extending on a first side of the curved body and a curved edge extending on a second side of the curved body opposite the first side. The curved edge has a proximal end and a distal end, wherein the proximal end is offset from the distal end in a first direction, wherein the proximal end is offset from the distal end in a second direction, and wherein the first direction is perpendicular to the second direction.

Abstract: A barbed rod device is provided for tissue closure and approximation. The device includes two or more subassemblies. Each subassembly includes a receiver having a central opening and centerline axis, a plurality of barbs extending radially outward from the receiver, and a linking rod extending from the receiver along the centerline axis of the receiver. The linking rod includes a locking end opposite the receiver. The locking end of a first subassembly is configured to engage the receiver of a second subassembly.

Abstract: Abdominal approximation devices and methods are described where one variation of the tissue securement assembly may generally include a fixation member having a length, a thickness control securement member which is adjustably securable along the length, and a frame which is adjustably securable to the thickness control securement member. The frame may have a relaxed configuration and a biasing configuration which imparts a biasing force against the thickness control securement member when in the biasing configuration such that the biasing force is applied at a distance from tissue to be approximated via the fixation member.

Abstract: A system for performing angioplasty and a method of utilizing same are provided. The system includes a balloon mounted on a catheter shaft and an expandable constraining structure mounted over the balloon. The expandable constraining structure includes a plurality of axial struts crossing a plurality of radially-expandable rings being for constraining said balloon such that isolated balloon regions protrude through openings in said constraining structure when the balloon is inflated.

Abstract: Soft tissue grafts, packaged soft tissue grafts, and methods of making and using soft tissue grafts are disclosed. One soft tissue graft includes processed tissue material having first and second opposed surfaces. The first and second opposed surfaces are bounded by first and second edges. The first edge has a concave shape that curves toward the second edge. The second edge has a convex shape that curves away from the first edge. The first surface comprises a plurality of apertures. At least one of the apertures is formed from a multi-directional separation in the first surface. One method of making a soft tissue graft includes positioning a cutting die on a surface of tissue material, pressing the cutting die into the tissue material to cut the tissue material, and processing the cut tissue material to create processed tissue material.

Abstract: A device for loading a leadless pacemaker onto a catheter-based delivery system includes a distal portion and a proximal portion. The distal portion includes a retention feature configured to receive the leadless pacemaker. The proximal portion is proximal the distal portion and includes a funneling structure opening toward the retention feature. The distal and proximal portions of the device are configured such that, when a distal end of the catheter-based delivery system is brought towards the proximal portion of the loading device and the leadless pacemaker is retained by the retention feature, the funneling structure guides features of the distal end of the catheter-based delivery system through an opening in an attachment feature located at a proximal end of the leadless pacemaker.

Abstract: An apparatus for treating an aneurysm in a blood vessel includes an occlusion element disposed on a wire, the occlusion element including a cover for covering a neck of an aneurysm and an inner anchoring member. The cover is configured to expand from a compressed configuration in a tube to an expanded configuration when advanced out of a distal end of the tube to cover the neck of the aneurysm. The cover includes a sphere of mesh material formed into a hemisphere including two layers of mesh that is formed by folding a top portion of the sphere into a bottom portion of the sphere. The inner anchoring member is coupled to and extends from the second surface of the cover and is configured to contact an interior surface of the aneurysm. The inner anchoring member may be a cylindrical stem extending from a central portion of the cover.

Abstract: The present disclosure pertains to medical devices. More particularly, the present disclosure pertains to devices, systems, and methods for securing tissue, such as a tissue defect or wound resulting from an endoscopic procedure, e.g., an endoscopic mucosal resection or submucosal dissection procedure. In one example, a device for securing tissue may include a loop portion configured to be disposed about a distal end of a delivery device in a delivery configuration and configured to be secured about the tissue in a deployed configuration. A locking member may be disposed on the loop portion. A tether portion having a proximal end extendable proximally within the delivery device and a distal portion extending from the loop portion slidably through the locking member.

Abstract: An implantable prosthesis and a method of attaching the prosthesis to a tissue structure disclosed. The prosthesis includes a body having a first side arranged to face the tissue structure having a defect and second side opposite the first side. One or more adhesive-filled pods are disposed on the first side of the body and selectively openable to supply an adhesive in between the tissue structure and the first side of the prosthesis body after the prosthesis body is positioned relative to the defect. The pods may be pierced, punctured, broken, and/or ruptured to supply the adhesive. A deployment device having a piercer may be used to puncture the pods.

Abstract: A delivery system includes a delivery catheter with a capsule configured to carry a prosthesis and a steering catheter for steering the delivery catheter. The delivery catheter can be advanced through a patient's vasculature to a target treatment area. The capsule can be opened and the prosthesis can be deployed into the target treatment area. Additionally, a method for delivering a prosthesis to a target treatment area includes advancing a delivery catheter through a patient's vasculature to the target treatment area, steering the delivery catheter toward the target treatment area, opening a capsule on the delivery catheter, and deploying the prosthesis into the target treatment area.

Abstract: A device set designed for PCNL surgery includes a puncture needle, a guidewire, a dilator, a balloon catheter, a sheath, and a drainage catheter which are all placed in a single package. A tip length of the dilator is substantially the same as a tip length of the balloon catheter. The device set may include a puncture needle, a guidewire, a plurality of dilators having different sizes, a sheath, and a drainage catheter, which are all placed in a single package, wherein all the dilators have substantially the same tip length.

Abstract: Wound closure devices and methods of using the wound closure devices are disclosed. The wound closure device comprises two clips. Each clip comprises a wedge-shaped body, a tab extending from a tip of the wedge-shaped body, an anchor extending from a base of the wedge-shaped body, and a locking mechanism positioned within the wedge-shaped body.