Patents Examined by Keith MacMillan
  • Modified dispersant compositions
    Patent number: 5505868
    Abstract: An oil soluble dispersant composition formed by reacting a basic nitrogen-containing ashless dispersant (i) with at least one dibasic acylating agent, (ii) with at least one phosphorus compound, and (iii) with at least one boron compound, said reactions (i), (ii) and (iii) being conducted concurrently or sequentially in any order such that the initial ashless dispersant is chemically modified via acylation in (i), by phosphorylation in (ii), and by boronation in (iii).
    Type: Grant
    Filed: October 6, 1992
    Date of Patent: April 9, 1996
    Assignee: Ethyl Petroleum Additives Limited
    Inventors: Helen T. Ryan, Roger Scattergood, Mark Rees
  • Biocidal compositions for industrial materials
    Patent number: 5504096
    Abstract: Disclosed herein is a method for preventing deterioration of an industrial material by using an azole derivative represented by the following formula ##STR1## wherein X means a halogen atom or a C.sub.1 -C.sub.5 alkyl, haloalkyl, phenyl, cyano or nitro group, n stands for 0 or an integer of 1-5, A denotes a nitrogen atom or CH, R.sub.1 and R.sub.2 mean individually a hydrogen atom or a C.sub.1 -C.sub.5 alkyl group, R.sub.3 denotes a hydrogen atom or a C.sub.1 -C.sub.3 alkyl group, and when n is an integer of 2-5, Xs may be the same or different. A biocidal composition for the method is also disclosed.
    Type: Grant
    Filed: October 29, 1993
    Date of Patent: April 2, 1996
    Assignee: Kureha Kagaku Kogyo K.K.
    Inventors: Masato Arahira, Toshihide Saishoji, Katsuhisa Ohsugi, Satoru Kumazawa
  • Use of 2,3 alkylcarbonyloxybenzoic acid in treating adult respiratory distress syndrome
    Patent number: 5504111
    Abstract: This invention relates to methods for treating Adult Respiratory Distress Syndrome (ARDS) which involves the administration of 2,3-alkylcarbonyloxybenzoic acid and salts thereof wherein the alkyl group has 2-18 carbon atoms.
    Type: Grant
    Filed: December 30, 1994
    Date of Patent: April 2, 1996
    Assignee: Medichem Research, Inc.
    Inventors: Michael T. Flavin, Deanna J. Nelson, Julian F. Borgia, deceased, Gary Jesmok
  • Perfluoroalkyl terminated urethane lubricants
    Patent number: 5502225
    Abstract: This invention relates to perfluoroalkyl group terminated urethanes, thiourethanes and ureas of the general formula(R--X--CONH).sub.m Awhere m is 1, 2 or 3, R is R.sub.f -E and optionally R.sub.1 with the proviso that at least one R is R.sub.f -E, R.sub.f is a perfluoroalkyl group, R.sub.1 is a hydrocarbon group, E is a divalent linking group, X is --O--, --S--, --NR.sub.2 -- and R.sub.2 is H or lower alkyl and A is R.sub.f E or R.sub.1 if m is 1 and a divalent or trivalent linking group if m is 2 or 3 respectively.Compounds of this general formula are useful as solid lubricants or as additives for waxes and resins providing lubricating properties.
    Type: Grant
    Filed: November 9, 1992
    Date of Patent: March 26, 1996
    Assignee: Dynax Corporation
    Inventors: Eduard K. Kleiner, Athanasios Karydas
  • Methods and compositions for treating urinary incontinence and other disorders using optically pure R-terodiline and hydroxylated derivatives thereof
    Patent number: 5492933
    Abstract: Methods and compositions are disclosed utilizing the optically pure R-isomers of terodiline or of the hydroxylated derivatives of terodiline, These compounds are potent drugs for the treatment of urinary incontinence, obstructive pulmonary disease and such other conditions as are related to the compounds' activity as anticholinergic agents.
    Type: Grant
    Filed: October 8, 1993
    Date of Patent: February 20, 1996
    Assignee: Sepracor, Inc.
    Inventors: Nancy M. Gray, James W. Young
  • Catechol derivatives, their physiologically acceptable salts, esters and use
    Patent number: 5489614
    Abstract: Known and new catechol derivates may be used as medicinal antioxidants in the prevention or treatment of tissue damage induced by lipid peroxidation. The conditions and diseases to be treated are for example heart disease, rheumatoid arthritis, cancer, inflammatory disease, a rejection reaction in organ transplants, ischemia, cancer and aging.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: February 6, 1996
    Assignee: Orion-yhtyma Oy
    Inventors: Tapio J. Korkolainen, Erkki A. O. Nissinen, Reijo J. Backstrom, Aino K. Pippuri
  • Crystals of N-(trans-4-isopropylcyclohexycarbonyl)-D-phenylalanine and methods for preparing them
    Patent number: 5488150
    Abstract: Stable crystals of N-(trans-4-isopropylcyclohexylcarbonyl)-D-phenylalanine may be produced by treating this compound with a solvent at a temperature of at least 10.degree. C. and forming crystals in the solvent at a temperature of at least 10.degree. C. For example, crystals may be formed by crystallization out of solution, or may be formed from solid particles of the compound suspended in a solvent. Crystals formed in this way have different melting point, infra red spectrum and X-ray diffraction patterns from previously known forms of the compound and have enhanced processability, eg. stability to grinding.
    Type: Grant
    Filed: December 14, 1993
    Date of Patent: January 30, 1996
    Assignee: Ajinomoto Co., Inc.
    Inventors: Michito Sumikawa, Yoshihito Koguchi, Takao Ohgane, Yasuo Irie, Satoji Takahashi
  • Method for treatment of acute renal failure
    Patent number: 5486519
    Abstract: A method is disclosed for treatment of acute renal failure which comprises administering to a warm-blooded mammal manifesting acute renal failure a small but effective amount of zaprinast sufficient to effect acceleration of recovery from said acute renal failure.
    Type: Grant
    Filed: August 22, 1994
    Date of Patent: January 23, 1996
    Inventor: James E. Greenwald
  • Method for treating endometriosis
    Patent number: 5482958
    Abstract: The present invention provides novel methods of lowering serum cholesterol and inhibiting smoother muscle cell proliferation, particularly restenosis, in humans, and inhibiting uterine fibroid disease and endometriosis in women comprising administering to a human/woman in need of treatment an effective amount of a compound of formula I ##STR1## wherein R is C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkoxy, halo, or trifluoromethyl;R.sup.1 and R.sup.2 each are the same or different C.sub.1 -C.sub.6 alkyl group;n is an integer from 2 to 6; andR.sup.3 and R.sup.4 each are independently C.sub.1 -C.sub.4 alkyl, orcombine to form a substituent selected from the group consisting of pyrrolidino, morpholino, piperidino, piperazino, 4-(C.sub.1 -C.sub.6 alkyl)piperazino, and 4-phenyl-piperazino;or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: April 10, 1995
    Date of Patent: January 9, 1996
    Assignee: Eli Lilly and Company
    Inventors: Henry U. Bryant, Jeffrey A. Dodge
  • Method for the treatment of uterine fibroid desease
    Patent number: 5472977
    Abstract: The present invention provides novel methods of lowering serum cholesterol and inhibiting smoother muscle cell proliferation, particularly restenosis, in humans, and inhibiting uterine fibroid disease and endometriosis in women comprising administering to a human/woman in need of treatment an effective amount of a compound of formula I ##STR1## wherein R is C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkoxy, halo, or trifluoromethyl;R.sup.1 and R.sup.2 each are the same or different C.sub.1 -C.sub.6 alkyl group;n is an integer from 2 to 6; andR.sup.3 and R.sup.4 each are independently C.sub.1 -C.sub.4 alkyl, or combine to form a substituent selected from the group consisting of pyrrolidino, morpholino, piperidino, piperazino, 4-(C.sub.1 -C.sub.6 alkyl)piperazino, and 4-phenyl-piperazino; or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: April 10, 1995
    Date of Patent: December 5, 1995
    Assignee: Eli Lilly and Company
    Inventors: Henry U. Bryant, Jeffrey A. Dodge
  • Treatment of non-insulin-dependent diabetes
    Patent number: 5470879
    Abstract: Antidiabetic composition, characterized in that it contains as active substance, in the free or combined state, at least one mono- or polyhydroxylated amino acid and/or its lactone forms and its amidated derivatives.
    Type: Grant
    Filed: December 23, 1994
    Date of Patent: November 28, 1995
    Assignee: Laboratories Monal
    Inventors: Yves Sauvaire, Gerard Ribes
  • Apoptosis regulating composition
    Patent number: 5464833
    Abstract: Apoptosis regulating compositions each comprising a member selected from a series of carbostyril derivatives and salts thereof, inclusive of carbostyril derivatives of general formula (1) ##STR1## and salts thereof, as an active ingredient are provided. The apoptosis regulating compositions of the invention are of use as anticancer agents, antiretrovirus agents, therapeutic agents for autoimmune diseases, therapeutic agents for thrombocytopenia, therapeutic agents for Alzheimer's disease, therapeutic agents for diseases of the liver, and cancer metastasis inhibitors, among others.
    Type: Grant
    Filed: April 19, 1994
    Date of Patent: November 7, 1995
    Assignee: Otsuka Pharmaceutical Co., Ltd.
    Inventors: Satoru Nakai, Koutoku Aihara, Hideo Tanaka, Hitomi Iba, Kazuyoshi Kawai, Hiroyuki Ichikawa, Seiji Akamatsu, Fumio Saito, Michiaki Tominaga, Masakazu Adachi
  • Crystals of N- (trans-4-isopropylcyclohexlycarbonyl)-D-phenylalanine and methods for preparing them
    Patent number: 5463116
    Abstract: Stable crystals of N-(trans-4-isopropylcyclohexylcarbonyl)-D-phenylalanine may be produced by treating this compound with a solvent at a temperature of at least 10.degree. C. and forming crystals in the solvent at a temperature of at least 10.degree. C. For example, crystals may be formed by crystallization out of solution, or may be formed from solid particles of the compound suspended in a solvent. Crystals formed in this way have different melting point, infra red spectrum and X-ray diffraction patterns from previously known forms of the compound and have enhanced processability, e.g., stability to grinding.
    Type: Grant
    Filed: February 2, 1994
    Date of Patent: October 31, 1995
    Assignee: Ajinomoto Co., Inc.
    Inventors: Michito Sumikawa, Yoshihito Koguchi, Takao Ohgane, Yasuo Irie, Satoji Takahashi
  • Method of inhibiting side effects of solvents containing ricinoleic acid or castor oil or derivatives thereof employing a thromboxane A.sub.2 receptor antagonist and pharmaceutical compositions containing such solvents
    Patent number: 5462726
    Abstract: A method is provided for inhibiting or preventing toxicity and other unwanted effects (a) caused by solvents for pharmaceuticals which solvents contain castor oil or ricinoleic acid or derivatives thereof, such as Cremophor, or (b) caused by a drug, such as cyclosporine A, dissolved or suspended in solvents such as ricinoleic acid or castor oil or derivative thereof, employing a thromboxane A.sub.2 receptor antagonist. Solvent compositions containing ricinoleic acid or castor oil or derivatives thereof and a thromboxane A.sub.2 receptor antagonist, and pharmaceutical compositions including a drug, solvent containing ricinoleic acid or castor oil or derivative thereof, and a thromboxane A.sub.2 receptor antagonist are also provided.
    Type: Grant
    Filed: December 17, 1993
    Date of Patent: October 31, 1995
    Assignee: Bristol-Myers Squibb Company
    Inventor: Nicholas J. Lodge
  • Method and composition for improving the weight gain of poultry
    Patent number: 5459162
    Abstract: There is disclosed an improved composition and method for improving the weight gain of poultry. The improved method comprises administering orally to poultry an effective amount of copper citrate. The improved composition comprises a feed for the poultry and an effective amount of copper citrate.
    Type: Grant
    Filed: August 17, 1994
    Date of Patent: October 17, 1995
    Assignee: Griffin Corporation
    Inventor: Gary B. Saxton
  • Dental compositions with zinc and bicarbonate salts
    Patent number: 5456902
    Abstract: A dental product is provided in a dual-compartment dispenser that includes a first and second composition in respective compartments thereof. The first composition includes a zinc salt while the second composition includes a bicarbonate salt. Preferably the first composition also contains a peroxygen compound or a C.sub.2 -C.sub.20 carboxylic acid. The zinc salt in combination with the bicarbonate salt achieves an enhanced antitartar effect.
    Type: Grant
    Filed: September 2, 1994
    Date of Patent: October 10, 1995
    Assignee: Chesebrough-Pond's USA Co., Division of Conopco, Inc.
    Inventors: David R. Williams, Christine W. Ryles, Stephen R. Barrow
  • Apioid analgesic without respiratory depression
    Patent number: 5457110
    Abstract: A biologically active preparation for human or veterinary use for the selective blockade of opioid binding sites of the brain responsible for respiratory depression containing in a biologically active quantity the codeinone derivative of general formula (I) or its saltR.sup.1 means amino-, hydroxyl-, --NH-phenyl or --NH--CO--NH.sub.2 groups,R.sup.2 means a hydrogen atom or a hydroxyl group.The invention also covers a process for selective blocking the opioid binding sites of the brain responsible for respiratory depression by administering to a patient in need of an analgetic a preparation containing a codeinone derivative of general formula (I) or its salt preferably three times per day in doses of 2.5-5 mg.
    Type: Grant
    Filed: May 19, 1994
    Date of Patent: October 10, 1995
    Assignee: Alkaloida Chemical Company, Ltd.
    Inventors: Anna Borsodi, Zsuzsa Furst, Sandor Hosztafi, Schafferne E. Varga, Beata Buzas, Tamas Friedmann, Sandor Benyhe, Maria Szucs
  • Method and composition for the treatment of apathy-amotivation syndrome
    Patent number: 5453428
    Abstract: In accordance with the present invention, neuropsychiatric symptoms of apathy-amotivation syndrome and particularly those symptoms in: Alzheimer's disease, multiple sclerosis, Huntington's chorea, frontal lobe lesions, and AIDS dementia can be ameliorated by treating a patient with a histamine H.sub.2 -antagonist that passes the blood-brain barrier. Suitable H.sub.2 -antagonists include famotidine and ranitidine. The H.sub.2 -antagonists may be co-administered with other compounds which are known to be useful in the treatment of the above neuropsychiatric conditions, and in one aspect of the invention can be formulated with such other compounds into a therapeutic composition.
    Type: Grant
    Filed: September 7, 1993
    Date of Patent: September 26, 1995
    Assignee: The Mount Sinai School of Medicine of the City of New York
    Inventor: Ram Kaminski
  • Methods for lowering serum cholesterol and inhibiting smooth muscle cell proliferation, restenosis, endometriosis, and uterine fibroid disease
    Patent number: 5453442
    Abstract: The present invention provides novel methods of lowering serum cholesterol and inhibiting smoother muscle cell proliferation, particularly restenosis, in humans, and inhibiting uterine fibroid disease and endometriosis in women comprising administering to a human/woman in need of treatment an effective amount of a compound of formula I ##STR1## wherein R is C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkoxy, halo, or trifluoromethyl;R.sup.1 and R.sup.2 each are the same or different C.sub.1 -C.sub.6 alkyl group;n is an integer from 2 to 6; andR.sup.3 and R.sup.4 each are independently C.sub.1 -C.sub.4 alkyl, or combine to form a substituent selected from the group consisting of pyrrolidino, morpholino, piperidino, piperazino, 4-(C.sub.1 -C.sub.6 alkyl)piperazino, and 4-phenyl-piperazino;or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: October 28, 1994
    Date of Patent: September 26, 1995
    Assignee: Eli Lilly and Company
    Inventors: Henry U. Bryant, Jeffrey A. Dodge
  • Phenyl butyl nitrone compositions and methods for treatment of oxidative tissue damage
    Patent number: RE35112
    Abstract: Compositions for treating tissue damage from ischemia contain PBN, or active derivatives thereof, which are active during ischemia in preventing ATP depletion of the cells which predisposes them to subsequent injury during reperfusion, and which are active during reperfusion as oxygen radical scavengers, in a suitable pharmaceutical carrier for systemic or local administration, especially to the CNS, spinal column and eyes. Based on animal studies, the dosage for treating damage due to stroke is in the range of 10 to 300 mg/kg. Similar dosages are useful in treating damage resulting from free radical generation during inflammation, either as a product of infection or exposure to inflammatory agents or abusive agents, including drugs and alcohol.
    Type: Grant
    Filed: June 18, 1993
    Date of Patent: December 5, 1995
    Assignees: Oklahoma Medical Research Foundation, University of Kentucky Research Foundation
    Inventors: John M. Carney, Robert A. Floyd