Abstract: Carboxylic acid derivatives of the formula: ##STR1## are provided, which are useful for treatment of androgen dependent diseases.

Abstract: An antidiabetic agent containing a spherical carbon (e.g., an activated spherical carbon or a spherical carbonaceous adsorbent) as an active ingredient. The antidiabetic agent can be used for treating diabetes, preferably by using the agent internally as an oral medicine and will not be painful to a patient at an injection site, unlike conventional injections of insulin. Moreover, unlike conventional antidiabetic agents, the antidiabetic agent of the present invention will not induce hypoglycemia.

Abstract: Compounds of the formula: ##STR1## useful as regulators of nitric oxide synthase that indirectly modulate cyclic guanosine monophosphate (cGMP), pharmaceutical compositions thereof, for treating disorders of vascular smooth muscles, macrophages, neurons, platelets, bronchial smooth muscles, optic muscles and gastrointestinal smooth muscles, sickle cell anemia and diabetes.

Abstract: There are provided important pyrroline and glycine intermediates, methods for the preparation of said intermediates and the use thereof in the manufacture of arylpyrrole insecticidal agents.

Abstract: Novel polycyanate compositions containing one or more mesogenic moieties as lateral substituents are disclosed which provide improved processability relative to polycyanates containing one or more mesogenic moieties in the main chain of the molecule. Molecular level ordering of the resulting thermosets is maintained much similar to that found thermosets of polycyanates which have one or more mesogenic moieties in the main chain.

Abstract: Disclosed is a method for extracting an amino acid ester from a hydrous solution which comprises adding thereto a water-insoluble organic solvent and then an amount of a base effective to liberate only a portion of the amino acid ester in free base form, and transferring the thus liberated amino acid ester in the free base form into the organic layer, and repeating the neutralization-extraction steps until all of the amino acid ester has been extracted.

Abstract: A dental product is provided in a dual-compartment dispenser that includes a first and second composition in respective compartments thereof. The first composition includes a zinc salt while the second composition includes a bicarbonate salt. Preferably the first composition also contains a peroxygen compound or a C.sub.2 -C.sub.20 carboxylic acid. The zinc salt in combination with the bicarbonate salt achieves an enhanced antitartar effect.

Abstract: The fiber-reactive formazan dyes of the formula ##STR1## in which n is the number 0, 1, 2 or 3, (R).sub.n is 0 to 3 substituents, independent of one another, from the group comprising halogen, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, C.sub.2-4 alkanoylamino, hydroxyl, carboxyl and sulfo and Z is a radical of the formula ##STR2## in which R.sub.1 is C.sub.1-4 alkyl, R.sub.2 is C.sub.1-4 alkyl, which is substituted by hydroxyl, halogen, cyano, carboxyl, C.sub.1-4 alkoxy, hydroxy-C.sub.2-4 alkoxy, HO--(CH.sub.2 CH.sub.2 --O).sub.2-4 --, sulfo or sulfato, R.sub.3 is C.sub.1-4 alkyl, which can be substituted by hydroxyl, halogen, cyano, carboxyl, C.sub.1-4 alkoxy, hydroxy-C.sub.2-4 alkoxy, sulfo or sulfato, R.sub.4 is hydrogen, halogen, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, carboxyl or sulfo, R.sub.5 is halogen, C.sub.1-4 alkyl or C.sub.1-4 alkoxy, m is the number 0, 1, 2 or 3 and (R6).sub.m is 0 to 3 substituents independent of one another, from the group comprising halogen, C.sub.1-4 alkyl, C.sub.

Abstract: Ortho-substituted benzyl esters of cyclopropanecarboxylic acids I ##STR1## where X is N or CH and A is one of the following cyclopropane radicals: ##STR2## where R.sup.1 is CN, C.sub.2 -C.sub.8 -alkyl, CF.sub.3, C.sub.3 -C.sub.8 -alkenyl, (C.sub.1 -C.sub.4 -alkoxycarbonyl, unsubstituted or substituted phenyl-C.sub.1 -C.sub.6 -alkyl or phenyl-C.sub.3 -C.sub.6 -alkenyl, ethoxyphenyl, 2- or 3-bromophenyl, 2- or 4-trifluoromethylphenyl, 2,4- or 2,6-difluorophenyl, 2-fluoro-6-chlorophenyl, 2,4- or 2,6-dimethylphenyl, 2,3,6-trichlorophenyl or trimethylsilyl, R.sup.2 is H or halogen, R.sup.3 is unsubstituted or substituted phenyl, R.sup.4 is CH.sub.3 or halogen and Hal is halogen, with the proviso that X is CH when R.sup.1 is CF.sub.3 or trimethylsilyl, are suitable as fungicides and for controlling pests.

Abstract: A direct compression granulated acetaminophen tableting composition is prepared by blending acetaminophen with a binder, disintegrant, lubricant and a small amount of water or alcohol, compacting the blend, preferably by roller compacting into sheets, and milling the compacted product into granulated particles of a desired particle size suitable for direct compression tableting.

Abstract: In a method of producing a keto acid having the general formula ##STR1## wherein R.sup.1 and R.sup.2 independently represent an alkyl of 1-6 carbons or a cycloalkyl of 4-8 carbons, by reacting an m-aminophenol having the general formula ##STR2## wherein R.sup.1 and R.sup.2 are the same as above, with phthalic anhydride, in an organic solvent, the improvement comprising effecting the reaction in an amount of the organic solvent which is insufficient to dissolve the keto acid produced in the reaction, so that at least a portion of the resultant keto acid crystallizes out of the solvent and allowing the reaction to proceed in a heterogeneous system.

Abstract: Provided are a carrier having at least one passing-through channel used for a catalyst for producing unsaturated esters, and a catalyst for producing unsaturated esters comprising an element belonging to Group VIII of the periodic table or compounds thereof carried on said carrier and a process for producing unsaturated esters characterized by the use of said catalyst. The use of the above catalyst markedly increase the space time yield of the obtained unsaturated esters.

Abstract: Synthesis of desferrioxamine B and analogs and homologs thereof beginning with O-protected, N-protected hydroxylamine, which is N-alkylated to produce a protected N-4-cyanoalkylhydroxylamine which is acylated with a suitable anhydride. The resulting half-acid amide is subjected to a series of high yield condensations and reductions which vide desferrioxamine B in high overall yield. Alternatively, polyether analogs of desferrioxamine B can be prepared by reacting an activated polyether with the O-protected, N-protected hydroxylamine and subjecting the resulting product to a series of similar steps.

Abstract: The invention includes selected novel optically active .alpha.-amino ketones which either are themselves useful or are intermediates for the preparation of known ketomethylene pseudopeptides useful as antibiotics, antibiotic enhancers, or enzyme inhibitors. Further, the present invention provides a method for dehydrogenation/asymmetrical hydrogenation to obtain essentially pure antipodes of ketomethylene pseudopeptides having two chiral centers.

Abstract: There are disclosed novel, highly stable sulfone peroxycarboxylic acids useful in detergent compositions or alone as bleaching agents which are represented by the formula ##STR1## wherein A and B are organic moieties bonded to the sulfur atom by a carbon atom and one of A and B contains from 1 to 4 ##STR2## groups bonded to carbon atoms.

Abstract: The present invention is directed to farnesyl pyrophosphate analogs which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention, and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.

Abstract: A process is disclosed for the preparation of a substituted diaminodiol.

Abstract: The invention provides compounds of the formula XX: M-Ar-CONH-R, where Ar represents an aromatic ring system, R-NH is the residue of an .alpha.-amino acid R-NH.sub.2 or oligopeptide R-NH.sub.2 and contains at least one carboxylic acid group in the form of a tertiary butyl ester and M represents a nitrogen mustard group of formula (a), where Y and L, which may be the same or different in a molecule, are leaving groups. The compounds are useful intermediates for the production of nitrogen mustard prodrugs.

Abstract: Process for the preparation of acyloxyalkanesulfonatesProcess for the preparation of acyloxyalkanesulfonates of the formula ##STR1## where R denotes C.sub.7 -C.sub.21 -alkyl or C.sub.7 -C.sub.21 -alkenyl, A denotes C.sub.2 -C.sub.4 -alkylene and M denotes an alkali metal atom or an alkaline earth metal atom, by esterification of carboxylic acids using salts of hydroxyalkanesulfonic acids, under mild reaction conditions, carboxylic acids of the general formula R--CO.sub.2 H being esterified using a salt of the formula HO--A--SO.sub.3 M in the presence of aqueous hydrochloric acid.

Abstract: Sulfonic acid stilbenes are disclosed which block the infection of cells by HSV, HIV and CMV.