Abstract: The present invention relates to a process by which a carboxylic acid/diol mixture is obtained from a slurry or cake carboxylic acid product without isolation of a substantially dry carboxylic acid solid. More specifically, the present invention relates to a process by which a terephthalic acid/ethylene glycol mixture suitable as a starting material for polyester or co-polyester production is obtained from a slurry or cake terephthalic acid product without isolation of a substantially dry terephthalic acid solid.

Abstract: An object of present invention is to provide a process of producing bisphenol A, and more particularly a process of producing bisphenol A having high purity and an excellent hue. In the present invention, in a crystallization step to form the slurry containing adduct crystals, (a) a fed solution of bisphenol A in phenol is cooled at the temperatures of at least two steps to form a slurry containing adduct crystals, (b) at least two crystallization stages having different cooling temperatures are provided, and (c) when the solid fraction of the slurry is A [% by weight] in the final crystallization stage prior to transporting the slurry into the solid-liquid separation step and the solid fraction of the slurry is B [% by weight] in the crystallization stage in which crystals are first formed, the value of B/A is kept 0.7 or less.

Abstract: A process for simultaneously producing a dihydroxybenzene and a diisopropylbenzene dicarbinol, which contains subjecting a diisopropylbenzene with an oxygen containing gas to obtain an oxidation reaction mixture containing a diisopropylbenzene dihydroperoxide and a diisopropylbenzene hydroxy hydroperoxide followed by an extraction separation step, a decomposition step, a distillation separation step, a reduction step and a post-treatment step in this order, the process containing purifying the diisopropylbenzene dicarbinol from the liquid containing the diisopropylbenzene dicarbinol obtained in the reduction step through purification operations containing crystallization, filtration and subsequent drying, and supplying a filtrate obtained by the filtration to the decomposition step and/or distillation separation step.

Abstract: The present invention relates to a continuous method for treating a crude phenol stream comprising methylbenzofuran and hydroxyacetone by passing the crude phenol stream through at least two reactors connected in series the reactors containing an acidic ion exchange resin, whereby the temperature in successive reactors decreases in flow direction of the phenol stream so that the temperature in the first reactor in flow direction of the phenol stream is between 100° C. and 200° C. and the temperature in the last reactor in flow direction of the phenol stream is between 50° C. and 90° C. without a thermal separation step between any of two successive reactors and to the use of this method in a process for making phenol.

Abstract: Hexafluoroisobutylene and its higher homologs are easily reacted with SO3 to give fluorosulfates of the formula CH2?C(R)CF2OSO2F, wherein R is a linear branched or cyclic fluoroalkyl group comprised of 1 to 10 carbon atoms and may contain ether oxygen. These compounds react under mild conditions with many nucleophiles to give CH2?C(R)CF2X, where X is derived from the nucleophile. This reaction provides a route to many substituted hexafluoroisobutylenes, which copolymerize easily with other fluoro- and hydrocarbon monomers such as vinylidene fluoride and ethylene.

Abstract: A process for producing a phenol, which comprises the following steps of: (1) oxidizing an alkylbenzene with an oxygen-containing gas to obtain an oxidation reaction mixture containing a hydroperoxide; (2) subjecting the oxidation reaction mixture to extraction operation with an alkaline aqueous solution to obtain an extract containing the hydroperoxide; (3) subjecting the extract obtained in the step (2) to extraction operation with an organic solvent to obtain an extract containing the hydroperoxide; (4) subjecting the extract obtained in the step (3) to water washing to obtain an oil layer containing the hydroperoxide, in which a content of the alkali has been reduced; and (5) subjecting the hydroperoxide contained in the oil layer obtained in the water washing step (4) to acidolysis to obtain a phenol, wherein a concentration of the hydroperoxide to be subjected to the water washing in the step (4), is 20% by weight or less.

Abstract: A method and a device for purifying 1,4-bis(bromodifluoromethyl)benzene are disclosed. In order to solve the problem of hard to purify and separate 1,4-bis(bromodifluoromethyl)benzene crude products, diphenylmethane that has a higher boiling point and does not interact with 1,4-bis(bromodifluoromethyl)benzene is mixed with the 1,4-bis(bromodifluoromethyl)benzene crude products for evaporation. Afterwards, the purity of the vaporized product is detected and only that reaching an expected purity is collected to obtain high-purity 1,4-bis(bromodifluoromethyl)benzene.

Abstract: Compositions and methods of use of borole derivatives, including benzoxaboroles, benzazaboroles and benzthiaboroles, as therapeutic agents for treatment of diseases caused by bacteria or viruses are disclosed, as well as methods for synthesis of said agents and compositions thereof.

Abstract: A compound selected from those of formula (I): Medicinal products containing the same which are useful in the treatment of disorders of the melatoninergic system.

Abstract: The present invention provides a process for producing (Z)-1-phenyl-1-diethylaminocarbonyl-2-hydroxymethylcyclopropane, which comprises reacting 2-oxo-1-phenyl-3-oxabicyclo[3.1.0]hexane with diethylamine in the presence of alkali metal alkoxide.

Abstract: A process for the preparation of high purity bisphenol A is disclosed. The multi-step process entails a process whereby bisphenol A of a purity of preferably at least 99.8% can be obtained.

Abstract: A novel process for the preparation of tolterodine, i.e. (R)—N, N-diisopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenylpropanamine, in the racemic form, as well as intermediates useful for its preparation.

Abstract: An aromatic amine derivative with a specific structure and an organic electroluminescence device which comprises at least one organic thin film layer comprising a light emitting layer sandwiched between a pair of electrode consisting of an anode and a cathode, wherein at least one of the organic thin film layer comprises the aromatic amine derivative singly or as its mixture component. The organic electroluminescence device which exhibits an enhanced current efficiency of light emission and emits blue light with a prolonged lifetime is realized.

Abstract: The present invention relates to a process for preparing enantiomerically enriched 2-butanol and to its use.

Abstract: The present invention relates to a process of manufacture of polytrimethylene ether glycol, in which one or more inorganic compounds selected from alkali metal carbonates are utilized during certain purification steps to reduce phase separation time.

Abstract: Isocyanatosilanes are prepared by themolyzing carbamatosilanes in a fluidized bed reactor containing fluidized solid particles. The process substantially avoids the deposition of solid reaction by products in the reactor.

Abstract: A process for producing a fluorine-containing diol represented by the formula [2], includes reducing a hydroxy ketone represented by the formula [1], by hydrogen in the presence of a ruthenium catalyst. The ruthenium catalyst may be a solid-phase catalyst in which ruthenium is carried on an activated carbon, alumina or silica.

Abstract: Process for the preparation of an alkynol with formula HC?C—CH(OH)—R2(formula 2) wherein R2 represents methyl, halomethyl or ethyl, wherein the corresponding silyl-protected alkynol ester with formula 1 wherein R1 represents H, or an optionally substituted alkyl, an optionally substituted alkenyl or an optionally substituted (hetero)aryl group, R2 is as defined above and A3Si represents a trisubstituted silyl group wherein each A independently represents an optionally substituted alkyl or an optionally substituted (hetero)aryl group, in the presence of water and at least an equivalent amount of amine functionalities is converted into the alkynol with formula 2. Preferably, the amount of water is between 0.5 and 3 equivalents calculated with respect to the amount of silyl-protected alkynol ester with formula (1).

Abstract: A compound of formula (Ia) or (Ib), wherein in each of formulae (Ia) and (Ib) R1 and R2, independently of one another, are H or CH3, and the use thereof as a sandalwood fragrance.

Abstract: A single-step process is disclosed for the ring alkylation of at least one N-alkyl-N?-phenyl-phenylenediamine with at least one olefin wherein the process comprises heating a mixture of the N-alkyl-N?-phenyl-phenylenediamine(s) and olefin(s) in the presence of a catalytic amount of at least one alkyl aluminum halide at a temperature of from about 50 to about 350° C. in a sealed vessel for from about one to about 30 hours.