Patents Examined by Kellette Gale
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Patent number: 7276624Abstract: Hexafluoroisobutylene and its higher homologs are easily reacted with SO3 to give fluorosulfates of the formula CH2?C(R)CF2OSO2F, wherein R is a linear, branched or cyclic fluoroalkyl group comprised of 1 to 10 carbon atoms and may contain ether oxygen. These compounds react under mild conditions with many nucleophiles to give CH2?C(R)CF2X, where X is derived from the nucleophile. This reaction provides a route to many substituted hexafluoroisobutylenes, which copolymerize easily with other fluoro- and hydrocarbon monomers such as vinylidene fluoride and ethylene.Type: GrantFiled: May 9, 2003Date of Patent: October 2, 2007Assignee: E. I. du Pont de Nemours and CompanyInventors: Victor Filippovich Cherstkov, Nina Ivanova Delyagina, Richard E. Fernandez, Viacheslav A. Petrov, Paul R. Resnick
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Patent number: 7271295Abstract: A process for the production of 4-hydroxybutyraldehyde is described. The process comprises reacting allyl alcohol with a mixture of carbon monoxide and hydrogen in the presence of a solvent and a catalyst system comprising a rhodium complex and a 2,3-O-isopropylidene-2,3-dihydroxy-1,4-bis[bis(3,5-di-n-alkylphenyl)phosphino]butane. The process gives high yield of 4-hydroxybutyraldehyde compared to 3-hydroxy-2-methylpropionaldehyde.Type: GrantFiled: October 13, 2006Date of Patent: September 18, 2007Assignee: Lyondell Chemical Technology, L.P.Inventors: Daniel F. White, Walter S. Dubner
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Patent number: 7271299Abstract: Optionally alkyl-substituted 1,4-butanediol is prepared from C4-dicarboxylic acids and/or of derivatives thereof by: a) a gas stream of the C4-dicarboxylic acid or the derivative thereof in a first reactor in the gas phase to obtain a product which contains mainly optionally alkyl-substituted ?-butyro-lactone; b) removing succinic anhydride from the product of step a); c) catalytically hydrogenating the product of step b) in a second reactor in the gas phase to obtain optionally alkyl-substituted 1,4-butanediol; d) removing the desired product from intermediates, by-products and any unconverted reactants; and e) optionally recycling unconverted intermediates into one or both hydrogenation stages. The catalysts employed in each of the hydrogenation stages comprise ?95% by weight of CuO, and ?5% by weight of an oxidic support, and the second reactor has a higher pressure than the first reactor.Type: GrantFiled: June 11, 2003Date of Patent: September 18, 2007Assignee: BASF AktiengesellschaftInventors: Michael Hesse, Stephan Schlitter, Holger Borchert, Markus Schubert, Markus Rösch, Nils Bottke, Rolf-Hartmuth Fischer, Alexander Weck, Gunther Windecker, Gunnar Heydrich
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Patent number: 7268260Abstract: This invention relates to 1,2-di(4-hydroxyaryl)tetrafluoroethanes of the general formula (I) wherein R are each, independently of one another, hydrogen, F, Cl, Br, I, CN, COOR2, C1-C4-alkyl, C1-C4-alkoxy, C1-C4-alkylthio, C1-C4-perfluoroalkyl, C1-C4-perfluoroalkoxy, C1-C4-perfluoroalkylthio, C1-C4-polyfluoroalkyl, C1-C4-polyfluoroalkoxy, or C1-C4-polyfluoroalkylthio, R2 is C1-C4-alkyl, and n is an integer from 0 to 4. This invention further relates to the preparation of such compounds as well as to precursors and intermediates that can be used in their preparation.Type: GrantFiled: August 3, 2006Date of Patent: September 11, 2007Assignee: LANXESS Deutschland GmbHInventors: Albrecht Marhold, Käthe Baumann
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Patent number: 7259281Abstract: The present invention provides novel compounds 2,4,4,4-tetrafluoro-1-butene and (E)- and (Z)-1,1,1,3-tetrafluoro-2-butenes. Furthermore, the present invention provides the following novel first and second processes for producing 2,4,4,4-tetrafluoro-1-butene and (E)- and (Z)-1,1,1,3-tetrafluoro-2-butenes. The first process is a process for producing 2,4,4,4-tetrafluoro-1-butene by heating 1,1,1,3,3-pentafluorobutane at from about 200° C. to about 700° C. The second process is a process for producing (E)- and (Z)-1,1,1,3-tetrafluoro-2-butenes by bringing 1,1,1,3,3-pentafluorobutane with a base. By the first and second processes, it is possible to obtain respective target fluorobutenes with high selectivity.Type: GrantFiled: August 21, 2006Date of Patent: August 21, 2007Assignee: Central Glass Company, LimitedInventors: Richard A. Du Boisson, Adam C. Alty
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Patent number: 7253324Abstract: Alkoxy aromatic compounds are conveniently dealkylated to the corresponding phenolic compounds by treatment with aluminum chloride/N,N-dimethyl aniline complex. Aromatic poly O-demethylation is a unique feature of this invention. This process is applicable to the manufacture of polyphenols such as Resveratrol, Oxyresveratrol, Gnetol.Type: GrantFiled: January 23, 2007Date of Patent: August 7, 2007Assignee: Sami Labs LimitedInventors: Muhammed Majeed, Samuel Manoharan Thomas, Kalyanam Nagabhushanam, Sivaprakash Kurumanghat Balakrishnan, Subbalakshmi Prakash
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Patent number: 7253325Abstract: Disclosed is a process for the preparation of alkylene glycols from the corresponding alkylene oxide, such as ethylene glycol from ethylene oxide, in the presence of water, a catalyst and, optionally, carbon dioxide. The catalyst is a SALEN-type compound which contains an amino group and an oxy or hydroxy group connected by a hydrocarbon, such as an alkyl or an alkylaryl. The SALEN-type compounds may be Schiff bases, i.e., a condensate product of a primary amine with an aldehyde, ketone or an alcohol. The SALEN-type compound may be a mono or bis compound and may be complexed with a Group 4-14 metal, such as aluminum, tin, vanadium, chromium, manganese, iron, cobalt or platinum.Type: GrantFiled: October 2, 2006Date of Patent: August 7, 2007Assignee: Saudi Basic Industries CorporationInventors: Jaap W. Van Hal, John S. Ledford, Xiankuan Zhang
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Patent number: 7250533Abstract: Processes for preparing cinacalcet are provided.Type: GrantFiled: May 16, 2006Date of Patent: July 31, 2007Assignee: Teva Pharmaceutical Industries LtdInventors: Revital Lifshitz-Liron, Amihai Eisenstadt, Shlomit Wizel, Sharon Avhar-Maydan, Yuriy Raizi, Revital Ramaty
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Patent number: 7247758Abstract: The present invention provides a simple and efficient method for producing high-purity 2,3,6,7,10,11-hexahydroxytriphenylene on an industrial scale. The method for producing 2,3,6,7,10,11-hexahydroxytriphenylene comprises reacting catechol with peroxide.Type: GrantFiled: October 20, 2004Date of Patent: July 24, 2007Assignee: Otsuka Chemical Co., Ltd.Inventor: Takashi Kameshima
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Patent number: 7211700Abstract: A antimicrobial compound, compositions containing the same, and method of using the same for reducing the presence of microorganism on a substrate or in a fluid environment comprising an antimicrobial effective carrier and at least one antimicrobial compounds including non-halogenated phenyl substituted phenol compounds.Type: GrantFiled: June 14, 2005Date of Patent: May 1, 2007Assignee: McNeil-PPC, Inc.Inventors: David Scott Harper, Robert A. Coburn, Constantine Georgiades, Andre Soshinsky, Marianne D. Huntley
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Patent number: 7208606Abstract: The invention pertains to a hydroformylation process for the conversion of an ethylenically unsaturated compound to an alcohol comprising a first step of reacting at an elevated temperature in a reactor the ethylenically unsaturated compound, carbon monoxide, hydrogen, and a phosphine-containing cobalt hydroformylation catalyst, which are dissolved in a solvent, followed by a second step of separating a mixture comprising the alcohol and heavy ends from a solution comprising the catalyst and the solvent, followed by a third step of recycling the solution to the reactor.Type: GrantFiled: October 10, 2006Date of Patent: April 24, 2007Assignee: Shell Oil CompanyInventors: Eit Drent, Jacoba Catherina Lucia Johanna Suykerbuyk
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Patent number: 7205442Abstract: A method of manufacturing a phenol product having a reduced concentration of a contaminating reaction by-product. The method includes contacting a phenol stream, having a concentration of the contaminating by-product, by contacting the phenol stream with an acidic catalyst under suitable purification reaction conditions. Also included is a composition comprising a sec-butyl benzene derived phenol product that has been purified by the removal of certain undesirable reaction by-products.Type: GrantFiled: January 21, 2004Date of Patent: April 17, 2007Assignee: Shell Oil CompanyInventor: Larry Wayne Payne
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Patent number: 7196232Abstract: Produce new 4,4?-dihydroxyphenyl bicyclohexenes that are useful as a material for liquid crystal polyester, polycarbonate, polyurethane or other synthetic resins or for photoresist used with display elements, semiconductors, etc., by thermally decomposing 4,4,4?4?-tetrahydroxyphenyl bicyclohexanes, preferably in the presence of alkali catalyst.Type: GrantFiled: October 16, 2003Date of Patent: March 27, 2007Assignee: Honshu Chemical Industry Co., Ltd.Inventors: Kouji Satomi, Hiroyasu Oono, Kenji Ekawa
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Patent number: 7189875Abstract: Disclosed herein is a process for the preparation of alkylated diarylamines comprising adding to said diarylamine an olefin mixture containing highly reactive fractions, as well as fractions exhibiting a relatively lower chemical reactivity, in the presence of an acidic clay catalyst at a temperature low enough to prevent substantial deactivation of the catalyst until the addition is complete and then increasing the temperature to increase the alkylation rate of the less reactive fractions.Type: GrantFiled: March 31, 2004Date of Patent: March 13, 2007Assignee: Crompton CorporationInventors: Karl J. Duyck, Timothy L. Lambert
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Patent number: 7189884Abstract: Disclosed in one embodiment is a process for the synthesis of 1,3,3,3-tetrafluoropropene that comprises (a) reacting a compound of formula (I) X1X2 with a compound of formula (II) CF3CH?CH2 to produce a reaction product comprising a compound of formula (III) CF3CHX1CH2X2, wherein X1 and X2 are each independently selected from the group consisting of hydrogen, chlorine, bromine and iodine, provided that X1 and X2 are not both hydrogen; (b) when X2 in formula (III) is not fluorine, fluorinating the compound of formula (III) to produce a reaction product comprising a compound of formula (III) wherein X1 is as described above and X2 is fluorine; and (c) exposing said compound of formula (III) to reaction conditions effective to convert said compound to 1,3,3,3-tetrafluoropropene.Type: GrantFiled: April 29, 2005Date of Patent: March 13, 2007Assignee: Honeywell InternationalInventors: Sudip Mukhopadhyay, Haridasan K. Nair, HsuehSung Tung, Michael Van Der Puy
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Patent number: 7179800Abstract: Compounds of the formula: wherein R, R1 and R4 are defined in the specification, and pharmaceutically acceptable salts, esters and tautomers thereof, having activity at peripheral cannabinoid receptors, commonly designated the CB2 receptor class. The compounds are useful for therapy, especially in the treatment of pain, inflammation and autoimmune disease.Type: GrantFiled: April 15, 2003Date of Patent: February 20, 2007Assignee: Virginia Commonwealth UniversityInventors: Billy R. Martin, Raj K. Razdan
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Patent number: 7161046Abstract: Disclosed is a process for the preparation of alkylene glycols from the corresponding alkylene oxide, such as ethylene glycol from ethylene oxide, in the presence of water, a catalyst and, optionally, carbon dioxide. The catalyst is a SALEN-type compound which contains an amino group and an oxy or hydroxy group connected by a hydrocarbon, such as an alkyl or an alkylaryl. The SALEN-type compounds may be Schiff bases, i.e., a condensate product of a primary amine with an aldehyde, ketone or an alcohol. The SALEN-type compound may be a mono or bis compound and may be complexed with a Group 4-14 metal, such as aluminum, tin, vanadium, chromium, manganese, iron, cobalt or platinum.Type: GrantFiled: September 30, 2004Date of Patent: January 9, 2007Assignee: Saudi Basic Industries CorporationInventors: Jaap W. Van Hal, John S. Ledford, Xiankuan Zhang
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Patent number: 7151191Abstract: Compounds and compositions for the delivery of active agents are provided. Methods of administration and preparation are provided as well.Type: GrantFiled: January 12, 2001Date of Patent: December 19, 2006Assignee: Emisphere Technologies, Inc.Inventors: Maria Aurora P. Boyd, Andrea Leone-Bay, Doris C. O'Toole
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Patent number: 7138551Abstract: A process for reducing the level of perfluoroalkanoic acids, perfluoroalkanoic esters, and perfluoroalkyliodides in fluorinated alcohols comprising heating a fluorinated alcohol, or mixtures thereof, containing said acids, esters, or iodides to a temperature of at least 175° C. in the presence of water and a base additive is disclosed.Type: GrantFiled: November 5, 2004Date of Patent: November 21, 2006Assignee: E. I. du Pont de Nemours and CompanyInventors: Alexander Borisovich Shtarov, Stephen James Getty, Axel Hans-Joachim Herzog
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Patent number: 7112703Abstract: A process for the production of bisphenol-A having low concentration of sulphur is disclosed. The process comprise a) reacting phenol with acetone in the presence of a sulfonic acid ion exchanger to form a product mixture containing water, bisphenol-A/phenol adduct, phenol and sulfurous particles, and b) filtering the product mixture to separate the sulfurous particles to obtain a purified product mixture that contains water, phenol and bisphenol-A/phenol adduct. In one embodiment of the process further comprise distilling the purified product mixture to remove the water to obtain a first material system that contains said adduct and phenol, crystallizing the adduct, and removing the phenol by filtration using a filtering apparatus to obtain crystalline adduct.Type: GrantFiled: January 26, 2005Date of Patent: September 26, 2006Assignee: Bayer MaterialScience AGInventors: Rainer Neumann, Ulrich Blaschke, Stefan Westernacher