Abstract: A feed additive which is effective for preventing and/or treating protozoiasis of livestock such as coccidiosis and for suppressing accumulation of fat of livestock is disclosed, which comprises (a) a triglyceride of a medium-chain fatty acid having 6 to 12 carbon atoms; and (b) at least one substance selected from a medium-chain fatty acid having 6 to 12 carbon atoms, a monoglyceride of the fatty acid and a diglyceride of the fatty acid. A feed for livestock containing the feed additive, and a method for preventing and/or treating protozoiasis of livestock and a method for suppressing excess accumulation of fat of livestock using the feed are also disclosed. The feed and method of the present invention are particularly effective for broiler.
Abstract: The present invention provides a veterinary treatment method for animals suffering from a high arousal state. The treatment employs a class of pharmacologically active compounds having a pyrimidinyl-piperazine ring structure of which the most preferred member is buspirone. These compounds are administered to a variety of different domestic animals and household pets exhibiting behavioral problems which often are refractory to other modes of treatment.
Abstract: Insecticidal and repellent compositions comprising ozonides of hydrocarbons are disclosed. Hydrocarbons which are believed to be active when prepared in accordance with the present invention include terpenes and unsaturated fatty acids derived from plant and animal sources. Other examples of suitable unsaturated hydrocarbons include natural and synthetic steroids, alkenes and their substituted derivatives, and other naturally or synthetically unsaturated hydrocarbons derived primarily from petroleum. Methods of use for the compositions are also disclosed.
Abstract: Compounds of formula (Ia), or pharmaceutically acceptable salts or solvates thereof, ##STR1## in which A, together with the nitrogen atom, represents --(CH.sub.2)p--, where p is an integer from 3 to 6, or an optionally substituted tetrahydroisoquinoline ring system;each of R.sub.1 and R.sub.2 are independently hydrogen, C.sub.1-6 alkyl, C.sub.2-6 alkenyl C.sub.3-6 cycloalkyl or C.sub.4-12 cycloalkylalkyl, or together form a C.sub.2-6 polymethylene or C.sub.2-6 alkenylene group, optionally substituted with a hetero-atom,R.sub.x is hydrogen, C.sub.1-6 alkyl or phenyl, or together with R.sub.1 forms a --(CH.sub.2).sub.3 -- or --(CH.sub.2).sub.4 -- group; and R comprises a substituted or unsubstituted carbocyclic or heterocyclic aromatic group;and compounds of formula (Ib) ##STR2## in which: R, R.sub.1, R.sub.2 and X are as defined in formula (Ia)R.sub.a is C.sub.1-6 alkyl or phenyl;R.sub.b is hydrogen or together with R.sub.a forms a --(CH.sub.2).sub.
Type:
Grant
Filed:
October 16, 1989
Date of Patent:
February 11, 1992
Assignee:
Dr. Lo. Zambeletti SpA
Inventors:
Roberto Colle, Antonio Pizzi, Geoffrey D. Clarke
Abstract: A method for feeding ruminants being fattened for meat production, a feed supplement and a complete feed for ruminants. In the method for feeding ruminants, the ruminants are fed sorbitol and at least one ionophore antibiotic in addition to their normal feedstuff. The feed supplement contains sorbitol and at least one ionophore antibiotic together with a carrier. The complete feed contains sorbitol and at least one ionophore antibiotic in addition to a normal feedstuff for ruminants. Feeding of sorbitol and at least one ionophore antibiotic to ruminants in addition to their normal feedstuff significantly improves feed efficiency.
Abstract: A process for stabilizing attenuated lyophilized vaccines with a compound having the general formula: ##STR1## wherein R1 is an oxygen atom or a sulphur atom and R2 is a NH.sub.2 group or a linear chain, unsaturated or not, selected from the group consisting of --O--C . . . , --NH--C . . . , and --C . . . .
Abstract: An emulsifiable concentrate comprising an agriculturally active chemical, a surfactant, an organic diluent and a solvent having first and second components, the first component being capable of solubilizing the agriculturally active chemical and the second component in conjunction with the surfactant being effective to disperse the agriculturally active chemical. The inventive concentrate allows for high concentrations of the active ingredient, exhibits excellent stability and produces highly stable compositions upon dilution with water.
Type:
Grant
Filed:
December 11, 1989
Date of Patent:
December 10, 1991
Assignee:
ISP Investments Inc.
Inventors:
Kolazi S. Narayanan, Ratan K. Chaudhuri, Manilal Dahanayake
Abstract: Snails and slugs are controlled by a method in which the plants to be protected from molluscs, or the environment of the said plants, are or is treated with 2-tert-butyl-4-chloro-5-(4-tert-butylbenzylthio)-3 (2H)-pyridazinone I ##STR1## Snail and slug baits or seed dressings contain the active ingredient I.
Type:
Grant
Filed:
July 6, 1990
Date of Patent:
November 5, 1991
Assignee:
BASF Aktiengesellschaft
Inventors:
Joachim Leyendecker, Christoph Kuenast, Peter Hofmeister
Abstract: A method of treatment of visceral pain in mammals, including humans, which method comprises the administration to the mammal in need of such treatment, an effective amount of a compound of formula (I) or a pharmaceutically acceptable salt thereof:X--CO--Y--Z (I)whereinX is a group of formula (a), (b), (c), (d) or (e): ##STR1## wherein R.sub.a to R.sub.d are selected from hydrogen, halogen or hydroxy;R.sub.1 is hydrogen and R.sub.2 is hydrogen or C.sub.1-4 alkyl; orR.sub.1 and R.sub.2 together are a bond;R.sub.3 to R.sub.7 are independently hydrogen or C.sub.1-6 alkyl; andR.sub.4 together with R.sub.2 may be C.sub.2-7 polymethylene when R.sub.1 is hydrogen; either R.sub.8 is C.sub.1-6 alkoxy;R.sub.9 is hydrogen;R.sub.10 is amino or C.sub.1-7 alkanoylamino; andR.sub.11 is halo or C.sub.1-6 alkylthio; orR.sub.8 is hydrogen;R.sub.9 is halo, C.sub.1-6 alkoxy or C.sub.1-6 alkyl;R.sub.10 is hydrogen or C.sub.1-6 alkoxy; andR.sub.11 is halo, C.sub.1-6 alkoxy or C.sub.
Abstract: Based upon the discovery thata porcupine attack of wood structures is due to the presence of sodium in the conventional resin used in the wood structures, the invention provides for replacing the base used in wood processing with potassium hydroxide or ammonium hydroxide or any other non-sodium base. Potassium hydroxide is found to be a specific deterrent to porcupines. A preferred resin formulation contains potassium hydroxide as the base, and an additive of potassium chloride in an amount of from 5% to 20%, and preferably 10%, by weight of the potassium hydroxide. The potassium-containing resin formulation may be used to make potassium-containing wood products, applied as an adhesive for gluing together wood objects accessible outdoors, mixed with a water-insoluble gum or paint or used to make potassium-containing panelling or shingles which are applied to existing wood structures to render them porcupine-proof.
Abstract: A method is described in which the feed utilization by livestock is improved by the incorporation in the feed or drinking water of the said livestock of certain compounds, with resultant increase in body weight, decrease in body fat and increase in body protein for the same food intake.
Abstract: A method for producing or maintaining weight loss by administering to a human a composition containing an effective amount of each of caffine, aspirin and ephedrine. The pharmaceutical composition can be administered concurrently with caloric restriction or in the absence of caloric restriction, for the purpose of reducing weight or maintaining body weight.
Abstract: The present invention provides stable pharmaceutical compositions containing disodium adenosine triphosphate (ATP-2Na) which are advantageous in that, as a result of the addition of a low-melting fat- or oil-like substance to ATP-2Na, the decomposition or the like of ATP-2Na is prevented and the content of ATP-2Na can be maintained at a high level even after the lapse of a number of days.The compositions according to this invention can be used advantageously, for example, in the treatment of cerebrovascular disorder, cardiac failure and asthenopia.
Abstract: The invention relates to weight gain-increasing compositions, particularly fodder supplement, premix, drinking water supplement, bolus and/or microcapsule containing 0.001 to 90% by weight of 1-(3,5-dihydroxyphenyl)-2-(tertiary butylamino)-ethanol or a physiologically acceptable acid addition salt thereof as active ingredient in admixture with inert solid and/or liquid carrier(s).
Type:
Grant
Filed:
July 5, 1989
Date of Patent:
September 10, 1991
Assignee:
Egis Gyogyszergyar
Inventors:
Ferenc Simon, Karoly Magyar, Attila Nagy, Lajos Fekete, Laszlo Puskas, Pal Fekete, Istvan Simonyi, Janos Egri, Katalin Zukovics nee Sumeg
Abstract: A drug/liposome composition comprising an aqueous suspension of liposomes and, entrapped in the lipid bilayer region of the liposomes, an anthraquinone drug containing quinone and hydroquinone functionalities on adjacent anthracene rings. An iron-specific trihydroxamic chelating agent contained in the bulk aqueous phase of the suspension and a lipophilic free-radical scavenger contained in the bilayer region of the liposome cooperate to reduce chemical modification of both drug and lipid components of the composition. A preferred composition containing doxorubicin and alpha-tocopherol entrapped in the liposomes, and ferrioxamine in the aqueous suspension phase is effective in treating human neoplasms, with significantly reduced side effects over those produced by free-drug administration.
Type:
Grant
Filed:
November 14, 1989
Date of Patent:
August 27, 1991
Assignees:
Hadasit Medical Research, Inc., Yissum Research and Development Company et al.
Abstract: The present invention relates to formulations containing unsaturated fatty acids for the synthesis of prostaglandins and hydroxy-fatty acids in biological systems and to the use of such formulations for the preparation of medicaments which are suitable for curing prostaglandin deficiencies in humans or animal, for example healing or preventing diseases of the gastro-intestinal tract.
Abstract: This invention involves a method for reducing neurotoxic side effects that can be caused when NMDA antagonists such as MK-801 are used as anti-convulsants, to prevent excitotoxic damage in the central nervous system, or for anesthetic purposes in human or veterinary medicine. This method involves the use of anti-cholinergic agents such as scopolamine, atropine, benztropine, trihexyphenidyl, biperiden, procyclidine, benactyzine, or diphenhydramine in conjunction with, or subsequent to, administration of an NMDA antagonist. These anti-cholinergic agents greatly reduce or eliminate the deleterious side effects that can accompany NMDA antagonists (such as convulsion potentiating effects, as well as vacuole formation, mitochondrial dissolution, and possible death of cingulate/retrosplenial cerebrocortical neurons), without interfering with the useful properties of the NMDA antagonists.
Abstract: Fish feed compositions supplemented with up to 0.5% L-carnitine, preferably between 0.01% to 0.3% L-carnitine, produce greater growth gains, decreased fat levels in tissues, and increased resistance to stress (ammonia toxicity) in fish, as compared to fish fed the same diet without supplemental carnitine.
Type:
Grant
Filed:
October 23, 1989
Date of Patent:
July 9, 1991
Assignees:
University of Georgia Research Foundation, Inc., Lonza Inc.
Inventors:
Gary J. Burtle, G. Larry Newton, Stephen A. Blum
Abstract: The insecticidal transparent emulsion of the present invention is obtained by mixing (A) at least one pyrethroidal insecticide as defined in the claims as an active ingredient; (B) a polar solvent containing mixed surface active agent containing at least one metal alkylbenzenesulfonate, at least one nonionic surface active agent having an HLB (hydro- and lipophilicity balance) of 10 to 18 and at least one polar solvent; and (C) water, so that the content of (B) in the mixture is equal to or more than that of (A) and 6% by weight or less and then diluting the resulting mixture. The insecticidal transparent emulsion of the present invention has the advantage that the solution state is unchanged even when the environmental temperature sharply moves up and down.
Abstract: New microbicidal compositions having improved microbicidal activity comprise a compound of formula I: ##STR1## or an acid addition salt thereof; in which Z is --CH.sub.2 CH.sub.2 --, --CH.sub.2 CH.sub.2 CH.sub.2 --, --CH(CH.sub.3)--CH(CH.sub.3)-- or --CH.sub.2 --CH(C.sub.1 -C.sub.10 alkyl)--; and Ar is a phenyl, thienyl, halothienyl or naphthyl group, or phenyl substituted with 1 to 3 halogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, cyano or nitro substituents; and a compound having the formula II: ##STR2## in which R is C.sub.1 -C.sub.4 alkyl, R.sup.1 is hydrogen or C.sub.1 -C.sub.4 alkyl, m is 0, 1, 2, 3 or 4 and n is 0, 1, 2, 3 or 4; new salts of (restricted) formula II, a process for their preparation and a method for combatting microbicidal plant diseases using the above mentioned compositions.