Patents Examined by Kevin Weddington
  • Patent number: 5462967
    Abstract: A feed additive which is effective for preventing and/or treating protozoiasis of livestock such as coccidiosis and for suppressing accumulation of fat of livestock is disclosed, which comprises (a) a triglyceride of a medium-chain fatty acid having 6 to 12 carbon atoms; and (b) at least one substance selected from a medium-chain fatty acid having 6 to 12 carbon atoms, a monoglyceride of the fatty acid and a diglyceride of the fatty acid. A feed for livestock containing the feed additive, and a method for preventing and/or treating protozoiasis of livestock and a method for suppressing excess accumulation of fat of livestock using the feed are also disclosed. The feed and method of the present invention are particularly effective for broiler.
    Type: Grant
    Filed: June 16, 1992
    Date of Patent: October 31, 1995
    Assignee: Kao Corporation
    Inventor: Masaharu Hayashi
  • Patent number: 5314888
    Abstract: The present invention provides a veterinary treatment method for animals suffering from a high arousal state. The treatment employs a class of pharmacologically active compounds having a pyrimidinyl-piperazine ring structure of which the most preferred member is buspirone. These compounds are administered to a variety of different domestic animals and household pets exhibiting behavioral problems which often are refractory to other modes of treatment.
    Type: Grant
    Filed: April 23, 1993
    Date of Patent: May 24, 1994
    Assignee: Trustees of Tufts College
    Inventors: Nicholas H. Dodman, Louis Shuster
  • Patent number: 5093326
    Abstract: Insecticidal and repellent compositions comprising ozonides of hydrocarbons are disclosed. Hydrocarbons which are believed to be active when prepared in accordance with the present invention include terpenes and unsaturated fatty acids derived from plant and animal sources. Other examples of suitable unsaturated hydrocarbons include natural and synthetic steroids, alkenes and their substituted derivatives, and other naturally or synthetically unsaturated hydrocarbons derived primarily from petroleum. Methods of use for the compositions are also disclosed.
    Type: Grant
    Filed: June 19, 1989
    Date of Patent: March 3, 1992
    Inventor: Stephen Herman
  • Patent number: 5087630
    Abstract: Compounds of formula (Ia), or pharmaceutically acceptable salts or solvates thereof, ##STR1## in which A, together with the nitrogen atom, represents --(CH.sub.2)p--, where p is an integer from 3 to 6, or an optionally substituted tetrahydroisoquinoline ring system;each of R.sub.1 and R.sub.2 are independently hydrogen, C.sub.1-6 alkyl, C.sub.2-6 alkenyl C.sub.3-6 cycloalkyl or C.sub.4-12 cycloalkylalkyl, or together form a C.sub.2-6 polymethylene or C.sub.2-6 alkenylene group, optionally substituted with a hetero-atom,R.sub.x is hydrogen, C.sub.1-6 alkyl or phenyl, or together with R.sub.1 forms a --(CH.sub.2).sub.3 -- or --(CH.sub.2).sub.4 -- group; and R comprises a substituted or unsubstituted carbocyclic or heterocyclic aromatic group;and compounds of formula (Ib) ##STR2## in which: R, R.sub.1, R.sub.2 and X are as defined in formula (Ia)R.sub.a is C.sub.1-6 alkyl or phenyl;R.sub.b is hydrogen or together with R.sub.a forms a --(CH.sub.2).sub.
    Type: Grant
    Filed: October 16, 1989
    Date of Patent: February 11, 1992
    Assignee: Dr. Lo. Zambeletti SpA
    Inventors: Roberto Colle, Antonio Pizzi, Geoffrey D. Clarke
  • Patent number: 5081146
    Abstract: A method for feeding ruminants being fattened for meat production, a feed supplement and a complete feed for ruminants. In the method for feeding ruminants, the ruminants are fed sorbitol and at least one ionophore antibiotic in addition to their normal feedstuff. The feed supplement contains sorbitol and at least one ionophore antibiotic together with a carrier. The complete feed contains sorbitol and at least one ionophore antibiotic in addition to a normal feedstuff for ruminants. Feeding of sorbitol and at least one ionophore antibiotic to ruminants in addition to their normal feedstuff significantly improves feed efficiency.
    Type: Grant
    Filed: October 20, 1989
    Date of Patent: January 14, 1992
    Assignee: Roquette Freres
    Inventors: Joseph P. Fontenot, Michel Huchette
  • Patent number: 5075110
    Abstract: A process for stabilizing attenuated lyophilized vaccines with a compound having the general formula: ##STR1## wherein R1 is an oxygen atom or a sulphur atom and R2 is a NH.sub.2 group or a linear chain, unsaturated or not, selected from the group consisting of --O--C . . . , --NH--C . . . , and --C . . . .
    Type: Grant
    Filed: June 21, 1989
    Date of Patent: December 24, 1991
    Assignee: Institut Merieux
    Inventors: Alain J. Francon, Bernard J. Montagnon
  • Patent number: 5071463
    Abstract: An emulsifiable concentrate comprising an agriculturally active chemical, a surfactant, an organic diluent and a solvent having first and second components, the first component being capable of solubilizing the agriculturally active chemical and the second component in conjunction with the surfactant being effective to disperse the agriculturally active chemical. The inventive concentrate allows for high concentrations of the active ingredient, exhibits excellent stability and produces highly stable compositions upon dilution with water.
    Type: Grant
    Filed: December 11, 1989
    Date of Patent: December 10, 1991
    Assignee: ISP Investments Inc.
    Inventors: Kolazi S. Narayanan, Ratan K. Chaudhuri, Manilal Dahanayake
  • Patent number: 5063232
    Abstract: Snails and slugs are controlled by a method in which the plants to be protected from molluscs, or the environment of the said plants, are or is treated with 2-tert-butyl-4-chloro-5-(4-tert-butylbenzylthio)-3 (2H)-pyridazinone I ##STR1## Snail and slug baits or seed dressings contain the active ingredient I.
    Type: Grant
    Filed: July 6, 1990
    Date of Patent: November 5, 1991
    Assignee: BASF Aktiengesellschaft
    Inventors: Joachim Leyendecker, Christoph Kuenast, Peter Hofmeister
  • Patent number: 5063231
    Abstract: A method of treatment of visceral pain in mammals, including humans, which method comprises the administration to the mammal in need of such treatment, an effective amount of a compound of formula (I) or a pharmaceutically acceptable salt thereof:X--CO--Y--Z (I)whereinX is a group of formula (a), (b), (c), (d) or (e): ##STR1## wherein R.sub.a to R.sub.d are selected from hydrogen, halogen or hydroxy;R.sub.1 is hydrogen and R.sub.2 is hydrogen or C.sub.1-4 alkyl; orR.sub.1 and R.sub.2 together are a bond;R.sub.3 to R.sub.7 are independently hydrogen or C.sub.1-6 alkyl; andR.sub.4 together with R.sub.2 may be C.sub.2-7 polymethylene when R.sub.1 is hydrogen; either R.sub.8 is C.sub.1-6 alkoxy;R.sub.9 is hydrogen;R.sub.10 is amino or C.sub.1-7 alkanoylamino; andR.sub.11 is halo or C.sub.1-6 alkylthio; orR.sub.8 is hydrogen;R.sub.9 is halo, C.sub.1-6 alkoxy or C.sub.1-6 alkyl;R.sub.10 is hydrogen or C.sub.1-6 alkoxy; andR.sub.11 is halo, C.sub.1-6 alkoxy or C.sub.
    Type: Grant
    Filed: May 7, 1990
    Date of Patent: November 5, 1991
    Assignee: Beecham Group p.l.c.
    Inventors: Gareth J. Sanger, Helen E. Marr
  • Patent number: 5061732
    Abstract: Based upon the discovery thata porcupine attack of wood structures is due to the presence of sodium in the conventional resin used in the wood structures, the invention provides for replacing the base used in wood processing with potassium hydroxide or ammonium hydroxide or any other non-sodium base. Potassium hydroxide is found to be a specific deterrent to porcupines. A preferred resin formulation contains potassium hydroxide as the base, and an additive of potassium chloride in an amount of from 5% to 20%, and preferably 10%, by weight of the potassium hydroxide. The potassium-containing resin formulation may be used to make potassium-containing wood products, applied as an adhesive for gluing together wood objects accessible outdoors, mixed with a water-insoluble gum or paint or used to make potassium-containing panelling or shingles which are applied to existing wood structures to render them porcupine-proof.
    Type: Grant
    Filed: January 22, 1990
    Date of Patent: October 29, 1991
    Inventor: Uldis Roze
  • Patent number: 5061709
    Abstract: A method is described in which the feed utilization by livestock is improved by the incorporation in the feed or drinking water of the said livestock of certain compounds, with resultant increase in body weight, decrease in body fat and increase in body protein for the same food intake.
    Type: Grant
    Filed: May 18, 1990
    Date of Patent: October 29, 1991
    Assignee: Merck & Co., Inc.
    Inventor: Larry A. Muir
  • Patent number: 5055460
    Abstract: A method for producing or maintaining weight loss by administering to a human a composition containing an effective amount of each of caffine, aspirin and ephedrine. The pharmaceutical composition can be administered concurrently with caloric restriction or in the absence of caloric restriction, for the purpose of reducing weight or maintaining body weight.
    Type: Grant
    Filed: April 26, 1990
    Date of Patent: October 8, 1991
    Inventor: Mitchell Friedlander
  • Patent number: 5055304
    Abstract: The present invention provides stable pharmaceutical compositions containing disodium adenosine triphosphate (ATP-2Na) which are advantageous in that, as a result of the addition of a low-melting fat- or oil-like substance to ATP-2Na, the decomposition or the like of ATP-2Na is prevented and the content of ATP-2Na can be maintained at a high level even after the lapse of a number of days.The compositions according to this invention can be used advantageously, for example, in the treatment of cerebrovascular disorder, cardiac failure and asthenopia.
    Type: Grant
    Filed: June 2, 1989
    Date of Patent: October 8, 1991
    Assignee: Senju Pharmaceutical Co., Ltd.
    Inventors: Tadashi Makino, Koji Doi
  • Patent number: 5047434
    Abstract: The invention relates to weight gain-increasing compositions, particularly fodder supplement, premix, drinking water supplement, bolus and/or microcapsule containing 0.001 to 90% by weight of 1-(3,5-dihydroxyphenyl)-2-(tertiary butylamino)-ethanol or a physiologically acceptable acid addition salt thereof as active ingredient in admixture with inert solid and/or liquid carrier(s).
    Type: Grant
    Filed: July 5, 1989
    Date of Patent: September 10, 1991
    Assignee: Egis Gyogyszergyar
    Inventors: Ferenc Simon, Karoly Magyar, Attila Nagy, Lajos Fekete, Laszlo Puskas, Pal Fekete, Istvan Simonyi, Janos Egri, Katalin Zukovics nee Sumeg
  • Patent number: 5043166
    Abstract: A drug/liposome composition comprising an aqueous suspension of liposomes and, entrapped in the lipid bilayer region of the liposomes, an anthraquinone drug containing quinone and hydroquinone functionalities on adjacent anthracene rings. An iron-specific trihydroxamic chelating agent contained in the bulk aqueous phase of the suspension and a lipophilic free-radical scavenger contained in the bilayer region of the liposome cooperate to reduce chemical modification of both drug and lipid components of the composition. A preferred composition containing doxorubicin and alpha-tocopherol entrapped in the liposomes, and ferrioxamine in the aqueous suspension phase is effective in treating human neoplasms, with significantly reduced side effects over those produced by free-drug administration.
    Type: Grant
    Filed: November 14, 1989
    Date of Patent: August 27, 1991
    Assignees: Hadasit Medical Research, Inc., Yissum Research and Development Company et al.
    Inventors: Yechezkel Barenholz, Alberto Gabizon
  • Patent number: 5043328
    Abstract: The present invention relates to formulations containing unsaturated fatty acids for the synthesis of prostaglandins and hydroxy-fatty acids in biological systems and to the use of such formulations for the preparation of medicaments which are suitable for curing prostaglandin deficiencies in humans or animal, for example healing or preventing diseases of the gastro-intestinal tract.
    Type: Grant
    Filed: February 1, 1989
    Date of Patent: August 27, 1991
    Assignee: Hoechst Aktiengesellschaft
    Inventor: Klaus U. Weithmann
  • Patent number: 5034400
    Abstract: This invention involves a method for reducing neurotoxic side effects that can be caused when NMDA antagonists such as MK-801 are used as anti-convulsants, to prevent excitotoxic damage in the central nervous system, or for anesthetic purposes in human or veterinary medicine. This method involves the use of anti-cholinergic agents such as scopolamine, atropine, benztropine, trihexyphenidyl, biperiden, procyclidine, benactyzine, or diphenhydramine in conjunction with, or subsequent to, administration of an NMDA antagonist. These anti-cholinergic agents greatly reduce or eliminate the deleterious side effects that can accompany NMDA antagonists (such as convulsion potentiating effects, as well as vacuole formation, mitochondrial dissolution, and possible death of cingulate/retrosplenial cerebrocortical neurons), without interfering with the useful properties of the NMDA antagonists.
    Type: Grant
    Filed: October 20, 1989
    Date of Patent: July 23, 1991
    Inventor: John W. Olney
  • Patent number: 5030657
    Abstract: Fish feed compositions supplemented with up to 0.5% L-carnitine, preferably between 0.01% to 0.3% L-carnitine, produce greater growth gains, decreased fat levels in tissues, and increased resistance to stress (ammonia toxicity) in fish, as compared to fish fed the same diet without supplemental carnitine.
    Type: Grant
    Filed: October 23, 1989
    Date of Patent: July 9, 1991
    Assignees: University of Georgia Research Foundation, Inc., Lonza Inc.
    Inventors: Gary J. Burtle, G. Larry Newton, Stephen A. Blum
  • Patent number: 5028623
    Abstract: The insecticidal transparent emulsion of the present invention is obtained by mixing (A) at least one pyrethroidal insecticide as defined in the claims as an active ingredient; (B) a polar solvent containing mixed surface active agent containing at least one metal alkylbenzenesulfonate, at least one nonionic surface active agent having an HLB (hydro- and lipophilicity balance) of 10 to 18 and at least one polar solvent; and (C) water, so that the content of (B) in the mixture is equal to or more than that of (A) and 6% by weight or less and then diluting the resulting mixture. The insecticidal transparent emulsion of the present invention has the advantage that the solution state is unchanged even when the environmental temperature sharply moves up and down.
    Type: Grant
    Filed: July 24, 1989
    Date of Patent: July 2, 1991
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Tadahiro Matsunaga, Kazunobu Dohara
  • Patent number: 5026719
    Abstract: New microbicidal compositions having improved microbicidal activity comprise a compound of formula I: ##STR1## or an acid addition salt thereof; in which Z is --CH.sub.2 CH.sub.2 --, --CH.sub.2 CH.sub.2 CH.sub.2 --, --CH(CH.sub.3)--CH(CH.sub.3)-- or --CH.sub.2 --CH(C.sub.1 -C.sub.10 alkyl)--; and Ar is a phenyl, thienyl, halothienyl or naphthyl group, or phenyl substituted with 1 to 3 halogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, cyano or nitro substituents; and a compound having the formula II: ##STR2## in which R is C.sub.1 -C.sub.4 alkyl, R.sup.1 is hydrogen or C.sub.1 -C.sub.4 alkyl, m is 0, 1, 2, 3 or 4 and n is 0, 1, 2, 3 or 4; new salts of (restricted) formula II, a process for their preparation and a method for combatting microbicidal plant diseases using the above mentioned compositions.
    Type: Grant
    Filed: June 1, 1987
    Date of Patent: June 25, 1991
    Assignee: Ciba-Geigy Corporation
    Inventor: Edward Nowak