Abstract: A method of treating an aqueous or non-aqueous system, including paints and adhesives, is described which comprises adding to the system a thiolan of the formula: ##STR1## wherein each of X and Y, which may be the same or different, represents fluorine, chlorine or bromine, in combination with an alkylene bisthiocyanate and a 2-N-alkyl-4-isothiazolin-3-one.
Type:
Grant
Filed:
May 17, 1989
Date of Patent:
June 11, 1991
Assignee:
W. R. Grace & Co.-Conn.
Inventors:
Douglas Clarkson, Richard P. Clifford, Alan Marshall
Abstract: The invention relates to a new class of compounds having important biochemical and pharmacological properties. More particularly, this invention relates to N-aralkyl piperidinemethanol derivatives which are potent and selective inhibitors of the binding of serotonin at the 5HT.sub.2 receptor site, and to the processes for their preparation and use.
Abstract: Wood preservatives containing a dimethylalkylamine, tridemorph, fenpropemorph or a mixture thereof, an emulsifier and a water-insoluble acid or a salt thereof, and a method for protectin wood from fungi.
Abstract: A composition for decreasing appetite comprising an indirect-acting sympathomimetic drug and tyrosine or a tyrosine precursor. The drug may be phenylpropanolamine, amphetamine, or ephedrine. The tyrosine enhances the known appetite-suppressing activity of the drug.
Abstract: A pharmaceutical or cosmetic composition for topical application comprises, in a physiologically acceptable support, the combination of benzoyl peroxide and at least one quaternary ammonium lipophilic salicylate having general formula (I): ##STR1## where: (i) R.sub.1, R.sub.2, R.sub.3 and R.sub.4 may be identical or different, representing a substituted or interrupted alkyl or cycloalkyl radical;(ii) R.sub.3 and/or R.sub.4 represent(s) the group:R.sub.8 --OC.sub.2 H.sub.3 R.sub.7 ].sub.n [OCH.sub.2 CHOH--CH.sub.2 ].sub.pwhere O.ltoreq.n.ltoreq.4 and p is 0 or 1; R.sub.8 represents H or an alkyl, alkenyl, alkylcycloalkyl or alkylanyl radical;(iii) R.sub.4 represents an alkylenephenyl radical;(iv), (v): R.sub.1 and R.sub.2 may form an aromatic or nonaromatic saturated or unsaturated heterocycle;(vi) R.sub.1, R.sub.2 and R.sub.3 together with nitrogen, may form polycyclic derivatives; and R.sub.5 represents a group having the formula: ##STR2## where n may vary from 0 to 10.
Type:
Grant
Filed:
November 23, 1988
Date of Patent:
May 28, 1991
Assignee:
L'Oreal
Inventors:
Michel Philippe, Michel Hocquaux, Henri Sebag, Irina Beck, Jean P. Laugier
Abstract: A stable biocide composition for industrial use which comprises 4,5-dichloro-1,2-dithiol-3-one and a mixture of 5-chloro-2- methyl-3-isothiazolone and 2-methyl-3-isothiazolone, together with a substantially anhydrous organic solvent for dissolving said ingredients.
Abstract: Water-based pesticide compositions are disclosed that are effective to kill molluscs, insects, and small rodents. The compositions are resistant to washing away by water, yet retain moisture such that the texture of the composition is such that pests find it palatable even after extended periods of time have passed after application. The compositions are environmentally safe and do not pose a significant toxicological threat to humans and pets.
Type:
Grant
Filed:
August 10, 1989
Date of Patent:
May 21, 1991
Assignee:
E. M. Matson, Jr., Company, Inc.
Inventors:
David L. Grassman, Scott P. Ager, Tamis L. Root
Abstract: Prevention of or therapeutically curing the disease of alcoholism comprises supplementing the diet with biologically available chromium, such as naturally occurring chelated chromium. A food bar containing chromium picolinate is also disclosed.
Abstract: A novel antimicrobial, aromatic and deodorizing agent composition and a method of reducing microbial concentration or inhibiting microbial growth using the composition are provided, which composition comprises a zeolote or porous glass carrier and a saturated monoterpene hydroperoxide as an active ingredient, the monoterpene hydroperoxide preferably selected from pinane hydroperoxide, thujane hydroperoxide, carane hydroperoxide, bornane hydroperoxide, paramenthane hydroperoxide, metamenthane hydroperoxide, and mixtures of the foregoing, etc.
Abstract: Androstane derivatives of the general Formula I ##STR1## in which R.sub.1 represents a hydrogen atom or a methyl group,X and Y each mean hydrogen atoms or together a carbon-carbon bond, andR.sub.2 symbolizes a hydrogen atom or an alkyl group with 1 to 6 carbon atoms,are pharmaceutically effective substances which have a distinct antiandrogenic effectiveness in topical application.
Type:
Grant
Filed:
July 13, 1989
Date of Patent:
April 23, 1991
Assignee:
Schering Aktiengesellschaft
Inventors:
Dieter Bittler, Henry Laurent, Petra Rach, Michael Topert
Abstract: The invention relates to an agent for the prophylaxis of cardiac infarcti and for the prevention or reinfarctions, and is characterized by the fact that said agent comprises a combination of magnesium amino dicarboxylic acid halides, basic magnesium amino dicarboxylic acid salts, and magnesium halides, singly or in combination, on the one hand, and acetylsalicylic acid, on the other hand, as well as conventional pharmaceutical carriers, diluents, and/or adjuvants, as required.
Type:
Grant
Filed:
May 1, 1989
Date of Patent:
April 9, 1991
Assignee:
Verla-Pharm Arzneimittelfabrik Apotheker H.J.V. Ehrlich GmbH & Co. KG.
Abstract: Ruminants are fed a water-insoluble polymer, which may be swollen (i.e. having absorbed water to form a gel) or unswollen. At least 0.04 kg of (swollen) polymers per day per 100 kg body weight is administered, and the polymer has not necessarily been used as a substrate for the preparation of feedstuff.Such methods are particularly advantageous when the animal is being fed on a diet causing acid conditions in the rumen, such as a diet of silage.A useful polymer is ammonium polyacrylate cross-linked by about 500 ppm methylene bisacrylamide ("MBA").The polymers enhance feed conversion rates and hence lower the effective cost of feeding the animals.
Type:
Grant
Filed:
March 11, 1987
Date of Patent:
April 2, 1991
Assignees:
Rene Pich, Hubert Issaurat, Barry A. Thompson
Abstract: Concentrated aqueous solutions of 1,2-benzisothiazolin-3-one are prepared by incorporating a buffering agent such that the pH of the solution is between about 3.0 and 7.0, and further adding a sufficient amount of glutaraldehyde such that a greater amount of such 1,2-benzisothiazolin-3-one is in solution than would be in solution if such glutaraldehyde were not present. Also disclosed is a synergistic biocidal composition comprising glutaraldehyde and 1,2-benzisothiazolin-3-one, as well as an aqueous-based industrial composition comprising such synergistic biocidal composition.
Type:
Grant
Filed:
April 20, 1989
Date of Patent:
April 2, 1991
Assignees:
Imperial Chemical Industries plc, ICI Americas Inc.
Abstract: The present invention provides (a) an activator for osteoblast comprising, as an active ingredient, a salt between (1) an organogermanium compound represented by the formula (I) ##STR1## [in the above formula (I), R.sub.1, R.sub.2 and R.sub.3 which may be the same or different, are independently a hydrogen atom, a lower alkyl group such as methyl, ethyl or the like, or an aryl group] and (2) a basic group-containing compound, and (b) a method for activating osteoblasts, which comprises administering in need of such treatment an effective amount of a salt between an organogermanium compound represented by the above formula (I) and a basic group-containing compound.
Type:
Grant
Filed:
November 28, 1988
Date of Patent:
March 26, 1991
Assignee:
ASAI Germanium Research Institute Co., Ltd.
Abstract: An agent for relieving radiogenic or drug-induced side effects, characterized by comprising a spergualin derivative of the following formula (I):NH.sub.2 --C(.dbd.NH)--NH--R.sub.1 --R.sub.2 --CONH--R.sub.3 --CONH--(CH.sub.2).sub.4 --NH--(CH.sub.2).sub.3 --NH--Xwherein R.sub.1 represents --(CH.sub.2).sub.4 --, --(CH.sub.2).sub.6 ##STR1## R.sub.2 represents --(CH.sub.2).sub.2 -- or --CH.dbd.CH--, R.sub.3 represents --(CH(OH)--CH(OMe)--, --CH.sub.2 -- or --(CH.sub.2).sub.m --CH(OH)--(CH.sub.2).sub.n -- (m represent an integer of 0,1 or 2 and n represents an integer of 1 or 2)X represents a hydrogen atom or a group formed by removing a hydroxyl group from a carboxyl group of an amino acid,or a pharmacologically acceptable salt thereof as an active ingredient.
Abstract: The invention encompasses mixtures of antimicrobial agents coencapsulated in liposomes which when administered in vivo exert an enhanced therapeutic effect. The therapeutic effectiveness of the coencapsulated antimocrobial agents is greater than that of the same combination administered either in solution or as a mixture of liposome populations each containing one of the antimicrobial agents.
Type:
Grant
Filed:
July 26, 1984
Date of Patent:
March 19, 1991
Assignee:
The Liposome Company, Inc.
Inventors:
Michael W. Fountain, Steven J. Weiss, Robert P. Lenk, Mircea C. Popescu, Richard S. Ginsberg
Abstract: The concentration of endogenous growth hormone in the bloodstream of an economic mammal is increased by the simultaneous administration of an estrogen and a growth hormone releasing factor.
Abstract: Novel substituted 2,3-diphenyl-1,2-dihydroquinoxalines are useful for promoting growth and improving feed conversion efficiencies in meat-producing animals. In addition, the novel compounds are useful for controlling coccidiosis in poultry.
Type:
Grant
Filed:
August 30, 1989
Date of Patent:
February 12, 1991
Assignee:
International Minerals & Chemical Corp.
Inventors:
Kurt G. R. Sundelin, Joseph P. Salanitro, Susan Stackhouse
Abstract: A process for preparing aqueous parenteral compositions of drugs which are weak bases and are only slightly soluble in water is disclosed. Aqueous parenteral compositions of the antifungal agent (.+-.) (2R*, 3R*)-2-(2,4-difluorophenyl)-3-methylsulfonyl-1-(1,2,4-triazol-1-yl)butan-2 -ol are also disclosed.
Abstract: Compositions of azole fungicides exhibiting reduced eye irritation are prepared by replacing a significant portion of the hydrocarbon solvent with a combination of propylene glycol and a long chain fatty alcohol.