Patents Examined by Kyung Sook Chang
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Patent number: 9290781Abstract: The present invention provides a method for producing a composition containing 2-acyl-lysophosphatidylserine, including (a) a step of obtaining a composition containing phosphatidylserine by allowing phospholipase D to act on a raw material containing phosphatidylcholine in the presence of serine and (b) a step of obtaining a composition containing 2-acyl-lysophosphatidylserine by allowing phospholipase A1 to act on the composition containing phosphatidylserine in the presence of one or more additives selected from the group consisting of the following (I), (II), and (III), in which (I) one or more salts selected from the group consisting of sulfate salts, phosphate salts, nitrate salts, citrate salts, and tartarate salts of monovalent cations, (II) a gum, and (III) an emulsifier.Type: GrantFiled: September 26, 2011Date of Patent: March 22, 2016Assignees: National University Corporation Tokyo University of Marine Science and Technology, Meiji Co., Ltd.Inventors: Kazunaga Yazawa, Tomoyuki Susa, Shoji Gotoh, Yasuhito Tashiro, Junichi Kawashima, Shigeyuki Imamura
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Patent number: 9283212Abstract: The present invention relates to unique delivery systems and the use of an imidazobenzodiazepine derivative, such as flumazenil either alone or in combination with other receptor antagonists in the treatment of disease or medical disorders.Type: GrantFiled: February 19, 2010Date of Patent: March 15, 2016Assignee: PALMAYA PTY LTDInventor: Alexander George Brian O'Neil
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Patent number: 9272071Abstract: The present invention relates porous osteoinductive nanocomposites and for the methods to prepare osteoinductive nanocomposites. The osteoinductive composites consist of biocompatible polymers and non-heated (or non-sintered), needle-shaped or plate-like calcium phosphate nanocrystals and the methods comprise the steps of: a. adding phosphate to a calcium solution thereby evoking precipitation of calcium phosphate nanocrystals; b. washing the nanocrystals with water and suspending them in an organic solvent or getting dry calcium phosphate nanocrystals after evaporating organic solvent; c.Type: GrantFiled: May 27, 2009Date of Patent: March 1, 2016Assignee: REVISIOS B.V. I.O.Inventors: Davide Barbieri, Huipin Yuan, Joost Dick De Bruijn
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Patent number: 9265775Abstract: Compositions, and methods of using such compositions, useful for injection into the posterior segments of human or animal eyes are provided. Such compositions include corticosteroid component-containing particles present in a therapeutically effective amount, a viscosity inducing component, and an aqueous carrier component. The compositions have viscosities of at least about 10 cps or about 100 cps at a shear rate of 0.1/second. In a preferred embodiment, the viscosity is in the range of from about 140,000 cps to about 300,000 cps. The compositions advantageously suspend the particles for prolonged periods of time.Type: GrantFiled: October 28, 2013Date of Patent: February 23, 2016Assignee: Allergan, Inc.Inventors: Robert T. Lyons, James N. Chang, John T. Trogden, Scott Whitcup
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Patent number: 9259401Abstract: The invention disclosed relates to a water-soluble composition having enhanced bioavailability useful for the treatment of depression which comprises a synergistic combination of curcumin, at least an antioxidant, a hydrophilic carrier and a fat. The invention also discloses a process for the preparation of the curcumin composition which comprises the steps of dissolving curcumin, at least one antioxidant, a hydrophilic carrier and a fat in a solvent to form a homogenous mass; warming the resultant mass at a temperature ranging from 25° C. to 60° C. for a period of 4 to 8 hours to obtain a dry wet mass; removing the solvent by evaporation to form dry mass and pulverizing the dry mass to form a fine powder.Type: GrantFiled: July 22, 2011Date of Patent: February 16, 2016Assignee: OMNIACTIVE HEALTH TECHNOLOGIES LTD.Inventors: Jayant Venkatesh Deshpande, Shrinivas Krishnarao Kulkarni
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Patent number: 9248142Abstract: Disclosed herein are compositions and methods for controlling fertility of a female subject. Particularly exemplified are compositions comprising sugar derivatives, such as 2-deoxyglucose, D-mannoheptulose; and/or 5-thio-D-glucose. Also disclosed herein are methods of preserving ova supply in a female subject that involves administering glucose derivatives. The composition typically includes a glucose derivative that affects Foxo3a expression.Type: GrantFiled: October 28, 2011Date of Patent: February 2, 2016Assignee: University of Florida Research Foundation, Inc.Inventors: Harry S. Nick, Kimberly J. Aiken, Sarah J. Barilovits, Justin S. Bickford, Dawn E. Beachy
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Patent number: 9248584Abstract: The process comprises delivering a spray solution comprising at least one solute in a solvent to a spray-drying apparatus, using a flash nozzle to atomize the spray solution into droplets within the spray-drying apparatus to remove at least a portion of the solvent from the droplets to form a plurality of particles, and collecting the particles. The spray solution is directed to a heat exchanger, thereby increasing the temperature of the spray solution to a temperature T2, wherein T2 is greater than T1. The flash nozzle comprises a central tube through which the spray solution is delivered and an outer tube through which a sweep gas is delivered. The central tube may have a first outer diameter at an inlet and a second outer diameter at an outlet, wherein the first outer diameter is greater than the second outer diameter.Type: GrantFiled: September 22, 2011Date of Patent: February 2, 2016Assignee: Bend Research, Inc.Inventors: Dwayne T. Friesen, David D. Newbold, John M. Baumann, Devon B. DuBose, Douglas L. Millard
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Patent number: 9226906Abstract: The present invention relates to a method and nutritional supplement which stimulates appetite and slows metabolism of a mammal, thereby enhancing weight gain for the mammal. The method of enhancing weight gain of the mammal comprises administering to the mammal an effective amount of at least two types of alkamide or isobutylamide compound extracted from Echinacea species along with an antioxidant and optionally minerals. The nutritional supplement of the present invention comprises an antioxidant and at least two types of alkamide or isobutylamide compounds derived from Echinacea species. Minerals such as zinc and magnesium can also be added to the nutritional supplement to provide even better effect.Type: GrantFiled: September 13, 2013Date of Patent: January 5, 2016Assignee: Supragenix, LLCInventors: Travis Kurt Alvord, Tyler Stevens Alvord
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Patent number: 9226496Abstract: Disclosed is a biomimetic adhesive belonging to prevention and treatment of plant pest. The components and ratio of raw materials thereof are as follows: 25-50% of soft acrylic monomer, 1-5% of acrylic monomer, 0.1-0.3% of nonionic emulsifier, 0.1-0.8% of anionic emulsifier, 0.2-0.6% of catalyst, 0.1-0.3% of antiseptic, 0.02-0.05% of defoamer, and deionized water as remainder. Fluorescent substances or insect pheromones can also be added to said biomimetic adhesive. The biomimetic adhesive of the present invention has good effect of insect sticking without environmental impact, has long time effect, is safe, non-toxic and non-polluting, and can be sprayed directly onto the surface of plant branch and leaves using an ordinary sprayer due to its low viscosity at room temperature. It also has no adverse effects on photosynthesis and normal growth of plants. The preparation method of the biomimetic adhesive is also disclosed.Type: GrantFiled: November 29, 2010Date of Patent: January 5, 2016Assignees: Institute of Medicinal Plant Development The Chinese Academy of Medical Sciences, Foshan Sanshui Xianghai Adhesive Co., Ltd.Inventors: Changqing Xu, Jun Chen, Liuying Yu
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Patent number: 9216148Abstract: Provided are a novel compound having skin-whitening, anti-oxidizing and PPAR activities and a medical use thereof, and the compound has skin-whitening activities for the suppression of tyrosinase, and accordingly, is useful for use in skin-whitening pharmaceutical composition or cosmetic products; has anti-oxidant activities, and accordingly, is useful for the prevention and treatment of skin-aging; and has PPAR activities, and in particular, PPAR? and PPAR? activities, and accordingly, is useful for use in pharmaceutical compositions or health foods which are effective for the prevention and treatment of obesity, metabolic disease, or cardiovascular disease.Type: GrantFiled: February 8, 2012Date of Patent: December 22, 2015Assignee: Pusan National University Industry-University Cooperation FoundationInventors: Hae Young Chung, Hyung Ryong Moon, Min Hi Park, Young Mi Ha, Yun Jung Park, Ji Young Park, Jin Ah Kim, Ji Yeon Lee, Kyung Jin Lee
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Patent number: 9211397Abstract: A patch for treatment of eyelid diseases that is provided with a support, a pressure-sensitive adhesive layer, and a release layer in this order, wherein (a) the pressure-sensitive adhesive layer includes the following (a-1) to (a-4): (a-1) a styrene-isoprene-styrene block copolymer, a tackifier resin, and a softening agent are contained; (a-2) a ratio (mass ratio) of the styrene-isoprene-styrene block copolymer and the tackifier resin is 1:2 to 1:4; (a-3) a content of the softening agent is 40% to 60% by mass; and (a-4) further 0.005% to 5% by mass of clobetasol or acid ester thereof is contained; and (b) the support has elastic modulus with a Young's modulus of 0.01 to 0.5 GPa: and a method for producing the patch for treatment of eyelid diseases including: forming a pressure-sensitive adhesive layer on a upper surface of a release layer.Type: GrantFiled: December 19, 2012Date of Patent: December 15, 2015Assignee: SENJU USA, INC.Inventors: Takahiro Ogawa, Akiharu Isowaki, Koji Kawahara, Takao Hiraoka, Mariko Tanaka, Chihiro Kenmochi
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Patent number: 9205041Abstract: A transdermal composition comprising ibuprofen or salts thereof and a gelling agent which can be used for the treatment of such disorders as pain, inflammation, arthritis, muscle spasm and associated symptoms in humans and animals.Type: GrantFiled: May 3, 2012Date of Patent: December 8, 2015Assignee: Aponia Laboratories, Inc.Inventors: Haigang Chen, Gareth Winckle, Christopher Riley
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Patent number: 9200242Abstract: The present invention relates to a thickener comprising at least one cationic polymer and at least one activator. The at least one cationic polymer is preparable by polymerization of a) at least one water-soluble ethylenically unsaturated monomer comprising at least one cationic monomer, optionally at least one anionic monomer and/or optionally at least one nonionic monomer, b) at least one ethylenically unsaturated associative monomer, c) optionally at least one crosslinker, and d) optionally at least one chain transfer agent. The ratio of activator to cationic polymer is >10 to 100 [% by weight/% by weight].Type: GrantFiled: November 7, 2012Date of Patent: December 1, 2015Assignee: BASF SEInventors: Christofer Arisandy, Reinhold J. Leyrer, Ouidad Benlahmar
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Patent number: 9192583Abstract: A multiparticulate composition includes a plurality of individual enteric coated cores containing one or more terpene-based active ingredients and having a continuous proteinaceous subcoating layer covering the individual cores and separating the individual cores from their respective enteric coatings. The continuous proteinaceous subcoating layer prevents volatile terpene-based active ingredients from leaving the core, even when the core is heated during processing or stored for long periods above room temperature. The multiparticulate composition may be used to treat gastrointestinal disorders.Type: GrantFiled: October 27, 2014Date of Patent: November 24, 2015Assignee: Zx Pharma, LLCInventors: Syed M. Shah, Fred Hassan
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Patent number: 9180124Abstract: Disclosed is nicotine containing solid oral transmucosal dosage forms containing a therapeutically effective amount of nicotine polacrilex, citric acid monohydrate, sucrose and liquid glucose. The dosage form is preferably in the form of lozenge.Type: GrantFiled: December 1, 2010Date of Patent: November 10, 2015Assignee: J. B. Chemicals and Pharmaceuticals LimitedInventors: Bharat Pravinchandra Mehta, Rajen Dhirubhai Shah, Manoj Kantilal Patel, Parmeshwar B. Bang
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Patent number: 9174940Abstract: The present invention relates the use of a compound, a pharmaceutical composition, compounds and a kit for treating or preventing disorders in a mammal responsive to TSH receptor mediated pathways, including disorders such as hyperthyroidism, Graves' disease, Graves Ophthalmopathy, Graves' associated pretibial dermopathy, nodular goitre and thyroid cancer comprising administering to said mammal an effective amount of a tetrahydroquinoline compound of Formula (I) or an pharmaceutically acceptable salt thereof.Type: GrantFiled: August 28, 2008Date of Patent: November 3, 2015Assignee: Merck Sharp & Dohme B.V.Inventors: Willem Frederik Johan Karstens, Paolo Giovanni Martino Conti, Cornelis Marius Timmers, Ralf Plate, Christianus Johannes Van Koppen
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Patent number: 9155705Abstract: The present invention relates to pharmaceutical compositions comprising fixed dose combinations of a DPP-4 inhibitor drug and a partner drug, processes for the preparation thereof, and their use to treat certain diseases.Type: GrantFiled: April 2, 2009Date of Patent: October 13, 2015Assignee: Boehringer Ingelheim International GmbHInventors: Thomas Friedl, Michael Braun, Kenji Egusa, Hikaru Fujita, Megumi Maruyama, Takaaki Nishioka
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Patent number: 9155758Abstract: The invention provides a method for treating or preventing heart failure in a subject, which includes administering to the subject in need thereof a therapeutically effective amount of a Poloxamer (e.g., Poloxamer 188).Type: GrantFiled: August 1, 2007Date of Patent: October 13, 2015Assignee: PHRIXUS PHARMACEUTICALS, INC.Inventor: Bruce Edward Markham
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Patent number: 9155694Abstract: A stabilized composition comprising at least one adrenergic compound and at least one antioxidant selected from the group consisting of a bisulfite, a metabisulfite and a sulfite compound.Type: GrantFiled: June 3, 2010Date of Patent: October 13, 2015Assignee: ALK AGInventors: Alan J. Baillie, Kenneth Macdonald, Pamela Porteous, Simon Hendry
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Patent number: 9149056Abstract: A pet food composition having at least two carotenoids. The carotenoids can include a keto-carotenoid and at least one non-keto-carotenoid. The keto-carotenoid can include astaxanthin. The keto-carotenoid can include astaxanthin ester. The non-keto-carotenoid can include beta-carotene and/or lutein.Type: GrantFiled: January 11, 2012Date of Patent: October 6, 2015Assignee: The Iams CompanyInventor: Jin Zhang