Patents Examined by L. Martinez
  • Macrocycles
    Patent number: 10738084
    Abstract: The invention relates to cyclic compounds of general formula (I): wherein R1, R2 and R3 are as defined in the specification, and their use as pharmaceuticals.
    Type: Grant
    Filed: June 30, 2016
    Date of Patent: August 11, 2020
    Assignee: Sentry Therapeutics Limited
    Inventors: Michael Peel, Andrew Scribner, Koichi Watashi, Satomi Shimura
  • Scarring reducing wound treatment
    Patent number: 10729748
    Abstract: Undue scarring of healing wounds is decreased and/or the relapse rate of wounds is lowered by applying a composition that includes hemoglobin to the wound area. At least 90% of the hemoglobin in the composition is provided in CO-charged form.
    Type: Grant
    Filed: February 29, 2016
    Date of Patent: August 4, 2020
    Assignee: MÖLNLYCKE HEALTH CARE AB
    Inventor: Michael Sander
  • Recombinant binding proteins targeting HER2 and serum albumin, and their uses
    Patent number: 10717772
    Abstract: New recombinant binding proteins, comprising designed ankyrin repeat domain(s) with binding specificity for HER2, and comprising designed ankyrin repeat domain(s) with binding specificity for serum albumin, are disclosed, as well as nucleic acids encoding such recombinant binding proteins, pharmaceutical compositions comprising such recombinant binding proteins or nucleic acids and the use of such recombinant binding proteins, nucleic acids or pharmaceutical compositions in the treatment of diseases.
    Type: Grant
    Filed: September 20, 2017
    Date of Patent: July 21, 2020
    Assignee: Molecular Partners AG
    Inventors: Clara Metz, Ulrike Fiedler, Ignacio Dolado, Heike Maria Strobel
  • Variant serum albumin with improved half-life and other properties
    Patent number: 10711050
    Abstract: The invention provides methods and materials for making and using variant serum albumin amino acid sequences which exhibit improved properties compared to wild type serum albumin sequences. The invention further provides methods and materials for making and using fusion proteins in which the variant serum albumin amino acid sequences are fused to a therapeutic or diagnostic agent, such as a therapeutic protein, or a functional fragment or variant thereof that maintains activity, and exhibits improved properties.
    Type: Grant
    Filed: May 25, 2018
    Date of Patent: July 14, 2020
    Assignee: ALBUMEDIX LTD
    Inventors: Michael March Schmidt, Eric Steven Furfine, Amy Jada Andreucci, Thomas M. Barnes
  • Assay device having controllable sample size
    Patent number: 10712340
    Abstract: Disclosed is an assay device which comprises a liquid sample addition zone, a reagent zone, a detection zone, and a wicking zone, all defining a fluid flow path. The device further comprises a reagent addition zone along and in fluid communication with the fluid flow path downstream of the sample addition zone and upstream of the detection zone. An interrupting wash is added at this reagent addition zone in accordance with the method of the subject invention to control sample volume. The interrupting wash fluid is added at a predetermined fill volume on the chip device and also serves to wash the detection channel and fill the remaining chip volume.
    Type: Grant
    Filed: January 18, 2013
    Date of Patent: July 14, 2020
    Assignee: ORTHO-CLINICAL DIAGNOSTICS, INC.
    Inventors: Edward R. Scalice, Philip C. Hosimer, Zhong Ding, James D. Kanaley, David A. Tomasso, Daniel P. Salotto, Timothy C. Warren
  • Methods of producing patient-specific anti-cancer therapeutics and methods of treatment therefor
    Patent number: 10712344
    Abstract: A method of preparing an antibody therapeutic is provided comprising: (a) providing a dissociated cell sample from at least one solid tumor sample obtained from a patient; (b) loading the dissociated cell sample into a microfluidic device having a flow region and at least one isolation region fluidically connected to the flow region; (c) moving at least one B cell from the dissociated cell sample into at least one isolation region in the microfluidic device, thereby obtaining at least one isolated B cell; and (d) using the microfluidic device to identify at least one B cell that produces antibodies capable of binding to cancer cells. The cancer cells can be the patient's own cancer cells. Also provided are methods of treating patients, methods of labeling or detecting cancer, engineered T or NK cells comprising antibodies or fragments thereof, and engineered antibody constructs.
    Type: Grant
    Filed: January 13, 2017
    Date of Patent: July 14, 2020
    Assignee: Berkeley Lights, Inc.
    Inventors: Kevin T. Chapman, George L. Fox, Peggy A. Radel, Mark P. White, Xiaohua Wang, Minha Park, Guido K. Stadler, Randall D. Lowe, Jr., Xiao Guan Radstrom, Jason M. McEwen, Gang F. Wang
  • Therapeutic vitamin D conjugates
    Patent number: 10702574
    Abstract: The invention provides non-hormonal vitamin D conjugated to apelin proteins that result in increased absorption, bioavailability or circulating half-life when compared to non-conjugated forms. In some embodiments, the vitamin D targeting groups are coupled to the apelin proteins via the third carbon on the vitamin D backbone.
    Type: Grant
    Filed: February 11, 2017
    Date of Patent: July 7, 2020
    Assignee: Extend Biosciences, Inc.
    Inventors: Tarik Soliman, Laura M. Hales, Daniel B. Hall, Christopher So, Howard P. Sard, Vishnumurthy Hegde
  • Targeting deregulated Wnt signaling in cancer using stabilized alpha-helices of BCL-9
    Patent number: 10703785
    Abstract: The invention provides structurally-constrained peptides by hydrocarbon stapling of a BCL9 HD2 helix for use as a therapeutic agent. The invention further provides methods and kits for use of the structurally-constrained peptide of the instant invention. The invention is based, at least in part, on the results provided herein demonstrating that hydrocarbon stapled helical peptides display excellent proteolytic, acid, and thermal stability, restore the native helical structure of the peptide, possess superior pharmacokinetic properties compared to the corresponding unmodified peptides, and are highly effective in binding to ?-catenin in vitro, in cellulo, and in vivo, disrupting the BCL-9/?-catenin interaction, and thereby interfering with deregulated Wnt/?-catenin signaling for therapeutic benefit in a variety of human diseases including human cancer.
    Type: Grant
    Filed: April 16, 2012
    Date of Patent: July 7, 2020
    Assignee: DANA-FARBER CANCER INSTITUTE, INC.
    Inventors: Loren D. Walensky, Ruben Carrasco, Gregory H. Bird
  • Protective solution for preventing or reducing reperfusion injury of the brain and the whole body
    Patent number: 10695407
    Abstract: The present invention relates to a protective solution for preventing or reducing reperfusion injury of the brain which contains magnesium ions and which has an osmolality of 350 to 600 mOsm/L, a pH value of 6.8 to 7.8 and albumin in an amount of 1 to 20% by weight.
    Type: Grant
    Filed: July 1, 2014
    Date of Patent: June 30, 2020
    Assignee: ResuSciTec GmbH
    Inventors: Christoph Benk, Friedhelm Beyersdorf, Georg Trummer
  • Nanopipette device and method for subcellular analysis
    Patent number: 10696962
    Abstract: Described herein are devices and methods for extracting cellular material from living cells and then depositing them into to a receptacle in a nanoliter scale. Using a nanopipette integrated into a scanning ion conductance microscope (SICM), extraction of mitochondrial DNA from human BJ fibroblasts and Green Fluorescent Protein (GFP) transcripts from HeLa/GFP cells was achieved with minimal disruption to the cellular milieu and without chemical treatment prior to obtaining the isolated sample. Success of the extraction was confirmed by fluorescence microscopy and PCR analysis of the extracted material. The method and apparatus may be applied to many different cell types and intracellular targets, allowing not only single cell analysis, but single subcellular compartment analysis of materials extracted in their native state.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: June 30, 2020
    Assignee: The Regents of the University of California
    Inventors: Paolo Actis, Michelle M. Maalouf, Nader Pourmand
  • Complement factor B analogs and their uses
    Patent number: 10689637
    Abstract: The invention provides polypeptides comprising a complement factor B analog. The invention also provides various complement factor B analogs including complement factor B analogs comprising a mutation of a free cysteine amino acid and related methods, nucleic acids and vectors. These complement factor B analogs and related methods, nucleic acids and vectors can be used to modulate a complement pathway or for the study and/or treatment of various conditions or diseases related to a complement pathway.
    Type: Grant
    Filed: July 3, 2019
    Date of Patent: June 23, 2020
    Assignee: Wellstat ImmunoTherapeutics, LLC
    Inventors: ChangHung Chen, Michael Kaleko, Beibei Li, Tianci Luo, Jeffrey Allan Miller, Ruigong Wang
  • Lateral flow assay device
    Patent number: 10688487
    Abstract: Lateral flow devices, methods and kits for performing lateral flow assays are provided.
    Type: Grant
    Filed: November 20, 2017
    Date of Patent: June 23, 2020
    Assignee: Bio-Rad Laboratories, Inc.
    Inventors: William Strong, Clayton T. McKee
  • Fluidic device, fluid control method, testing device, testing method, and fluidic device manufacturing method
    Patent number: 10677791
    Abstract: A fluidic device includes a valve configured to adjust a fluid flow in a first direction of a flow path. The fluidic device includes: a diaphragm of the valve; a first substrate having a groove that constitutes the flow path and a protrusion part at a position facing the diaphragm in the groove; and a second substrate to which the diaphragm is fixed at a first fixation part and a second fixation part, wherein a length from a first end part of the protrusion part to a second end part of the protrusion part seen in the first direction is greater than a length from the first fixation part to the second fixation part.
    Type: Grant
    Filed: December 21, 2016
    Date of Patent: June 9, 2020
    Assignee: NIKON CORPORATION
    Inventors: Kenji Miyamoto, Masaru Kato
  • System for detection of an analyte in a fluid
    Patent number: 10677792
    Abstract: The invention provides a system for detection of at least one analyte present in a fluid, the system comprising a detector comprising an assay configured to detect presence of the analyte in the fluid, the detector comprising a specimen sampling region for the fluid and a protective seal partially covering the detector, wherein only the specimen sampling region is uncovered by the fluid-protective seal, and wherein the fluid-protective seal provides resistance to acid. The system can be fully submerged in an acidic solution and still retain is functionality.
    Type: Grant
    Filed: August 30, 2018
    Date of Patent: June 9, 2020
    Inventor: Gideon Mor
  • Detection of polymeric analytes
    Patent number: 10656146
    Abstract: The present invention relates to methods for detecting polymeric analytes, especially biopolymers, and sensors for detecting the polymeric analytes. The present invention uses magnetic beads in a rotating magnetic field to provide a visual detection of the presence of a polymeric analyte, such as nucleic acids, lipids, polysaccharides, proteins, etc. When a polymeric analyte binds to the magnetic beads, application of a rotating magnetic field to the beads results in unique pinwheel formations. Without the presence of the polymeric analyte, the movement of the magnetic beads induced by the rotating magnetic field differs significantly from the pinwheel formations. The pinwheel, therefore, is used to detect the presence of polymeric analytes.
    Type: Grant
    Filed: September 10, 2010
    Date of Patent: May 19, 2020
    Assignee: University of Virginia Patent Foundation
    Inventors: James P. Landers, Daniel C. Leslie
  • Air capillary vent for a lateral flow assay device
    Patent number: 10656151
    Abstract: A lateral flow diagnostic assay device is defined by a substrate having a top surface that further includes a sample addition zone for receiving a sample, a transport and reaction zone, and a wicking zone. Each of the sample addition zone, reaction and transport zone and wicking zone are disposed on the top surface of the substrate and fluidically interconnected by means that permit lateral capillary flow along at least one fluid flow path from the sample addition zone to the wicking zone. The assay device further includes a capillary vent disposed in relation to the wicking zone, the capillary vent having an overall length and cross sectional area that creates a backpressure so as to control the flow rate of a sample applied to the assay device.
    Type: Grant
    Filed: January 27, 2017
    Date of Patent: May 19, 2020
    Assignee: ORTHO-CLINICAL DIAGNOSTICS, INC.
    Inventor: David A. Heavner
  • Sensor integration in lateral flow immunoassays and its applications
    Patent number: 10648976
    Abstract: Lateral flow immunoassay devices for determining the concentration of an analyte in a sample and methods for measuring analyte concentration in sample using such lateral flow immunoassay devices.
    Type: Grant
    Filed: February 22, 2018
    Date of Patent: May 12, 2020
    Assignee: Robert Bosch GmbH
    Inventors: Sam Kavusi, Frederik Kotz
  • Wound spray
    Patent number: 10646613
    Abstract: The present invention refers to a composition, comprising hemoglobin or myoglobin, wherein in at least 40% of said hemoglobin or myoglobin the oxygen binding site is charged by a non-O2 ligand, and at least one further ingredient, a method for preparing said composition and the use of hemoglobin or myoglobin charged with a non-oxygen ligand for external treatment of wounds.
    Type: Grant
    Filed: July 23, 2012
    Date of Patent: May 12, 2020
    Assignee: MÖLNLYCKE HEALTH CARE AB
    Inventors: Michael Sander, Harald Potzschke
  • Pediatric nutritional composition with milk peptides for healthy growth and development
    Patent number: 10639334
    Abstract: The present disclosure generally provides pediatric nutritional compositions comprising a protein source comprising an intact milk protein and a partially hydrolyzed milk protein, wherein about 5% to about 25% of total nitrogen content of the composition is non-protein nitrogen. The pediatric nutritional compositions described herein also comprise a fat source and a carbohydrate source. The partially hydrolyzed protein source, in certain embodiments, provides peptides that have similar structure and function to the peptides found in human milk.
    Type: Grant
    Filed: January 7, 2014
    Date of Patent: May 5, 2020
    Assignee: MEAD JOHNSON NUTRITION COMPANY
    Inventors: Dattatreya Banavara, Roseanne P. Batema
  • Diamond jewelry
    Patent number: D883850
    Type: Grant
    Filed: July 2, 2018
    Date of Patent: May 12, 2020
    Assignee: A.V. JEWELRY OF NY LTD.
    Inventor: Avi Matatov