Abstract: A dermal compositon comprising a drug, a multi-polymer of vinyl acetate, polyethylene and optionally one or more monomers, a natural or synthetic rubber and a tackifying agent. The ratio of the multipolymer to the rubber is, respectively, about 1:1 to about 10:1 and more preferably 1:1 to 5:1 and more preferably 3:1. The dermal composition can optionally contain a crosslinking agent, tackifiers, penetration enhancers and other ingredients known for use in adhesives for the transdermal delivery of drugs. The dermal compositions can be produced by a variety of methods known in the preparation of drug containing adhesive preparations including the homogenous mixing of the multi-polymer, drug and optional crosslinking agent and additional ingredients in aqueous solution followed by removal of excess water.

Abstract: An adhesive bandage having a well for receiving a medication supplied by the user and for confining the medication to a predetermined area. A flexible flap covers and seals the well.

Abstract: A transdermal drug delivery system which system comprises an impervious backing sheet and face membrane, the backing sheet and membrane secured together to form an intermediate reservoir. The face membrane is a macroporous membrane which has pores of sufficient size to avoid any rate control of the drug to be transdermally delivered to the user. The reservoir contains a viscous liquid base material selected to exude from the membrane to form a film and to occlude the skin of the user to force hydration of the stratum corneum with water from the lower layers of the epidermis of the user. The liquid base material contains an effective, therapeutic amount of the drug for transdermal delivery, such as the contraceptive steroid, which drug is highly soluble in the liquid base material.

Abstract: This invention relates to a method for administering systemically active agents including therapeutic agents through the skin or mucosal membranes of humans and animals in a transdermal device or formulation comprising topically administering with said systemic agent an effective amount of a membrane penetration enhancer having the structural formula ##STR1## wherein R.sup.1 and R.sup.2 are independently selected from the group consisting of alkyl radicals and cycloalkyl radicals comprising from 1 to 20 carbon atoms and R is selected from the group consisting of alkyl radicals and cycloalkyl radicals comprising from 1 to 30 carbon atoms; provided, however, that the total number of carbon atoms in said compound is 15 or more and the total number of carbon atoms in R.sup.1 and R.sup.2 is 5 or more.

Abstract: An apparatus for glossing a developer sheet is provided. The developer sheet has a thermoplastic developer resin on the surface thereof wherein the thermoplastic developer resin is capable of forming a film which imparts gloss upon the application of heat thereto. In the process, an arched plate is heated to a temperature sufficient to cause the thermoplastic developer resin to coalesce. The arched plate has a heat transfer limiting blanket thereon to maintain the flatness of the developer sheet. The developer sheet is fed between the convex side of the heated arched plate and a belt held snugly against the plate. The belt is driven so as to move the developer sheet over the heated arched plate.

Abstract: A combination pharmaceutical composition is described, together with the process for manufacturing said pharmaceutical composition wherein the active ingredients, namely triamterene and hydrochlorothiazide, are incorporated into a solid dosage form via a single wet granulation process utilizing an acid component. Said process simplifies the formulation and manufacturing, permits greater uniformity, and increases in vitro dissolution.

Abstract: A wound dressing is provided comprising a layer of chitin affixed to a layer of porous, expanded polytetrafluoroethylene (PTFE). The chitin may be laminated to the PTFE or it may penetrate into and be impregnated in the porous PTFE layer. The composite preferably has a pressure sensitive adhesive applied in a dot pattern on its surface to enable application and securing of the dressing over a wound.

Abstract: Disclosed is a novel process to prepare a solid product containing an oil-soluble substance (e.g. oil and fat, spice, flavor, vitamin, emulsifier, hormone, higher fatty acid, unsaponifiable substance and complex lipid), comprising adding to an oil-soluble liquid substance an aqueous maltose solution along with a maltose seed, and crystallizing beta-maltose hydrate to effect solidification of the mixture.

Abstract: A process of protective coating of iron and steel products is described, wherein an adherent and rough layer of scale is formed, on which is directly deposited a layer of a protective material. The qualities of the layer of scale result from the fact that the product is shaped hot and the speed of its cooling is controlled so that the resultant thickness of scale is less than a threshold of adherence characteristic of the material and of the temperature at the end of shaping. The layer of protective material is obtained by metallization with zinc or an alloy based on zinc. The invention is principally applicable to long iron and steel products, and in particular to reinforcing bars for concrete.

Abstract: A sustained release pharmaceutical plaster which is characterized in that it is a pharmaceutical preparation mainly composed of an adhesive compound layer and a supporter which supports the adhesive compound layer, inside of which there is an arrangement of hollow fibers, that have radially arranged open pores, with their tubular hollows filled with medicines.

Abstract: A method and apparatus for the tinning or hot solder coating of leads of electronic components wherein the components are individually transported through the tinning process by means of a vacuum gripping device and wherein the planarity and thickness of the solder coating is controlled using pressurized gaseous material.

Abstract: The invention involves a sustained release pharmaceutical capsule for oral administration comprising, in a capsule shell, a particulate mixture comprising an active drug ingredient which is a weak acid, neutral, or a weak base, polyvinylpyrrolidone, and carboxyvinylpolymer.

Abstract: A multilaminate transdermal drug delivery system containing only dissolved drug in the drug reservoir is described. The delivery system comprises a backing layer, a reservoir layer and a membrane layer, wherein the drug in the reservoir is completely dissolved and the control of delivery is effected by the joint action of reservoir and membrane.

Abstract: An automatic drug tape dispensing and metering device and a roll of drug tape housed in a small portable dispenser unit. The dispenser contains a measurement device for carefully measuring the length of tape as it is dispensed from the dispenser. A counter monitors the remaining doses of drug tape remaining within the dispenser. A timer device may be provided to alert the patient that it is time for the medicament to be dispensed. As the lid of the dispenser unit is opened, the measured length of drug tape is severed from the roll by a cutter blade incorporated into the lid. The device permits a physician to accurately customize the dosage and administration of the medicament to be given a patient by adjusting the tape length released for each single dose and selecting the time intervals between dosages.

Abstract: This invention provides orally administerable pharmaceutical formulations having a semi-solid matrix containing a hydrophilic substance capable of creating channels in a hydrophobic carrier matrix thereby providing a sustained rate of release of an active agent from the formulation.

Abstract: A device is disclosed for the controlled delivery of a beneficial agent. The agent is delivered to the environment surrounding the device at a substantially constant rate for a specified period with a reduced dependence on the environmental pH. The device is comprised of a core compartment containing (1) a charged, water insoluble, non-diffusible component and (2) at least one diffusable water soluble ionizable beneficial agent. The core is surrounded by a water insoluble wall containing leachable pore forming additive(s) dispersed throughout said wall, with said wall impermeable to core components (1) and permeable to beneficial agent(s) (2). In operation the insoluble charged component (often polymeric resins) and water soluble ionizable beneficial agent have the same electro-static charge and do not form an ion exchange complex.

Abstract: A process is provided for forming high purity polysilanes or polygermanes by electric discharge wherein the monosilane or monogermane is provided in a gaseous mixture with a carrier gas at atmospheric pressure. The polysilanes or polygermanes produced at atmospheric pressure are further deposited by various means onto a substrate as hydrogenated amorphous silicon or germanium. The polysilane may also be used for the deposition of hydrogenated amorphous silicon alloys.

Abstract: A paint shield for masking a door or window frame, or painting an adjacent wall and a method for its use are disclosed. The paint shield includes a substantially planar, rectangular portion of sheet like material. A substantially planar blade portion extends at right angles to the rectangular portion and has a width greater than or equal to the thickness of the frame to be masked. The blade portion terminates in a straight edge. A handle is affixed to the rectangular portion and is used to position the rectangular over the frame with the straight edge of the blade portion positioned against the wall at the intersection between the wall and the frame.

Abstract: A composition for the transmembranal, including transdermal, administration of a pharmaceutical preparation comprising cross-linked carboxymethylcellulose, an alcohol soluble poly (2-hydroxyethyl) methacrylate), a permeation enhancer, such as a mixture of linoleic acid and propylene glycol, and a biologically active material, as well as a device for administering the aforementioned composition to mammals, and also a method for administering transdermally to a mammal an effective amount of the aforementioned composition.

Abstract: A protective coating of finely divided abrasion resistant inerts carried in a corrosion resistant resin is diluted with a solvent and applied to a surface. The applied coating is cured to achieve either a single layer of inerts dispersed in the resin or two layers including a dense layer of inerts in resin covered by a thin layer of resin.