Abstract: A process for coating a metallic substrate, which comprisesapplying an electrocoating paint to a metallic substrate,then applying a barrier coating comprising a crosslinking hardenable resin and being capable of forming a barrier coat film having an elongation at break of at least 150% and a stress at break of at least 20 kg/cm.sup.2 to the electrocoated film,optionally applying an intermediate coating paint to the barrier coat, andfinally applying a top coating paint to the barrier coat or the intermediate coat.

Abstract: A medication and method for treating heartworms in dogs, which medication includes a time release capsule or tablet dosage structure which is characterized either by discrete elements (capsule) or an outer layer or layers (tablet) of vasoconstricting and bronchial dilating medications and an inner, time-released layer or pellets of diethylcarbamazine. The vasoconstrictors and bronchial dilators are designed to counteract life-threatening vasodilation and bronchial constriction resulting from the release of acetylcholine by the dog when the heartworms are attacked by the diethylcarbamazine. The solid dosage structure can be constructed by layering such vasoconstrictors and bronchial dilators as prednisone, ephedrine, digoxin and dextroamphetamine sulfate in separate layers or combining these ingredients in a single layer separated from the diethylcarbamazine by a time-release substance such as gelatin.

Abstract: There is provided a composition for the transdermal application of basic drugs which have a high specific activity. The drug is provided in combination with a fatty acid having a low molecular weight. Amongst others, the delivery system is suited for cholinergic and anticholinergic basic drugs. The compositions can be supported by a pad, bandage or the like. It is one of the advantages of the compositions of the invention that a prolonged effect can be obtained, with an essentially constant therapeutic level of the active ingredient.

Abstract: A transdermal delivery system for the administering of progesterone and an estradiol ester alone or in combination utilizing a polymer matrix having the drug(s) along with a permeation enhancer dispersed throughout.

Abstract: A method for the preparation of reactive metal surfaces whereby the finished surfaces are in a reactive, essentially reduced condition and controlled oxidation reactions are employed to chemically bond a film on the metal surface to protect the surface or to provide a selected surface characteristic. During preparation the surface is covered by a working fluid that is inert with respect to the metal being worked and which is a solvent for film forming molecules which are being applied to the surface. The film forming molecules are thus readily chemically bonded to the reactive metal under controlled conditions essentially simultaneously with surface preparation to form a chemically uniform film on the reactive metal surface. The film is thus formed in the absence substances which may also react with the substrate metal to form undesirable reaction by-products which interfere with creation of a uniform, chemically bonded film on the substrate and which can result in pitting of the metal surface.

Abstract: A diffusional drug delivery device is described which can provide for stability of the adhesive and system components, elimination of the initial burst of drug and hence irritation, and to provide for delayed onset of therapeutic effect along with delivery of a therapeutic agent at an optimum rate. The therapeutic agent in a first form which is suitable for storage, and the anhydrous activating means are inert when in an anhydrous environment. Moisture activates the system whereby the activating means provides an acidic or basic solution and the first form of the therapeutic agent is converted to a second form which is suitable for absorption through the skin or mucosa.

Abstract: Transdermal dosage compositions are prepared from hydrated poly(vinyl alcohol) gels and pharmacologically active substances without any chemicals such as crosslinking agents and catalysts. Heating process is not involved in the gel preparation. High water contents of the gels enable the stratum corneum to be swollen, resulting in high permeation of drugs through the skin.

Abstract: A method for sizing glass fibers upon formation is provided, employing a migration-resistant glass forming size composition which comprises an effective amount of a starch derivative having the formula ##STR1## wherein R is dimethylene or trimethylene, R' is a C.sub.8 -C.sub.18 alkyl or alkenyl group, and A is hydrogen or a monovalent cation.

Abstract: A transdermal medicament which contains, as a suspension in a viscous matrix, at least one solid active compound or auxiliary or at least one active compound adsorbed on a solid auxiliary is characterized in that the preparation of the suspensions is carried out by wet grinding in the presence of a medium-viscosity solution of the matrix or certain constituents thereof under low heat stress and shear stress.

Abstract: A method and apparatus are disclosed for the reactive vapor deposition of metal compounds onto a substrate. At least one metal is evaporated from an elongated evaporation crucible in an atmosphere consisting of a reaction gas at a pressure of no more than 10.sup.-1 mbar. The metal is evaporated by means of an electron beam having an acceleration voltage of at least 20 kv. The invention solves the problem of providing stable an repeatable operating conditions, even with an evaporation crucible of considerable length.

Abstract: The use of permeation enhancers permits the formulation of transdermal dosage forms for calcium antagonists. These dosage forms are administrable to humans and other mammals, e.g., bovines.

Abstract: A sheet-like preparation comprising a composition comprising (a) a drug, (b) gelatin or agar, (c) gluten, (d) a carboxyvinyl polymer, (e) a polyhydriic alcohol, (f) a gum and (g) wax as its essential constituents, and water in an amount of 0 to 30 w/w % based on the total weight of the essential constituents, and a sheet-like support which supports thereon said composition.The sheet-like preparation of this invention is useful, for example, as a preparation for oral cavity administration.

Abstract: A process for heavy-duty anticorrosion treatment of a metal article is provided wherein the article, promptly after being hot plated, is coated with a synthetic resin thereby to bake the resin on the plated article with the heat remaining in the plated article.

Abstract: A capsule for use in administering therapeutic agents to animals is made from a blend of(i) from 10-75% by weight of a material chosen from polyalkylene glycols of average molecular weight of from 2,000-20,000; and(ii) from 20-80% by weight of poly(ethylene oxide) of average molecular weight of from 80,000-1.times.10.sup.7.The preferred materials are polyethylene glycol of average molecular weight 3,000-5,000 and poly (ethylene oxide) of average molecular weight 300,000-800,000. It is possible to include therapeutic agents in the composition of the capsule as well as in its cavity. The capsules of this invention find particular application in the administering of trace elements, especially copper oxide needles, to animals.

Abstract: A method of minimizing the adherence of ice on substrates which comprises coating said substrates with a polysiloxane composition which changes into a rubbery elastic material in the presence of water or atmospheric moisture which comprises .alpha.,.omega.-dihydroxy-polydiorganosiloxane having a viscosity of about 500 to 2,000,000 centipoise at 20.degree. C. and a cross-linking agent with or without a hardening catalyst.

Abstract: Described is an article of manufacture useful for administration of pharmacologically-active substances, transdermally, orally or by means of subdermal implant comprising a solid vinyl plastisol layer for contacting a patient's tissue, internally or externally, the layer containing from about 20 up to about 70% by weight of a polyvinyl chloride resin or a polyvinyl chloride-polyvinyl acetate copolymer containing a minor proportion of vinyl acetate; from about 20-70% plasticizer composition; from about 0.5 up to 35% of a pharmacologically-active substance such as isosorbide dinitrate, nicotine, clonidine, guanfacine, indomethacin, glyceryl trinitrate and prostaglandin and optionally excipients.

Abstract: A medicinal plaster for dermally applied medication which is attachable to the skin, which comprises first and second parts joined in a housing which is closed at the top side and open on the lower side thereof towards the skin surface, said first part at the lower side comprising a drug-containing carrier substance which melts at approximately physiological body temperature; and said second part at the top side, which is affixed to said first part, comprises a porous and flexible synthetic material having approximately the same diameter as said first part.

Abstract: Adhesive medical tapes for oral mucosa comprising a support layer composed of an intestine-soluble polymer and a medicament-containing layer composed of a water-soluble polymer containing at least one kind of a steroid or non-steroid antiphlogistic and analgesic medicament.

Abstract: Therapeutic agent delivery devices and methods for using them in treatment of dental disease are disclosed. In the treatment of periodontal disease, a therapeutic agent such as tetracycline mixed in a polymeric matrix such as ethylene vinyl acetate copolymer is packed into the area to be treated and kept in place for a suitable time, during which the therapeutic agent diffuses out of the polymeric matrix, providing continuous therapy for the treatment site.

Abstract: A soldering apparatus includes a solder bath 40 and a component holder 43 positioned to lower an exposed tag of a component to contact solder in the solder bath 40. After removal from the bath the component is deliberately subjected to a mechanical shock when a limb of a bracket 44 strikes a turret plate 42 under the action of a spring 46. The shock causes a short time vibration in the component and spreads solder in tears which naturally form on the exposed tags to remove or substantially reduce those tears.