Patents Examined by Laura R. Cross
  • Process for preparing 6-oxo-(6H)-dibenz-[c,e][1,2]-oxaphosphorins (ODOPs)
    Patent number: 5650530
    Abstract: Optionally substituted ODOP is obtained by reaction of optionally substituted o-phenylphenol with PCl.sub.3 in the presence of Lewis acids at elevated temperature in a first stage, with according to the invention an excess of at least 0.05 mol of PCl.sub.3 per mol of o-phenylphenol being maintained during the entire reaction time, and, after removal of the PCl.sub.3, by hydrolysis in a second stage using 1-2 mol of H.sub.2 O per chlorine equivalent of the product of the first stage at 50.degree.-150.degree. C. and with removal of HCl and residual H.sub.2 O.
    Type: Grant
    Filed: September 12, 1995
    Date of Patent: July 22, 1997
    Assignee: Bayer Aktiengesellschaft
    Inventors: Hans-Josef Buysch, Volker Glock, Bernd Griehsel, Joachim Komoschinski
  • Process for the preparation of diesters of phosphonocarboxylic acid derivatives
    Patent number: 5648509
    Abstract: The addition of acid diesters of phosphorous acid onto alpha,beta-unsaturated carboxylic acid derivatives under basic catalysis is achieved with good yields if it is carried out in the presence of alkali metal alcoholates or phenolates and in the presence of halides, oxides or hydroxides of divalent metals. Co-use of these metal compounds allows relatively small mounts of metal alcoholates or phenolates to be used. The resulting reaction mixtures do not contain relatively large amounts of troublesome by-products.
    Type: Grant
    Filed: July 27, 1995
    Date of Patent: July 15, 1997
    Assignee: Ciba-Geigy Corporation
    Inventors: Salman Dermeik, Martina Wanner, Karl-Heinz Lemmer, Reinhold Braun
  • Antifungal agents, and compositions
    Patent number: 5648372
    Abstract: A compound represented by the general formula: ##STR1## wherein R.sup.1 and R.sup.2 denote a halogen atom or hydrogen atom; R.sup.3 means a hydrogen atom or lower alkyl group; l, r and m stand for 0 or 1; A is N or CH; W denotes an aromatic ring or a condensed ring thereof; X means another aromatic ring, an alkanediyl group, an alkenediyl group, or an alkynediyl group; Y stand for --S--, etc.; Z denotes a hydrogen atom, etc., or a salt thereof, and intermediates thereof or a salt thereof as well as processes for the preparation thereof, and pharmacetical composition suitable for use as an antifungal agent.
    Type: Grant
    Filed: February 1, 1995
    Date of Patent: July 15, 1997
    Assignee: Eisai Co., Ltd.
    Inventors: Toshihiko Naito, Katsura Hata, Yumiko Kaku, Akihiko Tsuruoka, Itaru Tsukada, Manabu Yanagisawa, Toshio Toyosawa, Kazumasa Nara
  • Two new crystal modifications of a diketopyrrolopyrrole pigment
    Patent number: 5646299
    Abstract: Diketopyrrolopyrrole of the formula ##STR1## in its .beta.-modification and in its .gamma.-modification. Both the .beta.-modification and the .gamma.-modification are suitable as pigments for coloring high-molecular weight organic material. In comparison to the .alpha.-modification, the .beta.-modification shows a shift in shade towards yellowish-red. The .gamma.-modification gives brilliant orange colorations.
    Type: Grant
    Filed: June 22, 1995
    Date of Patent: July 8, 1997
    Assignee: Ciba-Geigy Corporation
    Inventors: Zhimin Hao, Abul Iqbal, Fritz Herren
  • Substituted sulfonylphenylheterocycles as cyclooxygenase-2 and 5-lipoxygenase inhibitors
    Patent number: 5643933
    Abstract: This invention is in the field of antiinflammatory pharmaceutical agents and specifically relates to compounds, compositions and methods for treating disorders mediated by cyclooxygenase-2 or 5-lipoxygenase, such as inflammation.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: July 1, 1997
    Assignee: G. D. Searle & Co.
    Inventors: John J. Talley, James A. Sikorski, Bryan H. Norman, Roland S. Rogers, deceased, Balekudru Devadas, Matthew J. Graneto, Jeffery S. Carter
  • Process for the preparation of 2,2-difluorobenzo[1.3]dioxolecarbaldehydes
    Patent number: 5637737
    Abstract: 2,2-Difluorobenzo[1.3]dioxole-carbaldehydes are prepared in a particularly advantageous manner if methylbenzo[1.3]dioxoles are chlorinated, the resulting dichloromethyl-2,2-dichlorobenzo[1.3]dioxole is fluorinated with hydrogen fluoride and the dichloromethyl-2,2-difluorobenzo[1.3]dioxole obtained by this procedure is reacted with a carboxylic acid.
    Type: Grant
    Filed: August 14, 1996
    Date of Patent: June 10, 1997
    Assignee: Bayer Aktiengesellschaft
    Inventors: Peter Andres, Albrecht Marhold
  • Sodium enalapril complex and the use thereof to make sodium enalapril
    Patent number: 5637730
    Abstract: A process for making pure sodium enalapril is provided which includes the step of decomplexing essentially pure sodium enalapril-sodium iodide complex to yield essentially pure sodium enalapril.
    Type: Grant
    Filed: August 19, 1996
    Date of Patent: June 10, 1997
    Assignee: Brantford Chemicals Inc.
    Inventors: K. S. Keshava Murthy, Andrew Burchat, Gamini Weeratunga
  • Substituted cyclohexanol esters their use for treating diseases and pharmaceutical preparations
    Patent number: 5629311
    Abstract: Substituted cyclohexanol esters, their use for treating diseases, and pharmaceutical preparationsCyclohexanol esters of the formula I ##STR1## are described in which the radicals have the meaning given herein. The compounds are pharmacologically active and my therefore be used as pharmaceuticals, in particular for treating diabetes and other diseases which are characterized by an elevated secretion of glucose from the liver or by an elevated activity of the glucose-6-phosphatase system.
    Type: Grant
    Filed: July 19, 1996
    Date of Patent: May 13, 1997
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Horst Hemmerle, Gerrit Schubert, Peter Below, Andreas Herling, Hans-J org Burger
  • Tricyclic inhibitor of matrix metalloproteinases
    Patent number: 5627206
    Abstract: A tricyclic compound is described as well as pharmaceutical compositions of same, which is useful as an inhibitor of matrix metalloproteinases, particularly gelatinase A (72 kD gelatinase) for the treatment of multiple sclerosis or other autoimmune or inflammatory disorders dependent upon tissue invasion by leukocytes.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: May 6, 1997
    Assignee: Warner-Lambert Company
    Inventors: Donald Hupe, Linda Lea Johnson, Qi-Zhuang Ye
  • (2-imidazolin-2-yl) fused heteropyridine compounds intermediates for the preparation of and use of said compounds as herbicidal agents
    Patent number: 5622913
    Abstract: There are provided novel (2-imidazolin-2-yl) fused heteropyridine compounds, and intermediate compounds for the preparation thereof, and a method for controlling a wide variety of annual and perennial plant species therewith.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: April 22, 1997
    Assignee: American Cyanamid Company
    Inventors: Barrington Cross, Marinus Los, Robert F. Doehner, Jr., David W. Ladner, Jerry L. Johnson
  • Prodrug esters of phosphonosulfonate squalene synthetase inhibitors and method
    Patent number: 5618964
    Abstract: New prodrug esters of salt forms of the phosphonosulfonate squalene synthetase inhibitor having the structure ##STR1## are provided wherein R is alkyl, arylalkyl, aryl or acylthioalkyl. These prodrug esters inhibit cholesterol biosynthesis and therefore are used in lowering serum cholesterol and in treating atherosclerosis.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: April 8, 1997
    Assignee: Bristol-Myers Squibb Company
    Inventors: Peter T. W. Cheng, Michael A. Poss
  • Method for purifying O,S-dimethyl N-acetylphosphoramidothioate
    Patent number: 5616769
    Abstract: A method for purifying O,S-dimethyl N-acetyphosphoramidothioate, which is characterized by subjecting a crude crystal of O,S-dimethyl N-acetylphosphoramidothioate to recrystallization by using a two-phase solvent system comprising water and an organic which is an aromatic hydrocarbon, an aliphatic carboxylic acid ester or aliphatic ketone, wherein the amount of water is 0.1 to 2 parts by weight and the amount of the organic solvent is 1 to 20 parts by weight to 1 part by weight of the crude O,S-dimethyl N-acetylphosphoramidothioate.
    Type: Grant
    Filed: September 21, 1995
    Date of Patent: April 1, 1997
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Yoji Sakito, Mamoru Shirahata, Yujiro Kiyoshima, Kazuya Minamisaka, Atukazu Iwata
  • Process for purifying phosphoric esters
    Patent number: 5616768
    Abstract: A process for purifying a phosphoric ester, which comprises treating a crude phosphoric ester with an epoxy compound, heating the resultant in the presence of water, washing the resultant with water, and removing the residual water. The obtained phosphoric esters have low acid value and are excellent in physical properties such as heat resistance, resistance to hydrolysis and storage stability, and are useful as plasticizers and/or flame-retardants.
    Type: Grant
    Filed: June 19, 1995
    Date of Patent: April 1, 1997
    Assignee: Daihachi Chemical Industry Co., Ltd.
    Inventors: Shigeru Kawata, Kazuo Noguchi, Kenji Ako, Shin Nakamura
  • Methods of inhibiting phosphatase activity and treatment of disorders associated therewith using naphthopyrones and derivatives thereof
    Patent number: 5614642
    Abstract: The present invention relates to organic molecules capable of inhibiting protein tyrosine phosphatase activity. The invention further relates to the use of such molecules to modulate or regulate signal transduction by inhibiting protein tyrosine phosphatase activity. Finally, the invention relates to the use of such molecules to treat various disease states including diabetes mellitus.
    Type: Grant
    Filed: January 22, 1996
    Date of Patent: March 25, 1997
    Assignee: Sugen Inc.
    Inventors: Peng C. Tang, Gerald McMahon
  • Process for the recovery of tributyl phosphate from spent hydraulic oils
    Patent number: 5608099
    Abstract: A process for the recovery by distillation of tributyl phosphate (TBPO) from spent hydraulic oils, which are employed particularly in aircraft used for civilian air traffic.
    Type: Grant
    Filed: November 1, 1995
    Date of Patent: March 4, 1997
    Assignee: Bayer Aktiengesellschaft
    Inventors: Hans-G unter Fr ohlen, Hans-Dieter Block, Wolfgang Ohlendorf, Hans-Heinrich Moretto, Peter Schmidt
  • Stabilized isothiazolinone formulations
    Patent number: 5603866
    Abstract: A composition comprising A) an aqueous solution wherein the total content of 3-isothiazolinones is below 8 wt/%, and B) a stabilizing compound of the formula:[R.sub.x A--C.sub.6 H.sub.2 R.sup.1 R.sup.2 ].sub.y --Zwherein:R, R.sup.1 and R.sup.2 each independently represents hydrogen, a straight-chained or branched or cyclic alkyl radical, aralkyl or aryl;A is oxygen or nitrogen;Z represents AR.sub.x, R.sup.1, R.sup.2, alkoxy methylene, methylene or alkylidene;provided that when A is oxygen, x is 0 or 1 and when A is nitrogen, x is 1 or 2; and y is 1 or 2;exhibits improved stability.
    Type: Grant
    Filed: May 17, 1995
    Date of Patent: February 18, 1997
    Assignee: Bromine Compounds, Ltd.
    Inventors: Jeane Segall, Leonard M. Shorr
  • Methods of inhibiting phosphatase activity and treatment of disorders associated therewith using naphthopyrones and derivatives thereof
    Patent number: 5602171
    Abstract: The present invention relates to organic molecules capable of inhibiting protein tyrosine phosphatase activity. The invention further relates to the use of such molecules to modulate or regulate signal transduction by inhibiting protein tyrosine phosphatase activity. Finally, the invention relates to the use of such molecules to treat various disease states including diabetes mellitus.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: February 11, 1997
    Assignee: Sugen Inc.
    Inventors: Peng C. Tang, Gerald McMahon
  • (2-imidazolin-2-yl) fused heteropyridine compounds, intermediates for the preparation of and use of said compounds as herbicidal agents
    Patent number: 5599772
    Abstract: There are provided novel (2-imidazolin-2-yl) fused heteropyridine compounds, and intermediate compounds for the preparation thereof, and a method for controlling a wide variety of annual and perennial plant species therewith.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: February 4, 1997
    Assignee: American Cyanamid Company
    Inventors: Barrington Cross, Marinus Los, Robert F. Doehner, Jr., David W. Ladner, Jerry L. Johnson
  • (2-imidazolin-2-yl) fused heteropyridine compounds and use of said compounds as herbicidal agents
    Patent number: 5599773
    Abstract: There are provided novel (2-imidazolin-2-yl) fused heteropyridine compounds, and intermediate compounds for the preparation thereof, and a method for controlling a wide variety of annual and perennial plant species therewith.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: February 4, 1997
    Assignee: American Cyanamid Company
    Inventors: Barrington Cross, Marinus Los, Robert F. Doehner, Jr., David W. Ladner, Jerry L. Johnson
  • Pyrazoloquinolines
    Patent number: 5597821
    Abstract: The invention relates to compounds of the formulas ##STR1## wherein R.sub.1, R.sub.2, X and Z are as described herein. These compounds are useful as antitumor agents.
    Type: Grant
    Filed: December 15, 1994
    Date of Patent: January 28, 1997
    Inventors: Ronald L. Wolin, Adriano Afonso