Patents Examined by Laura R. Cross
  • Patent number: 5536745
    Abstract: Conformationally restricted aryl and heteroaryl ketones derived from monic acid have useful antibacterial properties.
    Type: Grant
    Filed: January 23, 1995
    Date of Patent: July 16, 1996
    Assignee: SmithKline Beecham p.l.c.
    Inventor: Neil D. Pearson
  • Patent number: 5536702
    Abstract: There are provided novel (2-imidazolin-2-yl) fused heteropyridine compounds, and intermediate compounds for the preparation thereof, and a method for controlling a wide variety of annual and perennial plant species therewith.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: July 16, 1996
    Assignee: American Cyanamid Co.
    Inventors: Barrington Cross, Marinus Los, Robert F. Doehner, Jr., David W. Ladner, Jerry L. Johnson
  • Patent number: 5536855
    Abstract: Glycidyl esters are prepared to have low chlorine, chloride, sodium and potassium contamination and a thixotropic index greater than 3.0 by a process that comprises reacting carboxylic mono- or dimer acids with glycidyl alcohols in a molar ratio of 1 to (0.9-4.0) using carbodiimide as the acylating agent and a pyridine-type catalyst. The pyridine-type catalyst is removed by strongly acidic ion exchange resin.
    Type: Grant
    Filed: March 4, 1994
    Date of Patent: July 16, 1996
    Assignee: National Starch and Chemical Investment Holding Corporation
    Inventors: Rose A. Schultz, Sharon Chaplinsky
  • Patent number: 5534484
    Abstract: There are provided novel (2-imidazolin-2-yl) fused heteropyridine compounds, and intermediate compounds for the preparation thereof, and a method for controlling a wide variety of annual and perennial plant species therewith.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: July 9, 1996
    Assignee: American Cyanamid Company
    Inventors: Barrington Cross, Marinus Los, Robert F. Doehner, Jr., David W. Ladner, Jerry L. Johnson
  • Patent number: 5534532
    Abstract: This invention relates to a class of novel aliphatic amino bis-aryl compounds containing at least four carbon atoms and an amino group either substituted thereon or incorporated therein and is further linked or bridged to two mono- and/or bicyclic rings. Compounds of this invention reduce levels of serum cholesterol in the body without significantly reducing mevalonic metabolite synthesis. This invention relates also to pharmacological compositions and method of treatment for lowering serum cholesterol levels using the compounds of this invention.
    Type: Grant
    Filed: January 25, 1995
    Date of Patent: July 9, 1996
    Assignee: Rhone-Poulenc Rorer Pharmaceuticals Inc.
    Inventors: Robert A. Groneberg, John R. Regan, Kent W. Neuenschwander, Anthony C. Scotese
  • Patent number: 5534483
    Abstract: There are provided novel (2-imidazolin-2-yl) fused heteropyridine compounds, and intermediate compounds for the preparation thereof, and a method for controlling a wide variety of annual and perennial plant species therewith.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: July 9, 1996
    Assignee: American Cyanamid Company
    Inventors: Barrington Cross, Marinus Los, Robert F. Doehner, Jr., David W. Ladner, Jerry L. Johnson
  • Patent number: 5534485
    Abstract: There are provided novel (2-imidazolin-2-yl) fused heteropyridine compounds, and intermediate compounds for the preparation thereof, and a method for controlling a wide variety of annual and perennial plant species therewith.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: July 9, 1996
    Assignee: American Cyanamid Company
    Inventors: Barrington Cross, Marinus Los, Robert F. Doehner, Jr., David W. Ladner, Jerry L. Johnson
  • Patent number: 5534487
    Abstract: The present invention provides a method of stabilizing solutions of 3-isothiazolone compounds using a stabilizing compound of the formula: ##STR1## wherein R is C.sub.1 -C.sub.6 alkyl; and compositions which comprise 3-isothiazolone compound, solvent and stabilizing compound.
    Type: Grant
    Filed: May 16, 1995
    Date of Patent: July 9, 1996
    Assignee: Rohm and Haas Company
    Inventor: Kevin F. Gironda
  • Patent number: 5532257
    Abstract: Production of a benzothiazole compound of the formula (I) ##STR1## wherein R.sup.1 is a halogen atom, R.sup.2 and R.sup.3 may be the same or different and each is a hydrogen atom or a halogen atom, R.sup.4 is a hydrogen atom, a halogen atom, a lower alkyl, an alkoxy or an alkyl mercapto and R.sup.5 is a hydrogen atom or a lower alkyl, or a pharmaceutically acceptable salt thereof.The compound of the formula (I) and a pharmaceutically acceptable salt thereof of the present invention have an aldose reductase inhibitory activity in mammals inclusive of human and have superior safety. Accordingly, they are useful as pharmaceutical compositions for the treatment of the complications of diabetes, such as faulty union of corneal injury, cataract, neurosis, retinopathy and nephropathy, particularly cataract and neurosis.
    Type: Grant
    Filed: November 25, 1994
    Date of Patent: July 2, 1996
    Assignees: Senju Pharmaceutical Co., Ltd, The Green Cross Corporation
    Inventors: Takema Hase, Takahiro Kumonaka, Chikako Shimizu, Hiroshi Hosono, Tomoji Aotsuka, Yoshiyuki Nakamura, Tetsuo Matsui, Hiromichi Ishikawa
  • Patent number: 5532207
    Abstract: There are provided novel (2-imidazolin-2-yl) fused heteropyridine compounds, and intermediate compounds for the preparation thereof, and a method for controlling a wide variety of annual and perennial plant species therewith.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: July 2, 1996
    Assignee: American Cyanamid Company
    Inventors: Barrington Cross, Marinus Los, Robert F. Doehner, Jr., David W. Ladner, Jerry L. Johnson
  • Patent number: 5527820
    Abstract: As new antibiotics are obtained delaminomycins A, B and C having a formula (I) or (I') shown below, or salts thereof. Delaminomycins preferentially inhibit T cells and are useful as immunosuppressants, antineoplastic agents and antibacterial agents. ##STR1## wherein X is a hydroxyl group for delaminomycin A, a methoxy group for delaminomycin B and a hydrogen atom for delaminomycin C.
    Type: Grant
    Filed: January 20, 1995
    Date of Patent: June 18, 1996
    Assignee: Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai
    Inventors: Masaaki Ishizuka, Mitsuhiro Ueno, Hironobu Iinuma, Hiroshi Naganawa, Masa Hamada, Kenji Maeda, Tomio Takeuchi
  • Patent number: 5527917
    Abstract: A process for the preparation of 1,2-benzisothiazoles of formula I ##STR1## wherein X is in any one of the 4 possible positions of the benzene ring and is hydrogen, halogen, nitro, C.sub.1 -C.sub.4 alkoxy, halo-C.sub.1 -C.sub.4 alkoxy, C.sub.2 -C.sub.4 alkenyloxy or C.sub.2 -C.sub.4 alkynyloxy, in which process a compound of formula II ##STR2## wherein X is as defined for formula I and R.sub.1 is hydrogen or an unsubstituted or substituted C.sub.1 -C.sub.12 hydrocarbon radical, is reacted in the presence of a catalytic amount of a strong acid.Compounds of formula I are known as pesticides, especially as nematicides.
    Type: Grant
    Filed: September 7, 1994
    Date of Patent: June 18, 1996
    Assignee: Ciba-Geigy Corporation
    Inventors: Hans-Ruedi Kanel, Arthur Wegmann, Denis Neff
  • Patent number: 5523152
    Abstract: Organic compounds having at least one ethylenically-unsaturated group are described, the organic compounds being suitable for use in coatable compositions as reactive diluents; compounds of the invention preferably have a divalent organic linking moiety devoid of reactive groups other than optional ethylenically-unsaturated groups, and a polar organic moiety and are particularly adept in solubilizing aminoplast resins having radiation-curable pendant groups.
    Type: Grant
    Filed: November 4, 1994
    Date of Patent: June 4, 1996
    Assignee: Minnesota Mining and Manufacturing Company
    Inventors: Ernest L. Thurber, Eric G. Larson, Alan R. Kirk, Gregg D. Dahlke
  • Patent number: 5523410
    Abstract: The present invention relates to synthetic intermediates useful for preparing amino acid derivatives possessing renin-inhibitory activity, and to processes for preparing the amino acid derivatives using the synthetic intermediates.
    Type: Grant
    Filed: January 3, 1995
    Date of Patent: June 4, 1996
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Kooji Kagara, Nobutaka Kawai, Koji Machiya, Tetsuo Furutera, Takashi Nakamura, Hiroki Omori
  • Patent number: 5523020
    Abstract: A clathrate compound composed of a water-soluble microbicide and a phenolic compound of formula (1) or (2): ##STR1##
    Type: Grant
    Filed: September 20, 1994
    Date of Patent: June 4, 1996
    Assignee: Kurita Water Industries Ltd.
    Inventors: Minoru Yagi, Kazumi Nakane, Yuriko Hiyane
  • Patent number: 5523308
    Abstract: Compounds of the Formula I: ##STR1## useful in the treatment of thrombin and trypsin related disorders.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: June 4, 1996
    Inventors: Michael J. Costanzo, Bruce E. Maryanoff
  • Patent number: 5523455
    Abstract: A compound of formula: ##STR1## in which R.sub.y represents a cyano or carboxymethyl group and its salts.
    Type: Grant
    Filed: May 16, 1995
    Date of Patent: June 4, 1996
    Assignee: Sanofi
    Inventors: Bernard Labeeuw, Danielle Gully, Francis Jeanjean, Jean-Charles Molimard, Robert Boigegrain
  • Patent number: 5523278
    Abstract: There are provided substituted benzisoxazole and benzisothiazole compounds having the structural formula I ##STR1## Further provided are compositions and methods comprising those compounds for the control of undesirable plant species.
    Type: Grant
    Filed: September 12, 1995
    Date of Patent: June 4, 1996
    Assignee: American Cyanamid Company
    Inventor: Peter J. Wepplo
  • Patent number: 5514643
    Abstract: The present invention relates to a novel 2-aminothiazolecarboxamide derivative represented by the following general formula (I): ##STR1## in which R.sup.1 -R.sup.5 are defined herein, which is a fungicidal agent useful for controlling phytopathogenic organisms. In addition, the present invention also relates to a process for preparing the novel 2-aminothiazolecarboxamide derivative of formula (I) and use of the compound of formula (I) as an agent for controlling phytopathogenic organisms.
    Type: Grant
    Filed: August 9, 1994
    Date of Patent: May 7, 1996
    Assignee: Lucky Ltd.
    Inventors: Yo S. Rew, Jinho Cho, Choon S. Ra, Sei-chang Ahn, Sung K. Kim, Yong-Hwan Lee, Bon Y. Jung, Woo B. Choi, Young H. Rhee, Man Y. Yoon, Sung W. Chun
  • Patent number: 5514685
    Abstract: The invention concerns the compounds of formulae ##STR1## wherein the substituents have various significances. They can be prepared by various methods, e.g. acylation, reduction, alkylation, etc. They are indicated for use as pharmaceuticals, in particular as immunosuppressant, antiproliferative and antiinflammatory agents.
    Type: Grant
    Filed: May 15, 1995
    Date of Patent: May 7, 1996
    Assignee: Sandoz Ltd.
    Inventor: Karl Baumann