Patents Examined by Leigh C. Maier
  • Patent number: 11975019
    Abstract: Polymer conjugates are provided that are capable of mimicking functions of natural proteoglycans found in the extracellular matrix of connective tissues. The polymer conjugates of the invention have utility in treating a subject suffering soft tissue conditions. Also provided are simple and scalable chemical processes for the preparation of the polymer conjugates of the invention.
    Type: Grant
    Filed: July 9, 2021
    Date of Patent: May 7, 2024
    Assignee: Glycologix, Inc.
    Inventor: Thomas H. Jozefiak
  • Patent number: 11976139
    Abstract: A preparation method of sodium hyaluronate with a full molecular weight distribution (MWD) is provided, including: step 1): spraying hydrogen peroxide on a sodium hyaluronate solid raw material, and conducting an ultraviolet (UV) irradiation treatment; step 2): dissolving a sodium hyaluronate degradation material in water, and adjusting a pH to higher than 7.0; step 3): subjecting a sodium hyaluronate alkaline solution to an ultrasonic treatment; step 4): preparing the sodium hyaluronate solid raw material into a sodium hyaluronate solution with a concentration of 0.1% to 1% (w/v), and thoroughly mixing the sodium hyaluronate solution in an addition proportion of 20% to 60% (v/v) with the sodium hyaluronate alkaline solution obtained after the ultrasonic treatment; and step 5): subjecting a resulting mixed solution to an adsorption treatment with diatomaceous earth and activated carbon, filtering for concentration, and drying a resulting concentrate to obtain the sodium hyaluronate with a full MWD.
    Type: Grant
    Filed: July 31, 2022
    Date of Patent: May 7, 2024
    Inventors: Peixue Ling, Huarong Shao, Qingkai Zeng
  • Patent number: 11963976
    Abstract: A pharmaceutical composition for treating an ischemic tissue, comprising: a core component and a matrix component, wherein the core component includes a heparin or derivative thereof and the matrix component includes a hyaluronan or derivative thereof, the pharmaceutical composition having a viscosity greater than 10 mPa-s.
    Type: Grant
    Filed: September 5, 2018
    Date of Patent: April 23, 2024
    Inventor: Lynn L. H. Huang
  • Patent number: 11958917
    Abstract: Compositions comprising mixtures of hydroxypropyl-?-cyclodextrin, wherein the compositions may be isomerically purified, and methods of isomerically purifying a mixture of hydroxypropyl-?-cyclodextrins.
    Type: Grant
    Filed: February 17, 2023
    Date of Patent: April 16, 2024
    Inventors: Steven Pfeiffer, Dustin McMinn, Gabor Benkovics
  • Patent number: 11938145
    Abstract: Low endotoxin fucan compositions comprising a therapeutically effective, medically acceptable fucan in a composition comprising less than about 0.2, 0.18, 0.1, 0.01, 0.001, or 0.0005 endotoxin units (EU) per milligram of the fucan are disclosed. Methods and systems for removing or reducing the amount of endotoxins from a starting fucan composition are also disclosed.
    Type: Grant
    Filed: July 24, 2019
    Date of Patent: March 26, 2024
    Assignee: ARC Medical Inc.
    Inventors: Christopher Michael Kevin Springate, Ian Millet, Sailesh Haresh Daswani, Hesong Sun, Aileen Shao Ting Yang, Hoi Ting Wong
  • Patent number: 11926544
    Abstract: The invention discloses a biological desulfurizer for removing organic sulfur in fracturing flowback fluid and application thereof. The biological desulfurizer includes a compound with a triazine structure formed by modifying chitosan with aldehydes and inorganic salts. The triazine structure has a good removal effect on hydrogen sulfide and organic sulfur such as mercaptan and sulfide. The biological desulfurizer of the invention has a sulfur capacity of up to 250 g/kg and a desulfurization efficiency of over 95% in 15 min. It can effectively remove the stink of sulfur-containing working water, improve the working environment of the well site, and reduce the impact of sulfur compounds on the atmospheric environment during the development of oil and gas fields.
    Type: Grant
    Filed: October 16, 2023
    Date of Patent: March 12, 2024
    Inventors: Xiaoqing Qiu, Xiang Wang, Guisheng Wang, Guofeng Li, Jiawei Zhang, Lei Song, Xia Wang, Qianli Xu, Puyan Hou
  • Patent number: 11918966
    Abstract: The invention relates to a method for treating a nanofibrillar cellulose hydrogel, wherein the method comprises the steps of: providing a nanofibrillar cellulose hydrogel, wherein the nanofibrillar cellulose is oxidized nanofibrillar cellulose, wherein the oxidation has been carried out through N-oxyl mediated catalytic oxidation of cellulose-based raw material, and has at most 50 ?mol of aldehyde groups per gram of dry nanofibrillar cellulose; and subjecting the nanofibrillar cellulose hydrogel to a heat treatment.
    Type: Grant
    Filed: April 16, 2021
    Date of Patent: March 5, 2024
    Inventor: Isko Kajanto
  • Patent number: 11911411
    Abstract: Polymer conjugates are provided that are capable of mimicking functions of natural proteoglycans found in the extracellular matrix of connective tissues. The polymer conjugates of the invention have utility in treating a subject suffering soft tissue degenerative conditions. Also provided are simple and scalable chemical processes for the preparation of the polymer conjugates of the invention.
    Type: Grant
    Filed: March 19, 2021
    Date of Patent: February 27, 2024
    Assignee: Glycologix, Inc.
    Inventors: Thomas H. Jozefiak, Richard W. Heidebrecht, Jr.
  • Patent number: 11912993
    Abstract: The present invention relates to a compound comprising a modified saccharide moiety conjugated to a nucleic acid. The compound is useful in medicine for RNA interference therapy or for research and diagnostic purposes. In particular, the compound is useful in treating liver disease.
    Type: Grant
    Filed: November 25, 2020
    Date of Patent: February 27, 2024
    Inventors: Christian Frauendorf, Mark Cameron
  • Patent number: 11905340
    Abstract: Nanocellulose containing a sulfuric acid group and/or a sulfo group, each of which is derived from a sulfuric acid treatment, and an anionic functional group derived from a hydrophilization treatment. The total amount of the sulfuric acid group and/or the sulfo group and the anionic functional group is more than 0.1 mmol/g and not more than 4.0 mmol/g. Also disclosed is a product including a mixture containing the nanocellulose and a method for producing the nanocellulose.
    Type: Grant
    Filed: September 5, 2019
    Date of Patent: February 20, 2024
    Inventors: Hideaki Nagahama, Yuuki Kinoshita, Toshiki Yamada
  • Patent number: 11905341
    Abstract: The present invention provides a process for producing a nanocellulose material, comprising: fractionating a lignocellulosic biomass feedstock in the presence of a solvent for lignin and water, but no acid catalyst, to generate cellulose-rich solids; and then mechanically treating the cellulose-rich solids to form a nanocellulose material comprising cellulose nanofibrils and/or cellulose nanocrystals. Many organic or inorganic solvents are possible. In some embodiments, the solvent for lignin is an oxygenated organic compound, such as a C1-C18 alcohol, e.g. ethanol, ethylene glycol, propanol, propanediol, glycerol, butanol, or butanediol. The solvent for lignin may be an aromatic alcohol, such as phenol, cresol, or benzyl alcohol. The solvent for lignin may be a ketone, an aldehyde, or an ether, such as methyl ethyl ketone or diethyl ether. The solvent for lignin may be a non-oxygenated alkane, olefin, or aromatic hydrocarbon. In some embodiments, the solvent for lignin is an ionic liquid.
    Type: Grant
    Filed: January 7, 2022
    Date of Patent: February 20, 2024
    Assignee: GranBio Intellectual Property Holdings, LLC
    Inventors: Kimberly Nelson, Theodora Retsina, Vesa Pylkkanen, Ryan O'Connor
  • Patent number: 11896607
    Abstract: The present invention relates to a carboxyalkyl chitosan having a zeta potential, measured at pH 7.5, that is less than or equal to ?20 mV, compositions comprising same, a process for manufacturing same, and various applications thereof, in particular in the field of therapy, rheumatology, ophthalmology, esthetic medicine, plastic surgery, internal surgery, dermatology or cosmetics.
    Type: Grant
    Filed: November 9, 2018
    Date of Patent: February 13, 2024
    Assignee: KiOmed Pharma
    Inventors: Mickaël Chausson, Pierre Douette, Sandrine Emilia Gautier, Philippe Vaesen, Houtaï Choumane, Guillermo Rocasalbas
  • Patent number: 11890344
    Abstract: The application of a highly controlled, micron-sized, branched, porous architecture to enhance the handling properties and degradation rate of hydrogels is described in the instant invention. A previously described pattern created through one-step nucleated crystallization in a hydrogel film creates tunable mechanical properties and/or chemical stability for use in tissue engineering applications. The bulk mechanical properties and the degradation rate of the material can be tuned easily by the addition or subtraction of crystalline structure or by the addition and subtraction of backfill material, making this useful for a variety of applications. Relevant mechanical properties that can be tuned through the application of this unique porosity are moduli, elasticity, tensile strength, and compression strength. The method of the present invention can be applied to biopolymers and natural materials as well as synthetic materials.
    Type: Grant
    Filed: February 11, 2022
    Date of Patent: February 6, 2024
    Assignee: Board of Regents, The University of Texas System
    Inventors: Sarah Mayes, Christine Schmidt
  • Patent number: 11883426
    Abstract: A method of treating or preventing methamphetamine related endothelial dysfunction in a patient comprising administering to the patient an effective dose of a pharmacologic composition; the composition comprising a therapeutic, the therapeutic including a hydrogen sulfide (H2S) donor, or a salt, solvate, ester, amide, clathrate, stereoisomer, enantiomer, prodrug or analogs thereof. The H2S donor may be one of sodium sulfide, diallyl trisulfide, diallyl disulfide, allicin, sugammadex, sulfanilamide, disulfiram, sulfonamide, sulfonates, sulfoxides, persulfides, polysulfides, and sulfones. The H2S donor may be sugammadex. The H2S donor may be administered in a dosage of between 0.5 mg/kg and 10.0 mg/kg.
    Type: Grant
    Filed: August 9, 2021
    Date of Patent: January 30, 2024
    Assignee: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
    Inventors: Christopher Kevil, Gopi K. Kolluru
  • Patent number: 11884754
    Abstract: [Object] An object is to provide a sulfonated fine cellulose fiber having excellent transparency, a sulfonated pulp fiber suitable for the sulfonated fine cellulose fiber, a method for producing these fibers, and a derivative pulp containing the sulfonated pulp fiber. [Means for achieving the object] The sulfonated pulp fiber of the present invention is a pulp fiber comprising a plurality of cellulose fibers, wherein a part of hydroxyl groups of the cellulose fibers of the pulp fiber is substituted with sulfo groups, an introduction amount of sulfur attributable to the sulfo groups is adjusted to be higher than 0.42 mmol/g while maintaining a fiber shape, and a water retention value of the pulp fiber is adjusted to 150% or more. Since the sulfonated pulp fiber has a predetermined water retaining property or more while maintaining the fiber shape, the degree of flexibility in handling can be improved.
    Type: Grant
    Filed: April 24, 2019
    Date of Patent: January 30, 2024
    Inventors: Shou Hiasa, Hiromi Uchimura, Tomoki Yabutani
  • Patent number: 11878030
    Abstract: Disclosed are ophthalmic formulations which use complexes called L/H-HA, obtainable by subjecting at least two fractions of hyaluronic acids and/or other glycosaminoglycans with different molecular weights to an appropriate heat cycle.
    Type: Grant
    Filed: August 27, 2021
    Date of Patent: January 23, 2024
    Assignee: Allergon S.A.
    Inventors: Mario De Rosa, Chiara Schiraldi
  • Patent number: 11878088
    Abstract: The invention includes chitosan nanofibers having enhanced structural integrity, compositions comprising such chitosan nanofibers, and related methods of use. In a particular aspect, electrospun chitosan nanofibers can be reversibly acylated to enhance structural integrity and promote healing and the formation of tissues in a subject. In another aspect, electrospun chitosan nanofibers comprising at least a portion of the amino groups protected, such as through N-tert-butoxycarbonyl groups, demonstrate enhanced structural integrity and promote healing and the formation of tissues in a subject. The invention also includes compositions and methods for producing a modified chitosan material having anti-inflammatory and pro-healing characteristics and methods of using the modified chitosan materials in a film, a gel, a membrane, microfibers, nanofibers, nano- or micro-particles/spheres and/or sponges. In some aspects, microspheres and methods of producing microspheres comprising modified chitosan are included.
    Type: Grant
    Filed: December 1, 2021
    Date of Patent: January 23, 2024
    Assignee: The University of Memphis Research Foundation
    Inventors: Joel D. Bumgardner, Hengjie Su, Tomoko Fujiwara, Daniel G. Abebe, Kwei-Yu Liu
  • Patent number: 11873350
    Abstract: A process for dissolving modified cellulose is disclosed. The process includes contacting modified cellulose with a solvent in a mixture to form swelled modified cellulose and then contacting the mixture with a salt to dissolve the swelled modified cellulose.
    Type: Grant
    Filed: April 19, 2021
    Date of Patent: January 16, 2024
    Assignee: Covidien LP
    Inventors: Valentino J. Tramontano, Joshua Kennedy, Philip D. Blaskovich, Rachit Ohri, Daniel S. Costa, Sajida Farooqi
  • Patent number: 11873351
    Abstract: There is provided a method for producing hydroxypropyl methyl cellulose phthalate (HPMCP), including an esterification step of reacting hydroxypropyl methyl cellulose with a carboxybenzoylating agent in the presence of an aliphatic carboxylic acid in a kneader reactor equipped with two or more stirring blades rotating around their own axes and orbitally revolving, to obtain a reaction product solution containing HPMCP; a precipitation step of precipitating the HPMCP by mixing the reaction product solution with water to obtain a suspension of the precipitated HPMCP; and a washing and recovery step of washing the HPMCP in the suspension and recovering the washed HPMCP. Further, there is provided HPMCP having yellowness at 20° C. of 10.0 or less, as determined in a 10% by mass solution of the HPMCP in acetone.
    Type: Grant
    Filed: October 29, 2020
    Date of Patent: January 16, 2024
    Assignee: Shin-Etsu Chemical Co., Ltd.
    Inventors: Taishi Kitaguchi, Junichi Matsubara, Mitsuhiro Yoshida
  • Patent number: 11865124
    Abstract: The present disclosure relates to compounds and methods of eradicating cancer stem cells by combining inhibitors of oxidative metabolism and glycolytic metabolism. Also described are compounds and methods of identifying a combination of inhibitors of oxidative metabolism and glycolytic metabolism to treat cancer stem cells.
    Type: Grant
    Filed: November 9, 2021
    Date of Patent: January 9, 2024
    Inventors: Michael P. Lisanti, Federica Sotgia