Abstract: The present disclosure relates generally to sol-gel polymer composites that comprise chitosan, a hydrophilic polymer, a polysiloxane, and a gelation agent in a suitable medium. Advantageously, the sol-gel polymer composite can form a durable seal or strong solid in response to one or more physiological stimulus. The disclosure further relates to medical and veterinary uses of the composite, particularly, methods and delivery systems for reducing or preventing the incidence of a mammary disorder in a dairy animal. More particularly, the disclosure includes methods and sol-gel polymer composite compositions for creating a physical barrier on the teat surface or in the teat canal or cistern of a non-human animal for prophylactic treatment of mammary disorders such as mastitis wherein the sol-gel polymer creates a seal in response to one or more physiological stimulus.
Type:
Grant
Filed:
April 19, 2018
Date of Patent:
September 20, 2022
Assignee:
Zoetis Services LLC
Inventors:
Christina Lee Brown, Derek James Sheehan, John Mark Heimlich, Todd Foster, Jeffrey Ellis Price, Sumitra Rajagopalan, Alexandre Therrien, Oscar Suarez, Nicholas Finn Cunningham
Abstract: The present invention generally relates to use of single isomer chemically modified cyclodextrins, namely, S-(carboxyalkyl)-thio-cyclodextrin salts in medication used for the prevention or treatment of lysosomal storage diseases. More particularly, the present invention relates to isomer-pure, single isomer hexakis-S-(carboxyalkyl)-hexathio-alpha-cyclodextrin sodium salts, heptakis-S-(carboxyalkyl)-heptathio-beta-cyclodextrin sodium salts and octakis-S-(carboxyalkyl)-octathio-gamma-cyclodextrin sodium salts in medication used for the prevention or treatment of lysosomal storage diseases.
Type:
Grant
Filed:
September 30, 2020
Date of Patent:
September 20, 2022
Assignee:
CYCLOLAB CYCLODEXTRIN RESEARCH AND DEVELOPMENT LABORATORY LTD.
Inventors:
Lajos Szente, István Puskas, Tamas Sohajda
Abstract: Fine cellulose fiber has a dispersion with a very high transparency and viscosity. A method is for producing the fine cellulose fiber. In the cellulose fiber, a part of hydroxy groups of cellulose fiber is substituted with a predetermined functional group to introduce an ester of phosphorus-oxo acid, and substituted with a carbamate group to introduce a carbamate. The method for producing fine cellulose fiber includes adding an additive (A) and an additive (B) including at least one of urea and a urea derivative to cellulose fiber, heating the mixture at 100 to 210° C., washing the mixture, and then fibrillating the mixture, the additive (B) being added in an amount of 0.01 to 100 mol based on 1 mol of the additive (A).
Abstract: A chlorinated derivative of hyaluronic acid or of a modified hyaluronic acid (chloramide) is provided. The chloramide has an amidic group (—NH—CO—). The hydrogen of the amidic group is substituted by a chlorine atom, according to the structural formula —NCl—CO—. The substitution degree of the hyaluronic acid or of the modified hyaluronic acid by chlorine is in an amount of from 50 to 100 %.
Type:
Grant
Filed:
August 17, 2019
Date of Patent:
August 30, 2022
Assignee:
CONTIPRO A.S.
Inventors:
Radovan Buffa, Ivana Basarabova, Martina Hermannova, Katerina Knotkova, Jaromir Kulhanek, Josef Chmelar, Tomá{hacek over (s)} Pitucha, Drahomira Chladkova, Helena Krejci, Hana Vagnerova, Martin Sojka, Lubos Sobotka, Vladimir Velebny
Abstract: An antimicrobial composition is provided. The composition comprises a chloramid of hyaluronic acid or of modified hyaluronic acid. The chloramid has an amidic group (—NH—CO—). The hydrogens of the amidic group are substituted by chlorine atoms according to the structural formula —NCl—CO—. The composition further comprises an iodide. The substitution degree of the hyaluronic acid or of the modified hyaluronic acid by chlorine is in an amount of from 50% to 100%.
Type:
Grant
Filed:
August 17, 2019
Date of Patent:
August 30, 2022
Assignee:
CONTIPRO A.S.
Inventors:
Radovan Buffa, Vit Svozil, Katerina Knotkova, Veronika Stepankova, Jaromir Kulhanek, Josef Chmelar, Lucie Marholdova, Ivana Basarabova, Michaela Moravkova, Helena Krejci, Kristyna Lipenska, Jaroslav Novotny, Stanislav Pepeliaev, Lubos Sobotka, Vladimir Velebny
Abstract: The present disclosure relates to synthetic mixtures of certain human milk oligosaccharides and uses thereof. Particular mixtures provided herein include: lacto-N-triose II, lacto-N-neotetraose, para-lacto-N-neohexaose, and, optionally, lactose; and lacto-N-triose II, lacto-N-tetraose, para-lacto-N-hexaose II, and, optionally, lactose. These mixtures are useful in the prevention and treatment of viral and bacterial infections.
Type:
Grant
Filed:
June 23, 2017
Date of Patent:
August 23, 2022
Assignee:
GLYCOM A/S
Inventors:
Nikolay Khanzhin, Markus Jondelius Hederos, Louise Kristine Vigsnæs, Bruce McConnell
Abstract: The invention relates to a process for the manufacture of an alkylfluoroacrylate starting from alkylfluoroacetate and an oxalic acid ester, wherein an alkane liquid under the reaction conditions is applied as the solvent in one of the reaction steps.
Abstract: Several embodiments of NO releasing structures are disclosed. In some embodiments, the structures are covalently modified to store and release nitric oxide. Some embodiments pertain to methods of making and use of these structures. The covalently modified polymer structures may be tailored to release nitric oxide in a controlled manner and are useful for treatment of various medical conditions.
Type:
Grant
Filed:
December 23, 2019
Date of Patent:
August 23, 2022
Assignee:
The University of North Carolina at Chapel Hill
Inventors:
Mark H. Schoenfisch, Mona Jasmine R. Ahonen, Lei Yang, Haibao Jin, Evan Scott Feura, Sara Elizabeth Maloney
Abstract: A medicament for preventing and/or treating a disease is disclosed, the disease is Alzheimer's disease, diabetes or senility; and the medicament includes a first active ingredient, and the first active ingredient includes one of carrimycin, isovalerylspiramycin I, isovalerylspiramycin II and isovalerylspiramycin III, or a combination of two or three of isovalerylspiramycin I, isovalerylspiramycin II and isovalerylspiramycin III.
Abstract: Compositions comprising 5-cholesten-3,25-diol, 3-sulfate (25HC3S) or pharmaceutically acceptable salt thereof and at least one cyclic oligosaccharide, e.g., a cyclodextrin (CD), are provided. The compositions may be used to prevent and/or treat a variety of diseases and conditions, including organ failure (e.g. acute liver failure), high cholesterol/high lipids, and various inflammatory diseases and conditions.
Type:
Grant
Filed:
November 10, 2020
Date of Patent:
August 9, 2022
Assignees:
Virginia Commonwealth University, Durect Corporation, The United States Government as Represented by The Department of Veterans Affairs
Inventors:
Shunlin Ren, Leyuan Xu, Yanxia Ning, Jin Koung Kim, WeiQi Lin, Andrew R. Miksztal, Hongwei Wu, Min L. Lee
Abstract: A method for the synthesis of alkyl ?-carboxy(hydroxyethyl) polysaccharides is described. The method includes methylating or ethylating a polysaccharide or providing a methylated or ethylated polysaccharide, hydroxyethylating the methylated or ethylated polysaccharide, and oxidizing the hydroxyethylated polysaccharide to form the ?-carboxy(hydroxyethyl) polysaccharide. A method for the synthesis of oxidized polysaccharides is also described. The method includes hydroxypropylating a polysaccharide and oxidizing the hydroxypropylated polysaccharides. A method for the production of a solid capable of forming a hydrogel is also described. The method includes combining a first solution comprising an oxidized oligo(hydroxypropyl) polysaccharide bearing one or more ketone groups with a second solution comprising an amine substituted polysaccharide to form a third solution, and removing solvent from the third solution to form the solid, or adding an additional solvent to the third solution to precipitate the solid.
Type:
Grant
Filed:
January 11, 2019
Date of Patent:
July 12, 2022
Assignee:
Virginia Tech Intellectual Properties, Inc.
Inventors:
Kevin Edgar, Brittany L. B. Nichols, Junyi Chen, Charles Frazier, Ann Norris
Abstract: A joint cavity injection preparation is provided. The active ingredient of the joint cavity injection preparation is deacetylated xanthan gum (XG). The deacetylated XG has a molecular weight of 500,000 to 20,000,000. The joint cavity injection preparation is prepared from deacetylated xanthan gum (XG), which has higher biocompatibility and safe wide-dosage range than existing joint cavity injection preparations prepared from XG.
Type:
Grant
Filed:
May 21, 2019
Date of Patent:
July 5, 2022
Assignees:
SHANDONG ACADEMY OF PHARMACEUTICAL SCIENCES, SHANDONG FREDA PHARMACEUTICAL GROUP CO., LTD.
Abstract: The present invention relates to a group of compounds derived from resveratrol having as substituents at least one silyl group which, in turn, can be substituted by different groups. The invention also relates to the therapeutic use of these compounds in inflammatory, neurological, and neurodegenerative diseases.
Type:
Grant
Filed:
November 23, 2017
Date of Patent:
June 21, 2022
Assignee:
Consejo Superior De Investigaciones Cientificas
Inventors:
Juan Carlos Morales Sánchez, Pablo Peñalver Puente, Efres Belmonte Reche, Elena González Rey, Maria Luisa Mateos Martin
Abstract: Provided herein are compounds, compositions, and methods for modifying mucus, including modifying mucus using nitric oxide-releasing biopolymers (e.g., NO-releasing chitosan oligosaccharides). In some embodiments, a compound, composition, and/or method of the present invention modifies one or more properties of mucus to increase mucus clearance in a subject and/or prevents the growth or kills one or more pathogens present in mucus of a subject.
Type:
Grant
Filed:
April 10, 2018
Date of Patent:
May 10, 2022
Assignee:
The University of North Carolina at Chapel Hill
Abstract: The present invention relates to a pharmaceutical composition, comprising Tecovirimat, cyclodextrin and an additive, and optionally a pharmaceutically acceptable excipient. The present invention also relates to a method for preparing the pharmaceutical composition. The composition improves the solubility of Tecovirimat in water by using cyclodextrin and meglumine in combination, as compared with the solubility of Tecovirimat in water by using cyclodextrin or meglumine alone.
Type:
Grant
Filed:
July 4, 2017
Date of Patent:
May 3, 2022
Assignee:
Institute of Pharmacology and Toxicology Academy of Military
Medical Sciences P.L.A. China
Inventors:
Wu Zhong, Meiyan Yang, Wei Gong, Yuli Wang, Chunsheng Gao, Xinbo Zhou, Song Li
Abstract: Provided is a particular form of natamycin that shows improved properties as a fungicide for use in agricultural applications. A preferred natamycin composition comprises a structuring agent and a surfactant. Said natamycin composition further comprises cellular matter from a natamycin-producing organism. The natamycin in a natamycin composition preferably has a surface area of less than 6 m2/g, and an average particle size of less than 6 micrometer. The invention further relates to methods, comprising contacting a plant or part thereof, a fungus, a fruit, a crop, a seed, and/or a soil with a natamycin composition of the invention.
Type:
Grant
Filed:
April 18, 2017
Date of Patent:
May 3, 2022
Assignee:
Arec Crop Protection B.V.
Inventors:
Wilhelmus Maria van der Krieken, Kieran P. Furlong
Abstract: Provided herein are conjugates of nucleoside antimetabolites and their analogs with ibandronate, pharmaceutical compositions including one or more of said conjugates, methods of synthesizing the same as well as methods of treating diseases and or conditions using the same.
Abstract: A new class of synthetic cyclodextrin dimers is described. Exemplary cyclodextrin dimers can treat atherosclerotic plaques by targeting various forms cholesterol both intracellularly and extracellularly. Also provided are methods of depleting atherosclerotic plaques of cholesterol, cholesterol esters, 7-ketocholesterol and 7-ketocholesterol esters by treatment with such cyclodextrins. Further described are subclasses of dimers that have high specificity for 7-ketocholesterol.
Type:
Grant
Filed:
January 3, 2020
Date of Patent:
March 22, 2022
Assignee:
UNDERDOG PHARMACEUTICALS, INC.
Inventors:
Matthew S. O'Connor, Milo Malanga, Michael Kope, Christina A. T. M. B. Tom, Amelia M. Anderson