Patents Examined by Lenora A Abel
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Patent number: 11970687Abstract: The invention concerns an installation for treating biological liquid by viral inactivation, comprising a main supply valve (4) for suppling biological liquid to treat, a first line (2) downstream of said valve and provided with a first main tank (7), a second line (3) downstream of said valve and provided with a second main tank (14), said second line being in parallel with said first line, and a third main tank (11) disposed at an outlet both from said first line and said second line and configured to be successively supplied by said first main tank and by said second main tank; said installation being configured such that in each of said first, second and third main treatment tanks, a determined volume of acid and a determined volume of base are introduced at least so as to adjust a pH of said biological liquid and to regulate a rate of drainage flow of said third main treatment tank so as to provide a continuous rate of flow of treated biological liquid at an outlet from said installation.Type: GrantFiled: May 15, 2019Date of Patent: April 30, 2024Assignee: EMD Millipore CorporationInventors: Laurent Jourdainne, Sebastien Cirou
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Patent number: 11952564Abstract: A bioreactor includes a base and a lid. The base includes two opposing curved or convoluted surfaces, two opposing flat surfaces, a window disposed on one of the flat surfaces, the window having a higher degree of transparency compared to other portions of the base, wherein images or videos of cells are captured through the window by non-invasive ISM device, and a rounded bottom. The lid is attachable to the base. The lid includes a shaft and a semipermeable membrane attached to the shaft, the semipermeable membrane being permeable to oxygen but impermeable to viruses and bacteria. The PAT-based online analysis directs the adaptive manipulations of bioreactor towards efficient, automated, and GMP-compliant clinical protocols of cell culture.Type: GrantFiled: August 30, 2022Date of Patent: April 9, 2024Assignee: Shanghai Longevity Co., Ltd.Inventors: Tian Xia, Ke Ma
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Patent number: 11944089Abstract: A portable temperature-controlled container for receiving and housing one or more handheld carriers, each handheld carrier configured to transfer samples to and from a temperature-controlled storage environment, the handheld carrier including a handle and a tray portion, the tray portion configured to be slid into a port of a rack or tower provided in the temperature-controlled storage environment in order to withdraw a sample located in the port, the portable temperature-controlled container including a housing having an opening forming an internal cavity configured to receive one or more handheld carriers, and a lid configured to substantially close the opening, where the housing includes a recess configured to receive the handle of the handheld carrier such that closing of the lid substantially seals the internal cavity when the one or more handheld carriers are placed in the housing.Type: GrantFiled: January 27, 2023Date of Patent: April 2, 2024Assignee: BLUECHIIP LIMITEDInventors: Ian Johnston, Andrew McLellan, Scott Turner
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Patent number: 11932842Abstract: An apparatus for bioprocessing includes a housing, a drawer receivable within the housing, the drawer including a plurality of sidewalls and a bottom defining a processing chamber, and a generally open top, the drawer being movable between a closed position in which the drawer is received within the housing, and an open position in which the drawer extends from the housing enabling access to the processing chamber through the open top, and at least one bed plate positioned within the processing chamber and configured to receive a bioreactor vessel.Type: GrantFiled: February 8, 2019Date of Patent: March 19, 2024Assignee: GLOBAL LIFE SCIENCES SOLUTIONS USA LLCInventors: Weston Blaine Griffin, Alex D Corwin, Xiaohua Zhang, Reginald Donovan Smith, Zhen Liu, Chengkun Zhang, Vandana Keskar, Brian Michael Davis, Kashan Shaikh
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Patent number: 11926815Abstract: A system, methods, and apparatus are described to collect and prepare single cells, nuclei, subcellular components, and biomolecules from specimens including tissues and in some embodiments use the single cells to form organoids or microtissues. The system can perform enzymatic and/or physical disruption of the tissue to dissociate it into single-cells and then use a hanging droplet method to form organoids or microtissues.Type: GrantFiled: March 9, 2023Date of Patent: March 12, 2024Assignee: S2 GENOMICS, INC.Inventors: Stevan Bogdan Jovanovich, Kaiwan Chear, Bruce Leisz, David Eberhart, John Bashkin
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Patent number: 11926811Abstract: A personal laboratory apparatus includes a plurality of life sciences laboratory modules disposed on or in a common housing. The laboratory modules include a cooling station, a heating station, an incubator, a bioreactor, and a removable fluidic cartridge that is fluidly coupled to the bioreactor. The personal laboratory apparatus can be sold as a kit with a wetware kit that includes laboratory hardware and ingredients for performing a genetic-engineering experiment. The wetware kit includes a plurality of test tubes and a pre-measured volume or mass of a plurality of materials, each pre-measured volume or mass disposed in a corresponding test tube.Type: GrantFiled: July 17, 2018Date of Patent: March 12, 2024Assignee: Amino Labs North IncorporatedInventors: Justin Pahara, Julie Legault
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Patent number: 11920119Abstract: A bioprocessing system includes a first module configured for enriching and isolating a population of cells, a second module configured for activating, genetically modifying, and expanding the population of cells, and a third module configured for harvesting the expanded population of cells.Type: GrantFiled: February 8, 2019Date of Patent: March 5, 2024Assignee: GLOBAL LIFE SCIENCES SOLUTIONS USA LLCInventors: Weston Blaine Griffin, Alex D Corwin, Xiaohua Zhang, Reginald Donovan Smith, Zhen Liu, Chengkun Zhang, Vandana Keskar, Brian Michael Davis, Kashan Shaikh
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Patent number: 11912970Abstract: Microfluidic devices, systems, and methods.Type: GrantFiled: May 15, 2018Date of Patent: February 27, 2024Assignee: THE UNIVERSITY OF CHICAGOInventors: Ce Zhang, Savas Tay
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Patent number: 11912973Abstract: A bioreactor includes a scaffold, a scaffold support, and a manifold. The scaffold is seeded with a plurality of cells. The scaffold has an extended state and a non-extended state. The scaffold support that selectively modifies a state of the scaffold from the non-extended state to the extended state. A manifold is configured to provide a medium to the scaffold. The state of the scaffold from the non-extended state to the extended state is modified at a rate tuned to maintain a cell density associated with the plurality of cells within a particular density range.Type: GrantFiled: June 1, 2023Date of Patent: February 27, 2024Assignee: Ark Biotech Inc.Inventors: Zheng Huang, Orianna Elysse Kane, Xiaoting Liang, Natalie Rose Rubio
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Patent number: 11898130Abstract: A cell culture equipment comprising a culture component permeable member 10 that is permeable to culture components, a culture vessel 30 that covers one side of the culture component permeable member 10 and holds a cell-containing medium, and a medium holding vessel 40 that covers the other side of the culture component permeable member 10 and holds a medium.Type: GrantFiled: August 20, 2019Date of Patent: February 13, 2024Assignees: Peace, Inc., FANUC CORPORATIONInventors: Koji Tanabe, Ryoji Hiraide, Kenta Suto, Kazunori Ban, Satoshi Kinoshita
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Patent number: 11898136Abstract: Some fluid coupling devices described herein are configured for use in fluid systems. For example, some embodiments described in this document are single-use, aseptic fluid coupling devices that can be coupled to create a sterile flow path therethrough. Some such aseptic couplings are genderless couplings such that two identical aseptic couplings can be coupled together and then latched to form a robust connection between the aseptic couplings.Type: GrantFiled: December 15, 2020Date of Patent: February 13, 2024Assignee: Colder Products CompanyInventors: Matthew Gregory Casura, Jonathan Steven Van Loon, Randall S. Williams
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Patent number: 11889830Abstract: An integrated system and method for preparing sperm cells to improve their survivability during cryopreservation are described herein. The system features a vessel, a controlled dispenser, and a dispense tube. The dispense tube has a first end fluidly connected to the dispenser and a second end disposed inside the vessel. The second end can be submerged in the sperm cell fluid. The controlled dispenser may be a syringe pump that includes a syringe for containing a cryoprotectant and a pushing mechanism for displacing the syringe. The syringe pump is configured to discharge the cryoprotectant through the dispense tube and into the vessel, thereby dispensing the cryoprotectant into the sperm cell fluid. Mixing of the fluids is achieved using a shaker table agitation.Type: GrantFiled: April 17, 2020Date of Patent: February 6, 2024Assignee: ABS GLOBAL, INC.Inventors: Domenic Busa, Michael Botts, Gary Klas, Johnathan Parker
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Patent number: 11882824Abstract: A vial sleeve for a cryogenic vial includes a cover portion including a side wall defining a cavity for receiving at least a portion of the vial, and a locking feature configured to operatively engage at least a portion of the vial for resisting movement of the vial relative to the vial sleeve. The vial sleeve may include a first label adhered to an exterior surface of the side wall and including a first set of indicia. The first set of indicia may be different from a second set of indicia included on a second label adhered to an exterior surface of the vial.Type: GrantFiled: July 31, 2019Date of Patent: January 30, 2024Assignee: Fisher BioServices Inc.Inventors: Abdul H. Ally, Bruce Simpson, Scott Hixon
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Patent number: 11884904Abstract: The subject matter of this application is using novel biological reactors for the fermentation of gases into liquid products. More specifically, the subject matter relates to the use of a Multiple-Pass Trickle Bed Reactor (MP-TBR) for the anaerobic or aerobic and biological fermentation of gases generated from industrial processes and/or from the gasification of biomass and other organic carbon sources. The products may include, but are not limited to, ethanol and other valuable chemicals.Type: GrantFiled: August 27, 2018Date of Patent: January 30, 2024Assignee: ICM, Inc.Inventors: Albert Bennett, Jonathan N. Orr
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Patent number: 11879118Abstract: A gel tray for a bacterial transformation lab exercise has a plastic body with four parallel gel channels and four filling ports, one for each channel into which unmodified bacteria and heat-shocked bacteria can be injected by students along with appropriate reaction constituents to demonstrate transformation of the bacteria under visualization. A seal may be provided to seal the tops of the gel channels and a lid can cover the gel tray during incubation.Type: GrantFiled: May 8, 2021Date of Patent: January 23, 2024Assignee: C.C. ImexInventors: Callen Elizabeth Hyland, Christopher Karl Schroeder, Rita Mei Yi Wong, Richard Tat Lee Chan
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Patent number: 11873471Abstract: A culture dish combination for embryo thawing and embryo transfer is provided. The culture dish combination includes a first culture dish and a second culture dish, the first culture dish includes a first dish cavity for thawing and laser-assisted hatching of frozen embryos, and an opening of the first dish cavity is upward. The second culture dish is detachably connected to the first culture dish, and the second culture dish includes a second dish cavity for balancing culture medium before the embryo transfer; the second culture dish further includes a third dish cavity surrounding the second dish cavity, and openings of the second dish cavity and the third dish cavity are upward. The culture dish combination solves problems of complex operations of thawing the frozen embryo, laser-assisted hatching and the embryo transfer, which increases the accuracy of the operation of embryo thawing and improves the stability of the incubator environment.Type: GrantFiled: February 3, 2023Date of Patent: January 16, 2024Assignee: ZHEJIANG UNIVERSITYInventors: Jin-peng Rao, Shen Tian, Chun Feng, Feng Qiu, Xiao-yun Wang, Fan Jin, Min Jin
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Patent number: 11866683Abstract: A cell culture apparatus includes a cell culture module including multiple cell culture chambers. A manifold connects the multiple cell culture chambers together along a side of the cell culture module. The manifold includes a side wall base structure connected to the side of the cell culture module and a column structure that is formed as a monolithic part of the side wall base structure. The column structure defines a fluid flow pathway through the manifold and to inlets to the cell culture chambers to allow filling and emptying of the cell culture chambers of liquid medium.Type: GrantFiled: November 5, 2018Date of Patent: January 9, 2024Assignee: CORNING INCORPORATEDInventors: Gregory Roger Martin, Allison Jean Tanner
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Patent number: 11845921Abstract: The invention relates to a device for examining a medium (100) inside a bioreactor (200; 201), comprising a sample-taking module (20) for taking a sample of the medium (100). The sample-taking module (20) comprises an uptake region (10; 10a; 10b) that can be arranged to make contact with the medium (100) inside the bioreactor (200; 201). At least two different membranes (15, 16) are positioned on the uptake region (10; 10a; 10b) of said sample-taking module (20), for the purpose of taking a sample of the medium (100).Type: GrantFiled: October 18, 2018Date of Patent: December 19, 2023Inventors: Christian Grimm, Henry Weichert, Mario Becker
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Patent number: 11834644Abstract: A pressure buffering system includes a housing, a pump module, a pressure sensor and a pressure cylinder. The pump module, the pressure sensor and the pressure cylinder are disposed in the housing. The pressure cylinder is communicated between the pump module and the pressure sensor. A biological culture device is further provided.Type: GrantFiled: September 9, 2020Date of Patent: December 5, 2023Assignee: Wistron CorporationInventors: Ziya Li, Huan-Chun Wu, Chun-Chih Lai
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Patent number: 11827873Abstract: The invention provides a structured cell growth matrix or assembly comprising a one or more spacer layers and one or more cell immobilization layers. The invention further provides a bioreactor comprising said matrix or assembly.Type: GrantFiled: July 20, 2020Date of Patent: November 28, 2023Assignee: UNIVERCELLS TECHNOLOGIES S.A.Inventors: José Castillo, Bastien Mairesse, Quentin Vanwalleghem