Abstract: A sustained release pharmaceutical preparation for percutaenous administration use mainly composed of a drug layer which is a layer made to contain drugs, to have no adhesiveness to the skin, but to be used in contact with the skin.

Abstract: A controlled release treatment composition and method of use are disclosed. The composition includes a bioadhesive and an effective amount of a treating agent. The bioadhesive is a water-swellable, but water-insoluble, fibrous, cross-linked carboxy-functional polymer containing (a) a plurality of repeating units of which at least about 80 percent contain at least one carboxyl functionality, and (b) about 0.05 to about 1.5 percent cross-linking agent substantially free from polyalkenyl polyether.

Abstract: A transdermal drug delivery device comprising a drug formulation-containing reservoir defined by a backing layer and a drug-permeable membrane layer, a peelable inner liner that underlies the reservoir and a portion of the backing/membrane outwardly of the reservoir periphery, an adhesive layer that underlies the inner liner and outwardly extending portions of the membrane/backing layers, and a peelable release liner layer that underlies the adhesive layer with a first permanent heat seal between the backing and the membrane about the perimeter of the reservoir and another concentric peelable (impermanent) heat seal between the membrane and the inner liner positioned underlying and at a radius not less than the first permanent heat seal, the heat seals and peelable barrier layer providing barriers that isolate the drug formulation from the adhesive.

Abstract: The invention relates to oral pharmaceutical compositions comprising a diphosphonic acid derivative and sodium laurylsulfate in the amount of 1.5 to 6% by weight, relative to the diphosphonic compound.

Abstract: A transdermal patch having a drug reservoir layer on a backing sheet, the drug reservoir layer comprises an adhesive gel base containing clebopride or a pharmaceutically acceptable salt thereof, the adhesive gel base containing as essential components, a water-soluble polymer, water and a water-holding agent. The use of such a patch permits adequate concentration of clebopride to be maintained in the blood over prolonged periods of time while avoiding the problems of multiple administrations of clebopride by conventional methods.

Abstract: The instant invention relates to a drug-delivery device for the controlled release of HMG-CoA reductase inhibitor salts, as the therapeutically active ingredient, into an environment of use which comprises:(A) a core composition comprising(1) a water insoluble, non-diffusible, charged resin entity, and(2) a diffusible, water soluble ionizable therapeutically active HMG-CoA reductase inhibitor salt carrying the same charge as said resin entity; and(B) an imperforate water insoluble wall surrounding said core composition and prepared from a semipermeable material substantially impermeable to core composition and permeable to the passage of an external fluid in the environment of use, with said wall having a means for release of the therapeutic agent through the water insoluble wall; or(C) a water insoluble wall surrounding said core composition and prepared from (1) a polymer material that is permeable to water but substantially impermeable to solute and (2) 0.

Abstract: A stabilized enteric coated aspirin granule product prepared by commingling the enteric coated aspirin granules with glutamic acid hydrochloride.

Abstract: Skin permeation enhancer compositions are provided which increase the permeability of skin to transdermally administered pharmacologically active agents. The composition contains diethylene glycol monoethyl or monomethyl ether in addition to an ester component such as propylene glycol monolaurate, methyl laurate or the like. The compositions are particularly useful in conjuction with the transdermal administration of steroid drugs such as progestogens and estrogens. Methods and drug delivery systems for using the enhancer compositions are provided as well.

Abstract: A recording liquid with well-balanced characteristics is provided which comprises a colorant and a liquid medium, and has a surface tension to 64 dyne/cm or more at 25.degree. C. and a viscosity of 2.5 centipoises or less at 25.degree. C. A recording method employing the recording liquid is also provided.

Abstract: A tamper evident pharmaceutical capsule which contains an active agent. The capsule is coated on its external surfaces to provide an indication of tampering.

Abstract: A composition of matter comprising a drug, a neutral hydrogel and an ionic hydrogel. The composition can be administered from a delivery system to a biological receptor over time.

Abstract: Composition of a cyclosporin and GLA and DGLA or derivative thereof convertible in the body thereto alone or in a pharmaceutical diluent or carrier.

Abstract: Tablets containing 1-2% by weight carboxymethylguar as a disintegrant are equivalent to tablets containing sodium carboxymethylcellulose in medicant release. These tablets can be made at a lower cost while still meeting Pharmacopeia standards.

Abstract: An acetaminophen-sustained release tablet or tablet layer is formed by making a wet granulation, using Povidone (PVP) in water or alcohol-water as the granulating fluid which is mixed with acetaminophen, hydroxyethyl cellulose, a wicking agent e.g. microcrystalline cellulose, then drying and milling the granulation and blending with dry powdered erosion promoter, e.g. pregelatinized starch, wicking agent, lubricant e.g. magnesium stearate and glidant e.g. silicon dioxide, and compressing the resultant granulation, which upon administration results in a slow release of the acetaminophen.

Abstract: A protective coating of finely divided abrasion resistant resin is diluted with a solvent and applied to a surface. The applied coating is cured to achieve either a single layer of inert dispersed in the resin, or two layers including a dense layer of inert in resin covered by a thin layer of resin, and to provide a glossy or matte appearance as desired.

Abstract: A dispensing device is disclosed for delivering a beneficial agent. The device comprises (1) a housing defining an internal space, (2) an expandable composition comprising a dense member in the space, (3) a composition comrising a beneficial agent and a non-toxic heat responsive carrier in the space, and (4) a passageway in the housing for delivering the beneficial agent from the dispensing device.

Abstract: A device is disclosed for delivering diltiazem at a controlled and substantially zero order rate over a prolonged period of time.

Abstract: An exothermic package body having a carrier layer comprising a medicinal component, and an exothermic layer which develops heat when exposed to the air to enhance absorption of the medicinal component through the skin, hence improving medicinal effects.

Abstract: An adhesive tape usable as an analgesic and antiinflammatory agent comprises a support member and an adhesive mass spread on the support member, which mass contains, as essential components, etofenamate as the active ingredient, a styrene-isoprene-styrene block copolymer as an adhesive ingredient, a tackifier resin, liquid paraffin as a softening agent, a liquid rubber as a softening agent and further an antioxidant.

Abstract: The slow release preparation obtained by the method of the invention reduces the number of times the medicine needs to be taken per day, and also provides lower peaks of concentration in the blood after the medicine has been taken while simultaneously ensuring that the lowest concentration in the blood remains higher over a period of time.