Patents Examined by Liban M Hassan
  • Patent number: 12139700
    Abstract: The invention relates to a A bioprocess control device having a number of control function units (12, 30) which are accommodated in a device housing (10), are designed for bioprocesses and are configured for carrying out control, conveying, measuring and/or sensor functionalities and In order to accommodate the plurality of control function units, the device housing has modular drawer assemblies (14, 32) which, relative to stationary housing frame of the device housing in an opening position and/or removal position, allow access for configuration and/or assembly to the control function unit accommodated in a relevant drawer assembly, and, in an operating and closure position which can be locked by locking means (60, 58), produce an electrically supplying as well as electronically function-identifying contact between the control function unit and the housing frame and/or electrical power supply (40) as well as system identification means (42) associated with a further drawer assembly.
    Type: Grant
    Filed: December 10, 2018
    Date of Patent: November 12, 2024
    Assignee: EPPENDORF SE
    Inventors: Wolfgang Recker, Guido Ertel, Falk Schneider, Tristan Hufen
  • Patent number: 12128410
    Abstract: A microfluidic apparatus includes a microfluidic chip for MicroOrganoSpheres (MOS) generation. A first channel is defined in a surface of the microfluidic chip and includes: a droplet generation portion including an inlet portion, a junction between the inlet portion and an emulsifying fluid channel, and a chamber downstream of the junction. A cross-sectional area of the chamber is larger than that of the inlet portion. The first channel includes a polymerization portion downstream of the droplet generation portion, the polymerization portion having a serpentine configuration. The apparatus includes a cartridge for MOS demulsification, including: a collection container; a substrate disposed on the collection container, and a membrane disposed between the collection container and the surface of the substrate. A second channel is defined in the surface of the substrate that faces the collection container and is fluidically connected to an output of the polymerization portion of the first channel.
    Type: Grant
    Filed: May 30, 2024
    Date of Patent: October 29, 2024
    Assignee: Xilis, Inc.
    Inventors: Bradley Scott Thomas, Timothy A. Miller, Daniel Nelson, Raheel Samuel, George Robinson, Tyler Welder
  • Patent number: 12098360
    Abstract: This invention relates to a system for obtaining a biomass measurement from a medium contained within a bioreactor. The system comprises a bioreactor having a port comprising an annular flange (15) and an upstanding collar (19), and a biomass sensing probe comprising an elongate body and at least one electrode (3) provided on a first region (1) of the body. The port is configured to receive the probe and form a watertight seal with the probe when it is located in the port with the first region (1) of the body exposed to the interior of the bioreactor.
    Type: Grant
    Filed: December 13, 2018
    Date of Patent: September 24, 2024
    Assignee: ABER INSTRUMENTS LIMITED
    Inventors: Steffan Jones, Peter Twiddy, Tim Pryce
  • Patent number: 12084641
    Abstract: A cell/tissue culture system comprising at least one bioreactor configured to hold at least one type of cell to cultivate tissue, a dialysis unit comprising a dialysis membrane, a fresh medium unit, and a waste removal unit configured to remove metabolic waste from dialysate, wherein the metabolic waste comprises ammonia and lactate, and wherein the waste removal unit comprises biocatalysts or enzymes configured to breakdown lactate and generate carbon sources that promote cell growth.
    Type: Grant
    Filed: August 5, 2021
    Date of Patent: September 10, 2024
    Assignee: AVANT MEATS COMPANY LIMITED
    Inventors: Po San Mario Chin, Kai Yi Carrie Chan, Chuen Wai Li, Tim Spitters
  • Patent number: 12084640
    Abstract: A submersible device submersible within an algae slurry contained within a pond of an algae bioreactor, the submersible device including a drive motor operable to actuate one or more driven devices that move the submersible device within the pond, a circulation device operable to circulate the algae slurry through the submersible device and discharge the algae slurry back into the pond from a discharge port provided on the submersible device, and a computer system that controls operation of the drive motor and the circulation device.
    Type: Grant
    Filed: October 28, 2020
    Date of Patent: September 10, 2024
    Assignee: ExxonMobil Technology and Engineering Company
    Inventors: Anjaneya S Kovvali, Everett J O'Neal, Patrick L Hanks, Mark A Deimund, Vinit Choudhary, Yesim Igci, Louis R Brown
  • Patent number: 12077736
    Abstract: An improved system of generating renewable energy is comprised of a specific configuration of mechanisms, materials, and processes that all function together as a single symbiotic system. In accordance with a preferred embodiment, the system cultivates aquatic biomass, then extracts triglycerides from said biomass. The extracted triglycerides are converted into biodiesel through transesterification. During the operation of the system, a continuous output of biofuel, thermal energy, steam, and electricity, is efficiently produced. These yields are precisely measured and repurposed as energy input at various points throughout system processes, thus resulting in a surplus output. Any embodiment of the disclosed system will generate a continuously renewable final product of biofuel and power.
    Type: Grant
    Filed: April 12, 2015
    Date of Patent: September 3, 2024
    Inventor: Dennis Steele
  • Patent number: 12077804
    Abstract: A microbial detection device and methods of use are provided. The device comprises a water-proof pouch that includes a first wall portion, a second wall portion, and a porous membrane filter disposed in the pouch between the first and second wall portions. The filter membrane divides the pouch into first and second compartments. A dry, cold water-soluble gelling agent is adhered to the pouch in the first compartment and an absorbent pad is disposed in the second compartment. A sealable sample port provides access to deposit a liquid into the first compartment.
    Type: Grant
    Filed: July 18, 2016
    Date of Patent: September 3, 2024
    Inventors: Evan D. Brutinel, Alexi J. Young, Delton R. Thompson, Jr.
  • Patent number: 12065633
    Abstract: A biological cell preservation or culturing arrangement (20) comprises a chamber defining a fluid retaining space (30) for retaining in use a body of fluid (34) and a deformable membrane (36) in communication with the fluid retaining space, and being manipulable by an electroactive polymer actuator arrangement (38) to undergo a defined topology change to induce in the fluid a pattern of fluid flow by which fluid is exchanged between a sub-region (46) immediately proximal the deformable membrane and a sub-region (48) removed from the deformable membrane.
    Type: Grant
    Filed: October 17, 2018
    Date of Patent: August 20, 2024
    Assignee: Koninklijke Philips N.V.
    Inventors: Eduard Gerard Marie Pelssers, Cornelis Petrus Hendriks, Reinhold Wimberger-Friedl, Mark Thomas Johnson, Achim Hilgers
  • Patent number: 12064771
    Abstract: The disclosure provides a device and method for rapidly changing temperatures of a sample. An example of the device include: a first plate; a second plate; and a heating/cooling layer disposed on either the first or second plate. The first plate and the second plate face each other and are configured to receive a fluid sample sandwiched therebetween. The method includes depositing the fluid sample on one or both of the two plates, pressing the plates to form a thin layer of the sample, and changing and/or maintaining the temperature of the sample. The device or method can be used in, for example, PCR.
    Type: Grant
    Filed: May 23, 2018
    Date of Patent: August 20, 2024
    Assignee: Essenlix Corporation
    Inventors: Stephen Y. Chou, Wei Ding, Hua Tan
  • Patent number: 12043824
    Abstract: A modular incubator comprising a housing structure divided into cells and having several incubator modules, each of which can be housed, in a removable manner, in a relative cell and is provided with an incubation chamber to incubate microbiological or cellular cultures. Each cell has a first group of connectors and each incubator module has a second group of connectors, each of which can be coupled to a corresponding connector of the first group of connectors of the relative cell when the incubator module is housed in said cell. The first group of connectors has at least one pneumatic connector communicating with at least one source of aeriform substance, and the second group of connectors has a corresponding pneumatic connector communicating with the relative incubation chamber to allow the aeriform substance to be introduced into the incubation chamber.
    Type: Grant
    Filed: November 23, 2020
    Date of Patent: July 23, 2024
    Inventors: Massimiliano Cesarini, Filippo Galassi, Alessia Zanelli
  • Patent number: 12031115
    Abstract: The invention relates to devices for the culture of cellular aggregates A comprising a three-dimensional network of interconnected vessels of a biocompatible liquid- and gas-permeable photo polymerised material, wherein the three-dimensional network is connected to a plurality of inlets and a plurality of outlets for the delivery of liquids, and overlayed with a secondary hydrogel network wherein the cellular aggregates are embedded. Herein defined vessels within the three-dimensional network are blocked, thereby defining at least one spatially segregated network within and structurally in contact with the three-dimensional network, wherein the at least one spatially segregated network is connected to a separate inlet and a separate outlet, allowing the supply of a liquid to a subregion within the three-dimensional network.
    Type: Grant
    Filed: January 30, 2019
    Date of Patent: July 9, 2024
    Assignee: KATHOLIEKE UNIVERSITEIT LEUVEN
    Inventors: Adrian Ranga, Sergii Grebeniuk
  • Patent number: 12024697
    Abstract: Disclosed herein is a single use continuous recovery, flow-through harvest vessel and corresponding method for harvesting culture medium and simultaneously either leaving the microcarrier beads behind in the vessel or flowing microcarrier beads and medium back into a bioreactor.
    Type: Grant
    Filed: September 7, 2021
    Date of Patent: July 2, 2024
    Assignee: GLOBAL LIFE SCIENCES SOLUTIONS USA LLC
    Inventors: Colin Tuohey, Thomas Erdenberger, Richard Damren, Michael Fisher, John Swibes
  • Patent number: 11999935
    Abstract: A bioreactor for use on a moving platform including a bag. According to a first aspect, the bag defines a three-dimensional geometrical shape including at least one lower collecting vertex in which at least two edges of the geometrical shape meet at an angle not greater than 90°. The bioreactor further includes at least one port or sensor arranged in the vicinity of the collecting vertex. According to a second aspect, the bag defines a two-dimensional geometrical shape or a three-dimensional geometrical shape. The geometrical shape includes at least one edge, in which at least two faces of the geometrical shape meet at an angle not greater than 90°. A longitudinal port/sensor element is arranged along the edge and includes several ports and/or sensors. A bioreactor motion system including a moving platform and a bioreactor according to the first or second aspect. A method of performing a bioprocess.
    Type: Grant
    Filed: April 24, 2020
    Date of Patent: June 4, 2024
    Assignee: SARTORIUS STEDIM BIOTECH GMBH
    Inventors: Gregory Bremer, Clint Kukla, Thorsten Adams, Fabian Tunzini, Rachel Delessert, Michael Bates
  • Patent number: 11999934
    Abstract: A microfluidic apparatus includes a microfluidic chip for MicroOrganoSpheres (MOS) generation. A first channel is defined in a surface of the microfluidic chip and includes: a droplet generation portion including an inlet portion, a junction between the inlet portion and an emulsifying fluid channel, and a chamber downstream of the junction. A cross-sectional area of the chamber is larger than that of the inlet portion. The first channel includes a polymerization portion downstream of the droplet generation portion, the polymerization portion having a serpentine configuration. The apparatus includes a cartridge for MOS demulsification, including: a collection container; a substrate disposed on the collection container, and a membrane disposed between the collection container and the surface of the substrate. A second channel is defined in the surface of the substrate that faces the collection container and is fluidically connected to an output of the polymerization portion of the first channel.
    Type: Grant
    Filed: October 11, 2023
    Date of Patent: June 4, 2024
    Assignee: Xilis, Inc.
    Inventors: Bradley Scott Thomas, Timothy A. Miller, Daniel Nelson, Raheel Samuel, George Robinson, Tyler Welder
  • Patent number: 11986787
    Abstract: A method for enhancing mixing and aeration of a liquid reaction medium in a toroidal bioreactor vessel includes dispensing a liquid reaction medium into an interior of a toroidal bioreactor vessel, the interior being bounded by an inner surface, a textured surface being arranged on at least a portion of the inner surface, the textured surface having a plurality of upstanding protuberances. The toroidal bioreactor vessel is rotated in an orbital motion such that there is a resonant frequency traveling wave of the fluid orbiting in one direction in the interior of the toroidal bioreactor vessel when a particular orbital speed is imparted to the toroidal bioreactor vessel.
    Type: Grant
    Filed: September 28, 2020
    Date of Patent: May 21, 2024
    Assignee: Finesse Solutions, Inc.
    Inventors: Mark D. Selker, Barbara Paldus
  • Patent number: 11976262
    Abstract: A biological culture unit comprises a chamber body and a valve plate. The chamber body has defined therein a growth chamber and an aliquot chamber. The valve plate is disposed on the top surface of the chamber body and is movable to define selectable configurations of the biological culture unit for: (1) loading the growth chamber; (3) transferring an aliquot from the growth chamber to the aliquot chamber via a path defined within the biological culture unit in the transfer position; and (4) extracting the aliquot from the aliquot chamber. The selectable positions may further include (2) a growth position, and (5) a termination position for putting a termination agent into the growth and aliquot chambers. The valve plate may further include a neutralizer port that is aligned with the aliquot chamber in the loading position, for loading a neutralizing agent into the aliquot chamber.
    Type: Grant
    Filed: August 26, 2020
    Date of Patent: May 7, 2024
    Assignee: BATTELLE MEMORIAL INSTITUTE
    Inventors: Charles L. Desanti, Ryan W. Daly, David Charles Seibert, Jr., Patrick Norris, John Bartholomew, Sherry K. Blight
  • Patent number: 11976260
    Abstract: The invention relates to a photobioreactor (1) for cultivating phototrophic microorganisms (such as microalgae for example), comprising a reactor element (2) which has a plurality of rising pipes (3a) and falling pipes (3b) for a liquid culture medium (4) containing the microorganisms and which has a distributing pipe (5). The upper ends (6) of each of the rising pipes (3a) and the falling pipes (3b) are connected to the distributing pipe (5) in a liquid-permeable manner. The invention is characterized in that both the culture medium (4) as well as a gas chamber (9) above the culture medium (4) for receiving gas bubbles (10) rising out of the culture medium (4) are provided in the distributing pipe (5) in the operating state, wherein a boundary surface (11) is arranged between the culture medium (4) and the gas chamber (9) in the distributing pipe (5).
    Type: Grant
    Filed: August 30, 2017
    Date of Patent: May 7, 2024
    Assignee: ECODUNA AG
    Inventors: Franz Emminger, Silvia Fluch
  • Patent number: 11965151
    Abstract: A biological sterilization indicator is disclosed that in some embodiments comprises a housing having a first enclosure and a second enclosure, an ampule containing a liquid growth medium, and an insert disposed at least partially in the first enclosure. The insert may have a platform including a top surface, an abutment surface, and a side surface, as well as a first void disposed in the platform and configured to allow passage of a first volume of the liquid growth medium into the second enclosure and a second void disposed through at least a portion of the side surface and configured to allow passage of a second volume of the liquid growth medium into the second enclosure. Methods of using the indicator are also disclosed.
    Type: Grant
    Filed: January 22, 2021
    Date of Patent: April 23, 2024
    Assignee: ASP Global Manufacturing GMBH
    Inventor: Behnam Amin
  • Patent number: 11959058
    Abstract: A cell processing system comprising an enclosure 601, an outer enclosure 701 that envelops the enclosure 601, an intake air purification filter 602 provided in the enclosure 601, that purifies gas that has been drawn in from outside the enclosure 601, a circulating apparatus, inside the outer enclosure 701, that circulates gas inside and outside the enclosure 601 in such a manner that gas in the outer enclosure 701 is drawn into the enclosure 601 through the intake air purification filter 602 and gas inside the enclosure 601 is discharged into the outer enclosure 701, and a cell processing apparatus for processing of cells, disposed inside the enclosure 601.
    Type: Grant
    Filed: July 26, 2022
    Date of Patent: April 16, 2024
    Assignee: I Peace, Inc.
    Inventors: Koji Tanabe, Ryoji Hiraide
  • Patent number: 11958052
    Abstract: The thermocycling inspection device includes a holder-accommodating space 10 for accommodating the chip holder 50 therein, a thermocycling section 20 for heating and cooling the inspection chip 60, and a detector 30 for taking a picture of the inspection chip 60, and when the thermocycling section 20 heats or cools or when a picture is taken by the detector 30, the thermocycling section 20 is disposed on one side of the holder-accommodating space 10, the detector 30 is disposed on other side of the holder-accommodating space 10, and the holder-accommodating space 10 is formed such that an optical axis of the detector 30 and a sample introducing port 62 match with each other. According to this, polymerase chain reaction can be carried out, and inspection can be carried out using the inspection chip which carries out the polymerase chain reaction.
    Type: Grant
    Filed: April 6, 2017
    Date of Patent: April 16, 2024
    Assignee: METABOSCREEN CO., LTD.
    Inventors: Ryuichi Sekizawa, Ryoko Aso, Hiroshi Mitsutake