Patents Examined by Liban M Hassan
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Patent number: 12139700Abstract: The invention relates to a A bioprocess control device having a number of control function units (12, 30) which are accommodated in a device housing (10), are designed for bioprocesses and are configured for carrying out control, conveying, measuring and/or sensor functionalities and In order to accommodate the plurality of control function units, the device housing has modular drawer assemblies (14, 32) which, relative to stationary housing frame of the device housing in an opening position and/or removal position, allow access for configuration and/or assembly to the control function unit accommodated in a relevant drawer assembly, and, in an operating and closure position which can be locked by locking means (60, 58), produce an electrically supplying as well as electronically function-identifying contact between the control function unit and the housing frame and/or electrical power supply (40) as well as system identification means (42) associated with a further drawer assembly.Type: GrantFiled: December 10, 2018Date of Patent: November 12, 2024Assignee: EPPENDORF SEInventors: Wolfgang Recker, Guido Ertel, Falk Schneider, Tristan Hufen
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Patent number: 12128410Abstract: A microfluidic apparatus includes a microfluidic chip for MicroOrganoSpheres (MOS) generation. A first channel is defined in a surface of the microfluidic chip and includes: a droplet generation portion including an inlet portion, a junction between the inlet portion and an emulsifying fluid channel, and a chamber downstream of the junction. A cross-sectional area of the chamber is larger than that of the inlet portion. The first channel includes a polymerization portion downstream of the droplet generation portion, the polymerization portion having a serpentine configuration. The apparatus includes a cartridge for MOS demulsification, including: a collection container; a substrate disposed on the collection container, and a membrane disposed between the collection container and the surface of the substrate. A second channel is defined in the surface of the substrate that faces the collection container and is fluidically connected to an output of the polymerization portion of the first channel.Type: GrantFiled: May 30, 2024Date of Patent: October 29, 2024Assignee: Xilis, Inc.Inventors: Bradley Scott Thomas, Timothy A. Miller, Daniel Nelson, Raheel Samuel, George Robinson, Tyler Welder
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Patent number: 12098360Abstract: This invention relates to a system for obtaining a biomass measurement from a medium contained within a bioreactor. The system comprises a bioreactor having a port comprising an annular flange (15) and an upstanding collar (19), and a biomass sensing probe comprising an elongate body and at least one electrode (3) provided on a first region (1) of the body. The port is configured to receive the probe and form a watertight seal with the probe when it is located in the port with the first region (1) of the body exposed to the interior of the bioreactor.Type: GrantFiled: December 13, 2018Date of Patent: September 24, 2024Assignee: ABER INSTRUMENTS LIMITEDInventors: Steffan Jones, Peter Twiddy, Tim Pryce
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Patent number: 12084641Abstract: A cell/tissue culture system comprising at least one bioreactor configured to hold at least one type of cell to cultivate tissue, a dialysis unit comprising a dialysis membrane, a fresh medium unit, and a waste removal unit configured to remove metabolic waste from dialysate, wherein the metabolic waste comprises ammonia and lactate, and wherein the waste removal unit comprises biocatalysts or enzymes configured to breakdown lactate and generate carbon sources that promote cell growth.Type: GrantFiled: August 5, 2021Date of Patent: September 10, 2024Assignee: AVANT MEATS COMPANY LIMITEDInventors: Po San Mario Chin, Kai Yi Carrie Chan, Chuen Wai Li, Tim Spitters
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Patent number: 12084640Abstract: A submersible device submersible within an algae slurry contained within a pond of an algae bioreactor, the submersible device including a drive motor operable to actuate one or more driven devices that move the submersible device within the pond, a circulation device operable to circulate the algae slurry through the submersible device and discharge the algae slurry back into the pond from a discharge port provided on the submersible device, and a computer system that controls operation of the drive motor and the circulation device.Type: GrantFiled: October 28, 2020Date of Patent: September 10, 2024Assignee: ExxonMobil Technology and Engineering CompanyInventors: Anjaneya S Kovvali, Everett J O'Neal, Patrick L Hanks, Mark A Deimund, Vinit Choudhary, Yesim Igci, Louis R Brown
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Patent number: 12077736Abstract: An improved system of generating renewable energy is comprised of a specific configuration of mechanisms, materials, and processes that all function together as a single symbiotic system. In accordance with a preferred embodiment, the system cultivates aquatic biomass, then extracts triglycerides from said biomass. The extracted triglycerides are converted into biodiesel through transesterification. During the operation of the system, a continuous output of biofuel, thermal energy, steam, and electricity, is efficiently produced. These yields are precisely measured and repurposed as energy input at various points throughout system processes, thus resulting in a surplus output. Any embodiment of the disclosed system will generate a continuously renewable final product of biofuel and power.Type: GrantFiled: April 12, 2015Date of Patent: September 3, 2024Inventor: Dennis Steele
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Patent number: 12077804Abstract: A microbial detection device and methods of use are provided. The device comprises a water-proof pouch that includes a first wall portion, a second wall portion, and a porous membrane filter disposed in the pouch between the first and second wall portions. The filter membrane divides the pouch into first and second compartments. A dry, cold water-soluble gelling agent is adhered to the pouch in the first compartment and an absorbent pad is disposed in the second compartment. A sealable sample port provides access to deposit a liquid into the first compartment.Type: GrantFiled: July 18, 2016Date of Patent: September 3, 2024Inventors: Evan D. Brutinel, Alexi J. Young, Delton R. Thompson, Jr.
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Patent number: 12065633Abstract: A biological cell preservation or culturing arrangement (20) comprises a chamber defining a fluid retaining space (30) for retaining in use a body of fluid (34) and a deformable membrane (36) in communication with the fluid retaining space, and being manipulable by an electroactive polymer actuator arrangement (38) to undergo a defined topology change to induce in the fluid a pattern of fluid flow by which fluid is exchanged between a sub-region (46) immediately proximal the deformable membrane and a sub-region (48) removed from the deformable membrane.Type: GrantFiled: October 17, 2018Date of Patent: August 20, 2024Assignee: Koninklijke Philips N.V.Inventors: Eduard Gerard Marie Pelssers, Cornelis Petrus Hendriks, Reinhold Wimberger-Friedl, Mark Thomas Johnson, Achim Hilgers
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Patent number: 12064771Abstract: The disclosure provides a device and method for rapidly changing temperatures of a sample. An example of the device include: a first plate; a second plate; and a heating/cooling layer disposed on either the first or second plate. The first plate and the second plate face each other and are configured to receive a fluid sample sandwiched therebetween. The method includes depositing the fluid sample on one or both of the two plates, pressing the plates to form a thin layer of the sample, and changing and/or maintaining the temperature of the sample. The device or method can be used in, for example, PCR.Type: GrantFiled: May 23, 2018Date of Patent: August 20, 2024Assignee: Essenlix CorporationInventors: Stephen Y. Chou, Wei Ding, Hua Tan
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Patent number: 12043824Abstract: A modular incubator comprising a housing structure divided into cells and having several incubator modules, each of which can be housed, in a removable manner, in a relative cell and is provided with an incubation chamber to incubate microbiological or cellular cultures. Each cell has a first group of connectors and each incubator module has a second group of connectors, each of which can be coupled to a corresponding connector of the first group of connectors of the relative cell when the incubator module is housed in said cell. The first group of connectors has at least one pneumatic connector communicating with at least one source of aeriform substance, and the second group of connectors has a corresponding pneumatic connector communicating with the relative incubation chamber to allow the aeriform substance to be introduced into the incubation chamber.Type: GrantFiled: November 23, 2020Date of Patent: July 23, 2024Inventors: Massimiliano Cesarini, Filippo Galassi, Alessia Zanelli
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Patent number: 12031115Abstract: The invention relates to devices for the culture of cellular aggregates A comprising a three-dimensional network of interconnected vessels of a biocompatible liquid- and gas-permeable photo polymerised material, wherein the three-dimensional network is connected to a plurality of inlets and a plurality of outlets for the delivery of liquids, and overlayed with a secondary hydrogel network wherein the cellular aggregates are embedded. Herein defined vessels within the three-dimensional network are blocked, thereby defining at least one spatially segregated network within and structurally in contact with the three-dimensional network, wherein the at least one spatially segregated network is connected to a separate inlet and a separate outlet, allowing the supply of a liquid to a subregion within the three-dimensional network.Type: GrantFiled: January 30, 2019Date of Patent: July 9, 2024Assignee: KATHOLIEKE UNIVERSITEIT LEUVENInventors: Adrian Ranga, Sergii Grebeniuk
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Patent number: 12024697Abstract: Disclosed herein is a single use continuous recovery, flow-through harvest vessel and corresponding method for harvesting culture medium and simultaneously either leaving the microcarrier beads behind in the vessel or flowing microcarrier beads and medium back into a bioreactor.Type: GrantFiled: September 7, 2021Date of Patent: July 2, 2024Assignee: GLOBAL LIFE SCIENCES SOLUTIONS USA LLCInventors: Colin Tuohey, Thomas Erdenberger, Richard Damren, Michael Fisher, John Swibes
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Patent number: 11999935Abstract: A bioreactor for use on a moving platform including a bag. According to a first aspect, the bag defines a three-dimensional geometrical shape including at least one lower collecting vertex in which at least two edges of the geometrical shape meet at an angle not greater than 90°. The bioreactor further includes at least one port or sensor arranged in the vicinity of the collecting vertex. According to a second aspect, the bag defines a two-dimensional geometrical shape or a three-dimensional geometrical shape. The geometrical shape includes at least one edge, in which at least two faces of the geometrical shape meet at an angle not greater than 90°. A longitudinal port/sensor element is arranged along the edge and includes several ports and/or sensors. A bioreactor motion system including a moving platform and a bioreactor according to the first or second aspect. A method of performing a bioprocess.Type: GrantFiled: April 24, 2020Date of Patent: June 4, 2024Assignee: SARTORIUS STEDIM BIOTECH GMBHInventors: Gregory Bremer, Clint Kukla, Thorsten Adams, Fabian Tunzini, Rachel Delessert, Michael Bates
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Patent number: 11999934Abstract: A microfluidic apparatus includes a microfluidic chip for MicroOrganoSpheres (MOS) generation. A first channel is defined in a surface of the microfluidic chip and includes: a droplet generation portion including an inlet portion, a junction between the inlet portion and an emulsifying fluid channel, and a chamber downstream of the junction. A cross-sectional area of the chamber is larger than that of the inlet portion. The first channel includes a polymerization portion downstream of the droplet generation portion, the polymerization portion having a serpentine configuration. The apparatus includes a cartridge for MOS demulsification, including: a collection container; a substrate disposed on the collection container, and a membrane disposed between the collection container and the surface of the substrate. A second channel is defined in the surface of the substrate that faces the collection container and is fluidically connected to an output of the polymerization portion of the first channel.Type: GrantFiled: October 11, 2023Date of Patent: June 4, 2024Assignee: Xilis, Inc.Inventors: Bradley Scott Thomas, Timothy A. Miller, Daniel Nelson, Raheel Samuel, George Robinson, Tyler Welder
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Patent number: 11986787Abstract: A method for enhancing mixing and aeration of a liquid reaction medium in a toroidal bioreactor vessel includes dispensing a liquid reaction medium into an interior of a toroidal bioreactor vessel, the interior being bounded by an inner surface, a textured surface being arranged on at least a portion of the inner surface, the textured surface having a plurality of upstanding protuberances. The toroidal bioreactor vessel is rotated in an orbital motion such that there is a resonant frequency traveling wave of the fluid orbiting in one direction in the interior of the toroidal bioreactor vessel when a particular orbital speed is imparted to the toroidal bioreactor vessel.Type: GrantFiled: September 28, 2020Date of Patent: May 21, 2024Assignee: Finesse Solutions, Inc.Inventors: Mark D. Selker, Barbara Paldus
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Patent number: 11976262Abstract: A biological culture unit comprises a chamber body and a valve plate. The chamber body has defined therein a growth chamber and an aliquot chamber. The valve plate is disposed on the top surface of the chamber body and is movable to define selectable configurations of the biological culture unit for: (1) loading the growth chamber; (3) transferring an aliquot from the growth chamber to the aliquot chamber via a path defined within the biological culture unit in the transfer position; and (4) extracting the aliquot from the aliquot chamber. The selectable positions may further include (2) a growth position, and (5) a termination position for putting a termination agent into the growth and aliquot chambers. The valve plate may further include a neutralizer port that is aligned with the aliquot chamber in the loading position, for loading a neutralizing agent into the aliquot chamber.Type: GrantFiled: August 26, 2020Date of Patent: May 7, 2024Assignee: BATTELLE MEMORIAL INSTITUTEInventors: Charles L. Desanti, Ryan W. Daly, David Charles Seibert, Jr., Patrick Norris, John Bartholomew, Sherry K. Blight
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Patent number: 11976260Abstract: The invention relates to a photobioreactor (1) for cultivating phototrophic microorganisms (such as microalgae for example), comprising a reactor element (2) which has a plurality of rising pipes (3a) and falling pipes (3b) for a liquid culture medium (4) containing the microorganisms and which has a distributing pipe (5). The upper ends (6) of each of the rising pipes (3a) and the falling pipes (3b) are connected to the distributing pipe (5) in a liquid-permeable manner. The invention is characterized in that both the culture medium (4) as well as a gas chamber (9) above the culture medium (4) for receiving gas bubbles (10) rising out of the culture medium (4) are provided in the distributing pipe (5) in the operating state, wherein a boundary surface (11) is arranged between the culture medium (4) and the gas chamber (9) in the distributing pipe (5).Type: GrantFiled: August 30, 2017Date of Patent: May 7, 2024Assignee: ECODUNA AGInventors: Franz Emminger, Silvia Fluch
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Patent number: 11965151Abstract: A biological sterilization indicator is disclosed that in some embodiments comprises a housing having a first enclosure and a second enclosure, an ampule containing a liquid growth medium, and an insert disposed at least partially in the first enclosure. The insert may have a platform including a top surface, an abutment surface, and a side surface, as well as a first void disposed in the platform and configured to allow passage of a first volume of the liquid growth medium into the second enclosure and a second void disposed through at least a portion of the side surface and configured to allow passage of a second volume of the liquid growth medium into the second enclosure. Methods of using the indicator are also disclosed.Type: GrantFiled: January 22, 2021Date of Patent: April 23, 2024Assignee: ASP Global Manufacturing GMBHInventor: Behnam Amin
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Patent number: 11959058Abstract: A cell processing system comprising an enclosure 601, an outer enclosure 701 that envelops the enclosure 601, an intake air purification filter 602 provided in the enclosure 601, that purifies gas that has been drawn in from outside the enclosure 601, a circulating apparatus, inside the outer enclosure 701, that circulates gas inside and outside the enclosure 601 in such a manner that gas in the outer enclosure 701 is drawn into the enclosure 601 through the intake air purification filter 602 and gas inside the enclosure 601 is discharged into the outer enclosure 701, and a cell processing apparatus for processing of cells, disposed inside the enclosure 601.Type: GrantFiled: July 26, 2022Date of Patent: April 16, 2024Assignee: I Peace, Inc.Inventors: Koji Tanabe, Ryoji Hiraide
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Patent number: 11958052Abstract: The thermocycling inspection device includes a holder-accommodating space 10 for accommodating the chip holder 50 therein, a thermocycling section 20 for heating and cooling the inspection chip 60, and a detector 30 for taking a picture of the inspection chip 60, and when the thermocycling section 20 heats or cools or when a picture is taken by the detector 30, the thermocycling section 20 is disposed on one side of the holder-accommodating space 10, the detector 30 is disposed on other side of the holder-accommodating space 10, and the holder-accommodating space 10 is formed such that an optical axis of the detector 30 and a sample introducing port 62 match with each other. According to this, polymerase chain reaction can be carried out, and inspection can be carried out using the inspection chip which carries out the polymerase chain reaction.Type: GrantFiled: April 6, 2017Date of Patent: April 16, 2024Assignee: METABOSCREEN CO., LTD.Inventors: Ryuichi Sekizawa, Ryoko Aso, Hiroshi Mitsutake