Patents Examined by Lisa J. Hobbs
  • Factor VIII polymer conjugates
    Patent number: 8003760
    Abstract: The invention is a proteinaceous construct comprising a Factor VIII molecule which is conjugated to a water-soluble polymer via carbohydrate moieties of Factor VIII, and methods of preparing same.
    Type: Grant
    Filed: January 8, 2010
    Date of Patent: August 23, 2011
    Assignees: Baxter International Inc., Baxter Healthcare S.A.
    Inventors: Peter Turecek, Juergen Siekmann
  • Factor VIII polymer conjugates
    Patent number: 7985839
    Abstract: The invention is a proteinaceous construct comprising a Factor VIII molecule which is conjugated to a water-soluble polymer via carbohydrate moieties of Factor VIII, and methods of preparing same.
    Type: Grant
    Filed: January 8, 2010
    Date of Patent: July 26, 2011
    Assignees: Baxter International Inc., Baxter Healthcare S.A.
    Inventors: Peter Turecek, Juergen Siekmann
  • Factor VIII polymer conjugates
    Patent number: 7985838
    Abstract: The invention is a proteinaceous construct comprising a Factor VIII molecule which is conjugated to a water-soluble polymer via carbohydrate moieties of Factor VIII, and methods of preparing same.
    Type: Grant
    Filed: January 8, 2010
    Date of Patent: July 26, 2011
    Assignees: Baxter International Inc., Baxter Healthcare S.A.
    Inventors: Peter Turecek, Juergen Siekmann
  • Factor VIII polymer conjugates
    Patent number: 7982010
    Abstract: The invention is a proteinaceous construct comprising a Factor VIII molecule which is conjugated to a water-soluble polymer via carbohydrate moieties of Factor VIII, and methods of preparing same.
    Type: Grant
    Filed: January 8, 2010
    Date of Patent: July 19, 2011
    Assignees: Baxter International Inc., Baxter Healthcare S.A.
    Inventors: Peter Turecek, Juergen Siekmann
  • Processes for producing cellooligosaccharide
    Patent number: 7947656
    Abstract: A process of producing cellooligosaccharide, comprising enzymatically decomposing, in the presence of cellulase, a water-insoluble natural cellulosic material having an average degree of polymerization not greater than 700, an average particle size not greater than 100. A process of producing cellooligosaccharide, comprising enzymatically decomposing, in the presence of cellulase, a water-insoluble natural cellulosic material having an average degree of polymerization not greater than 700, containing 10% or more by mass of a colloidal cellulose component and a diethyl ether-soluble substance content less than 1% by mass.
    Type: Grant
    Filed: July 26, 2005
    Date of Patent: May 24, 2011
    Assignee: Asahi Kasei Chemicals Corporation
    Inventors: Naoaki Yamasaki, Ichiro Ibuki, Koji Isaka
  • Biological-based catalyst to delay plant development processes
    Patent number: 7943549
    Abstract: The present invention is directed to methods for delaying a plant development process comprising exposing a plant or plant part to one or more bacteria or enzymes. In specific embodiments, the one or more bacteria are selected from the group consisting of Rhodococcus spp., Pseudomonas chloroaphis, Brevibacterium ketoglutamicum, and a mixture comprising any combination of these bacteria. Apparatuses for delaying a plant development process comprising a catalyst that comprises one or more of the above bacteria.
    Type: Grant
    Filed: April 2, 2007
    Date of Patent: May 17, 2011
    Assignee: Georgia State University Research Foundation, Inc.
    Inventors: George E. Pierce, Sangeeta Ganguly, Gene K. Drago
  • Methods for the detection of microbial contaminants
    Patent number: 7939291
    Abstract: The invention provides methods and compositions for the detection and/or quantification of a microbial contaminant, for example, a bacterial endotoxin or a glucan, in a sample. In particular, the invention provides a test cartridge useful in the practice of hemocyte lysate-based assays for the detection and/or quantification of a microbial contaminant in a sample. In addition, the invention provides methods of making and using such cartridges. In addition, the invention provides a rapid, sensitive, multi-step kinetic hemocyte lysate-based assay for the detection and/or quantification of a microbial contaminant in a sample. In addition, the invention provides a glucan-specific lysate that can be used in a variety of assay formats, including, for example, a test cartridge, optionally configured to perform a kinetic assay.
    Type: Grant
    Filed: August 1, 2007
    Date of Patent: May 10, 2011
    Assignee: Charles River Laboratories, Inc.
    Inventors: Norman R. Wainwright, Foster T. Jordan
  • Methods and compositions for rapidly detecting and quantifying viable
    Patent number: 7939314
    Abstract: Methods and compositions detect and quantify viable Legionella. Dip-slides that include an absorbent medium, growth promoting, and growth selective substances are useful in rapid detection and quantification of microcolonies of Legionella. Most probable number method of detection and quantification of Legionella are disclosed.
    Type: Grant
    Filed: November 25, 2008
    Date of Patent: May 10, 2011
    Assignee: Phigenics, LLC
    Inventor: William F. McCoy
  • Methods and compositions for rapidly detecting and quantifying viable
    Patent number: 7935521
    Abstract: Methods and compositions detect and quantify viable Legionella. Dip-slides that include an absorbent medium, growth promoting, and growth selective substances are useful in rapid detection and quantification of microcolonies of Legionella. Most probable number method of detection and quantification of Legionella are disclosed.
    Type: Grant
    Filed: March 15, 2006
    Date of Patent: May 3, 2011
    Assignee: Phigenics, LLC
    Inventor: William F. McCoy
  • Process for producing lactoperoxidase
    Patent number: 7932069
    Abstract: A process for producing lactoperoxidase, including: a step (1) for bringing one or more milk materials into contact with a cation exchanger having weakly acidic groups as ion exchange groups to thereby effect adsorption treatment; a step (2) for washing the cation exchanger after the adsorption treatment; a step (3) for bringing the cation exchanger after the washing into contact with a leaching solvent to thereby obtain a leaching solution having lactoperoxidase eluted into the leaching solvent; a step (4) for concentrating the leaching solution through an ultrafiltration membrane to thereby effect precipitation in the concentrated leaching solution; and a step (5) for obtaining a lactoperoxidase solution by removing the precipitation from the concentrated leaching solution.
    Type: Grant
    Filed: February 8, 2005
    Date of Patent: April 26, 2011
    Assignee: Morinaga Milk Industry Co., Ltd.
    Inventors: Nobuo Ichihashi, Koji Yamauchi, Kouichirou Shin, Tetsuya Ando
  • Production of glucuronic acid using myo-inositol oxygenase from cryptococcus neoformans
    Patent number: 7923231
    Abstract: A method is disclosed for increasing the specific activity of myo-inositol oxygenase. The method includes incubating a mixture including myo-inositol oxygenase and a non-sulfur containing reductant under conditions effective to increase the specific activity of the myo-inositol oxygenase. Also disclosed are methods for producing D-glucuronic acid and glucurono-?-lactone comprising incubating a mixture including myo-inositol, myo-inositol oxygenase, and oxygen under conditions effective to form 5 grams D-glucuronic acid per liter of the mixture to 400 grams D-glucuronic acid per liter of the mixture. Glucurono-?-lactone can be produced from the D-glucuronic acid product. Also disclosed are organisms and nucleic acids suitable for use in such methods.
    Type: Grant
    Filed: December 17, 2004
    Date of Patent: April 12, 2011
    Assignee: Cargill, Incorporated
    Inventors: Brian Brazeau, Jean-Claude De Troostembergh, Paula M. Hicks, Holly Jessen, Sara C. McFarlan, Willy Obyn, Fernando A. Sanchez-Riera, William A. Schroeder
  • Method of recovering lipase activity
    Patent number: 7923224
    Abstract: The present invention discloses a method of recovering lipase activity which comprises the steps of using a lipase derived from Thermomyces sp. and immobilized on a carrier, or a lipase powder composition which comprises a filter aid and the lipase derived from Thermomyces sp. and immobilized on a carrier which is crushed into the average particle size of 1 ?m or larger and smaller than 300 ?m in an esterification or transesterification reaction; and washing said lipase or lipase powder composition with triacylglycerol. According to this method, the decreased lipase activity can be effectively recovered.
    Type: Grant
    Filed: November 7, 2008
    Date of Patent: April 12, 2011
    Assignee: The Nisshin OilliO Group, Ltd.
    Inventors: Satoshi Negishi, Junko Suzuki, Yoshie Yamauchi
  • Method for obtaining mesenchymal stem cells
    Patent number: 7915039
    Abstract: The invention relates to the field of cell biology. In detail it relates to the obtainment of mesenchymal stem cells from human tissue. This invention might be applicable in healing within the frame of the treatment of several diseases. Due to the invention it will be possible to obtain mesenchymal stem cells from human tissue with high homogeneity of the cell suspension, since the used method for obtaining mesenchymal stem cells from human tissue comprises the crushing and enzymatical treatment of the tissue with collagenase solution in Eagle medium in the Dulbecco modification, removal of erythrocytes by the aid of the lysis solution and subsequent filtration of the prepared suspension; as human tissue fat tissue or decidual or amniotic placenta membrane or chorion placenta stroma is used, whereas the filtration is performed sequentially by the use of filters comprising a pore size of 100 ?m and 10 ?m.
    Type: Grant
    Filed: January 4, 2008
    Date of Patent: March 29, 2011
    Inventor: Alexander S. Teplyashin
  • Methods and compositions for rapidly detecting and quantifying viable
    Patent number: 7901932
    Abstract: Methods and compositions detect and quantify viable Legionella and other heterotrophic aerobic bacteria. Dip-slides that include an absorbent medium, growth promoting, and growth selective substances are useful in rapid detection and quantification of microcolonies of Legionella. Most probable number method of detection and quantification of Legionella are disclosed.
    Type: Grant
    Filed: March 15, 2007
    Date of Patent: March 8, 2011
    Assignee: Phigenics, LLC
    Inventor: William F. McCoy
  • Activation of mutated RAC-PK
    Patent number: 7897371
    Abstract: The invention concerns RAC-PK and fragments thereof, as well as activators and inhibitors of RAC-PK for use as medicaments, particularly in the treatment of diseases concerned with abnormalities in processes modulated by insulin, such as cellular proliferation, insulin deficiency and/or excess blood sugar levels. Moreover, the invention provides RAC-PK for use in screening potential mimics or modulators thereof. A method for screening for agents capable of affecting the activity of GSK3 is also disclosed. The invention further provides a screening kit comprising the RAC-PK as an active principle, and a method for screening compounds which are candidate mimics or modulators of RAC-PK activity comprising detecting specific interactions between the candidate compounds and RAC-PK. There is also provided a process for activating RAC-PK comprising treatment thereof with a phosphatase inhibitor.
    Type: Grant
    Filed: March 5, 2007
    Date of Patent: March 1, 2011
    Assignee: Novartis AG
    Inventors: Dario Alessi, Mirjana Andjelkovic, Philip Cohen, Peter David Cron, Darren Cross, Brian A. Hemmings
  • Storage-stable glucose oxidase
    Patent number: 7892536
    Abstract: The present invention provides methods and compositions comprising at least one glucose oxidase enzyme, wherein the glucose oxidase has improved storage stability. In some preferred embodiments, the glucose oxidase enzyme is stable after exposure to elevated temperatures. In some alternative preferred embodiments, the glucose oxidase has improved storage stability in liquid formulations. In some particularly preferred embodiments, the present invention provides methods and compositions comprising glucose oxidase(s) obtained from Aspergillus sp. In some more particularly preferred embodiments, the glucose oxidase is obtained from A. niger. The present invention finds use in applications involving cleaning, including personal care applications.
    Type: Grant
    Filed: December 18, 2007
    Date of Patent: February 22, 2011
    Assignee: Daniso US Inc.
    Inventors: Bradley R. Kelemen, Suzanne E. Lantz
  • N?-acyl-L-lysine-specific aminoacylase
    Patent number: 7888079
    Abstract: The present invention provides an aminoacylase having superior abilities in specifically acylating and hydrolyzing e-amino group of Lys, and a method of producing N?-acyl-L-lysine. The present invention provides N?-acyl-L-lysine-specific aminoacylase containing the amino acid sequence of SERPXTTLLRNGDVH (X unknown) at the N-terminal, and a method of producing N?-acyl-L-lysine comprising acting the aminoacylase on L-Lys and a carboxylic acid.
    Type: Grant
    Filed: August 21, 2007
    Date of Patent: February 15, 2011
    Assignees: Ajinomoto Co., Inc., National University Corporation Okayama University
    Inventors: Kazuhiro Nakanishi, Koreyoshi Imamura, Hiroyuki Imanaka, Mayuko Koreishi, Noriki Nio
  • System and methods for measuring a skin protection factor
    Patent number: 7888001
    Abstract: The present invention is a system and methods of establishing a Melanocyte Protection Factor (MPF), which indicates the level of protection against DNA damage to a target cell, such as the level of protection a particular sunscreen offers against UVA rays when compared to the unprotected case, i.e., no sunscreen. The present invention determines and records levels of stable melanin radicals (SMR) in a target cell. Light is applied to the target cell forming light-induced melanin radicals (LIR). The levels of SMR and intensity of LIR are measured to determine the amount of incident light reaching the target cell.
    Type: Grant
    Filed: July 10, 2007
    Date of Patent: February 15, 2011
    Assignee: STC.UNM
    Inventor: Graham S. Timmins
  • Method of stabilising or reactivating a creatinine sensor with a divalent manganese ion
    Patent number: 7888061
    Abstract: A method is provided for stabilizing a creatinine sensor comprising creatininase as a bioactive molecule. The creatininase is stabilised by exposing it to a sufficient amount of a divalent manganese ion. This result may be obtained by exposing the sensor to a solution comprising the divalent manganese ion or by introducing a composition within the sensor providing sustained release of the divalent manganese ion.
    Type: Grant
    Filed: May 16, 2006
    Date of Patent: February 15, 2011
    Assignee: Radiometer Medical ApS
    Inventors: Thomas Kjaer, Jens Østergaard, Tina Kristensen
  • Polymer-factor VIII-von Willebrand factor-conjugates
    Patent number: 7884075
    Abstract: The present invention relates to a proteinaceous construct (also designated as polymer-VWF-conjugate) comprising plasmatic and/or recombinant von Willebrand factor (VWF), said VWF being bound to at least one physiologically acceptable polymer molecule, as well as to a complex between said proteinaceous construct and at least one factor VIII (FVIII) protein. The physiologically acceptable polymer molecule can be, for instance, polyethylene glycol (PEG) or polysialic acid (PSA). Further the present invention relates to methods for prolonging the in vivo-half-life of VWF or FVIII in the blood of a mammal having a bleeding disorder associated with functional defects of or deficiencies of at least one of FVIII or VWF.
    Type: Grant
    Filed: December 23, 2005
    Date of Patent: February 8, 2011
    Assignees: Baxter International Inc., Baxter Healthcare S.A.
    Inventors: Friedrich Scheiflinger, Peter Turecek, Juergen Siekmann