Patents Examined by Lore R Jarrett
  • Patent number: 11642672
    Abstract: Microfluidic network device (2) configured to supply reagents to a biological tissue sampling device (1), comprising a plurality of microfluidic inlet channels (12) connected to respective sources of said reagents, at least one common outlet channel (22), and a plurality of valves (36) interconnecting an outlet end (14) of each of said plurality of inlet channels to said at least one common outlet channel.
    Type: Grant
    Filed: March 21, 2017
    Date of Patent: May 9, 2023
    Inventors: Diego Gabriel Dupouy, Ata Tuna Ciftlik, Martin Gijs, Pierre Joris
  • Patent number: 11639908
    Abstract: A cartridge assembly, and method of using the same, is provided. The assembly includes a sample processing card and a substrate attached thereto. The card has an injection port for receiving a test sample; at least one metering chamber; a mixing material source for introducing mixing material(s) to the metering chamber; fluid communication channels fluidly connecting the injection port and the mixing material source to the metering chamber; and at least one output port for delivering the test sample to a sensor (e.g., GMR sensor). The substrate has associated therewith: the sensor for sensing analytes in the test sample; electrical contact portions for an electrical connection with a reader unit; and a memory chip. The assembly further includes a pneumatic interface with port(s) and corresponding communication channel(s) fluidly connected to card.
    Type: Grant
    Filed: July 26, 2019
    Date of Patent: May 2, 2023
    Inventors: Todd Michael Klein, Keping Song, Minggan Li, Chad Brian Rheault, Wei Wang, Gemma Roselle Mendonsa
  • Patent number: 11630054
    Abstract: The present application concerns in-situ intrusive probe systems and methods. The probe systems described herein can be installed flush to a hydrocarbon containing structure, such as a pipeline, vessel, or other piping system carrying crude, gas or sour products. The probe systems include hydrogen induced cracking (HIC)-resistant microstructure such that as atomic hydrogen permeates the probe surface, the probe captures recombined hydrogen gas. The pressure of the resultant hydrogen gas buildup is measured and predictions as to the HIC activity of that area can be made.
    Type: Grant
    Filed: December 1, 2020
    Date of Patent: April 18, 2023
    Inventors: Abdelmounam Sherik, Abderrazak Traidia
  • Patent number: 11612888
    Abstract: The disclosure is directed to a device that includes an upper container configured to receive a fluid sample collected from a mammal into a first opening, the first opening opposite a second opening and a membrane covering at least a portion of the second opening, the membrane configured to allow transmission of a portion of the fluid sample through the membrane.
    Type: Grant
    Filed: January 3, 2018
    Date of Patent: March 28, 2023
    Assignee: The Research Foundation for The State University of New York
    Inventors: Srinivas Pentyala, Sahana Pentyala
  • Patent number: 11608440
    Abstract: Novel reaction media for electron donating and electron accepting components in colour-change compositions are described. The compound is of formula (VI); R1, and R2 are independently selected from an optionally substituted linear or branched alkyl group, alkenyl group, alkoxy group, aryl group and an alkylene aryl group having from 5 to 22 carbon atoms; X1 and X2 are independently selected from —OC(O)—, —CO2— and O; Y1, and Y2 are independently selected from hydrogen, halogen, R1, —OR1; y is independently 0 or 1; and suitably the groups R1X1— and —X2R2 are independently in the ortho or meta position. The compounds are useful in ink compositions, writing implements containing the compound and medical and industrial applications in which temperature sensitive colour change may be required.
    Type: Grant
    Filed: September 5, 2016
    Date of Patent: March 21, 2023
    Assignee: Thermographic Measurements Ltd
    Inventors: Bagavant Shivkumar, Philippe Marrec
  • Patent number: 11585798
    Abstract: The invention is directed towards dielectric materials, BaTiO3, BaZrO3, and/or BaTi1-xZrxO3, such that 0?x?1, for detecting, sensing, filtering, reacting, or absorbing toxic chemicals, such as chemical warfare agents (“CWAs”) and their structural analogs, toxic industrial chemicals and narcotics, wherein the dielectric material is incorporated into a sensor for detecting, sensing, filtering, reacting, or absorbing the toxic chemicals.
    Type: Grant
    Filed: February 7, 2019
    Date of Patent: February 21, 2023
    Assignee: The United States of America as Represented by the Secretary of the Army
    Inventor: Jennifer R Soliz
  • Patent number: 11571697
    Abstract: The present disclosure relates to a sampling and sensing device and a method of using the sampling and sensing device for collecting and sensing chemical or biological analytes. The sampling and sensing device comprises a handle and a foldable head having a sampling region and a sensing region. A sensor chip may be disposed in the sensing region and a sampling wipe may be disposed in the sensing region. The sampling region is configured to collect an analyte. After the analyte is collected on the sampling region, the sampling and sensing device can be folded to make the sampling region in contact with or face the sensing region to transfer the analyte to the sensing region for analysis.
    Type: Grant
    Filed: November 7, 2019
    Date of Patent: February 7, 2023
    Inventors: Bo Xiao, Xiaoyue Du
  • Patent number: 11567023
    Abstract: A molecular detection apparatus of an embodiment includes: a first detector which includes a first sensor containing a MOF having a fluorescence emitting property, a light source which irradiates the MOF with light, and a light receiver which receives fluorescence from the MOF; a second detector which includes a sensor layer electrodes electrically connected with the sensor layer; and a type discrimination and concentration calculation part which discriminates a type of the molecules to be detected based on a measurement result measured by the first detector, and calculates a concentration of the molecules a measurement result measured by the second detector based on a discrimination result of a type of the molecules.
    Type: Grant
    Filed: September 14, 2018
    Date of Patent: January 31, 2023
    Inventors: Hirohisa Miyamoto, Yasushi Shinjo, Ko Yamada, Mitsuhiro Oki
  • Patent number: 11559770
    Abstract: A fluid processing system may include a flow control cassette comprising at least one interface sensor chamber in fluid communication with at least one of a plurality of separate channels, the at least one interface sensor chamber defined at least in part by a wall, and at least one capacitive sensor disposed on the wall of the at least one interface sensor chamber. The fluid processing system may include, in the alternative or in addition, at least one syringe comprising a wall defining a barrel having a first end and a second end, the barrel having a bore with or without a piston or plunger disposed therein, and at least one capacitive sensor disposed on an outer surface of the wall of the syringe.
    Type: Grant
    Filed: October 20, 2020
    Date of Patent: January 24, 2023
    Assignee: Fenwal, Inc.
    Inventor: Christopher J. Wegener
  • Patent number: 11559974
    Abstract: A method of manufacturing a microfluidic system or microfluidic device having at least one channel includes providing a base sheet, providing a deformable intermediate layer, providing a cover film, and laminating the base sheet, the intermediate layer and the cover film so that a back surface of the intermediate layer is attached to a front surface of the base sheet and a back surface of the cover film is attached to a front surface of the intermediate layer opposite to the back surface thereof, thereby forming a laminate comprising the base sheet, the intermediate layer and the cover film. Further, the method includes applying pressure to the front surface of the intermediate layer through the cover film so as to deform the intermediate layer, thereby forming the at least one channel. The invention also relates to a microfluidic system or microfluidic device) manufactured by this method.
    Type: Grant
    Filed: September 13, 2018
    Date of Patent: January 24, 2023
    Inventors: Karl Heinz Priewasser, Devin Martin
  • Patent number: 11529629
    Abstract: The present invention relates to a biosensor, including: a blood cell separation membrane which separates blood cells from blood and allows plasma components to pass through; a microfluid channel through which the plasma components that have passed through the blood cell separation membrane flow; a lower substrate which allows the plasma components that have passed through the blood cell separation membrane to flow along the microfluid channel; and a pillar which connects the blood cell separation membrane and the lower substrate, in which an electrode is disposed in the pillar, and the pillar pushes and lifts the blood cell separation membrane by a predetermined distance. The biosensor of the present invention allows plasma, which is difficult to pass through the blood cell separation membrane due to surface tension, to easily pass through.
    Type: Grant
    Filed: May 12, 2020
    Date of Patent: December 20, 2022
    Assignee: BBB INC.
    Inventors: Hyundoo Hwang, Dongsik Han, Jaekyu Choi
  • Patent number: 11524292
    Abstract: Embodiments of the invention provide a microfluidic chip having microfluidic structures formed on a surface. The structures form an input channel, an output channel, auxiliary channels, and a hydraulic resistor structure connecting the input channel to the output channel via the auxiliary channels. The resistor structure includes N flow resistor portions (N?2), which are connected to the auxiliary channels. The chip further includes at least N?1 actuatable valves, which are arranged in respective ones of the auxiliary channels. The actuation state of the valves can determine the effective hydraulic resistance of the resistor structure. The valves can be electrogates, each including a liquid-pinning trench arranged in a respective one of the auxiliary channels that define a flow path for a liquid introduced therein, so as to form an opening that extends across said flow path. Each electrogate can further include an electrode extending across the flow path.
    Type: Grant
    Filed: February 21, 2019
    Date of Patent: December 13, 2022
    Assignee: International Business Machines Corporation
    Inventors: Marie Salva, Yuksel Temiz, Yulieth Cristina Arango, Onur Gökçe, Emmanuel Delamarche
  • Patent number: 11504713
    Abstract: Viral filters include a filter member featuring a first surface and a second surface and having a thickness extending between the first and second surfaces in a first direction, and a plurality of channels formed in the filter member, each of the channels having a channel axis, where during use, a solution carrying a viral load flows in a direction parallel to the first surface, and at least a portion of the viral load enters the membrane through the first surface and propagates in the first direction, and where for at least 50% of the channels in the filter member, the channel axis is oriented at an angle of between 5 degrees and 85 degrees relative to the first direction.
    Type: Grant
    Filed: March 11, 2020
    Date of Patent: November 22, 2022
    Assignee: Genzyme Corporation
    Inventors: Tarl Vetter, Kevin Brower
  • Patent number: 11491486
    Abstract: Aspects of the present disclosure describe systems, methods, and structures for acoustic wave-based separation of particulates in a fluidic flow. Illustrative systems, methods, and structures according to aspects of the present disclosure may advantageously provide for the continuous, label-free, non-invasive separation of the particulates that include—among other types—difficult-to-separate biological particulates and in particular those in blood including circulating tumor cells and micro-blood-borne particles and other subgroups of extracellular vesicles including nanoscale exosomes.
    Type: Grant
    Filed: August 29, 2018
    Date of Patent: November 8, 2022
    Assignee: Duke University
    Inventors: Jun Huang, Mengxi Wu
  • Patent number: 11493522
    Abstract: A fixed bed (10) is provided for a fixed-bed reactor (100). The fixed bed (10) contains a particulate carrier and at least one reactive substance. The carrier is a silicate compound and the reactive substance is an organometallic pyridine compound. A method for preparing such a fixed bed is provided. The method includes the steps of preparing the carrier, preparing an impregnation and treating the carrier with the impregnation. In addition, a gas-measuring tube is provided with a correspondingly prepared fixed bed as well. A method uses organometallic pyridinium compounds, especially pyridinium dichromate, in a fixed-bed reactor for detecting alcohol compounds and for preparing formaldehyde and/or acetaldehyde.
    Type: Grant
    Filed: May 11, 2016
    Date of Patent: November 8, 2022
    Inventors: Jan Boeckmann, Stefanie Brett
  • Patent number: 11484878
    Abstract: Disclosed is method of manufacturing a microchannel chip by joining together a resin channel substrate having microchannels formed on at least one side thereof and a resin lid substrate, the method including: a step (A) wherein surface modification treatment is applied on joining surfaces of the channel substrate and the lid substrate; and a step (B) wherein, after the step (A), the joining surfaces of the channel substrate and the lid substrate are mated and the channel substrate and the lid substrate are pressurized under heating via a fluid or an elastic body having a durometer hardness of E20 or less.
    Type: Grant
    Filed: March 14, 2018
    Date of Patent: November 1, 2022
    Inventors: Daido Chiba, Kunihito Arai, Taichi Sawaguchi, Mitsukazu Aizawa, Noriyuki Aritome
  • Patent number: 11478793
    Abstract: In an example implementation, a microfluidic device includes a first layer with a first microfluidic channel and a second layer with a second microfluidic channel. The first and second channels are adjacent to one another at a channel intersection, and a conductive membrane valve extends across and covers the channel intersection to separate the first and second channels. The microfluidic device includes a conductive trace to open the membrane valve and join the first and second channels by supplying an electric current to heat and melt a thinned region of the membrane valve.
    Type: Grant
    Filed: October 30, 2017
    Date of Patent: October 25, 2022
    Assignee: Hewlett-Packard Development Company, L.P.
    Inventors: Viktor Shkolnikov, Chien-Hua Chen, Michael W Cumbie
  • Patent number: 11480563
    Abstract: Medical test cards for detecting analytes are provided including a substantially planar body, an analyte detection means, an opening feature, and an optical code. The analyte detection means is enclosed within the planar body and is configured to provide a colorimetric change when a portion of the analyte detection means is contacted with the analyte. The opening feature is configured to provide access to the analyte detection means and the optical code includes information identifying the analyte detection means. Uses of such medical test cards include accessing the analyte detection means enclosed within the planar body by using the opening feature and contacting the analyte detection means with the sample. The optical code is read using an imaging device to identify the analyte detection means and the analyte detection means is imaged following contact with the sample using the imaging device.
    Type: Grant
    Filed: March 25, 2019
    Date of Patent: October 25, 2022
    Assignee: TestCard Ltd.
    Inventors: Luke Heron, Andrew Botham
  • Patent number: 11467069
    Abstract: The sampling chip dividing instrument includes: a main body block; a space that is provided inside the main body block, has an opening leading to an outer surface of the main body block, and fits in and contains the cut portion of the sampling chip through the opening; and an surrounding portion that is provided outside the space at a periphery of the opening, and receives a sample scattered from a break portion of the sampling chip divided near the opening.
    Type: Grant
    Filed: January 5, 2017
    Date of Patent: October 11, 2022
    Inventors: Ippei Takauchi, Shinobu Kudoh
  • Patent number: 11467459
    Abstract: An electrochromic device comprising a substrate, a set of electrodes disposed on or within the substrate, and a layer comprising ?-WO3 disposed in electrical communication with the set of electrodes, wherein the layer of ?-WO3 exhibits polarization switching are described. Methods of making and using the electrochromic devices are also described. The electrochromic devices are used for detecting acetone in a fluid. The observed change in color of the ?-WO3 layer can be correlated with a subject's medical condition, such as diabetes.
    Type: Grant
    Filed: February 5, 2019
    Date of Patent: October 11, 2022
    Assignee: Ohio State Innovation Foundation
    Inventors: Pelagia I. Gouma, Owen Oladele Abe