Abstract: Viral filters include a filter member featuring a first surface and a second surface and having a thickness extending between the first and second surfaces in a first direction, and a plurality of channels formed in the filter member, each of the channels having a channel axis, where during use, a solution carrying a viral load flows in a direction parallel to the first surface, and at least a portion of the viral load enters the membrane through the first surface and propagates in the first direction, and where for at least 50% of the channels in the filter member, the channel axis is oriented at an angle of between 5 degrees and 85 degrees relative to the first direction.

Abstract: Aspects of the present disclosure describe systems, methods, and structures for acoustic wave-based separation of particulates in a fluidic flow. Illustrative systems, methods, and structures according to aspects of the present disclosure may advantageously provide for the continuous, label-free, non-invasive separation of the particulates that include—among other types—difficult-to-separate biological particulates and in particular those in blood including circulating tumor cells and micro-blood-borne particles and other subgroups of extracellular vesicles including nanoscale exosomes.

Abstract: A fixed bed (10) is provided for a fixed-bed reactor (100). The fixed bed (10) contains a particulate carrier and at least one reactive substance. The carrier is a silicate compound and the reactive substance is an organometallic pyridine compound. A method for preparing such a fixed bed is provided. The method includes the steps of preparing the carrier, preparing an impregnation and treating the carrier with the impregnation. In addition, a gas-measuring tube is provided with a correspondingly prepared fixed bed as well. A method uses organometallic pyridinium compounds, especially pyridinium dichromate, in a fixed-bed reactor for detecting alcohol compounds and for preparing formaldehyde and/or acetaldehyde.

Abstract: Disclosed is method of manufacturing a microchannel chip by joining together a resin channel substrate having microchannels formed on at least one side thereof and a resin lid substrate, the method including: a step (A) wherein surface modification treatment is applied on joining surfaces of the channel substrate and the lid substrate; and a step (B) wherein, after the step (A), the joining surfaces of the channel substrate and the lid substrate are mated and the channel substrate and the lid substrate are pressurized under heating via a fluid or an elastic body having a durometer hardness of E20 or less.

Abstract: Medical test cards for detecting analytes are provided including a substantially planar body, an analyte detection means, an opening feature, and an optical code. The analyte detection means is enclosed within the planar body and is configured to provide a colorimetric change when a portion of the analyte detection means is contacted with the analyte. The opening feature is configured to provide access to the analyte detection means and the optical code includes information identifying the analyte detection means. Uses of such medical test cards include accessing the analyte detection means enclosed within the planar body by using the opening feature and contacting the analyte detection means with the sample. The optical code is read using an imaging device to identify the analyte detection means and the analyte detection means is imaged following contact with the sample using the imaging device.

Abstract: In an example implementation, a microfluidic device includes a first layer with a first microfluidic channel and a second layer with a second microfluidic channel. The first and second channels are adjacent to one another at a channel intersection, and a conductive membrane valve extends across and covers the channel intersection to separate the first and second channels. The microfluidic device includes a conductive trace to open the membrane valve and join the first and second channels by supplying an electric current to heat and melt a thinned region of the membrane valve.

Abstract: An electrochromic device comprising a substrate, a set of electrodes disposed on or within the substrate, and a layer comprising ?-WO3 disposed in electrical communication with the set of electrodes, wherein the layer of ?-WO3 exhibits polarization switching are described. Methods of making and using the electrochromic devices are also described. The electrochromic devices are used for detecting acetone in a fluid. The observed change in color of the ?-WO3 layer can be correlated with a subject's medical condition, such as diabetes.

Abstract: The sampling chip dividing instrument includes: a main body block; a space that is provided inside the main body block, has an opening leading to an outer surface of the main body block, and fits in and contains the cut portion of the sampling chip through the opening; and an surrounding portion that is provided outside the space at a periphery of the opening, and receives a sample scattered from a break portion of the sampling chip divided near the opening.

Abstract: Methods are provided for determining the amount of an IGF-I and/or IGF-II protein in a sample using high resolution/high accuracy mass spectrometry. The methods generally comprise enriching an IGF-I and/or IGF-II protein in a sample, ionizing an IGF-I and/or IGF-II protein from the sample to generate IGF-I and/or IGF-II protein ions, and determining the amount of IGF-I and/or IGF-II protein ions with high resolution/high accuracy mass spectrometry.

Abstract: Examples include microfluidic devices. Example microfluidic devices comprise a microfluidic channel, a capillary chamber, and a fluidic actuator. The microfluidic channel is fluidly connected to the capillary chamber. The capillary chamber is to restrict flow of fluid therethrough. The fluidic actuator is positioned proximate the capillary chamber. The fluidic actuator is to actuate to thereby initiate flow of fluid through the capillary chamber.

Abstract: Viral filters include a filter member featuring a first surface and a second surface and having a thickness extending between the first and second surfaces in a first direction, and a plurality of channels formed in the filter member, each of the channels having a channel axis, where during use, a solution carrying a viral load flows in a direction parallel to the first surface, and at least a portion of the viral load enters the membrane through the first surface and propagates in the first direction, and where for at least 50% of the channels in the filter member, the channel axis is oriented at an angle of between 5 degrees and 85 degrees relative to the first direction.

Abstract: Systems and methods for using microfluidic devices to concentrate cells, to perform buffer changes, to sort cells based on size, and/or to isolate particular types of cells in a rapid manner, are presented. Cells flow into a matrix of posts, wherein the posts are distributed along diagonal lines in the chamber. The cells are deflected in a lateral manner, towards a side of a chamber and are collected upon exiting the chamber.

Abstract: A pathological specimen preparation device includes a stage portion including a stage, a reagent supply portion 150 capable of supplying a reagent to a substrate W mounted on the stage, a washing portion capable of supplying a washing solution to the substrate, an electric field stirring portion capable of stirring the reagent or the washing solution supplied to the substrate by applying an electric field to the reagent or the washing solution, and a control unit, wherein the washing portion, the reagent supply portion, and the electric field stirring portion are sequentially disposed in a Y direction as a first direction, and the device includes a stage transport mechanism that moves the stage in the Y direction, and a stage tilting mechanism that tilts the stage in an X direction as a second direction crossing the Y direction when the stage is positioned in the washing portion.

Abstract: A diagnostic device is described herein that can be used to perform magneto-optical detection and discernment of crystals within a biofluid sample. A magnetic field can be applied by the diagnostic device in a direction relative to light traveling through the sample. The presence of a crystal can be determined based on the magneto-optical properties of the sample. The detected crystal can be one of two similar crystal types that may be in the biofluid sample. The two similar crystal types can exhibit different magneto-optical properties under a magnetic field in a different direction. Accordingly, the type of crystal can be discerned by applying the magnetic field in the different direction as light travels through the sample. Discernment of the type of crystal can lead to diagnosis of the particular disease condition and subsequent proper treatment of the disease condition.

Abstract: Disclosed is a liquid sending method for sending liquid to a sample processing chip having a flow path formed therein, the method including: measuring a flow of a second liquid which is different from a first liquid which is introduced into the flow path in the sample processing chip; controlling the flow of the second liquid on the basis of the measured flow; and introducing the first liquid into the flow path in the sample processing chip by means of the second liquid of which flow is controlled.

Abstract: A microchannel device includes: a channel unit which is configured of a plurality of channel members which are laminated in a thickness direction to define a microchannel, at least one of the channel members being made of a material having elasticity; and a holding member which is provided separately from or integrally with the channel unit and holds the channel unit in a state of being compressed in the thickness direction.

Abstract: Sampling systems and techniques that increase pickup efficiency and shedding efficiency of an analyst of interest collected from a surface are provided. In one aspect, an absorbent swab collects an analyte of interest, such as a hazardous contaminant, from a test area demarcated by a template. The sampling techniques can include swab speed and force protocols specifying how fast and how hard the user should apply the swab across the surface to improve pickup efficiency. The sampling techniques can include instructions for inverting a container enclosing the swab and collected contaminant to improve shedding efficiency from the swab.

Abstract: According to some aspects, a sample isolation kit is provided. The sample isolation kit includes a housing configured to detachably couple to a sample fluid channel of a microchip and provide a sample to the microchip. The housing and the microchip are coupled using a hermetic seal. The sample isolation kit further includes a storage housing configured to detachably couple to an isolation channel of the microchip and receive a target biological sample isolated from the sample by the microchip. The storage housing and the microchip are coupled using a hermetic seal.

Abstract: Fluorescent test paper for detecting mercury ions is firstly prepared, the fluorescent test paper including a fluorescence development area and a standard fluorescent colorimetric card. With reference to an excited color corresponding to a reference channel in the standard colorimetric card, the color corresponding to a carbon quantum dots distribution area on the fluorescent test paper is observed to check the fluorescence detection environment during detection with the fluorescent test paper. In colorimetric detection of the content of mercury ions, the concentration of Hg2+ is detected based on an excited color, in the standard colorimetric card, that corresponds to a standard mercury ion sample and is closest to a color signal in a copper nanoclusters distribution area on the fluorescent test paper.

Abstract: A disposable system, in some embodiments, includes a multi-channel or multi-chamber test cartridge device configured to operate with a testing system for evaluation of hemostasis in a subject by in vitro evaluation of a test sample from the subject. The disposable system, in some embodiments, is configured to interrogate the test sample to evaluate clot stiffness, strength, or other mechanical properties of the test sample to assess the function of various physiological processes occur during coagulation and/or dissolution of the resulting clot.