Patents Examined by Louise W Humphrey
  • Patent number: 11932880
    Abstract: The present invention provides a protein having pentosidine oxidase activity, a method for measuring pentosidine comprising: contacting the protein with a specimen; and detecting a change caused by the contact, and the like.
    Type: Grant
    Filed: February 27, 2019
    Date of Patent: March 19, 2024
    Assignee: Kikkoman Corporation
    Inventors: Kazuya Marushima, Yuka Saito, Yuki Tsukada, Takuya Sato, Yasuko Araki, Atsushi Ichiyanagi
  • Patent number: 11879123
    Abstract: Modified probiotics, pharmaceutical compositions thereof, and methods of modulating and treating disorders are disclosed.
    Type: Grant
    Filed: June 21, 2018
    Date of Patent: January 23, 2024
    Assignee: Synlogic Operating Company, Inc.
    Inventors: Dean Falb, Adam B. Fisher, Vincent M. Isabella, Jonathan W. Kotula, David Lubkowicz, Paul F. Miller, Yves Millet, Sarah Elizabeth Rowe
  • Patent number: 11839635
    Abstract: A method against Salmonella typhimurium infection includes using a composition containing cultures of Lactobacillus rhamnosus LRH10 which is deposited at the Deutsche Sammlung von Mikroorganismen and Zellkulturen (DSMZ) GmbH under an accession number DSM 32786, Lactobacillus paracasei LPC12 which is deposited at the DSMZ GmbH under an accession number DSM 32785, Lactobacillus fermentum LF26 which is deposited at the DSMZ GmbH under an accession number DSM 32784, Streptococcus thermophilus ST30 which is deposited at the DSMZ GmbH under an accession number DSM 32788, and Lactobacillus helveticus LH43 which is deposited at the DSMZ GmbH under an accession number DSM 32787.
    Type: Grant
    Filed: September 28, 2022
    Date of Patent: December 12, 2023
    Assignee: SYNBIO TECH INC.
    Inventors: Shih-Hsuan Lin, Ai-Hua Hsu, Chia-Chia Lee
  • Patent number: 11826336
    Abstract: This disclosure relates to nutritional formulas and uses for treating or preventing a gastrointestinal condition and/or motor-planning speech and/or coordinator difficulties. In certain embodiments, this disclosure relates to a nutritional formula comprising medium chain fatty acids, or esters thereof (such as and tri-, di-, mono-glycerides, or alkyl esters), unsaturated fatty acids, and a vitamin E and optionally other nutrients. In certain embodiments, any of the compounds or nutrients may be in alternative salt forms.
    Type: Grant
    Filed: June 1, 2021
    Date of Patent: November 28, 2023
    Assignees: Emory University, Children's Healthcare of Atlanta, Inc.
    Inventor: Claudia R. Morris
  • Patent number: 11814757
    Abstract: A method of forming a substrate includes mapping a three dimensional spatial distribution of at least one structural protein fiber of extracellular matrix of biological material of interest, designing a fiber assembly pattern based on an intrinsic pattern of the at least one structural protein fiber of the extracellular matrix of the biological material, and assembling fibers based on the fiber assembly pattern to form the substrate.
    Type: Grant
    Filed: June 15, 2016
    Date of Patent: November 14, 2023
    Assignee: BIOCONIX PTY LTD.
    Inventor: Melissa Knothe Tate
  • Patent number: 11806375
    Abstract: An algal biomass and supernatant derived from at least one species of algae exhibits the ability to maintain general health in humans and non-human animals and promote a healthy immune system in them. Food, feed and nutritional supplements comprising an algal biomass or supernatant derived from at least one species of algae are described. Methods of maintaining general health or promoting a healthy immune system in humans and non-human animals comprises administering to the animal in need thereof an algal biomass or supernatant derived from at least one species of algae, or an extract, derivative or homeopathic compound derived from the algae species, biomass or supernatant, or a composition thereof.
    Type: Grant
    Filed: February 15, 2017
    Date of Patent: November 7, 2023
    Assignee: Zivo Bioscience, Inc.
    Inventors: Andrew A. Dahl, Amy E. Steffek
  • Patent number: 11807847
    Abstract: The invention belongs to the field of cosmetic biotechnology, and specifically relates to an Enterobacter that degrades hyaluronic acid and a cultivation method and application thereof. The Enterobacter sp. CGJ001 of the present invention was deposited in the China General Microbiological Culture Collection Center on Oct. 10, 2019, and the preservation number is CGMCC NO. 18661. The Enterobacter strain can efficiently produce hyaluronidase, and can be used in the process of preparing low molecular hyaluronic acid and oligomeric hyaluronic acid from high molecular hyaluronic acid. The enzyme has high specificity towards hyaluronic acid, excellent thermal stability and pH stability, and is suitable for large-scale industrial application. Thus, it can replace the traditional hyaluronidase extracted from expensive animal tissues. There should be broad application prospects in the fields of medicine and cosmetics.
    Type: Grant
    Filed: August 8, 2022
    Date of Patent: November 7, 2023
    Assignee: JIANGNAN UNIVERSITY
    Inventors: Jinsong Shi, Zhenghong Xu, Jinsong Gong, Wei Liu, Hui Li, Jianying Qian, Lei Liu, Qing Li, Mengyi Zhang, Chuanli Kang
  • Patent number: 11807586
    Abstract: Synthetic compositions comprising a plant element and at least one fungal endophyte are described. The fungal endophyte is capable of improving plant tolerance to biotic stress as compared to a reference plant element not further comprising the endophyte. Examples of biotic stress include the biotic stress caused by a nematode, an aphid, a fleahopper, a lygus bug, a stink bug, a soy looper, a cabbage looper, or a fungus.
    Type: Grant
    Filed: December 22, 2017
    Date of Patent: November 7, 2023
    Assignee: THE TEXAS A&M UNIVERSITY SYSTEM
    Inventor: Gregory A. Sword
  • Patent number: 11793196
    Abstract: The present invention relates to a fusion protein having a targeting sequence, exosporium protein, or exosporium protein fragment that targets the fusion protein to the exosporium of a recombinant Bacillus cereus family member and an enzyme having serine protease activity, wherein the enzyme having serine protease activity is from Bacillus firmus or is a variant of such enzyme. The present invention also provides a recombinant Bacillus cereus family member that expresses such fusion protein and exosporium fragments derived from such recombinant Bacillus cereus family member. Methods of using such recombinant Bacillus cereus family members or exosporium fragments derived therefrom for nematode control are also provided.
    Type: Grant
    Filed: March 18, 2020
    Date of Patent: October 24, 2023
    Assignee: Bayer CropScience LP
    Inventors: Damian Curtis, Kevin Bugg
  • Patent number: 11786601
    Abstract: A pegylated, circularly permuted construct of the CapD enzyme (a gamma glutamyl transferase enzyme acting as a hydrolase specific to poly-?-D-glutamic acid) is used to treat anthrax and other bacterial infections, including but not limited to infection with strains that are resistant to available antibiotics.
    Type: Grant
    Filed: January 18, 2022
    Date of Patent: October 17, 2023
    Assignee: The Government of the United States of America, as represented by the Secretary of the Navy
    Inventors: Patricia M. Legler, Arthur M. Friedlander, Jaimee R. Compton
  • Patent number: 11767545
    Abstract: A microorganism having at least one SPX gene encoding SPX protein responsive to phosphorus deficiency, and characterized in that a function of the SPX protein is decreased or lost by introducing gene mutation into the SPX gene.
    Type: Grant
    Filed: September 6, 2019
    Date of Patent: September 26, 2023
    Assignees: HIROSHIMA UNIVERSITY, TOKYO INSTITUTE OF TECHNOLOGY, MAZDA MOTOR CORPORATION
    Inventors: Atsushi Sakamoto, Kumiko Okazaki, Takashi Yamamoto, Hiroyuki Ohta, Koichi Hori, Shinsuke Shimizu, Akihide Takami, Seiji Nomura, Fumihiko Saito
  • Patent number: 11759486
    Abstract: A method for treating an immune disease caused by a Th1/Th2 imbalance in favor of a Th2 shift in a subject including administering a composition comprising Lactobacillus plantarum CJLP133 strain KCTC 11403BP to the subject in need thereof.
    Type: Grant
    Filed: October 21, 2020
    Date of Patent: September 19, 2023
    Assignee: CJ CHEILJEDANG CORP.
    Inventors: Bong Joon Kim, Heon Woong Jung, Se Hee Hwang, Jin Hee Lee, Kang-Pyo Lee, Kwang Woo Hwang, Tae Joon Won
  • Patent number: 11744865
    Abstract: A composition for inhibiting lipofuscin accumulation or removing lipofuscin is disclosed. A Chryseobacterium sp. strain, a lysate of the Chryseobacterium sp. strain, a culture of the Chryseobacterium sp. strain, or an extract of the lysate or culture is included in the composition. The composition provides an anti-aging effect by inhibiting lipofuscin accumulation or removing lipofuscin. The composition also provides an effect of preventing, ameliorating or treating the diseases caused by the lipofuscin accumulation, such as skin hyperpigmentation, Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, myocardial infarction and age-related macular degeneration.
    Type: Grant
    Filed: April 22, 2022
    Date of Patent: September 5, 2023
    Assignee: Amorepacific Corporation
    Inventors: Eunmi Kim, Juewon Kim, Si Young Cho, Mihee Ji
  • Patent number: 11746067
    Abstract: The present invention comprises methods and compositions comprising a microalgae consortium. A composition comprises at least one genera of microalgae flocculated by Paenibacillus polymyxa strain, Strain 2, deposited under the Budapest Treaty as ATCC Accession No. PTA-12841. Methods of treating the soil comprise adding a composition of the present invention to soil.
    Type: Grant
    Filed: October 29, 2019
    Date of Patent: September 5, 2023
    Assignee: Core Intellectual Properties Holdings, LLC
    Inventors: Luke Blotsky, Karin L. Hastings, Derex Q. Zellars
  • Patent number: 11740249
    Abstract: Provided herein are compositions and methods for detection and analysis of intracellular binding of a bioactive agent to a cellular target. In particular, bioactive agents tethered to fluorophores, cellular targets fused to bioluminescent reporters, and methods of detecting and analyzing the interaction of bioactive agents with cellular targets therewith.
    Type: Grant
    Filed: September 4, 2018
    Date of Patent: August 29, 2023
    Assignee: Promega Corporation
    Inventors: Carolyn W. Hitko, Thomas Kirkland, Thomas Machleidt, Rachel Friedman Ohana, Matt Robers, Keith Wood
  • Patent number: 11732277
    Abstract: A method for producing high purity iron oxide nanoparticles using nanoparticle-producing cells, including: a) a pre-growth step that includes amplifying the nanoparticle-producing cell(s) in a pre-growth and/or fed-batch medium/media, and b) a growth step that includes amplifying the nanoparticle-producing cell(s) originating from the pre-growth step in a growth and/or fed-batch medium/media, wherein the pre-growth and/or growth and/or fed-batch medium/media comprise(s), per kilogram or liter of pre-growth and/or growth and/or fed-batch medium/media: i) no more than 0.005 gram of yeast extract, and ii) no more than 0.001 gram of CMR agent selected from boric acid and nitrilotriacetic acid, wherein the fed-batch medium when it is present is a medium that supplements the pre-growth and/or growth medium/media, and wherein more nanoparticles are produced in the growth step than in the pre-growth step.
    Type: Grant
    Filed: October 1, 2019
    Date of Patent: August 22, 2023
    Assignee: NANOBACTERTE
    Inventor: Edouard Alphandery
  • Patent number: 11730779
    Abstract: The present invention provides a lactic acid bacterial composition for inhibiting the activity of Escherichia coli and/or treating or preventing jaundice, the composition including: a Bifidobacterium animalis subsp. lactis CP-9 strain and a Lactobacillus salivarius subsp. salicinius AP-32 strain. The present invention further provides a method for inhibiting growth of Escherichia coli, the method including the step(s) of: administering the foregoing lactic acid bacterial composition to a subject in need thereof. The present invention additionally provides a method for treating or preventing jaundice, the method including the step(s) of: administering the foregoing lactic acid bacterial composition to a subject in need thereof.
    Type: Grant
    Filed: February 11, 2022
    Date of Patent: August 22, 2023
    Assignee: GLAC BIOTECH CO., LTD
    Inventors: Hsieh-Hsun Ho, Yi-Wei Kuo, Jia-Hung Lin, Hui-Shan Wang, Yen-Yu Huang, Wen-Yang Lin, Ko-Chiang Hsia
  • Patent number: 11732009
    Abstract: A nanoparticle activity sensor containing a reporter and at least one tuning domain that modifies a distribution or residence time of the activity sensor when administered to a patient. When administered to the patient, the activity sensor enters cells or tissue where it is cleaved by enzymes specific to a physiological state such as a disease to release a detectable analyte. The tuning domains include molecular structures that modulate distribution or decay by protecting the particle from premature cleavage and indiscriminate hydrolysis, shielding the particle from immune detection and clearance, or by targeting the particle to specific tissue, bodily fluids, or cell types.
    Type: Grant
    Filed: March 15, 2019
    Date of Patent: August 22, 2023
    Assignee: GLYMPSE BIO, INC.
    Inventors: Sangeeta Bhatia, Gabriel Kwong, Eric Huang, Sirshendu Roopom Banerjee, Andrew Warren, Sophie Cazanave
  • Patent number: 11725193
    Abstract: [Problem] To provide a glucose dehydrogenase with high thermal stability to be used in blood sugar measurement. [Solution to Problem to problem] A modified glucose dehydrogenase with an excellent property of high thermal stability that can be obtained by modifying some of amino acids constituting a protein such as a wild-type glucose dehydrogenase, a polynucleotide encoding the enzyme, a method for manufacturing the enzyme, a method for measuring glucose using the enzyme, a measuring reagent composition and a biosensor, and methods for manufacturing the measuring reagent composition and the biosensor.
    Type: Grant
    Filed: May 25, 2018
    Date of Patent: August 15, 2023
    Assignee: IKEDA FOOD RESEARCH CO., LTD.
    Inventors: Michinari Honda, Hirokazu Sanada, Ryo Takenaka, Takafumi Takumi, Takahiro Fujii
  • Patent number: 11718842
    Abstract: A dehydrated composition containing a particle encapsulating one or more microorganisms is provided. The composition is useful for controlling the release of the microorganisms following rehydration and propagation within the particle.
    Type: Grant
    Filed: July 24, 2019
    Date of Patent: August 8, 2023
    Assignee: LAVIE BIO LTD.
    Inventors: Michael Ionescu, Galit Kuznets, Amir Bercovitz, Yossi Singer, Hagai Karchi